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| 1 | Nature:通过控制血管生长来开发治疗癌症等多种疾病的新型疗法显示文摘最近,一项刊登在国际杂志Nature上的研究报告中,来自耶鲁大学的研究人员通过研究揭示了如何通过控制血管发育来帮助开发治疗心血管疾病以及癌症的新型疗法。 | Yu, Pengchun Wilhelm, Kerstin Dubrac, Alexandre Tung, Joe K. Alves, Tiago C. Fang, Jennifer S. Xie, Yi Zhu, Jie Chen, Zehua De Smet, Frederik Zhang, Jiasheng Jin, Suk-Won Sun, Lele Sun, Hongye Kibbey, Richard G. Hirschi, Karen K. Hay, Nissim Carmeliet, Peter Chittenden, Thomas W. Eichmann, Anne Potente, Michael Simons, Michael | 2017 | 现代生物医学进展2017，17，22： | 9 |
| 2 | Prehistoric agriculture development in the Yunnan-Guizhou Plateau, southwest China: Archaeobotanical evidence显示文摘The origin, development and expansion of prehistoric agriculture in East Asia have been widely investigated over the past two decades using archaeobotanical analysis from excavated Neolithic and Bronze Age sites. Research on prehistoric agriculture has predominantly focused in the valleys of the Yellow River and the Yangtze River. Agricultural development during the Neolithic and Bronze Age periods in the Yunnan-Guizhou Plateau of southwest China, an important passageway for human migration into Southeast Asia, still remains unclear. In this paper, based on macrofossil and microfossil analysis and radiocarbon dating at the Shilinggang site, we investigate plant subsistence strategies in the Nujiang River valley during the Bronze Age period. Combined with previous archaeobotanical studies in the Yunnan-Guizhou Plateau, we explore agricultural development processes in this area during the Neolithic and Bronze Age. Our results indicate that rice and foxtail millet were cultivated in Shilinggang around 2500 cal a BP. Three phases of prehistoric agricultural development in the Yunnan-Guizhou Plateau can be identified: rice cultivation from 4800–3900 cal a BP, mixed rice and millet crop(foxtail millet and broomcorn millet) cultivation from 3900–3400 cal a BP, and mixed rice, millet crop and wheat cultivation from 3400–2300 cal a BP. The development of agriculture in the Yunnan-Guizhou Plateau during the Neolithic and Bronze Age periods was primarily promoted by prehistoric agriculture expansion across Eurasia, agricultural expansion which was also affected by the topographic and hydrological characteristics of the area. | LI HaiMing ZUO XinXin KANG LiHong REN LeLe LIU FengWen LIU HongGao ZHANG NaiMeng MIN Rui LIU Xu DONG GuangHui | 2016 | Science China Earth Sciences2016，59，8： | 6 |
| 3 | Petrogenesis and tectonic implications of Indosinian granitoids from Western Qinling Orogen,China:Products of magma-mixing and fractionation显示文摘The Western Qinling Orogen(WQO) is characterized by voluminous distribution of Indosinian granitoids,the formation of which provides an important window to unravel the geochemical and geodynamic evolution and associated metallogeny.Here we investigate a group of intrusions termed 'Five Golden Flowers' based on petrological,geochemical,zircon U-Pb geochronological and Lu-Hf isotopic studies on the granitoids and their mafic microgranular enclaves(MMEs).Our results show that these intrusions are genetically divided into two types,namely,magma-mixing and highly fractionated.The Jiaochangba,Lujing,Zhongchuan,and Luchuba granitoids are biotite monzogranites(220±0.8 Ma to 217±2.6 Ma) with abundant coeval MMEs(220±.1 Ma to 217±2.7 Ma).The rocks contain moderate to high SiO2,high MgO,Rb,Sr,Ba,and Th contents,but low TiO2,P2 O5,and Sc values,A/CNK of <1.1,and a range of εHf(t) values of-11.7 to +2.23 with corresponding TDM2values of 1967-1228 Ma.The MMEs possess K-feldspar megacrysts,abundant acicular apatites,and show lopsided textures.They have lower SiO2,Al2 O3,and Th contents,but higher MgO,TiO2,and Sc,with εHf(t) values of-18.0 to +3.18 and TDM1 of 849-720 Ma.The data indicate that the MMEs were derived from a magma sourced from the enriched lithospheric mantle.We suggest that these host granitoids were produced by partial melting of latePaleoproterozoic to early-Mesoproterozoic lower crust with the involvement of Neoproterozoic SCLM-derived mafic magmas.The Baijiazhuang pluton is dominantly composed of leucogranite(muscovite granite and twomica monzogranite,216±1.5 Ma) without MMEs.The rocks are peraluminous with high A/CNK(1.06-1.27).Compared