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| 1 | Antimicrobial Activity of the Methanolic Extract and Compounds from the Stem Bark of Drypetes tessmanniana显示文摘从茎评估甲醇摘录的抗菌剂活动的目的 Drypetes tessmanniana ,部分( DTB1-5 )以及混合物吠叫[ friedelin ( 2 ), 3,7-dioxofriedelane ( 3 ), 3,15-dioxofriedelane ( 4 ), 3 尾-O-(E) -3,5-dihydroxycinnamoyl-11-oxo-olean-12-ene ( 6 ),和 3 尾, 6 伪- dihydroxylup-20 ( 29 ) -ene ( 7 )。方法琼脂圆盘散开被用来决定上述样品的敏感,虽然 microdilution 方法被用于最小的禁止的集中(MIC ) 和最小的 microbicidal 集中(MMC ) 的决心。散开测试显示出的结果粗略的摘录能阻止所有的生长,这测试了有机体。所有另外的样品显示出选择活动。部分 DTB2 的禁止的效果在 63.7% 上被注意, 54.6% 上的 DTB1 和 DBT3,虽然 DTB4 和 DTB5 开是活跃的, 11 中的 9.1% 个测试了有机体。测试混合物为混合物阻止了 81.8% 测试微生物引起的种类的生长 3 和 4, 36.7% 为化合物 6,和 18.2% 为化合物 7。MIC 决心的结果为 DTB 和化合物显示了可察觉的价值 4 在 81.8% 测试有机体上。为另外的样品, MIC 在 0 鈥 ? 上被检测 3.7% 。为粗略的摘录和部分(DTB2 ) 的最低 MIC 价值(78.12 渭 g /mL ) 在 M 上被观察。audouinii。为孤立的混合物(156.25 渭 g /mL ) 的相应价值与混合物被注意 3 在 S 上。faecalis 并且 4 在 M 上。audouinii audouinii。MMC 决心的结果建议大多数学习微生物上的测试样品的 microbicidal 效果能被期望。结论从茎的甲醇摘录 Drypetes 吠叫。象一些孤立的混合物一样的 tessmanniana (Euphorbiaceae ) 可能是新抗菌剂药的潜在的来源。关键词 Drypetes tessmanniana - Euphorbiaceae - 混合物 - 抗菌剂活动为科学由国际基础支持了(没有。IFS/2624-3F ) 。 | Victor Kuete Marlise D.J.Dongfack Armelle T.Mbaveng Marie-Christine Lallemand Hanh T.Van-Dufat Jean-Duplex Wansi Elisabeth Seguin Francois Tillequin Jean Wandji | 2010 | Chinese Journal of Integrative Medicine2010，16，4： | 7 |
| 2 | Antibacterial and Antibiotic-Potentiation Activities of Some Cameroonian Food Plants against Multi-Drug Resistant Gram-Negative Bacteria显示文摘Objective:To evaluate the in vitro antibacterial properties and the ability to potentiate some common antibiotics effects of the methanol extracts of 11 Cameroonian food plants on 29 Gram-negative bacteria expressing multidrug resistant(MDR) phenotypes.Methods:The antimicrobial activity of the extracts was performed using the broth microdilution method.The phytochemical screening of these extracts was also performed using standard methods.Resutts:Ocimum basilicum,Gnetum africanum and Eucalyptus robusta extracts possessed an antibacterial activity against all the 29 studied bacteria.The extracts from G.africanum and E.robusta were the most active with the lowest minimal inhibitory concentration of 64 μg/mL on Escherichia coli AG100 A for both extracts and also against Klebsiella pneumoniae K24 for G.africanum.When tested in the presence of phenylalanine-arginine β-Naphtylamide(PA β N),an efflux pump inhibitor,the extract of Thymus vulgaris and E.Robusta showed the best activities on most tested strains.E.Robusta extract showed good synergistic effects,improving the activity of commonly used antibiotics in about 85%of cases.Conclusion:The overall results obtained provide the baseline information for the use of the tested plants in the treatment of bacterial infections. | Simplice B.Tankeo Stephen T.Lacmata Jaures A.K.Noumedem Jean P.Dzoyem Jules R Kuiate Victor Kuete | 2014 | Chinese Journal of Integrative Medicine2014，20，7： | 7 |
