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1Herbal decoctosome is a novel form of medicine显示文摘Traditionally, herbal medicine is consumed by drinking decoctions produced by boiling herbs with water. The functional components of the decoction are heat stable. Small RNAs(sRNAs) were reported as a new class of functional components in decoctions. However, the mechanisms by which sRNAs survive heat treatment of the decoction and enter cells are unclear.Previous studies showed that plant-derived exosome-like nanoparticles(ELNs), which we call botanosomes, could deliver therapeutic reagents in vivo. Here, we report that heat-stable decoctosomes(ELNs) from decoctions have more therapeutic effects than the decoctions in vitro and demonstrate therapeutic efficacy in vivo. Furthermore, sRNAs, such as HJT-sRNA-m7 and PGY-sRNA-6, in the decoctosome exhibit potent anti-fibrosis and anti-inflammatory effects, respectively. Decoctosome is comprised of lipids, chemical compounds, proteins, and s RNAs. A medical decoctosome mimic is called bencaosome. A single lipid sphinganine(d22:0) identified in the decoctosome was mixed and heated with the synthesized sRNAs to form the simplest bencaosome. This simple bencaosome structure was identified by critical micelle concentration(cmc) assay that sRNAs coassembled with sphinganine(d22:0) to form the lipid layers of vesicles. The heating process facilitates co-assembly of sRNAs and sphinganine(d22:0) until a steady state is reached. The artificially produced sphinganine-HJT-sRNA-m7 and sphinganinePGY-sRNA-6 bencaosomes could ameliorate bleomycin-induced lung fibrosis and poly(I:C)-induced lung inflammation, respectively, following oral administration in mice. Our study not only demonstrates that the herbal decoctosome may represent a combinatory remedy in precision medicine but also provides an effective oral delivery route for nucleic acid therapy.Xiaoyun Li Zhu Liang Jianchao Du Zhiqing Wang Song Mei Zhiqing Li Yan Zhao DANDan Zhao Yiming Ma Jun Ye Jiantao Xu Yu Zhao Jiahui Chang Yuhao Qin Lanlan Yu Chenxuan Wang Chengyu Jiang 2019Science China(Life Sciences)2019,62,3:26
2GC-MS, GC-O and OAV analyses of key aroma compounds in Jiaozi Steamed Bread显示文摘Jiaozi Steamed Bread(JSB)has a unique aroma as a traditional staple food in China.The volatile compounds in JSBwere extracted by simultaneous distillation and extraction(SDE)and headspace solid-phasemicroextraction(HS-SPME).These volatile substances were analyzed by gas chromatography-mass spectrometry(GC-MS)and gas chromatographyolfactometry-mass spectrometry(GC-O-MS).The results demonstrated that 61 volatile compounds were identified totally in samples,of which 15 were confirmed as potent aroma compounds with odor active values(OAVs)>1.The 15 potent aroma compounds were ethanol,1-butanol,1-pentanol,1-hexanol,heptanol,1-octen-3-ol,3-methyl-1-butanol,hexanal,heptanal,nonanal,(E)-2-heptenal,benzaldehyde,(E,E)-2,4-decadienal,2-pentylfuran and naphthalene.The SDEmethod had better linearity with coefficients of determination(R2)equal to or higher than 0.9991.Furthermore,the SDE method also achieved lower sensitivity and better repeatability and recovery than HS-SPME.This work provides reference method and parameters for future research on the flavor of JSB for commercial products.Yuanhui Wang Jingwen Zhao Fei Xu Xiaoyun Wu Wenxuan Hu Yongfeng Chang Lanlan Zhang Jie Chen Changhong Liu 2020Grain & Oil Science and Technology2020,3,1:17
3Ultrahigh-Q silicon racetrack resonators显示文摘An ultrahigh-Q silicon racetrack resonator is proposed and demonstrated with uniform multimode silicon photonic waveguides.It consists of two multimode straight waveguides connected by two multimode waveguide bends(MWBs).In particular,the MWBs are based on modified Euler curves,and a bent directional coupler is used to achieve the selective mode coupling for the fundamental mode and not exciting the higher-order mode in the racetrack.In this way,the fundamental mode is excited and propagates in the multimode racetrack resonator with ultralow loss and low intermode coupling.Meanwhile,it helps achieve a compact 180°bend to make a compact resonator with a maximized free spectral range(FSR).In this paper,for the chosen 1.6μm wide silicon photonic waveguide,the effective radius Reffof the designed 180°bend is as small as 29μm.The corresponding FSR is about 0.9 nm when choosing 260μm long straight waveguides in the racetrack.The present high-Q resonator is realized with a simple standard single-etching process provided by a multiproject wafer foundry.The fabricated device,which has a measured intrinsic Q-factor as high as 2.3×10~6,is the smallest silicon resonator with a>106Q-factor.LONG ZHANG LANLAN JIE MING ZHANG YI WANG YIWEI XIE YAOCHENG SHI DAOXIN DAI 2020Photonics Research2020,8,5:7
