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| 1 | Computational design in architecture:Defining parametric,generative,and algorithmic design显示文摘Computation-based approaches in design have emerged in the last decades and rapidly became popular among architects and other designers.Design professionals and researchers adopted different terminologies to address these approaches.However,some terms are used ambiguously and inconsistently,and different terms are commonly used to express the same concept.This paper discusses computational design(CD)and proposes an improved and sound taxonomy for a set of key CD terms,namely,parametric,generative,and algorithmic design,based on an extensive literature review from which different definitions by various authors were collected,analyzed,and compared. | Ines Caetano Luis Santos Antonio Leitao | 2020 | Frontiers of Architectural Research2020，9，2： | 6 |
| 2 | Osteoblasts are inherently programmed to repel sensory innervation显示文摘Tissue innervation is a complex process controlled by the expression profile of signaling molecules secreted by tissue-resident cells that dictate the growth and guidance of axons.Sensory innervation is part of the neuronal network of the bone tissue with a defined spatiotemporal occurrence during bone development.Yet,the current understanding of the mechanisms regulating the map of sensory innervation in the bone tissue is still limited.Here,we demonstrated that differentiation of human mesenchymal stem cells to osteoblasts leads to a marked impairment of their ability to promote axonal growth,evidenced under sensory neurons and osteoblastic-lineage cells crosstalk.The mechanisms by which osteoblast lineage cells provide this nonpermissive environment for axons include paracrine-induced repulsion and loss of neurotrophic factors expression.We identified a drastic reduction of NGF and BDNF production and stimulation of Sema3A,Wnt4;and Shh expression culminating at late stage of OB differentiation.We noted a correlation between Shh expression profile,OB differentiation stages,and OB-mediated axonal repulsion.Blockade of Shh activity and signaling reversed the repulsive action of osteoblasts on sensory axons.Finally,to strengthen our model,we localized the expression of Shh by osteoblasts in bone tissue.Overall,our findings provide evidence that the signaling profile associated with osteoblast phenotype differentiating program can regulate the patterning of sensory innervation,and highlight osteoblast-derived Shh as an essential player in this cue-induced regulation. | Luis Leitao Estrela Neto Francisco Conceicao Ana Monteiro Marina Couto Cecilia JAlves Daniela MSousa Meriem Lamghari | 2020 | Bone Research2020，8，3： | 4 |
| 3 | 慢性阻塞性肺疾病急性加重住院患者的痰微生物族谱与其一年病死率相关显示文摘背景呼吸系统中的微生态失衡可促进气道炎症、损害局部免疫力,在慢性阻塞性肺疾病(慢阻肺)急性加重的发病机制中发挥重要作用。本研究分析了住院慢阻肺急性加重患者的痰微生物族谱与随访后该群患者的1年病死率的相关性。方法本研究收集慢阻肺急性加重住院患者的痰液样本,通过16S rRNA基因测序对微生物族谱进行了评价,最后根据患者1年的生存情况进行分析,应用Cox比例风险回归模型获得相关的风险比(HR)。 | Leitao Filho FS Alotaihi NM Ngan D 张明强 牟向东 | 2019 | 中华结核和呼吸杂志2019，42，4： | 3 |
| 4 | Whole exome sequencing identifies an AMBN missense mutation causing severe autosomal-dominant amelogenesis imperfecta and dentin disorders显示文摘Tooth development is a complex process that involves precise and time-dependent orchestration of multiple genetic, molecular,and cellular interactions. Ameloblastin(AMBN, also named 'amelin' or 'sheathlin') is the second most abundant enamel matrix protein known to have a key role in amelogenesis. Amelogenesis imperfecta(AI [MIM: 104500]) refers to a genetically and phenotypically heterogeneous group of conditions characterized by inherited developmental enamel defects. The hereditary dentin disorders comprise a variety of autosomal-dominant genetic symptoms characterized by abnormal dentin structure affecting either the primary or both the primary and secondary teeth. The vital role of Ambn in amelogenesis has been confirmed experimentally using mouse models. Only two cases have been reported of mutations