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| 1 | Strong prognostic value of nodal and bone marrow micro-involvement in patients with pancreatic ductal carcinoma receiving no adjuvant chemotherapy显示文摘AIM: To study the prognostic value of adjuvant chemo-therapy in patients with pancreatic, ductal adenocar-cinoma.METHODS: Lymph nodes from 106 patients with resectable pancreatic ductal adenocarcinoma were systematically sampled. A total of 318 lymph nodes classified histopathologically as tumor-free were examined using sensitive immunohistochemical assays. Forty-three (41%) of the 106 patients were staged as pT1/2, 63 (59%) as pT3/4, 51 (48%) as pN0, and 55 (52%) as pN1. The study population included 59 (56%) patients exhibiting G1/2, and 47 (44%) patients with G3 tumors. Patients received no adjuvant chemo- or radiation therapy and were followed up for a median of 12 (range: 3.5 to 139) mo.RESULTS: Immunostaining with Ber-EP4 revealed nodal microinvolvement in lymph nodes classified as “tumor free” by conventional histopathology in 73 (69%) out of the 106 patients. Twenty-nine (57%)of 51 patients staged histopathologically as pN0 had nodal microinvolvement. The five-year survival probability for pN0-patients was 54% for those without nodal microinvolvement and 0% for those with nodal microinvolvement. Cox-regression modeling revealed the independent prognostic effect of nodal microinvolvement on recurrence-free (relative risk 2.92, P = 0.005) and overall (relative risk 2.49, P = 0.009) survival.CONCLUSION: The study reveals strong and independent prognostic significance of nodal microinvolvement in patients with pancreatic ductal adenocarcinoma who have received no adjuvant therapy. The addition of immunohistochemical findings to histopathology reports may help to improve risk stratification of patients with pancreatic cancer. | Emre F Yekebas Dean Bogoevski Michael Bubenheim Bjrn-Christian Link Jussuf T Kaifi Robin Wachowiak Oliver Mann Asad Kutup Guellue Cataldegirmen Lars Wolfram Andreas Erbersdobler Christoph Klein Klaus Pantel Jakob R Izbicki | 2006 | World Journal of Gastroenterology2006，12，40： | 3 |
| 2 | Endoscopic ultrasound staging in gastric cancer:Does it help management decisions in the era of neoadjuvant treatment显示文摘 | Kutup A Vashist YK Groth S | | 0，，06： | 1 |
| 3 | Quality control of endoscopic ul-trasound in preoperative staging of esophageal cancer显示文摘 | Kutup A Link BC Schurr PG | | 0，，08： | 1 |
| 4 | Crossing the Rubicon: When Pancreatic Resection with Curative Intent Ends in an R2 Status显示文摘 | Maximilian Bockhorn MD Guellue Cataldegirmen MD Asad Kutup MD Andreas Marx MD Christoph Burdelski MD Jogesh K. Vashist MD Oliver Mann MD Lena Liebl MD Alexandra K?nig MD Jakob R. Izbicki MD Emre F. Yekebas MD | 2009 | Annals of Surgical Oncology2009，，5： | 1 |
| 5 | Surgical treatment in chronic pancreatitis timing and type of procedure 显示文摘 | Bachmann K Kutup A Mann O | 2010 | Best Pract Res Clin Gastroenterol2010，24，3： | 1 |
| 6 | Quo Vadis STARR? A Prospective Long-Term Follow-Up of Stapled Transanal Rectal Resection for Obstructed Defecation Syndrome显示文摘 | Oliver Zehler Yogesh K. Vashist Dean Bogoevski Maximillian Bockhorn Emre F. Yekebas Jakob R. Izbicki Asad Kutup | 2010 | Journal of Gastrointestinal Surgery2010，，9： | 1 |
| 7 | Current diagnosis and futurefor therapeutic strategies in adenocarci- noma of the esophagus, gastric cardia, and upper gastric third 显示文摘 | Kutup A Yekebas EF Izbicki JR | 2010 | Recent Results Cancer Res2010，182，： | 1 |
| 8 | Surgery of esophageal cancer显示文摘 | Uzunoglu F G Reeh M Kutup A | 2013 | Langenbecks Arch Surg2013，398，2： | 1 |
| 9 | Current diagnosis and future impact of micrometastases for therapeutic strategies in adenocarci- morea of the esophagus, gastric cardia, and upper gastric thrid 显示文摘 | Kutup A Yekebas EF Izbicki JR | 2010 | Recent Results Cancer Res2010，182，： | 1 |
| 10 | Surgical treatment in chronic pancreatitis:timing and type of procedure显示文摘 | Bachmann K Kutup A Mann O | | 0，，03： | 1 |
| 11 | Surgery of esophageal cancer显示文摘 | Uzunoglu FG Reeh M Kutup A | 2013 | Langenbecks Arch Surg2013，398，2： | 1 |
| 12 | Surgical treatment in chro-nic pancreatitis timing and type of procedure显示文摘 | Bachmann K Kutup A Mann 0 | 2010 | Best Pract ResClin Gastroenterol2010，24，3： | 1 |
| 13 | Quality control of endoscopic ultrasound in preoperative staging of esophageal cancer显示文摘 | Kutup A Link BC Schurr PG | 2007 | Endoscopy2007，39，8： | 1 |
| 14 | Surgical treatment in chronic panereatitis timing and type of procedure显示文摘 | Chmann K Kutup A Mann O etal | 2010 | Best Pract Res Clin Gastroenterol2010，24，1： | 1 |
| 15 | Staging and outcome depending on surgical treatment in adenocarcinomas of the oesophagogastric junction显示文摘 | M. Reeh S. Mina M. Bockhorn A. Kutup M. F. Nentwich A. Marx G. Sauter T. R?sch J. R. Izbicki D. Bogoevski | 2012 | Br J Surg2012，，10： | 1 |
| 16 | Is the Whipple procedure harmful for long-term outcome in treatment of chronic pancreatitis? 15-years follow-up comparing the outcome after pylorus-preserving pancreatoduodenectomy and Frey procedure in chronic pancreatitis显示文摘 | Bachmann K Tomkoetter L Kutup A | 2013 | Ann Surg2013，258，5： | 1 |
| 17 | Is the Whipple procedure harmful for long-term outcome in treatment of chronic pancreatitis? 15-years follow-up comparing the outcome after pyloruspreserving pancreatoduodenectomy and Frey procedure in chronic pancreatitis显示文摘 | Bachmann K Tomkoetter L Kutup A | 2013 | Ann Surg2013，258，5： | 1 |
| 18 | Is the Whipple procedure harmful for long-term outcome in treatment of chronic pancreatitis 15-years follow-up comparing the outcome after pylorus-preserving pancreatoduodenectomy and Frey procedure in chronic pancreatitis显示文摘 | Bachmann K Tomkoetter L Kutup A | | 0，，05： | 1 |
| 19 | Surgical treatment in chronic pancreatitis timing and type of procedure显示文摘 | Kai Bachmann Asad Kutup Oliver Mann Emre Yekebas Jakob R. Izbicki | 2010 | Best Practice & Research Clinical Gastroenterology2010，，3： | 1 |
| 20 | Quality control of endoscopic ultrasound in preoperative staging of esophageal cancer显示文摘 | Kutup A Link BC Schurr PG | 2007 | Endoscopy2007，39，8： | 1 |
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