4Microstructure and composition evolution of a single-crystal superalloy caused by elements interdiffusion with an overlay NiCrAlY coating on oxidation显示文摘MCrAlY(M=Ni and/or Co)overlay coating is widely used as a protective coating against high temperature oxidation and corrosion.However,due to its big difference in chemical composition with the underlying superalloy,elements interdiffusion occurs inevitably.One of the direct results is the formation of interdiffusion zone(IDZ)and secondary reaction zone(SRZ)with a high density of fine topological closed-packed phases(TCPs),weakening dramatically the mechanical properties of the alloy substrate.It is by now the main problem of modern high-temperature metallic coatings,but there are still hardly any reports studying the formation,growth and transformation of IDZ and SRZ in deep,as well as the precipitation of TCPs.In this work,a typical NiCrAlY coating is deposited by arc ion plating on a single-crystal superalloy N5.Elements interdiffusion between them and its relationship on microstructure were clarified.Cr rather than Al from the coating diffuses into the alloy at high temperatures and segregates immediately beneath their interface,contributing largely to the formation of IDZ.Simultaneously,diffusion of Ni from the deep alloy to IDZ leads to the formation and continuous expansion of SRZ.Lanlan Yang Minghui Chen Jinlong Wang Yanxin Qiao Pingyi Guo Shenglong Zhu Fuhui Wang 2020Journal of Materials Science & Technology2020,42,10:7
5Express,on of the novel adipokine ClqTNF-related protein 4 (CTRP4) suppresses colitis and colitis- associated colorectal cancer in mice显示文摘Yang Luo Xiaotong Wu Zhuang Ma Weifeng Tan Lanlan Wang Daxiang Na Guoying Zhang Ang Yin He Huang Dan Xia Yingmei Zhang Xueying Shi Lu Wang 2016Cellular & Molecular Immunology2016,13,5:6
6Comprehensive precursor anomaly research based on earthquake corresponding relevancy spectrum显示文摘With the aim to the quantification of anomaly identification and extraction for observed or analyzed records, we present two statistical methods of earthquake corresponding relevancy spectrum(ECRS)and sliding mean relevancy (SMR).With ECRS method,we can obtain the abnormal confidence attribute of data in different value ranges.Based on the relevancy spectrum in different studied time-intervals,we convert the original time sequence into relevancy time sequence, and can obtain the SMR time series by using the multi-point cumulative sliding mean method.Then we can identify the seismic precursor anomaly.We test this method by taking the time sequence ofη-value in the northern Tianshan region as original data.The result shows that when the studied time-interval is 18 months,the precursor anomaly can be identified better from sliding mean relevancy.The anomaly corresponding rate is 83 percent,the earthquake corresponding rate is 86 percent,and the anomaly is characteristic of the middle term.To try the research on multi-parameter comprehensive application, we take the Kalpin tectonic block in Xinjiang as our studied region,and analyze the spatial and temporal abnormal characters of multi-parameter sliding extreme-value relevancy(MSER)before mid-strong earthquakes in the Kalpin block.The result indicates that ECRS and SMR sequence in different time-intervals can not only be used to identify the precursor anomaly of single-item data,but also offer the data of quantitative single-item anomaly for comprehensive earthquake analysis and prediction.Haitao Wang Qiong Wang Lanlan Tang 2009Earthquake Science2009,22,6:5
7The effects of oleanolic acid on atherosclerosis in different animal models显示文摘Hanqiong Luo Jine Liu Qiong Ouyang Chunxiao Xuan Lanlan Wang Tingting Li Jun Liu 2017Acta Biochimica et Biophysica Sinica2017,49,4:4
