|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 英国胃肠病学会关于胃癌风险患者的诊断和管理指南显示文摘胃癌预后较差,部分原因在于诊断较晚。胃癌的危险因素包括幽门螺杆菌(H.pylori,HP)感染和胃癌家族史,尤其是遗传性弥漫性胃癌和恶性贫血。胃癌发展的阶段包括慢性胃炎、胃黏膜萎缩(GA)、胃黏膜肠化生(GIM)和异型增生。胃癌早期发现和提高生存率的关键是在内镜检查前以非侵入性方式识别高危人群。然而,尽管生物标志物可能有助于检测慢性萎缩性胃炎,但尚无足够的证据支持其用于人群筛查。高质量内镜检查是胃癌早期发现的重要组成部分,图像增强内镜结合组织病理学活检是GA和GIM最佳的诊断方法,并能准确进行风险分层。按照悉尼标准从胃窦、角切迹、小弯和大弯进行活检,既能明确诊断,也能对胃癌进行风险分层。理想状态应当是在高质量内镜检查中对GA或GIM区域活检。英国属于低危地区,可根据需要接受常规诊断性胃镜检查,但没有足够证据支持筛查,对于广泛GA或GIM的患者,每3年检查内镜。对于胃异型增生和早期癌,只要满足标准,内镜下黏膜切除术或内镜黏膜下剥离术的治疗有效,成功率高,复发率低。 | Matthew Banks David Graham Marnix Jansen TakujiGotoda Sergio Coda Massimiliano di Pietro NoriyaUedo Pradeep Bhandari D Mark Pritchard Ernst J Kuipers Manuel Rodriguez-Justo Marco R Novelli KrishRagunath Neil Shepherd Mario Dinis-Ribeiro 乌雅罕(译) 张冬雪(译) 牛占岳(校) 刘鑫(校) 丁士刚(译/校) | 2020 | 中华胃肠内镜电子杂志2020，7，2： | 10 |
| 2 | Emerging roles of the intestine in control of cholesterol metabolism显示文摘The liver is considered the major “control center” for maintenance of whole body cholesterol homeostasis. This organ is the main site for de novo cholesterol synthesis, clears cholesterol-containing chylomicron remnants and low density lipoprotein particles from plasma and is the major contributor to high density lipoprotein (HDL; good cholesterol) formation. The liver has a central position in the classical definition of the reverse cholesterol transport pathway by taking up periphery-derived cholesterol from lipoprotein particles followed by conversion into bile acids or its direct secretion into bile for eventual removal via the feces. During the past couple of years, however, an additional important role of the intestine in maintenance of cholesterol homeostasis and regulation of plasma cholesterol levels has become apparent. Firstly, molecular mechanisms of cholesterol absorption have been elucidated and novel pharmacological compounds have been identified that interfere with the process and positively impact plasma cholesterol levels. Secondly, it is now evident that the intestine itself contributes to fecal neutral sterol loss as a cholesterol-secreting organ. Finally, very recent work has unequivocally demonstrated that the intestine contributes significantly to plasma HDL cholesterol levels. Thus, the intestine is a potential target for novel anti-atherosclerotic treatment strategies that, in addition to interference with cholesterol absorption, modulate direct cholesterol excretion and plasma HDL cholesterol levels. | Janine K Kruit Albert K Groen Theo J van Berkel Folkert Kuipers | 2006 | World Journal of Gastroenterology2006，12，40： | 4 |
| 3 | A numerical model of gas-fluidized beds显示文摘 | Kuipers J A M Van Duin K J Van Beckum F P H | 1992 | Chem Eng Sci1992，47，5： | 4 |
| 4 | Adenoma detection with cap-assisted colonoscopy versus regular colonoscopy: a randomised controlled trial显示文摘 | Thomas R de Wijkerslooth Esther M Stoop Patrick M Bossuyt Elisabeth M H Mathus-Vliegen Jan Dees Kristien M A J Tytgat Monique E van Leerdam Paul Fockens Ernst J Kuipers Evelien Dekker | 2012 | Gut2012，，10： | 3 |