| 3 | 智能脉冲仪治疗颈型颈椎病的临床效果显示文摘目的观察Impulse IQ智能脉冲仪治疗颈型颈椎病临床疗效及其机理研究。方法将2018年6月至12月40例颈型颈椎病患者按照随机数字表法随机分为脉冲枪组(n=20)和牵引组(n=20),两组均接受常规康复治疗(近红外线),15min/次;脉冲枪组加用Impulse IQ智能脉冲仪,10min/次;牵引组加用颈椎牵引,15min/次;上述所有治疗1次/d,5次/周,共治疗4周。以疼痛量表(McGill)和颈椎残障功能指数(NDI)作为疗效评估指标;采用表面肌电图记录患者患侧斜方肌上束及颈夹肌的肌电信号,以平均肌电值(AEMG)和中位频率(MF)作为表面肌电信号评估指标;通过颈椎X线侧位片Borden法测量颈椎曲度弓深值(D)。结果治疗后,两组患者McGill指数和NDI指数评分均较治疗前显著降低(P<0.01);患侧斜方肌上束和颈夹肌AEMG均较治疗前减小(P<0.05,P<0.01),且两组患侧斜方肌上束AEMG比较有统计学差异(P<0.05);两组患者患侧斜方肌上束和颈夹肌MF均大于治疗前(P<0.01);两组患者颈椎曲度D值较治疗前均有明显改善(P<0.01)。结论智能脉冲治疗仪和颈椎牵引治疗颈型颈椎病均能进一步缓解患者颈部疼痛,改善颈椎残障功能;脉冲治疗仪方便、实用、耗时短。 | 曹雪丽 华启海 江勇 徐磊 Kuete KCD 王敏 | 2019 | 中国临床研究2019，32，8： | 7 |
| 4 | Control of malaria and other vector-borne protozoan diseases in the tropics: enduring challenges despite considerable progress and achievements显示文摘Vector-borne protozoan diseases represent a serious public health challenge,especially in the tropics where poverty together with vector-favorable climates are the aggravating factors.Each of the various strategies currently employed to face these scourges is seriously inadequate.Despite enormous efforts,vaccines-which represent the ideal weapon against these parasitic diseases—are yet to be sufficiently developed and implemented.Chemotherapy and vector control are therefore the sole effective attempts to minimize the disease burden.Nowadays,both strategies are also highly challenged by the phenomenon of drug and insecticide resistance,which affects virtually all interventions currently used.The recently growing support from international organizations and governments of some endemic countries is warmly welcome,and should be optimally exploited in the various approaches to drug and insecticide research and development to overcome the burden of these prevalent diseases,especially malaria,leishmaniasis,Human African Trypanosomiasis(HAT),and Chagas disease. | Denis Zofou Raymond B Nyasa Dickson S Nsagha Fidele Ntie-Kang Henry D Meriki Jules Clement N Assob Victor Kuete | 2014 | Infectious Diseases of Poverty2014，3，1： | 4 |
| 5 | High Risk Factors of Pancreatic Carcinoma显示文摘Over the past decades, cancer has become one of the toughest challenges for health professionals. The epidemiologists are increasingly directing their research efforts on various malignant tumor worldwide. Of note, incidence of cancers is on the rise more quickly in developed countries. Indeed, great endeavors have to be made in the control of the life-threatening disease. As we know it, pancreatic cancer(PC) is a malignant disease with the worst prognosis. While little is known about the etiology of the PC and measures to prevent the condition, so far, a number of risk factors have been identified. Genetic factors, pre-malignant lesions, predisposing diseases and exogenous factors have been found to be linked to PC. Genetic susceptibility was observed in 10% of PC cases, including inherited PC syndromes and familial PC. However, in the remaining 90%, their PC might be caused by genetic factors in combination with environmental factors. Nonetheless, the exact mechanism of the two kinds of factors, endogenous and exogenous, working together to cause PC remains poorly understood. The fact that most pancreatic neoplasms are diagnosed at an incurable stage of the disease highlights the need to identify risk factors and to understand their contribution to carcinogenesis. This article reviews the high risk factors