8Holocene climatic and environmental changes recorded in Baahar Nuur Lake core in the Ordos Plateau, Inner Mongolia of China显示文摘A 5.3 m lake core was drilled in Baahar Nuur Lake in the Ordos Plateau, and measurements of meangrain size, organic δ 13C (δ 13Corg), organic carbon content (TOC), C/N, carbonate content, carbonate δ 13C(δ 13Ccar) and δ 18O (δ 18Ocar) were conducted for retrieving the Holocene chronosequence of climaticchanges based on 15 AMS 14C dates. The record documented four major stages of climate change inthe Ordos Plateau: (IV) a cold and dry condition before ~7.65 14C ka BP; (III) a warm and humid stagebetween ~7.65 and ~5.40 ka BP; (II) a generally drier and cooler climate since ~5.40 ka BP with twohumid events occurring from ~4.70 to ~4.60 ka BP and from ~4.20 to ~3.70 ka BP, and (I) a dry climatecharacterized by complete desiccation of the lake after 3.70 ka BP. Stage III can be further divided intothree sub-stages: (IIIa) a warm and humid episode from ~7.65 to ~6.70 ka BP, (IIIb) a warm and relativelydry episode from ~6.70 to ~6.20 ka BP, and (IIIc) the magthermal and maghumid episode of the Holo-cene from ~6.20 to ~5.40 ka BP.GUO LanLan FENG ZaoDong LI XinQing LIU LianYou WANG LiXia 2007Chinese Science Bulletin2007,52,7:4
9AdipoRon prevents L-thyroxine or isoproterenol-induced cardiac hypertrophy through regulating the AMPK-related pathway显示文摘Cardiac hypertrophy is a risk factor which can intrigue heart failure.In the present study,we explored whether AdipoRon attenuates isoprenaline (ISO) or L-thyroxine-induced cardiac hypertrophy in Sprague-Dawley (SD) rats and whether the anti-hypertrophy effect is mediated by AMPK-related pathway.Here,cardiac hypertrophy was induced by injection of L-thyroxine or ISO in SD rats.In the treatment group,AdipoRon was co-administered.We examined the effects of AdipoRon on cardiac hypertrophy and hypertrophy signaling pathway.The weight of SD rats was recorded every day.Rats were killed for collection of blood and heart under anesthesia.The left heart weight and heart weight were weighed.Paraffin-embedded heart tissue regions (4 μm) were stained with hematoxylin and eosin or Masson to detect left heart hypertrophy and myocardial fibrosis.The serum BNP levels were determined by using an enzyme-linked immunosorbent assay.The mRNA levels of ANP,BNP,PGC-1α,and ERRα were evaluated by real-time PCR analysis.The protein expression levels of PGC-1α,ERRα,and pAMPK/AMPK were determined by western blot analysis.The results showed that AdipoRon significantly reversed heart weight (HW)/ body weight (BW) ratio,left ventricular (LV)/BW ratio,serum BNP level and the mRNA level of ANP and BNP induced by ISO or L-thyroxine.ISO or L-thyroxine reduced both the mRNA level and protein level of ERRα and PGC-1α,and also reduced the protein level of pAMPK/AMPK.However,AdipoRon reversed ISO or L-thyroxine-induced changes of pAMPK/AMPK,ERRα,and PGC-1α.Our data indicated that the effects of AdipoRon are mediated partly by activating AMPK-related pathway,and AdipoRon plays a potential role in the prevention of cardiac hypertrophy.Xinlei Hu Qiong Ou-Yang Lanlan Wang Tingting Li Xiaoxue Xie Jun Liu 2019Acta Biochimica et Biophysica Sinica2019,51,1:3
10Introduction of pokeweed antiviral protein cDNA into Brassica napus and acquisition of transgenic plants resistant to viruses显示文摘Using cotyledonary petioles as explants, the PAP cDNA controlled by wound-in-ducible promoter has been introduced into Brassica napus by coculture with Agrobacterium tumefaciens and laser microbeam puncture respectively. Regenerated plants resistant to gen-tamycin have been selected out. PCR amplification and Southern blotting analysis indicated that PAP cDNA together with wound-inducible promoter had been integrated into Brassica genome with transformation frequencies of 2.0% and 1.7% for two transformation methods respectively. The test of virus challenge showed that these transgenic Brassica plants were resistant in different degrees to mechanically inoculated TuMV.ZHANG Haiyan , TIAN Yingchuan , ZHOU Yihua , DANG Benyuan LAN Haiyan , SONG Guiying , WANG Lanlan , LIU Guizhen , ZHANG Lihua and CHEN ZhenghuaInstitute of Genetics , Chinese Academy of Sciences , Beijing 100101, China Institute of Microbiology , Chinese Academy of Sciences , Beijing 100080, China 1999Chinese Science Bulletin1999,44,8:3