with the other four granitoids,the Baijiazhuang leucogranite shows higher SiO2 content,markedly lower concentrations of TiO2,MgO,Al2 O3,CaO,and Fe2 O3T,and lower LREE/HREE and(La/Yb)N values.These leucogranites are also rich in Rb,Th,and U,and display marked depletions in Ba,Sr,Ti,and Eu,indicating that they experienced significant fractionation.Zircon εHf(t) values(-10.2 to-3.27) and TDM2(1868-1424 Ma),as well as the Nb/Ta and K2 O/Na2 O values are similar to the other four granitoids,indicating that they are likely to have been derived from a similar source;with sediments playing only a minor role in the magma generation.The low contents of Yb and Y suggest that their partial melting was controlled by garnets and micrographic texture of K-feldspar reflects high-temperature melting through undercooling.Based on the above features,we infer that the Baijiazhuang leucogranite likely represents the product of high degree fractionation of the I-type biotite monzogranite magma which generated the other four granitoids at relatively high temperatures,within magma chambers at mid-crust depths.We propose that the granitoid suite was formed in the transitional setting from synto post-collision during the collisional orogeny between the SCB and NCB,following break-off of the subducted South China Block lithosphere during 220-216 Ma. | Xiao Xiong Laimin Zhu Guowei Zhang M.Santosh Hang Jiang Jun Zheng Anlin Guo Lele Ding | 2020 | Geoscience Frontiers2020，11，4： | 6 |
| 4 | Effects of grain boundary ternary alloy doping on corrosion resistance of(Ce,Pr,Nd)-Fe-B permanent magnets显示文摘To satisfy the application of different environments,grain boundary doping is commonly used in the preparation of sintered magnets to improve the coercivity and the corrosion resistance.In this paper,the alloys were prepared by mixing different ratios of the master alloy(Ce,Pr,Nd)-Fe-B and the sintering aid(Pr,Nd)-Al.The coercivity of sintered(Ce,Pr,Nd)-Fe-B magnet is substantially enhanced by doping 2 wt%of(Pr,Nd)-Al,while the maximum energy product decreases slightly.We systematically investigated the corrosion behavior and micro structure of the sintered magnets in order to determine the mechanism of the degradation.The sintered(Ce,Pr,Nd)-Fe-B magnets with 2 wt% of(Pr,Nd)-Al addition exhibit the decreasing corrosion rate compared with others,due to the distribution of intergranular phases.The electrode potential difference between the main phase and the RE-rich phase is reduced by the addition of Al,improving the potential and stability of RE-rich phase due to the higher electrode potential of Al than that of Nd,Pr or Ce.In addition,the element distribution of the magnets doped by(Pr,Nd)-Al indicates that the Al-rich shell formed at the marginal area of the Ce-rich phase improves its stability.Therefo re,intergranular adding te rnary(Pr,Nd)-Al alloy powders results in both high coe rcivity and good corrosion resistance synchronously. | Xin Wang Minggang Zhu Feng Xi Meiling Zhang Fei Liu Yingjian Guo Lele Zhang Guangrui Zhang Wei Li | 2021 | Journal of Rare Earths2021，39，8： | 6 |
| 5 | Effectiveness and clinical benefit of a therapy of combined non-pharmaceutical Traditional Chinese Medicine for knee osteoarthritis: a randomized controlled study显示文摘OBJECTIVE: To compare the efficacy of honey mouthwash 12.5% and chlorhexidine solution 0.2% to reduce the rate of oropharyngeal bacterial colonization in mechanically-ventilated patients.METHODS: This study was a randomized, single blind, phase Ⅲ controlled clinical trial. Sixty patients newly admitted to internal and trauma Intensive Care Units of the two educational hospitals of Sanandaj city affiliated with Kurdistan University of Medical Sciences were selected by convenience sampling and allocated to two groups of 30 patients using random blocks design. In each group,the mouthwash was applied twice a day for four consecutive days. Swab samples were taken from the mouth and throat of all patients three times a day(pre-intervention, two days, and four days after the intervention) and then the samples were transferred onto the blood agar and eosin methylene blue(EMB) culture plates and investigated for bacterial growth and colonization after 24-48 h.RESULTS: The findings showed