contributing to the development of PC, to provide information for clinicians and epidemiologists. | Soriba Naby Camara 殷涛 杨明 李响 龚琼 周静 赵刚 杨智勇 Tajoo Aroun Martin Kuete Sonam Ramdany Alpha Kabinet Camara Aissatou Taran Diallo 冯珍 宁辛 熊炯新 陶京 钦琪 周伟 崔静 黄敏 郭尧 勾善淼 王博 刘涛 Ohoya Etsaka Terence Olivier Tenin Conde Mohamed Cisse Aboubacar Sidiki Magassouba Sneha Ballah Naby Laye Moussa Keita Ibrahima Sory Souare Aboubacar Toure Sadamoudou Traore Abdoulaye Korse Balde Namory Keita Naby Daouda Camara Dusabe Emmanuel 吴河水 王春友 | 2016 | Journal of Huazhong University of Science and Technology(Medical Sciences)2016，36，3： | 3 |
| 6 | A new friedelane triterpenoid and saponin with moderate antimicrobial activity from the stems of Drypetes laciniata显示文摘新 friedelane 类型 triterpene 说出 3-hydroxyfriedelane-7,12,22-trione,以及九已知的混合物从 Drypetes laciniata 兔笼的整个茎被孤立。(Euphorbiaceae ) 。他们的结构根据分光镜的方法被建立。新 triterpene 衍生物和已知的 saponin 为抗菌剂和抗真菌的活动被测试,他们显得中等积极。 | Simone Veronique Fannang Victor Kuete Celine Mbazoa Djama Marlise Diane J.Dongfack Jean Duplex Wansi Francois Tillequin Elisabeth Seguin Elizabeth Chosson Jean Wandji | 2011 | Chinese Chemical Letters2011，22，2： | 2 |
| 7 | Isobavachalcone:An Overview显示文摘Isobavachalcone (IBC ) 或(E)-1-[2,4-dihydroxy-3-(3-methyl-2-butenyl)-phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one 或(E)-4,2,4-trihydroxy-3-prenylchalcone;2,4,4-trihydroxy-3-prenyl-transchalcone,是班 flavonoid 的 prenylated chalcone,第一在 1968 从 Psoralea 孤立 corylifolia。IBC 被知道拥有大量生物活动,抗菌剂,抗真菌, anticancer,反反向的 transcriptase, antitubercular 和抗氧化剂。混合物从植物家庭被孤立,主要 Moraceae 和 Fabaceae。这评论一起拿出 IBC 上的知识,和罐头为未来研究和物价稳定措施成就用作起点。 | Victor Kuete Louis P.Sandjo | 2012 | Chinese Journal of Integrative Medicine2012，18，7： | 2 |
| 8 | Potential of Cameroonian Plants and Derived Products against Microbial Infections: A Review显示文摘 | Victor Kuete | 2010 | Planta Med2010，，14： | 2 |
| 9 | Antimicrobial activity of the crude extracts and compounds from Ficus chlamydocarpa and Ficus cordata (Moraceae) 显示文摘 | Kuete V Ngameni B Fotso Simo C C | 2008 | J Ethnopharmacol2008，120，1： | 1 |
| 10 | Antibacterial ac- tivity of some natural products against bacteria expressing a ul- tidrug-resistant phenotype 显示文摘 | Kuete V Alibert-Franco S Eyong KO | 2011 | Int J Antimicrob Agents2011，37，2： | 1 |
| 11 | Antimicrobial activity of the methanolic extracts and compounds from Vistula laurentii De Wild (Guttiferae) 显示文摘 | Kuete V Nguemeving J R Beng V P | 2007 | Journal of Ethnopharmacology2007，109，： | 1 |
| 12 | Activity of three cytotoxic isoflavonoids from Erythrina excelsa and Erythrina senegalensis (neobavaisoflavone, sigmoidin H and isoneorautenol) toward multi- factorial drug resistant cancer cells 显示文摘 | Kuete V Sandjo LP Kwamou GMN | 2014 | Phytomedicine2014，21，5： | 1 |
| 13 | Antibac-terial activity of some natural products against bacteria expressinga multidrug-resistant phenotype 显示文摘 | KUETE V ALIBERT-FRANCO S EYONG KO | 2011 | Int J Antimicrob Agents2011，37，2： | 1 |
