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| 1 | Metabolic positron emission tomography imaging of cancer:Pairing lipid metabolism with glycolysis显示文摘The limitations of fluorine-18 fluorodeoxy-D-glucose(FDG)in detecting some cancers has prompted a longstandin search for other positron emission tomography(PET tracers to complement the imaging of glycolysis i oncology, with much attention paid to lipogenesis base on observations that the production of various lipid an lipid-containing compounds is increased in most cancers Radiolabeled analogs of choline and acetate have now been used as oncologic PET probes for over a decade showing convincingly improved detection sensitivit over FDG for certain cancers. However, neither cholin nor acetate have been thoroughly validated as lipogeni biomarkers, and while acetyl-Co A produced from acetat is used in de-novo lipogenesis to synthesize fatty acids acetate is also consumed by various other syntheti and metabolic pathways, with recent experimenta observations challenging the assumption that lipogenesi is its predominant role in all cancers. Since tumor detected by acetate PET are also frequently detected b choline PET, imaging of choline metabolism might serv as an alternative albeit indirect marker of lipogenesis particularly if the fatty acids produced in cancer cell are mainly destined for membrane synthesis throug incorporation into phosphatidylcholines. Aerobic glycolysi may or may not coincide with changes in lipid metabolism resulting in combinatorial metabolic phenotypes that ma have different prognostic or therapeutic implications Consequently, PET imaging using dual metabolic tracers in addition to being diagnostically superior to imagin with individual tracers, could eventually play a greate role in supporting precision medicine, as efforts t develop small-molecule metabolic pathway inhibitors ar coming to fruition. To prepare for this advent, clinical an translational studies of metabolic PET tracers must g beyond simply estimating tracer diagnostic utility, and aim to uncover potential therapeutic avenues associated wit these metabolic alterations. | Sandi A Kwee John Lim | 2016 | World Journal of Radiology2016，8，11： | 2 |
| 2 | Protein aggregates seem to playa key role among the parameters influencing the antigenicity of inter-feron alpha (IFN-a ) in normal and transgenic mice 显示文摘 | Braun A Kwee L Labow MA | 1997 | PharmRes1997，14，10： | 1 |
| 3 | The influence of top management team's corporate governance orientation on strategic renewal trajectories 显示文摘 | Kwee Z Van den Bosch F A J Volberda H W | 2011 | Journal of Management Studies2011，48，5： | 1 |
| 4 | FDG- PET for diagnosing prosthetic joint infection: systematic review and metaanalysis 显示文摘 | KWEE T C KWEE R M ALAVI A | 2008 | Eur J Nucl Med Mol Imaging2008，35，11： | 1 |
| 5 | FDG-PET for diagnosing pros-thetic joint infection: systematic review and meta analysis显示文摘 | Kwee TC Kwee RM Alavi A | 2008 | EurJ Nucl Med Mol Imaging2008，35，11： | 1 |
| 6 | Nononcological applications of positron emission tomography for evaluation of the thorax 显示文摘 | Kwee TC Torigian DA Alavi A | 2013 | J Thorac Imaging2013，28，1： | 1 |
| 7 | Emergency peripartum hysterectomy: a prospective study in the Netherlands显示文摘 | Kwee A Bots M L Visser G H | 2006 | ur J Obstet Gynccol Reprod Biol2006，124，2： | 1 |
| 8 | Whole-body MRI for the detection of bone marrow involvementin lymphoma : prospective study in 116 patients and comparisonwith FDG-PET 显示文摘 | HUGO JA ADAMS THOMAS C KWEE MALOU A | 2013 | Eur Radiol2013，23，8： | 1 |
| 9 | Obstetric management and outcome of pregnancy in women with a history of caesarean section in the Netherlands显示文摘 | Kwee A Bots ML Visser GH | 2007 | Eur J Obstet Gynecol Reprod Biol2007，132，2： | 1 |
| 10 | Pregnancy after uterine rupture: a report of 5 cases and a review of the literature 显示文摘 | Lim AC Kwee A Bruinse HW | 2005 | Obstet Gynecol Surv2005，60，9： | 1 |
| 11 | The NF-kB negative regulator TNFAIP3 (A20) is inactivated by somatic mutations and genomic deletions in marginal zone B-cell lymphomas 显示文摘 | Novak U Rinaldi A Kwee I | 2009 | Blood2009，113，20： | 1 |
| 12 | Whole- body MRI, including diffusion- weighted imaging, for staging lymphoma: Comparison with CTin a prospective multicenter study显示文摘 | Kwee T C Vermoolen M A Akkerman E A | 2014 | Journal of Magnetic Resonance Imaging2014，40，1： | 1 |
| 13 | Emergency peripartum hysterectomy:A prospective study in the Netherlands显示文摘 | Kwee A Bots M L Visser G H | 2006 | Eur J Obstet Gynecol Reprod Biol2006，124，2： | 1 |
| 14 | Obstetric management and outcome of pregnancy in women with a history of caesarean section in the Netherlands 显示文摘 | Kwee A Bots ML Visser GH | 2007 | Eur J Obstet Gynecol Reprod Biol2007，132，2： | 1 |
| 15 | Emergency peripartum hysterectomy:a prospective study in The Netherlands显示文摘 | Kwee A Bots ML Visser GH | | 0，，2： | 1 |
| 16 | The NF-κB negative regulator TNFAIP3 (A20) is inactivated by somatic mutations and genomic deletions in marginal zone lymphomas显示文摘 | Novak U Rinaldi A Kwee I | 2009 | Blood2009，113，20： | 1 |
| 17 | The effect of Chinese herbal medicines (CHM) on menopausal symptoms compared to hormone replacement therapy (HRT) and placebo显示文摘 | Kwee SH Tan HH Marsman A | | 0，，01： | 1 |
| 18 | Protein aggregates seem to play a key role among the parameters influencing the antigenicity of interferon alpha (IFN-) in normal and transgenic mice 显示文摘 | Braun A Kwee L Labow M | 1997 | Pharmaceutical Research1997，14，10： | 1 |
| 19 | Concomitant MYC and microRNA cluster miR-17-92 (C13 or f 25 ) amplification in human mantle cell lymphoma 显示文摘 | Rinaldi A Poretti G Kwee I | 2007 | Leuk Lymphoma2007，48，2： | 1 |
| 20 | Obsteric management and outcome of pregnancy in women with a history of caesarean section ill tile Netherlands 显示文摘 | Kwee A Bots ML Visser GH | 2007 | Am J Obstet Gynecol2007，197，： | 1 |
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