| 5 | Challenges in the management of acute peptic ulcer bleeding显示文摘 | James YW Lau Alan Barkun Dai-ming Fan Ernst J Kuipers Yun-sheng Yang Francis KL Chan | 2013 | The Lancet2013，，9882： | 3 |
| 6 | Aberrant p53 protein expression is associated with an increased risk of neoplastic progression in patients with Barrett’s oesophagus显示文摘 | Florine Kastelein Katharina Biermann Ewout W Steyerberg Joanne Verheij Marit Kalisvaart Leendert H J Looijenga Hans A Stoop Laurens Walter Ernst J Kuipers Manon C W Spaander Marco J Bruno | 2013 | Gut2013，，12： | 2 |
| 7 | Interleukins in atherosclerosis:molecular pathway sand therapertic potential显示文摘 | Von der Thusen JH Kuiper J van Berkel TJ | 2003 | Pharmacol Rev2003，55，1： | 1 |
| 8 | Receptors, mediators, and mechanisms involved in bacterial sepsis and septic shock显示文摘 | Van Amersfoort ES Van Berkel TJ Kuiper J | 2003 | Ctin Microbiol Rev2003，16，3： | 1 |
| 9 | Qualitative Simulation: Then and Now显示文摘 | | 1993 | Artificial Intelligence1993，59，： | 1 |
| 10 | Theoretical comparison of packed bed and fluidized bed membrane reactors for methane reforming显示文摘 | Gallucci F Sintannaland M V Kuipers J A M | 2010 | Int J Hydrogen Energy2010，35，13： | 1 |
| 11 | Influence of size and polarity of rsidue 31 in porcine pancreatic-phospholipase A2 on catalytic properties显示文摘 | Kuipers OP Kerver J Van Meerohergen J | 1990 | Protein Engineering 19901990，599，： | 1 |
| 12 | Differential distribution and regulation of estrogen receptor-alpha and receptor-beta within the female rat brain显示文摘 | Otherland M Kuiper GG Gustasson J | 1998 | Mol Brain Res1998，54，3： | 1 |
| 13 | Numerical simulation of gas-liquid-solid flows using a combined front tracking and discrete particle method显示文摘 | Annaland M V S Deen N G Kuipers J A M | 2005 | Chemical Engineering Science2005，60，11： | 1 |
| 14 | β-helix and ice-binding properties of a hyperactive antifreeze protein from an insect 显示文摘 | Graether sp Kuiper M J Gagne S M | 2000 | Nature2000，406，： | 1 |
| 15 | Upregulation of the transcription factor TFEB in t ( 6 ; 11 ) ( p21 ; q13 ) -positive renal cell carcinomas due to promoter substitution 显示文摘 | Kuiper RP Schepens M Thijssen J | 2003 | Hum Mol Gen- et2003，12，14： | 1 |
| 16 | Local Immune Regulation of Mucosal Inflammation by Tacroli- mus显示文摘 | Lambers ME Kuipers E J van Dieren JM | 2010 | Digest Dis Sci2010，55，9： | 1 |
| 17 | Critical comparison of hydrodynamic models for gas-solid fluidized beds-- Part I: bubbling gas-solid fluidized beds operated with a jet显示文摘 | Patil D J van Sint Annaland M Kuipers J A M | 2005 | Chemical Engineering Science2005，60，1： | 1 |
| 18 | Evaluation o{ the as- tronomical time scale for the Paleocene and earliest Eocene 显示文摘 | Hilgen F J Kuiper K F Lourens L J | 2010 | Earth and Planetary Science Letters2010，300，13： | 1 |
| 19 | Cobalt particle size effects in the Fischer-Tropsch reaction studied with carbon nanofiber supported catalysts显示文摘 | Bezemer G L Bitter J H Kuipers H P | 2006 | J Am Chem Soc2006，128，12： | 1 |
| 20 | Reasoning with qualitative models显示文摘 | | 1993 | Artificial Intelligence (S0004-3702)1993，59，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员