| 14 | Plant-derived secondary metabolites as the main source of efflux pump inhibitors and methods for identification显示文摘The upsurge of multiple drug resistance(MDR)bacteria substantially diminishes the effectiveness of antibiotic arsenal and therefore intensifies the rate of therapeutic failure.The major factor in MDR is efflux pump-mediated resistance.A unique pump can make bacteria withstand a wide range of structurally diverse compounds.Therefore,their inhibition is a promising route to eliminate resistance phenomenon in bacteria.Phytochemicals are excellent alternatives as resistance-modifying agents.They can directly kill bacteria or interact with the crucial events of pathogenicity,thereby decreasing the ability of bacteria to develop resistance.Numerous botanicals display noteworthy efflux pumps inhibitory activities.Edible plants are of growing interest.Likewise,some plant families would be excellent sources of efflux pump inhibitors(EPIs)including Apocynaceae,Berberidaceae,Convolvulaceae,Cucurbitaceae,Fabaceae,Lamiaceae,and Zingiberaceae.Easily applicable methods for screening plant-derived EPIs include checkerboard synergy test,berberine uptake assay and ethidium bromide test.In silico highthroughput virtual detection can be evaluated as a criterion of excluding compounds with efflux substrate-like characteristics,thereby improving the selection process and extending the identification of EPIs.To ascertain the efflux activity inhibition,real-time PCR and quantitative mass spectrometry can be applied.This review emphasizes on efflux pumps and their roles in transmitting bacterial resistance and an update plant-derived EPIs and strategies for identification. | Armel Jackson Seukep Victor Kuete Lutfun Nahar Satyajit DSarker Mingquan Guo | 2020 | Journal of Pharmaceutical Analysis2020，10，4： | 1 |
| 15 | Antimicrobial activity of the methanolic extract and compounds from Morus mesozygia stem bark 显示文摘 | Kuete V Fozing D C Kapehe W F | 2009 | JEthnopharmacol2009，124，3： | 1 |
| 16 | Rotational ver- tebral artery occlusion : A mechanism of verteb robasilar in suffi- ciency显示文摘 | KUET HERTA NEB1T GM CLARK WM | 1997 | Neurosurgery1997，41，： | 1 |
| 17 | Cytotoxicity and modes of action of four naturally occuring benzophenones: 2,2′,5,6′-Tetrahydroxybenzophenone, guttiferone E, isogarcinol and isoxanthochymol显示文摘 | Victor Kuete Patricia D. Tchakam Benjamin Wiench Bathelemy Ngameni Hippolyte K. Wabo Michel F. Tala Marlyse L. Moungang Bonaventure T. Ngadjui Tetsuya Murayama Thomas Efferth | 2013 | Phytomedicine2013，，6： | 1 |
| 18 | Antimicrobial activity of the methanolic extract from the stem bark of Tridesmostemon omphalocarpoides ( Sapotaceae ) 显示文摘 | Kuete V Tangmouo J G Beng V P | 2006 | Journal of Ethnophar-macology2006，104，12： | 1 |
| 19 | Antibacterial activity of some natural products against bacteria expressing a multidrug-resistant phenotype 显示文摘 | Kuete V Alibert-Franco S Eyong KO | 2011 | International Journal of Antimicrobial Agents2011，37，： | 1 |
| 20 | Antibacterial Activities of Selected Cameroonian Plants and Their Synergistic Effects with Antibiotics against Bacteria Expressing MDR Phenotypes显示文摘 | Stephen T. Lacmata Victor Kuete Jean P. Dzoyem Simplice B. Tankeo Gerald Ngo Teke Jules R. Kuiate Jean-Marie Pages Namrita Lall | 2012 | Evidence-Based Complementary and Alternative Medicine2012，，： | 1 |
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