11A predicted NEDD8 conjugating enzyme gene identified as a Capsicum candidate Rf gene using bulk segregant RNA sequencing显示文摘Cytoplasmic male sterility(CMS)is an important tool for producing F1 hybrids,which can exhibit heterosis.The companion system,restorer-of-fertility(Rf),is poorly understood at the molecular level and would be valuable in producing restorer lines for hybrid seed production.The identity of the Rf gene in Capsicum(pepper)is currently unclear.In this study,using bulked segregant RNA sequencing(BSR-seq),a strong candidate Rf gene,Capana06g002866,which is annotated as a NEDD8 conjugating enzyme E2,was identified.Capana06g002866 has an ORF of 555 bp in length encoding 184 amino acids;it can be cloned from F1 plants from the hybridization of the CMS line 8A and restorer line R1 but is not found in CMS line 8A.With qRT-PCR validation,Capana06g002866 was found to be upregulated in restorer accessions compared to sterile accessions.The relative expression in flower buds increased with the developmental stage in F1 plants,while the expression was very low in all flower bud stages of the CMS lines.These results provide new insights into the Rf gene in pepper and will be useful for other crops utilizing the CMS system.Bingqiang Wei Paul W.Bosland Zhenghai Zhang Yongfu Wang Gaoyuan Zhang Lanlan Wang Jihua Yu 2020Horticulture Research2020,7,1:3
12Suburbanization and Subcentering of Population in Beijing Metropolitan Area:A Nonparametric Analysis显示文摘This study focuses on the suburbanization and subcentering of population and examines the nature of spatial restructuring in terms of the population distribution in the Beijing metropolitan area.Instead of the classic density function approach,we employ the nonparametric analysis to characterize the spatial pattern of population densities in the Beijing metropolitan area and identify the suburban subcenters.Our findings suggest that the population has spread with rapid urban growth in the Beijing metropolitan area,and the compact urban form has been replaced by a more dispersed polycentric spatial distribution.However,compared with the decentralization of western cities,the spatial extent of the decentralization of population in the Beijing metropolitan area is quite limited.The rapid growth of population in the near suburbs has expedited the sprawl of the central city,with a larger central agglomeration of population dominating the metropolitan area.In this sense,the spatial pattern of the Beijing metropolitan area is still characterized by the continuous compactness.However,our findings do provide the evidence that the city has been turning to a polycentric structure.We find significant population subcenters have emerged in the suburbs of Beijing since the 1980s.But the polycentricity emerged in the Beijing metropolitan area is very different by nature from that observed in Western cities.The subcenters emerged are adherent to the development scheme planned for the city,so it can be referred to as the so called 'planned polycentricity'.SUN Tieshan HAN Zhenhai WANG Lanlan LI Guoping 2012Chinese Geographical Science2012,22,4:3
13Radiolarian biostratigraphy in the Southern Bering Sea since Pliocene显示文摘Detailed radiolarian biostratigraphy in the Plio-Pleistocene was analyzed by using samples from IODP Site U1340 that was drilled to a core depth of 604 m in the southern Bering Sea.A total of 227 species belonging to 102 genera were identified.Based on the distributions of the radiolarian index species at Site U1340,five radiolarian zones since the Pliocene were established in the southern Bering Sea for the first time,and 25 radiolarian bioevents were recognized.Their ages were estimated on the basis of the age-depth plot that was constructed by the synthetical datum of the effective biostratigraphic and magnetostratigraphic events.The radiolarian zones at Site U1340 were systematically compared with those in its adjacent regions since the late Early Pliocene,which further improved and interpreted the biostratigraphic datum as well as their correlations in the middle-high latitude of the North Pacific.In addition,the comparative results of radiolarian zones show that Botryostrobus aquilonaris Zone emended in this paper is equivalent to the upper part of the same zone defined by Hays,1970,and Druppatractus irregularis-Dorydruppa bensoni Zone as well as Spongodiscus sp.Zone,newly proposed in this paper,are well correlated with Cycladophora sakaii Zone and Stylatractus universus Zone in the subarctic North Pacific,respectively.ZHANG Qiang CHEN MuHong ZHANG LanLan WANG RuJian XIANG Rong HU WeiFen 2014Science China Earth Sciences2014,57,4:3
