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| 1 | Reproducibility of thrombus volume quantification in multicenter computed tomography pulmonary angiography studies显示文摘AIM To evaluate reproducibility of pulmonary embolism(PE) clot volume quantification using computed tomography pulmonary angiogram(CTPA) in a multicenter setting.METHODS This study was performed using anonymized data in conformance with HIPAA and IRB Regulations(March 2015-November 2016). Anonymized CTPA data was acquired from 23 scanners from 18 imaging centers using each site's standard PE protocol. Two independent analysts measured PE volumes using a semi-automated region-growing algorithm on an FDA-approved image analysis platform. Total thrombus volume(TTV) was calculated per patient as the primary endpoint. Secondary endpoints were individual thrombus volume(ITV), Qanadli score and modified Qanadli score per patient. Inter-and intra-observer reproducibility were assessed using intra-class correlation coefficient(ICC) and BlandAltman analysis. RESULTS Analyst 1 found 72 emboli in the 23 patients with a mean number of emboli of 3.13 per patient with a range of 0-11 emboli per patient. The clot volumes ranged from 0.0041-47.34 cm3(mean +/-SD, 5.93 +/-10.15 cm3). On the second read, analyst 1 found the same number and distribution of emboli with a range of volumes for read 2 from 0.0041 – 45.52 cm3(mean +/-SD, 5.42 +/-9.53 cm3). Analyst 2 found 73 emboli in the 23 patients with a mean number of emboli of 3.17 per patient with a range of 0-11 emboli per patient. The clot volumes ranged from 0.00459-46.29 cm3(mean +/-SD, 5.91 +/-10.06 cm3). Inter-and intraobserver variability measurements indicated excellent reproducibility of the semi-automated method for quantifying PE volume burden. ICC for all endpoints was greater than 0.95 for inter-and intra-observer analysis. Bland-Altman analysis indicated no significant biases.CONCLUSION Semi-automated region growing algorithm for quantifying PE is reproducible using data from multiple scanners and is a suitable method for image analysis in multicenter clinical trials. | Audrey E Kaufman Alison N Pruzan Ching Hsu Sarayu Ramachandran Adam Jacobi Indravadan Patel Lee Schwocho Michele F Mercuri Zahi A Fayad Venkatesh Mani | 2018 | World Journal of Radiology2018，10，10： | 3 |
| 2 | Total dose effects in composite Nitride- Oxide films显示文摘 | Sung- Chul Lee Raparla A Li Y F | 2000 | IEEE Transactions on Nuclear Science2000，47，6： | 2 |
| 3 | How often are angiotentensin Ⅱ and aldosterrone concentrations raised during chronic ACEinhibitortreatment in cardiacfailure显示文摘 | MAC FADYEN R J LEE A F MORTON J J | 1999 | Heart1999，82，1： | 2 |
| 4 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017，25，5： | 2 |
| 5 | Pentachlorophenols sorption by organoclay显示文摘 | Boyd S A Sun S Lee J F | 1998 | Clays Clay Miner1998，36，2： | 1 |
| 6 | Role of GGF/Neuregulin Signaling in Interactions between Migrating Neurons and Radial Glia in the Developing Cerebral Cortex显示文摘 | Anton E S Marehionni M A Lee K F | 1997 | Development1997，124，18： | 1 |
| 7 | Time-domain finite- element methods 显示文摘 | Lee J F Lee R Cangellaris A | 1997 | IEEE Transaction on Antennas and Propagation1997，45，3： | 1 |
| 8 | Investigation of candidate VRM topologies for future microprocessors显示文摘 | Zhou X Wong P Xu P Lee F C Huang A Q | 2000 | IEEE Transactions on Power Electronics2000，15，6： | 1 |
| 9 | Peri-operative hyperglycemia: a consideration for general surgery? 显示文摘 | Bower W F Lee P Y Kong A P | 2010 | Am J Surg2010，199，2： | 1 |
| 10 | Attenuating organic contaminant mobility by soil modification显示文摘 | Boyd S A Lee J F Mortland M M | 1988 | Nature1988，333，26： | 1 |
| 11 | Agenetic framework for floral patterning显示文摘 | Parcy F Nilsson O Busch M A Lee I Weigel D | 1998 | Nature1998，395，： | 1 |
| 12 | Novel full bridge zero-voltage transition PWM DC/DC Converter for high power applications显示文摘 | Sabate J A Lee F C | 1994 | APEC1994，8，2： | 1 |
| 13 | Factors affecting risk of symptomatic temporal lobe necrosis:significance of fractional dose and treatment time显示文摘 | Lee A W KWong D L Leung S F | 2002 | Int J Radiat Oneol Biol Phys2002，53，1： | 1 |
| 14 | Retrospective analysis of 5037 patients with nasopharyngeal carcinoma treated during 1976 - 1985:overall survival and patterns of failure 显示文摘 | Lee A W Poon Y F Foo W | 1992 | Int J Radial Oncol Biol Phys1992，23，： | 1 |
| 15 | Properties of Wet-mixed Fiber Reinforced Sbotcrete and Fiber Reinforced Concrete with Similar Composition显示文摘 | Leung C K Y Lai R Lee A Y F | 2005 | Cement and Concrete Research2005，35，： | 1 |
| 16 | Dynamic contrast-enhanced magnetic resonance ima-ging as a predictor of outcome in head-and-neck squa- mous cell carcinoma patients with nodal metastases 显示文摘 | SHUKLA-DAVE A LEE N Y JANSEN J F | 2012 | Int J Radiat Oncol Biol Phys2012，82，： | 1 |
| 17 | A roadmap for traffic en- gineering in SDN-OpenFlow networks 显示文摘 | AKYILDIZ I F LEE A WANG P | 2014 | Computer Networks2014，，71： | 1 |
| 18 | TRAF1-C5 as a risk locus for rheumatoid arthritis:a genome-wide study显示文摘 | Plenge R M Seielstad M Padyukov L Lee A T Remmers E F Ding B | 2007 | N Engl J Med2007，357，： | 1 |
| 19 | Fixation, not death,reduces sensitivity of DTI in detecting optic nerve damage显示文摘 | Sun S W Liang H F Xie M Oyoyo U Lee A | 2009 | Neuroimage2009，44，： | 1 |
| 20 | A framework for capacity planning and machine configuration in flexible assembly systems显示文摘 | Lee H F Srinivasan M M Yano C A | 2006 | Int J Flex Manuf Syst2006，18，： | 1 |
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