| 2 | IFNγsignaling integrity in colorectal cancer immunity and immunotherapy显示文摘The majority of colorectal cancer patients are not responsive to immune checkpoint blockade(ICB).The interferon gamma(IFNγ)signaling pathway drives spontaneous and ICB-induced antitumor immunity.In this review,we summarize recent advances in the epigenetic,genetic,and functional integrity of the IFNγsignaling pathway in the colorectal cancer microenvironment and its immunological relevance in the therapeutic efficacy of and resistance to ICB.Moreover,we discuss how to target IFNγsignaling to inform novel clinical trials to treat patients with colorectal cancer. | Wan Du Timothy L.Frankel Michael Green Weiping Zou | 2022 | Cellular & Molecular Immunology2022，19，1： | 1 |
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