that oropharyngeal colonization was not significantly different between the two groups, pre-intervention, two days,and four days after the intervention(P > 0.05). Rinsing with honey mouthwash 12.5% led to the inhibition of Staphylococcus aureus and Pseudomonas aeruginosa on the fourth day of the intervention in all samples.CONCLUSION: None of the studied solutions contributed to the reduction of oropharyngeal bacterial colonization. It seems that the growth inhibition of Staphylococcus aureus and Pseudomonas aeruginosa by the honey 12.5% mouthwash in mechanically-ventilated patients need further investigation. | Zhang Lele Yuan Haixin | 2020 | Journal of Traditional Chinese Medicine2020，40，3： | 6 |
| 6 | Refined chronology of prehistoric cultures and its implication for re-evaluating human-environment relations in the Hexi Corridor,northwest China显示文摘The reconstruction of high-resolution chronologies for prehistoric cultures is a prerequisite for understanding the history of human evolution and its relationship with environmental change, and is valuable for exploring the trajectory of transcontinental cultural exchanges in prehistoric time. The Hexi Corridor of northwest China was one of the earliest centers for long-distance culture exchange in the prehistoric world. The timing and sequence of cultural changes in this area remains poorly understood resulting from the lack of radiometric age control. This paper presents a refined radiocarbon(14 C) chronology to resolve the timing of human occupation and cultural evolution in the Hexi Corridor. Radiocarbon dating of crop remains, which have an annual life cycle, has the advantage of eliminating problems such as the carbon stored in ‘old wood’. As a result,14C dates from crop remains are used to test the validity of the14C dates derived from charcoal, bone and plant remains. The resultant database of ages is modelled using the Bayesian approach. The updated chronology presented in this paper shows generally good agreement with the original dates used to constrain cultural evolution in the Hexi Corridor. However, the occupation of the corridor by the Shajing and Shanma Late Bronze Age-Early Iron Age cultures appears to have taken place ~300 years later than previously thought. On the basis of comparing this updated chronology of cultural evolution with palaeoclimatic and historical records, it is proposed that the collapse of the Shajing and Shanma cultures occurred as a result of geopolitical impact rather than climate change. | Yishi YANG Shanjia ZHANG Chris OLDKNOW Menghan QIU Tingting CHEN Haiming LI Yifu CUI Lele REN Guoke CHEN Hui WANG Guanghui DONG | 2019 | Science China Earth Sciences2019，62，10： | 5 |
| 7 | The RNA-binding protein Musashi2 governs osteoblast-adipocyte lineage commitment by suppressing PPARγsignaling显示文摘Osteoporosis caused by aging is characterized by reduced bone mass and accumulated adipocytes in the bone marrow cavity. How the balance between osteoblastogenesis and adipogenesis from bone marrow mesenchymal stem cells(BMSCs) is lost upon aging is still unclear. Here, we found that the RNA-binding protein Musashi2(Msi2) regulates BMSC lineage commitment. Msi2 is commonly enriched in stem cells and tumor cells. We found that its expression was downregulated during adipogenic differentiation and upregulated during osteogenic differentiation of BMSCs. Msi2 knockout mice exhibited decreased bone mass with substantial accumulation of marrow adipocytes, similar to aging-induced osteoporosis. Depletion of Msi2 in BMSCs led to increased adipocyte commitment. Transcriptional profiling analysis revealed that Msi2 deficiency led to increased PPARγ signaling.RNA-interacting protein immunoprecipitation assays demonstrated that Msi2 could inhibit the translation of the key adipogenic factor Cebpα, thereby inhibiting PPAR signaling. Furthermore, the expression of Msi2 decreased significantly during the aging process of mice, indicating that decreased Msi2 function during aging contributes to abnormal accumulation of adipocytes in bone marrow and osteoporosis. Thus, our results provide a putative biochemical mechanism for aging-related osteoporosis, suggesting that modulating Msi2 function may benefit the treatment of bone aging. | Jinlong Suo Sihai Zou Jinghui Wang Yujiao Han Lingli Zhang Chenchen Lv Bo Jiang Qian Ren Long Chen Lele Yang Ping Ji Xianyou Zheng Ping Hu Weiguo Zou | 2022 | Bone Research2022，10，3： | 5 |
