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| 1 | Can baseline ML Flow test results predict leprosy reactions? An investigation in a cohort of patients enrolled in the uniform multidrug therapy clinical trial for leprosy patients in Brazil显示文摘Background:The predictive value of the serology to detection of IgM against the Mycobacterium leprae-derived phenolic glycolipid-I/PGL-I to identify leprosy patients who are at higher risk of developing reactions remains controversial.Whether baseline results of the ML Flow test can predict leprosy reactions was investigated among a cohort of patients enrolled in The Clinical Trial for Uniform Multidrug Therapy for Leprosy Patients in Brazil(U-MDT/CT-BR).Methods:This was a descriptive study focusing on the main clinical manifestations of leprosy patients enrolled in the U-MDT/CT-BR from March 2007 to February 2012 at two Brazilian leprosy reference centers.For research purposes,753 leprosy patients were categorized according to a modified Ridley-Jopling(R&J)classification and according to the development of leprosy reactions(reversal reaction/RR and erythema nodosum leprosum/ENL),and whether they had a positive or negative bacillary index/BI.Results:More than half of the patients(55.5%)reported leprosy reaction:18.3%(138/753)had a RR and 5.4%(41/753)had ENL.Leprosy reactions were more frequent in the first year following diagnosis,as seen in 27%(205/753)of patients,while 19%(142/753)developed reactions during subsequent follow-up.Similar frequencies of leprosy reactions and other clinical manifestations were observed in paucibacillary(PB)and multibacillary(MB)leprosy patients treated with U-MDT and regular MDT(R-MDT)(P=0.43 and P=0.61,respectively).Compared with PB patients,leprosy reactions were significantly more frequent in MB patients with a high BI,and more patients developed RR than ENL.However,RR and neuritis were also reported in patients with a negative BI.At baseline,the highest rate of ML Flow positivity was observed in patients with a positive BI,especially those who developed ENL,followed by patients who had neuritis and RR.Among reaction-free patients,81.9%were ML Flow positive,however,the differences were not statistically significant compared to reactional patients(P=0.45).Conclusions:MB and PB patients treated with R-MDT and U-MDT showed similar frequencies of RR and other clinical manifestations.Positive ML Flow tests were associated with MB leprosy and BI positivity.However,ML Flow test results at baseline showed limited sensitivity and specificity for predicting the development of leprosy reactions. | Emerith Mayra Hungria Regiane Morillas Oliveira Gerson Oliveira Penna Lúcio Cartaxo Aderaldo Maria Araci de Andrade Pontes Rossilene Cruz Heitor de SáGonçalves Maria Lúcia Fernandes Penna Ligia Regina Franco Sansigolo Kerr Mariane Martins de Araújo Stefani Samira Bührer-Sékula | 2016 | Infectious Diseases of Poverty2016，5，1： | 2 |
| 2 | Serum oxytocin levels in patients with depression and the effects of gender and antidepressant treatment显示文摘 | OZSOY S ESEL E KULA M | 2009 | Psychiatry Res2009，169，3： | 1 |
| 3 | Impairment of slow inactivation as a common mechanism for periodic paralysis in DIIS4 - S5 显示文摘 | Bendahhou S Cummins TR Kula RW | 2002 | Neurology2002，58，8： | 1 |
| 4 | Stabilization of NAD-dependent formate dehydrogenase from Candida boidinii by site-directed mutagenesis of cysteine residues显示文摘 | SLUSARCZYK H FELBER S KULA M R | 2000 | European journal of biochemistry2000，267，5： | 1 |
| 5 | Technetium-99m-tetrofosmin imaging with incremental nitroglycerin infusion to detect severely ischaemic but viable myocardium:a comparative study with thallium-201显示文摘 | Kula M Tutus A Unal S | 2003 | Nucl Med Commun2003，24，9： | 1 |
| 6 | Potentials of curcumin as an antidepressant显示文摘 | Kulkarni S hir A kula KK | 2009 | Scientific World Journal2009，9，： | 1 |
| 7 | Technetium - ^99m - tetrofosmin imaging with incremental nitroglycerin infusion to detect severely ischaemic but viable myocardium: a comparative study with thallium - 201显示文摘 | Kula M Tutus A Unal S | 2003 | Nucl Med Commun2003，24，9： | 1 |
| 8 | Stabilization of NAD- dependent formate dehydrogenase from Candida boidinii by sitedirected mutagenesis of cysteine residues 显示文摘 | Slusarczyk H Felber S Kula MR | 2000 | Eur J Biochem2000，267，5： | 1 |
| 9 | Giant right atrial aneurysm: case report 显示文摘 | lmren Y Halit V Kula S | 2006 | Int J Cardiol2006，112，3： | 1 |
| 10 | High Optical Anisotropy Nematic Single Compounds and Mixtures显示文摘 | Gauza S Kula P Dabrowski R | 2012 | Trans Electr Electron Mater2012，13，1： | 1 |
| 11 | Patch - an-tenna miniaturization using recently available ceramic sub-strates 显示文摘 | KULA J S PSYCHOUDAKIS D UAO W J | 2006 | IEEE Antennas and Propagation Magazine2006，48，6： | 1 |
| 12 | Central mervors and cardiovascular effects of iv infusions of ropivacaine,buivacaine and plscibo in Voluneeenrs显示文摘 | Knudsen K Suur Kula MB Blomerg S | 1997 | Br J Anaesth1997，78，： | 1 |
| 13 | Stabilization of NAD-dependent formate dehydrogenase from Candida boi- dinii by site-directed mutagensis of cysteine residues显示文摘 | SLUSARCZYK H FELBER S KULA M R | 2000 | Euro- pean Journal of Biochemistry2000，267，5： | 1 |
| 14 | Serum oxytocin levels in patients with de- pression and the effects of gender and antidepressant treatment显示文摘 | Ozsoy S Esel E Kula M | 2009 | Psy- chiatry Res2009，169，3： | 1 |
| 15 | Plasma membrane-associated protein tyrosine phosphatase activity in hamster spermatozoa显示文摘 | Uma D K Kula N J Shivaji S | 1999 | Mol Reprod Dev1999，53，： | 1 |
| 16 | Circadian variation of QTc dispersion in children with vasovagal syncope 显示文摘 | Kula S Olgunturk R Tunaoglu FS | 2004 | Int J Cardio12004，97，3： | 1 |
| 17 | Subclinical alveolar involvement in ulcerative colitis显示文摘 | GURSOY S GUVEN K KULA M | 2005 | Inflamm Bowel Dis2005，11，： | 1 |
| 18 | Sex differences in lower extremity biomechanics during single leg landings 显示文摘 | Schmitz R J Kulas A S Perrin D H | 2007 | Clinical Biomechanics2007，22，6： | 1 |
| 19 | Doppler tissue imaging provides an estimate of pulmonary arterial pressure in children with pulmonary hypertension due to congenital intracardiac shunts显示文摘 | Cevik A Kula S Olgunturk R | 2013 | Congenit Heart Dis2013，8，： | 1 |
| 20 | Clinical isolates of Trichomonas vaginalis concurrently infected by strains of up to four Trichomonasvirus species(family Totiviridae)显示文摘 | Goodman R P Freret T S Kula T | 2011 | Journal of Virology2011，85，9： | 1 |
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