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| 1 | Precore/basal core promoter mutants and hepatitis B viral DNA levels as predictors for liver deaths and hepatocellular carcinoma显示文摘AIM: To conduct a retrospective study in 400 chronic hepatitis B patients in order to identify hepatitis B viral factors associated with complications of liver disease or development of hepatocellular carcinoma.METHODS: The mean follow-up time was 83.6 ± 39.6 mo. Alpha-fetoprotein test and abdominal ultrasound were used for cancer surveillance. Hepatitis B basal core promoter mutants, precore mutants, genotypes, hepatitis B viral DNA (HBV DNA) level and hepatitis B e antigen (HBeAg) were measured. Univariate analysis and logistic regression were used to assess odds ratios for viral factors related to liver deaths and hepatocellular carcinoma development. RESULTS: During follow-up, 38 patients had liver deaths not related to hepatocellular carcinoma. On multivariate analysis, older age [odds ratio: 95.74 (12.13-891.31); P < 0.0001], male sex [odds ratio: 7.61 (2.20-47.95); P = 0.006], and higher log10 HBV DNA [odds ratio: 4.69 (1.16-20.43); P < 0.0001] were independently predictive for these liver related deaths. Also, 31 patients developed hepatocellular carcinoma. Multivariate analysis showed that older age [odds ratio: 26.51 (2.36-381.47); P = 0.007], presence of precore mutants [odds ratio: 4.23 (1.53-19.58); P = 0.02] and presence of basal core promoter mutants [odds ratio: 2.93 (1.24-7.57); P = 0.02] were independent predictors for progression to hepatocellular carcinoma.CONCLUSION: Our results show that high levels of baseline serum HBV DNA are associated with non- hepatocellular carcinoma-related deaths of liver failure, while genetic mutations in the basal core promoter and precore regions are predictive for development of hepatocellular carcinoma. | Myron J Tong Lawrence M Blatt Jia-Horng Kao Jason Tzuying Cheng William G Corey | 2006 | World Journal of Gastroenterology2006，12，41： | 11 |
| 2 | Reninoma: case report and literature review显示文摘 | Lara Wong Thomas HS Hsu Mark G Perlroth Lawrence V Hofmann Claudia M Haynes Laurence Katznelson | 2008 | Journal of Hypertension2008，，2： | 2 |
| 3 | Microemulsion-based media as novel drug delivery systems 显示文摘 | Lawrence M J Rees G D | 2000 | Advanced Drug Delivery Reviews2000，45，1： | 1 |
| 4 | Subaperture testing of aspheres with annular zones显示文摘 | Liu Y M Lawrence G N Koliopoulos C L | 1988 | Appl Opt1988，27，21： | 1 |
| 5 | Microemulsion-based media as novel drug delivery systems显示文摘 | LAWRENCE M J REES G D | 2000 | Adv Drug Deliv Rev2000，45，： | 1 |
| 6 | Direct protein interaction underlies gene-for-gene specificity and coevolution of the flax resistance genes and flax rust avirulence genes显示文摘 | Dodds P N Lawrence G J Catanzariti A M | 2006 | Proc Natl Acad Sci USA2006，103，： | 1 |
| 7 | The Melampsora lini AvrL567 avirulence genes are expressed in haustoria and their products are recognized inside plant cells 显示文摘 | Dodds P N Lawrence G J Catanzariti A M | 2004 | The Plant Cell2004，16，： | 1 |
| 8 | Toxic moieties in ruminal and duodenal digesta and in milk, and hepatic integrity in cattle given diets based on rapeseed meals of different glucosinolate con tents either untreated or treated with heat or formaldehyde显示文摘 | Subuh A M H Rowa T G Lawrence T L J | 1995 | Animal Feed Science and Technology1995，52，： | 1 |
| 9 | Heter-duplex molecules formed between allelic sequences cause nonparental RAPD bands显示文摘 | Aylifle M A Lawrence G J Ellis J G | 1994 | Nucleic Acid Res1994，22，： | 1 |
| 10 | A multicriteria approach to performance measurement in hospitals:A DEA approach显示文摘 | LAWRENCE K D LAWRENCE S M KLEINMAN G | 1999 | Advances in Mathematical Programming and Financial Planning1999，5，： | 1 |
| 11 | Haustorially expressed secreted proteins from flax rust are highly enriched for avirulence elicitors显示文摘 | Catanzariti A M Dodds P N Lawrence G J | 2006 | Plant Cell2006，18，： | 1 |
| 12 | The CCSM4 landsimulations, 1850-2005: assessment of surface climate and newcapabilities 显示文摘 | Lawrence D M Oleson K W Flanner M G | 2011 | J Climate2011，25，： | 1 |
| 13 | Design of a grating spectrometer from a 1 : 10ffner mirror system显示文摘 | KWO D LAWRENCE G CHRISP M | 1987 | SPIE1987，818，： | 1 |
| 14 | Determining Robust Impacts of Land-Use-Induced Land Cover Changes on Surface Climate over North America and Eurasia: Results from the First Set of LUCID Experiments显示文摘 | de Noblet-Ducoudré Nathalie Boisier Juan-Pablo Pitman Andy Bonan G B Brovkin V Cruz Faye Delire C Gayler V van den Hurk B J J M Lawrence P J van der Molen M K Müller C Reick C H Strengers B J Voldoire A | 2012 | EN2012，，9： | 1 |
| 15 | Haustorially expressed secreted proteins from flax rust are highly enriched for avirulence elicitors 显示文摘 | Catanzariti A M Dodds P N Lawrence G J | 2006 | The Plant Cell2006，18，： | 1 |
| 16 | Direct quantification of rare earth element concentrationsin natural waters by ICP-MS 显示文摘 | Lawrence M G Greig A Collerson K D Kamber B S | 2006 | Applied Geochemistry2006，21，： | 1 |
| 17 | Kallikreins on ste- roids: structure, function, and hormonal regulation of prostate - specific antigen and the extended kallikrein locus 显示文摘 | LAWRENCE M G LAI J CLEMENTS J A | 2010 | Endocr Rev2010，31，4： | 1 |
| 18 | Rare earth elementand yttrium variability in South East Queensland waterways显示文摘 | Lawrence M G Greig A Collerson K D | 2006 | Aquatic Geochemistry2006，12，1： | 1 |
| 19 | MR imaging evaluation of endometrial carcinoma:results of an NCI cooperative study显示文摘 | Hedvig H Lawrence V R Gregory M G | 1991 | Radiology1991，179，6： | 1 |
| 20 | Thin film flow over spinning discs:The effect of surface topography and flow rate modulation显示文摘 | Matar O K Sisoev G M Lawrence C J | 2008 | Chemical Engineering Science2008，63，8： | 1 |
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