| 8 | Effect of acupuncture therapies combined with usual medical care on knee osteoarthritis显示文摘OBJECTIVE: To observe the effect of acupuncture or electroacupuncture(EA) combined with usual medical care for treating knee osteoarthritis(KOA).METHODS: A total of 90 patients with KOA were randomly allocated to 3 groups: usual care group(UC group, n = 30) was treated by pharmacological treatment of non-steroidal anti-inflammatory drugs(NSAIDs) and drugs for activating blood circulation(Ds-ABC), acupuncture(AP) combined with usual care group(UC group)(AP + UC group, n =30) and EA combined with UC group(EA + UC group, n = 30). The primary outcome measurements included pain visual analogue scale/score(VAS), Western Ontario and McMaster Universities Osteoarthritis Index(WOMAC Index) and its subscales. Secondary outcome measurement was Assessment of Quality of Life instrument version of the 36-item Short Form Health Survey(AQoL-SF36).RESULTS: By the end of the 1 st week, AP + UC group and EA + UC group exhibited statistically significant improvements in primary outcome measures, except for WOMAC stiffness, compared with the UC group(P < 0.05). Moreover, the energy/fatigue domain of AQoL-SF36 in the AP + UC group showed better results than UC group(P < 0.05). By the end of the 2 nd week, all the primary outcome measures revealed that either the AP + UC or EA +UC group demonstrating remarkable advantages compared with the UC group(P < 0.05). The social functioning and general health domains of AQoLSF36 in the two acupuncture-intervention groups were improved significantly than UC group(P <0.05). We also found the energy/fatigue and emotional wellbeing domains of AQoL-SF36 in the EA +UC group demonstrated better results than UC group(P < 0.05).CONCLUSION: AP or EA combined with usual care is more effective than usual care alone for the treatment of KOA, the intervention of electric current in the process of acupuncture may improve more domains of AQoL-SF36 in KOA patients. | Zhang Lele Yuan Haixin Zhang Lei Li Jian Li Hongmei | 2019 | Journal of Traditional Chinese Medicine2019，39，1： | 5 |
| 9 | DNA-mediated coordinative assembly of upconversion hetero-nanostructures for targeted dual-modality imaging of cancer cells显示文摘superstructures has enormous potential in material sciences and engineering. Despite the potential,controlled assembly of different kinds of NPs into spatially addressable hybrid configurations still remains a formidable challenge. Herein, we report a simple and universal strategy for DNA-mediated assembly of CdTe quantum dots(QDs) and lanthanide-doped upconversion nanoparticles(UCNPs). Such DNA-QD/UCNPs heterostructures not only maintains both fluorescent properties of QDs and upconversion luminescence behaviors of UCNPs, but also offers a polyvalent DNA surface, allowing for targeted dual-modality imaging of cancer cells using an aptamer. The hetero-assembly mediated by the DNA à inorganic interfacial interaction may provide a scalable way to fabricate hybrid superstructures of both theoretical and practical interests. | Wenting Xue Zhenghan Di Ya Zhao Aiping Zhang Lele Li | 2019 | Chinese Chemical Letters2019，30，4： | 4 |
| 10 | A Silicon Monoxide Lithium-Ion Battery Anode with Ultrahigh Areal Capacity显示文摘Silicon monoxide(SiO)is an attractive anode material for next-generation lithium-ion batteries for its ultra-high theoretical capacity of 2680 mAh g−1.The studies to date have been limited to electrodes with a rela-tively low mass loading(<3.5 mg cm^(−2)),which has seriously restricted the areal capacity and its potential in practical devices.Maximizing areal capacity with such high-capacity materials is critical for capitalizing their potential in practi-cal technologies.Herein,we report a monolithic three-dimensional(3D)large-sheet holey gra-phene framework/SiO(LHGF/SiO)composite for high-mass-loading electrode.By specifically using large-sheet holey graphene building blocks,we construct LHGF with super-elasticity and exceptional mechanical robustness,which is essential for accommodating the large volume change