|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Hematopoietic stem cell-derived adipocytes and fibroblasts in the tumor microenvironment显示文摘The tumor microenvironment(TME) is complex and constantly evolving. This is due, in part, to the crosstalk between tumor cells and the multiple cell types that comprise the TME, which results in a heterogeneous population of tumor cells and TME cells. This review will focus on two stromal cell types, the cancerassociated adipocyte(CAA) and the cancer-associated fibroblast(CAF). In the clinic, the presence of CAAs and CAFs in the TME translates to poor prognosis in multiple tumor types. CAAs and CAFs have an activated phenotype and produce growth factors, inflammatory factors, cytokines, chemokines, extracellular matrix components, and proteases in an accelerated and aberrant fashion. Through this activated state, CAAs and CAFs remodel the TME, thereby driving all aspects of tumor progression, including tumor growth and survival, chemoresistance, tumor vascularization, tumor invasion, and tumor cell metastasis. Similarities in the tumorpromoting functions of CAAs and CAFs suggest that a multipronged therapeutic approach may be necessary to achieve maximal impact on disease. While CAAs and CAFs are thought to arise from tissues adjacent to the tumor, multiple alternative origins for CAAs and CAFs have recently been identified. Recent studies from our lab and others suggest that the hematopoietic stem cell, through the myeloid lineage, may serve as a progenitor for CAAs and CAFs. We hypothesize that the multiple origins of CAAs and CAFs may contribute to the heterogeneity seen in the TME. Thus, a better understanding of the origin of CAAs and CAFs, how this origin impacts their functions in the TME, and thetemporal participation of uniquely originating TME cells may lead to novel or improved anti-tumor therapeutics. | Ying Xiong Lindsay T Mc Donald Dayvia L Russell Ryan R Kelly Katie R Wilson Meenal Mehrotra Adam C Soloff Amanda C LaRue | 2015 | World Journal of Stem Cells2015，7，2： | 6 |
| 2 | Novel microbial diversity adherent to plant biomass in the herbivore gastrointestinal tract, as revealed by ribosomal intergenic spacer analysis and rrs gene sequencing 显示文摘 | LARUE R YU Z PARISI V A | 2005 | Environmental Microbiology2005，7，4： | 1 |
| 3 | A wild type porcine encephalomyocarditis virus containing a short poly(C) tract is pathogenic to mice, pigs, and cynomolgus macaques显示文摘 | Larue R Myers S Brewer L | 2003 | J Virol2003，77，17： | 1 |
| 4 | A real-time intrusion system based on learning program behavior显示文摘 | Ammons G Bodik R Larus J R | 2002 | ACM SIGPLAN NOTICES2002，，01： | 1 |
| 5 | A mutation in Pisumsativum cv'sparkle'conditioning decreased nodulation and increased iron uptake and leaf necrosis显示文摘 | Kneen B E Larue T A Welch R M Weeden N F | 1990 | Plant Physiol1990，93，： | 1 |
| 6 | Fish and Meat De- mand in Canada: Regional Differences and Weak Separability 显示文摘 | Lambert R Larue B Yomy C | 2006 | Agriculture Business2006，22，2： | 1 |
| 7 | Pressure elec- troosmotic dewatering with continuous removal of elec- trolysis products 显示文摘 | Larue O Wakeman R J Tarleton E S | 2006 | Chemical Engineering Science2006，61，14： | 1 |
| 8 | Guidelines for naming nonprimate APOBEC3 genes and proteins 显示文摘 | LaRue R S Andresdottir V Blanchard Y | 2004 | J Virol2004，83，： | 1 |
| 9 | RAGE mediates amyloid-beta peptide transport across the blood-brain barrier and accumulation in brain显示文摘 | Deane R Du Y S R Larue B | 2003 | Nature Medicine2003，9，7： | 1 |
| 10 | Endothelial protein C re-ceptor-assisted transportof activated protein C across the mouse-blood-brain barrier 显示文摘 | Deane R LaRue B Sagare AP | 2009 | J Cereb Blood Flow Metab2009，29，1： | 1 |
| 11 | Optimally profiling and tracing programs 显示文摘 | Thomas Ball James R Larus | 1994 | ACM Transactions on Programming Languages and Systems1994，16，4： | 1 |
| 12 | Influence of experience on postural control:effect of expertise in gymnastics 显示文摘 | Gautier G Thouvarecq R Larue J | 2008 | J Mot Behav2008，40，5： | 1 |
| 13 | Pressure electroosmotic dewatering with continuous of electrolysis products显示文摘 | LARUE O WAKEMAN R J TARLETON E S | 2006 | Chemical Engineering Science2006，61，14： | 1 |
| 14 | A wild-type porcine encephalomyocarditis virus containing a short poly (C) tract is pathogenic to mice,pigs and cynomolgus macaques显示文摘 | LaRue R Myers S Brewer L | 2003 | J Virol2003，77，17： | 1 |
| 15 | Optimization of glucosinolate separation by micellar electrokinetic capillary chromatography using a Doehlert' s experimental design 显示文摘 | PAUGAM L MENARD R LARUE J P | 1999 | J Chromatogra A1999，864，： | 1 |
| 16 | Molecular mechanisms of retroviral integration site selection显示文摘 | KVARATSKHELIA M SHARMA A LARUE R C | 2014 | Nucleic Acid Res2014，42，10： | 1 |
| 17 | Making pointer-based data structures cache conscious 显示文摘 | Chilimbi T M Hill M D Larus J R | 2000 | Computer2000，33，12： | 1 |
| 18 | Transplanting encephalomyocarditis virus-infected porcine islet cells reverses diabetes in recipient mice but also transmits the virus显示文摘 | Brewer L LaRue R Hering B | 2004 | Xenotransplantation2004，11，2： | 1 |
| 19 | A wildtype porcine encepha显示文摘 | LARUE R MYERS S BREWER L | 2003 | J Virol2003，77，： | 1 |
| 20 | Novel microbial di-versity adherent to plant biomass in the herbivore gas-trointestinal tract, as revealed by ribosomal intergenicspacer analysis and rrs gene sequencing 显示文摘 | LARUE R YU Z T PARISI V A | 2005 | Environ-mental Microbiology2005，7，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员