14Construction of trace silver modified core@shell structured Pt-Ni nanoframe@CeO2 for semihydrogenation of phenylacetylene显示文摘The Pt-Ni nanoframe catalysts have attracted great interest owing to their unique electronic structure and excellent catalytic performance. However, the stability of the tenu ous edges of nano frame-structures is dissatisfactory and their un iversal applicati ons in catalytic market beyond electrocatalytic reactions are yet to be tapped and explored. Herein, we developed a new core@ shell structured Pt-Ni nanoframe@CeO2 (Pt-Ni NF@CeO2) composite via etching the Ni from inhomogeneous Pt-Ni rhombic dodecahedra (Pt-Ni RD) by cerium(lll) acetate hydrate (Ce(OAc)3). In this path, Pt-Ni RD was used as self-sacrificial 怕mplate, while the Ce(OAc)3 serves as the provider of the Ce3* source and OH' for the formation of CeO2 shell, etchant of Pt-Ni RD, and the surface modification agent. By this way, the etching of Pt-Ni RD and the formation of the CeO2 shell are simultaneously proceeded to form the final Pt-Ni NF@CeO2 in one step. The obtained Pt-Ni NF@CeO2 exhibits strong in terfacial charge tran sfer interactio n betwee n Pt-Ni NF core and CeO2 shell eve n without reductio n treatment, leading to enhan ced catalytic activity in the hydrogenation of phenylacetylene. After introduction of trace silver, the Pt-Ni-Ag4.9 NF@CeO2 achieves remarkable catalytic performa nee for the selective con versi on of phe ny lacetyle ne to styrene: high con version (100%), styre ne selectivity (86.5%), and good stability. It reveals that enc apsulatio n n oble metal nano frames into metal oxide to form core @ shell structured hybrids will in deed enhance their stability and catalytic properties. Particularly, this work expends the application of noble metal nanoframes materials to hydrogenation reacti ons.Yan Long Jian Li Lanlan Wu Qishun Wang Yu Liu Xiao Wang Shuyan Song Hongjie Zhang 2019Nano Research2019,12,4:3
15Effect of aging treatment on microstructure and corrosion behavior of a Fe-18Cr-15Mn-0.66N stainless steel显示文摘The effect of aging treatment on the microstructure and corrosion behavior of a Fe-18Cr-15Mn-0.66N high-nitrogen stainless steel(HNSS) in 3.5 wt.% Na Cl solution was investigated using a series of electrochemical tests, scanning electronic microscopy(SEM), X-ray diffraction(XRD) and X-ray photoelectron spectroscopy(XPS). The results showed that the aging treatment led to the precipitation of CrN particles along the grain boundaries and their morphologies changed from dispersive particles to continuous network as the aging time increased up to 60 min. Aging time had minor effects on the corrosion potential and corrosion current density, but resulted in the sharp decrease in the pitting corrosion potential.The passive film behaved as a n-type semiconductor, and the donor density of the passive film increased with the aging time. Meanwhile, the fraction of stable oxide(CrO) in the passive film decreased with the aging time. It demonstrates that the aging treatment deteriorated the protectiveness of the passive film, hence weakened the corrosion resistance of HNSS.Yanxin Qiao Xinyi Wang Lanlan Yang Xiaojing Wang Jian Chen Zhengbin Wang Huiling Zhou Jiasheng Zou Fuhui Wang 2022Journal of Materials Science & Technology2022,,12:3
16Progress of Fabrication and Applications of Electrospun Hierarchically Porous Nanofibers显示文摘In recent years,electrospun nanofibers have attracted great attention for their facile adjustable structure,morphology feature and chemical composition.Especially,significant interest has been devoted to the development of electrospun nanofibers with multiscale pores from micropores and mesopores to macropores,owing to their large specific surface area,hierarchical pore structures,abundant active sites and many other unique properties and applications.This review presents an overview on the design strategies,preparation methods,physical properties and applications of electrospun hierarchical porous nanofibers.At first,electrospinning fabrication of nanofibers with different types of pores including micropores,mesopores,macropores and hierarchical pores are introduced.Then the structures,properties of electrospun porous nanofibers and their applications in several important areas,such as catalysis,energy storage,adsorption and separation,heat insulation and flame retardant,sound absorption and wave absorption,sensor and biomedical are summarized.At last,challenges and potential opportunities of electrospun porous nanofibers in the future are highlighted.Ranran Liu Lanlan Hou Guichu Yue Huaike Li Jiesan Zhang Jing Liu Beibei Miao Nü Wang Jie Bai Zhimin Cui Tianxi Liu Yong Zhao 2022Advanced Fiber Materials2022,4,4:3