of SiO and ensuring the structure integrity even at ultrahigh mass loading.Additionally,the 3D porous graphene network structure in LHGF ensures excellent electron and ion transport.By systematically tailoring microstructure design,we show the LHGF/SiO anode with a mass loading of 44 mg cm^(−2)delivers a high areal capacity of 35.4 mAh cm^(−2)at a current of 8.8 mA cm^(−2)and retains a capacity of 10.6 mAh cm^(−2)at 17.6 mA cm^(−2),greatly exceeding those of the state-of-the-art commercial or research devices.Furthermore,we show an LHGF/SiO anode with an ultra-high mass loading of 94 mg cm^(−2)delivers an unprecedented areal capacity up to 140.8 mAh cm^(−2).The achievement of such high areal capacities marks a critical step toward realizing the full potential of high-capacity alloy-type electrode materials in practical lithium-ion batteries. | Jiang Zhong Tao Wang Lei Wang Lele Peng Shubin Fu Meng Zhang Jinhui Cao Xiang Xu Junfei Liang Huilong Fei Xidong Duan Bingan Lu Yiliu Wang Jian Zhu Xiangfeng Duan | 2022 | Nano-Micro Letters2022，14，3： | 4 |
| 11 | Oxygen‑Deficient β‑MnO_(2)@Graphene Oxide Cathode for High‑Rate and Long‑Life Aqueous Zinc Ion Batteries显示文摘Recent years have witnessed a booming interest in grid-scale electrochemical energy storage,where much attention has been paid to the aqueous zinc ion batteries(AZIBs).Among various cathode materials for AZIBs,manganese oxides have risen to prominence due to their high energy density and low cost.However,sluggish reaction kinetics and poor cycling stability dictate against their practical application.Herein,we demonstrate the combined use of defect engineering and interfacial optimization that can simultaneously promote rate capability and cycling stability of MnO_(2) cathodes.β-MnO_(2) with abundant oxygen vacancies(VO)and graphene oxide(GO)wrapping is synthesized,in which VO in the bulk accelerate the charge/discharge kinetics while GO on the surfaces inhibits the Mn dissolution.This electrode shows a sustained reversible capacity of~129.6 mAh g^(−1) even after 2000 cycles at a current rate of 4C,outperforming the state-of-the-art MnO_(2)-based cathodes.The superior performance can be rationalized by the direct interaction between surface VO and the GO coating layer,as well as the regulation of structural evolution ofβ-MnO_(2) during cycling.The combinatorial design scheme in this work offers a practical pathway for obtaining high-rate and long-life cathodes for AZIBs. | Shouxiang Ding Mingzheng Zhang Runzhi Qin Jianjun Fang Hengyu Ren Haocong Yi Lele Liu Wenguang Zhao Yang Li Lu Yao Shunning Li Qinghe Zhao Feng Pan | 2021 | Nano-Micro Letters2021，13，11： | 3 |
| 12 | Spontaneous caving and gob-side entry retaining of thin seam with large inclined angle显示文摘Based on the research method of combining simulation analysis with field testing by distinct element process UDEC, we have analyzed the roof deformation and failure laws and roadway support technology of gob-side entry retaining in a thin seam with a large inclined angle. The results show that during exploitation in seams with large inclined angle, rotational subsidence of the main roof under the gob area is small and can maintain balance, so there is no need to provide artificial permanent support resistance for the main roof near the upper side to control rotational subsidence. Obstructed by the dense scrap rail,waste rock from the immediate roof caving slides from the upper gob area to the lower area and fills it,which strikes a balance between the immediate roof under the goaf after it fractures into large pieces and filling waste rocks. | Zhang Yongqin Tang Jianxin Xiao Daqiang Sun Lele Zhang Weizhong | 2014 | International Journal of Mining Science and Technology2014，24，4： | 3 |
