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| 1 | Mammary gland growth and vascularity at parturition and during lactation in primiparous ewes fed differing levels of selenium and nutritional plane during gestation显示文摘Background: Objectives were to examine the effects of selenium(Se) supply and maternal nutritional plane during gestation on mammary gland growth, cellular proliferation, and vascularity at parturition and d 20 of lactation. Rambouillet primiparous ewes(n = 84) were allocated to treatments in a 2 x 3 factorial. Factors were dietary Se(adequate Se [ASe, 11.5 μg/kg BW] or high Se [HSe, 77.0 μg/kg BW]) and nutritional plane(60% [RES], 100% [CON], or 140% [EXC]). At parturition, lambs were removed and 42 ewes(7/treatment) were necropsied. Remaining ewes were fed a common diet meeting requirements for lactation and mechanically milked twice daily until necropsy on d 20. At both necropsy periods, mammary glands were dissected and tissues harvested. Samples were analyzed for RNA, DNA, and protein content, cell proliferation, and vascularity. Where interactions were present(P ≤ 0.05), least squares means from the highest-order interaction are presented. Results: Final body weight of ewes was least(P ≤ 0.002) in RES, intermediate for CON, and greatest for EXC, regardless of stage of the ewe at necropsy(parturition or d 20 of lactation). In ewes necropsied at parturition, mammary glands were heavier(P = 0.02) in EXC compared to RES, with CON intermediate. Concentration of RNA(mg/g) was decreased(P = 0.01) in EXC compared to CON at parturition. There was a tendency(P = 0.07) for a Se by nutrition interaction in percentage of cells proliferating where ASe-EXC ewes had greater(P ≤ 0.02) number of proliferating cells then all other treatments. Mammary vascular area tended(P = 0.08) to be affected by a Se by nutrition interaction where ASe-CON had less(P = 0.007) vascular area than HSe-CON ewes. In ewes necropsied at d 20 of lactation, the number of alveoli per area was decreased(P ≤ 0.05) in RES compared to CON and EXC-fed ewes. Conclusions: Results of this study indicate that proper maternal nutritional plane during gestation is important for mammary gland development, even out to d 20 of lactation. | Tammi L Neville Allison M Meyer Arshi Reyaz Pawel B Borowicz Dale A Redmer Lawrence P Reynolds Joel S Caton Kimberly A Vonnahme | 2013 | Journal of Animal Science and Biotechnology2013，4，4： | 3 |
| 2 | The polities of organizational learning:Integrating power into the 41 framework显示文摘 | Lawrence T B Mauws M K Dyck B | 2005 | Academy of Management Review2005，30，1： | 1 |
| 3 | CT angiography in acute ischemic stroke:preliminary results显示文摘 | Piero V Lawrence N T Neil M B | 2002 | Stroke2002，33，： | 1 |
| 4 | High resolution and precisely dated record of weathering and hydrological dynamics recorded by manganese and rare earth elements in a stalagmite from central China 显示文摘 | Zhou H Y Chi B Q Lawrence M | 2008 | Quaternary Research2008，68，3： | 1 |
| 5 | Injectable biomaterials and vertebral endplate treatment for repair and regeneration of the intetwertebral disc 显示文摘 | Lawrence M Andrew B Carter J | 2006 | Eur Spine J2006，3，： | 1 |
| 6 | Non-ionic oil-in-water mieroemulsions: The effect of oil type on phase behaviour 显示文摘 | Warisnoicharoen W Lansley A B Lawrence M J | 2000 | lnt J Pharm2000，198，： | 1 |
| 7 | Determining Robust Impacts of Land-Use-Induced Land Cover Changes on Surface Climate over North America and Eurasia: Results from the First Set of LUCID Experiments显示文摘 | de Noblet-Ducoudré Nathalie Boisier Juan-Pablo Pitman Andy Bonan G B Brovkin V Cruz Faye Delire C Gayler V van den Hurk B J J M Lawrence P J van der Molen M K Müller C Reick C H Strengers B J Voldoire A | 2012 | EN2012，，9： | 1 |
| 8 | Acute central ghrelin and GH secretagogues induce feeding and activate brain appetite centers显示文摘 | Lawrence C B Snape A C Baudoin F M H | 2002 | Endocrinology2002，143，1： | 1 |
| 9 | Direct quantification of rare earth element concentrationsin natural waters by ICP-MS 显示文摘 | Lawrence M G Greig A Collerson K D Kamber B S | 2006 | Applied Geochemistry2006，21，： | 1 |
| 10 | The insulin-like growth factor(IGF)-depcndent IGF protein-4 protease secreted by human fibroblasts is pregnancy-associated plasma protein-A显示文摘 | LAWRENCE J B OXVIG C OVERGAARD M T | 1999 | Proc Natl Acad Sci USA1999，96，： | 1 |
| 11 | TPM3-AIJK and TPM4-ALK oncogenes in inflammatory myofibroblastie tunlol8显示文摘 | Lawrence B Perez Atayde A Hibbard M K | 2000 | Am J Pathol2000，157，2： | 1 |
| 12 | Determining Robust Impacts of Land-Use-Induced Land Cover Changes on Surface Climate over North America and Eurasia: Results from the First Set of LUCID Experiments显示文摘 | de Noblet-Ducoudré Nathalie Boisier Juan-Pablo Pitman Andy Bonan G B Brovkin V Cruz Faye Delire C Gayler V van den Hurk B J J M Lawrence P J van der Molen M K Müller C Reick C H Strengers B J Voldoire A | 2012 | EN2012，，9： | 1 |
| 13 | Nonionic oil-in water microemulsions:the effect of oil type on phase behavior显示文摘 | WARISNOICHAROEN W LANSLEY A B LAWRENCE M J | 2000 | Int J Pharm2000，198，： | 1 |
| 14 | Industrialized animal pro- duction: A major source of nutrient and microbial pollu- tion to aquatic ecosystems显示文摘 | Michael A M Lawrence B C | 2003 | Population and Environ- ment2003，24，5： | 1 |
| 15 | High-precision anal- ysis on annual variations of heavy metals, lead isotopes and rare earth elements in mangrove tree rings by inductively coupled plasma mass spectrometry显示文摘 | Yu K F Kamber B S Lawrence M G | 2007 | Nuclear Instruments and Meth- ods in Physics Research Section B : Beam Interactions with Ma- terials and Atoms2007，255，2： | 1 |
| 16 | A review of behavior al factors in- volved in the development and continued per formance of stereotypic behaviours in pigs显示文摘 | Lawrence A B Terlouw E M | 1993 | Journal of Animal Science1993，71，： | 1 |
| 17 | Activation of the aryl hydrocarbon receptor is essential for mediating the anti-inflammatory effects of a novel low-molecular-weight compound 显示文摘 | Lawrence B P Denison M S Novak H | 2008 | Blood2008，112，4： | 1 |
| 18 | Network management: emerging trends and challenges显示文摘 | ERFANI S LAWRENCE V B MALEK M | 1999 | Bell Labs Technical Journal1999，4，4： | 1 |
| 19 | Preferential allocation to beneficial symbiont with spatial structure maintains mycorrhizal mutualism显示文摘 | BEVER J D RICHARDSON S C LAWRENCE B M | 2009 | Ecology Letters2009，12，： | 1 |
| 20 | PRL-releasingpeptide reduces food intake and may mediate satiety signaling显示文摘 | Lawrence C B Ellacott K L Luckman S M | 2002 | Endocrinology2002，143，： | 1 |
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