of AMBN associated with non-syndromic human AI. However, no AMBN missense mutations have been reported to be associated with both human AI and dentin disorders.We recruited one kindred with autosomal-dominant amelogenesis imperfecta(ADAI) and dentinogenesis imperfecta/dysplasia characterized by generalized severe enamel and dentin defects. Whole exome sequencing of the proband identified a novel heterozygous C-T point mutation at nucleotide position 1069 of the AMBN gene, causing a Pro to Ser mutation at the conserved amino acid position 357 of the protein. Exfoliated third molar teeth from the affected family members were found to have enamel and dentin of lower mineral density than control teeth, with thinner and easily fractured enamel, short and thick roots, and pulp obliteration. This study demonstrates, for the first time, that an AMBN missense mutation causes non-syndromic human AI and dentin disorders. | Ting Lu Meiyi Li Xiangmin Xu Jun Xiong Cheng Huang Xuelian Zhang Aiqin Hu Ling Peng Decheng Cai Leitao Zhang Buling Wu Fu Xiong | 2018 | International Journal of Oral Science2018，10，4： | 3 |
| 5 | Reproductive outcomes of patients undergoing radical trachelectomy for early-stage cervical cancer显示文摘 | C.H. Kim N.R. Abu-Rustum D.S. Chi G.J. Gardner M.M. Leitao J. Carter R.R. Barakat Y. Sonoda | 2012 | Gynecologic Oncology2012，，3： | 2 |
| 6 | Lower incisor extraction in Class I and Class 11 malocclusions: case reports显示文摘 | Leitao PM | 2004 | Prog Orthod2004，5，2： | 1 |
| 7 | Evidence of differential chromosome loss in aneuploid karyotypes of the Pacific oyster,Crassostrea gigas显示文摘 | Leitao A Boudry P Thiriot-Quievreux C | 2001 | Genome2001，44，4： | 1 |
| 8 | Recurrent cervical cancer显示文摘 | Leitao MM Jr Chi DS | 2002 | Curr Treat Options Oncol2002，3，2： | 1 |
| 9 | Biogenic amines in wines: influence of oenological factors显示文摘 | MARQUES A P LEITAO M C SAN ROMAO M V | 2008 | Food Chemistry2008，107，2： | 1 |
| 10 | Oncologic outcome of fertility-sparing radical trachelectomy versus radical hysterectomy for stage IB1 cervical carcinoma 显示文摘 | Diaz J P Sonoda Y Leitao M M | 2008 | Gynecol Oncol2008，111，2： | 1 |
| 11 | Incidence of lymphnode and ovarian metastases in leiomyosarcoma of the uterus显示文摘 | Leitao MM Sonoda Y Brennan MF | 2003 | Gynecol Oncol2003，91，1： | 1 |
| 12 | A multiscale method for the reassembly of two-dimensional fragmented objects 显示文摘 | Leitao H C G Stolfi J | 2002 | IEEE Trans Patt Anal Machine Intell2002，24，： | 1 |
| 13 | Effects of growth temperature on alginate synthesis and enzymes in Pseudomonas aeruginosa variants 显示文摘 | Leitao JH Fialho AM and Sa-Correia I | 1992 | J Gen Microbiol1992，138，： | 1 |
| 14 | Three-dimensional models of non-steroidal ligands:a comparative molecular field analysis显示文摘 | Menezesa I R A Leitao A Montanari C A | 2006 | Steroids2006，71，： | 1 |
| 15 | Management of Endometrial Precancers显示文摘 | Trimble CL Method M Leitao M | 2012 | Obstet Gynecol2012，120，： | 1 |
| 16 | Oncologic outcome of fertility-sparing radical trachelectomy versus radical hysterectomy for stage IB1 cervical carcinoma显示文摘 | Diaz JP Sonoda Y Leitao MM | | 0，，02： | 1 |
| 17 | Applying landscape ecologieal concepts and metries in sustainable landscape plan- ning显示文摘 | Leitao A B Ahern J | 2002 | Landscape and Urban Planning2002，59，2： | 1 |
| 18 | Comparison of D&C and office endometrial biopsy accuracy in patients with FIGO grade 1 endometrial adenocarcinoma显示文摘 | Leitao MM Jr Kehoe S Barakat RR | 2009 | Gynecol Oncol2009，113，1： | 1 |
| 19 | A Multiscale Method for the Reassembly of Two-Dimensional Fragmented Objects显示文摘 | Leitao H C C Stolfi J | 2002 | IEEE Transactions and Pattern Analysis and Machine Intelligence2002，24，9： | 1 |
| 20 | Posterior reduc- tion and anterior lumbar interbody fusion in symp- tomatic low-grade adult isthmic spondylolisthesis: short term radiological and functional outcome显示文摘 | Spruit M Pavlov PW Leitao J | 2002 | Eur Spine J2002，11，5： | 1 |
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