| 13 | Sonodynamic therapy with immune modulatable two-dimensional coordination nanosheets for enhanced anti-tumor immunotherapy显示文摘Ultrasound with deep penetration depth and high security could be adopted in sonodynamic therapy(SDT)by activating sonosensitizers to generate cytotoxic reactive oxygen species(ROS).Herein,two-dimensional(2D)coordination nanosheets composed of Zn^(2+)and Tetrakis(4-carboxyphenyl)porphyrin(TCPP)are fabricated.While exhibiting greatly enhanced ultrasoundtriggered ROS generation useful for noninvasive SDT,such Zn-TCPP 2D nanosheets show high loading capacity of oligodeoxynudeotides such as cytosine—phosphorothioate-guanine(CpG),which is a potent toll like receptor 9(TLR9)agonist useful in activating immune responses.Highly effective SD T of primary tumors could release tumor-associated antigens,which working together with Zn-TCPP/CpG adjuvant nanosheets could function like whole-tumor-cell vaccines and trigger tumor-specific immune responses.Interestingly,ultrasound itself could strengthen anti-tumor immune responses by improving the tumor-infiltration of T cells and limiting regulatory T cells in the tumor microenvironment.Thus,SDT using Zn-TCPP/CpG nanosheets after destruction of primary tumors could induce potent antitumor immune responses to inhibit distant abscopal tumors without direct SD T treatment.Moreover,SDT with Zn-TCPP/CpG could trigger strong immunological memory effects to inhibit cancer recurrence after elimination of primary tumors.Therefore,the 2D coordination nanosheet may be a promising platform to deliver potent SDT-triggered immunotherapy for highly effective cancer treatment. | Wenjun Zhu Qian Chen Qiutong Jin Yu Chao Lele Sun Xiao Han Jun Xu Longlong Tian Jinglei Zhang Teng Liu Zhuang Liu | 2021 | Nano Research2021，14，1： | 3 |
| 14 | Heterojunction Incorporating Perovskite and Microporous Metal–Organic Framework Nanocrystals for Efficient and Stable Solar Cells显示文摘In this paper,we present a facile approach to enhance the efficiency and stability of perovskite solar cells(PSCs)by incorporating perovskite with microporous indium-based metal–organic framework[In12O(OH)16(H2O)5(btc)6]n(In-BTC)nanocrystals and forming heterojunction light-harvesting layer.The interconnected micropores and terminal oxygen sites of In-BTC allow the preferential crystallization of perovskite inside the regular cavities,endowing the derived films with improved morphology/crystallinity and reduced grain boundaries/defects.Consequently,the In-BTC-modified PSC yields enhanced fill factor of 0.79 and power conversion efficiency(PCE)of 20.87%,surpassing the pristine device(0.76 and 19.52%,respectively).More importantly,over 80%of the original PCE is retained after 12 days of exposure to ambient environment(25°C and relative humidity of^65%)without encapsulation,while only about 35%is left to the pristine device. | Xuesong Zhou Lele Qiu Ruiqing Fan Jian Zhang Sue Hao Yulin Yang | 2020 | Nano-Micro Letters2020，12，6： | 3 |
| 15 | Dramatic shifts in intestinal fungal community between wintering Hooded Crane and Domestic Goose显示文摘Background:The intestinal microbiota play remarkable roles in maintaining the health of their hosts.Recent studies focused on gut bacterial diversity in birds and poultry,with little information about the ecological functions of their gut fungal community.Methods:The high-throughput sequencing was applied to compare intestinal fungal community structure between Hooded Crane(Grus monacha)and Domestic Goose(Anser anser domesticus),and infer the potential pathogens of each species at Shengjin Lake of China.Results:Intestinal fungal alpha diversity was higher in Hooded Crane than Greylag Goose(Anser anser).Gut fungal community composition showed dramatic shifts between the two species.Hooded Cranes mainly eat Vallisneria natans and Potamogeton malaianus,while artificial hurl food(i.e.,paddy)was the main food resource for Domestic Geese,suggesting that the variations in fungal community might be induced by different diets between the two hosts.Two enriched genera(i.e.,Acremonium and Rhodotorula)which could increase host's digestion were detected in guts of Hooded Cranes.In addition,there were 42 pathogenic amplicon sequence variants(ASVs),17%of which shared in Hooded Crane and Greylag Goose.The Hooded Crane had higher gut fungal pathogenic diversity and abundance relative to Greylag Goose.Conclusions:The study demonstrated that divergence in intestinal fungal community structure might be induced by different diets between wintering Hooded Crane and Domestic Goose.Hooded Crane might rely more on their gut fungal taxa to acquire nutrients from indigestible food resources.Our study also implied that more research should focus on intestinal pathogens in wild birds and domestic poultry,as they might increase risk of disease in other animals,even human beings.The degree of cross infection in pathogens among wild birds and sympatric poultry should be clearly verified in future study. | Xingjia Xiang Lele Jin Zhuqing Yang Nazhong Zhang Feng Zhang | 2021 | Avian Research2021，12，1： | 3 |