17Discovery of a series of dimethoxybenzene FGFR inhibitors with 5H-pyrrolo[2,3-b]pyrazine scaffold: structure–activity relationship, crystal structural characterization and in vivo study显示文摘Genomic alterations are commonly found in the signaling pathways of fibroblast growth factor receptors(FGFRs). Although there is no selective FGFR inhibitors in market, several promising inhibitors have been investigated in clinical trials, and showed encouraging efficacies in patients. By designing a hybrid between the FGFR-selectivity-enhancing motif dimethoxybenzene group and our previously identified novel scaffold, we discovered a new series of potent FGFR inhibitors, with the best one showing sub-nanomolar enzymatic activity. After several round of optimization and with the solved crystal structure, detailed structure–activity relationship was elaborated. Together with in vitro metabolic stability tests and in vivo pharmacokinetic profiling, a representative compound(35) was selected and tested in xenograft mouse model, and the result demonstrated that inhibitor 35 was effective against tumors with FGFR genetic alterations, exhibiting potential for further development.Peng Wei Bo Liu Ruifeng Wang Yinglei Gao Lanlan Li Yuchi Ma Zhiwei Qian Yuelei Chen Maosheng Cheng Meiyu Geng Jingkang Shen Dongmei Zhao Jing Ai Bing Xiong 2019Acta Pharmaceutica Sinica B2019,9,2:2
18Local Practices on Transfer of Development Rights in China: Background, Mode, Challenge and BreakthroughWANG Hui, PhD, Part-time Researcher, Peking University-Lincoln Institute Center Associate Professor,Zhejiang University, Hangzhou, P. R. China. WANG Lanlan, PhD, Part-time Researcher, Peking University-Lincoln Institute Center Assistant Professor, Central University of Finance and Economics,Beijing, P. R. China. TAO Ran, PhD, Part-time Researcher, Peking University-Lincoln Institute Center Professor, RenminUniversity of China, Beijing, P. R. China. SHI Ke 2012China City Planning Review2012,21,1:2
19C4 Rice-an Ideal Arena for Systems Biology Research显示文摘Engineering the C4 photosynthetic pathway into C3 crops has the potential to dramatically increase the yields of major C3 crops. The genetic control of features involved in C4 photosynthesis are still far from being understood; which partially explains why we have gained little success in C4 engineering thus far. Next generation sequencing techniques and other high throughput technologies are offering an unprecedented opportunity to elucidate the developmental and evolutionary processes of C4 photosynthesis. Two contrasting hypotheses about the evolution of C4 photosynthesis exist, i.e. the master switch hypothesis and the incremental gain hypothesis. These two hypotheses demand two different research strategies to proceed in parallel to maximize the success of C4 engineering. In either case, systems biology research will play pivotal roles in identifying key regulatory elements controlling development of C4 features, identifying essential biochemical and anatomical features required to achieve high photosynthetic efficiency, elucidating genetic mechanisms underlining C4 differentiation and ultimately identifying viable routes to engineer C4 rice. As a highly interdisciplinary project, the C4 rice project will have far-reaching impacts on both basic and applied research related to agriculture in the 21st century.Xin-Guang Zhu Lanlan Shan Yu Wang William Paul Quick 2010Journal of Integrative Plant Biology2010,52,8:2
20Erratum to:Herbal decoctosome is a novel form of medicine显示文摘Following the published article,we noticed an error duplication in Figure 5G“control”and“PGY-6”that was introduced during the revised process,with an attempt to replace it with higher-resolution images.Here we provide the original data in the first submitted manuscript(Figure 5G).Xiaoyun Li Zhu Liang Jianchao Du Zhiqing Wang Song Mei Zhiqing Li Yan Zhao Dandan Zhao Yiming Ma Jun Ye Jiantao Xu Yu Zhao Jiahui Chang Yuhao Qin Lanlan Yu Chenxuan Wang Chengyu Jiang 2020Science China(Life Sciences)2020,63,9:2
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