| 16 | Flavone from Zhongjiefeng(Herba Sarcandrae Glabrae) inhibits platelet apoptosis in immune-induced bone marrow failure through mitochondrial pathway显示文摘OBjECTIVE: To investigate the effect of Flavone from Zhongjiefeng(Herba Sarcandrae Glabrae) on the platelet number in immune-induced bone marrow failure(BMF) and its mechanism of mitochondrial apoptotic pathway.METHODS: Immune-induced BMF model, established in mice, was randomly divided into four groups: normal control group without BMF, BMF control group, cyclosporine(CSA) group and flavone group(n = 10 in each group). Mice were given0.027 g/kg cyclosporine or 0.2 g/kg flavone lavage daily in either the cyclosporine or flavone group respectively. Platelet count, mitochondrial transmembrane potential(ΔΨm), cytochrome C(Cyt C), phosphatidylserine(PS), changes of calcium ion(Ca^(2+)),and protein expression of mitochondrial apoptotic pathway including B-cell lymphoma-2(bcl-2) Homologous Antagonist-Killer Protein(Bak), bcl-2-associated X protein(Bax), caspase-3, caspase-8, and caspase-9 were examined and compared.RESULTS: Compared with the normal control group, the BMF group had significantly lower levels of platelet count, ΔΨm, and expressions of caspase family proteins as well as higher levels of Cyt C, PS,Ca^(2+), and expressions of Bak and Bax(all P < 0.05).Compared with the BMF group, the CSA and flavone groups had significantly higher ΔΨm and expressions of caspase family proteins(all P < 0.05)whereas the levels of Cyt C, PS, Ca^(2+), and expressions of Bak and Bax were reduced(all P < 0.05).More importantly, the flavone group had higher levels of Cyt C, Ca^(2+)and expressions of Bak and Bax compared with the CSA group(all P < 0.05), while the levels of PS and caspase family proteins were reduced(all P < 0.05).CONCLUSION: Flavone from Zhongjiefeng(Herba Sarcandrae Glabrae) significantly increases the platelet number and prevents its apoptosis through mitochondrial pathway. | Jiang Yiling Zheng Qin Zhang Aiping Cui Lele Xia Lemin Luo Meihong | 2017 | Journal of Traditional Chinese Medicine2017，37，5： | 2 |
| 17 | Genome-wide evolution of MAPKs family and their expression in response to bacterial infection in seahorse Hippocampus erectus显示文摘Seahorses have evolved many unique biological traits,including a male brood pouch,the absence of caudal and pelvic fins,and the lack of spleen and gut-associated lymphatic tissue.The mitogenactivated protein kinases(MAPKs)are known to be involved in various important biological processes including growth,differentiation,immunity,and stress responses.Therefore,we hypothesized that the adaptive evolution and expression of the MAPK gene family in seahorse may differ from those of other teleost species.We identified positive selection sites in the erk2,erk5,jnk1,and p38αMAPK genes of the lined seahorse Hippocampus erectus and tiger-tailed seahorse Hippocampus comes.A novel expression profile of MAPK cascade genes was found in seahorse larvae during the first day after birth based on the RNA-seq data of H.erectus,which refl ected vital signs of immune response to its parental immune system.The expression patterns of the four positively selected MAPK genes were analyzed following the bacterial challenge of Vibrio fortis,revealing their upregulation pattern in brood pouch and other immune tissues.This study enriched our knowledge of the evolution of the H.erectus MAPK subfamilies,and could help better understanding the functional role of MAPKs in teleosts. | Kai WANG Xin WANG Qiang ZOU Han JIANG Rongrong ZHANG Yanan TIAN Lele ZHANG Qiang LIN | 2021 | Journal of Oceanology and Limnology2021，39，6： | 2 |
| 18 | Functional-template directed self-assembly(FTDSA) of mesostructured organic-inorganic hybrid materials显示文摘Since the discovery of a surfactant directed self-assembly approach for the fabrication of mesoporous silica in 1992,increasing attention has been focused on the design and synthesis of mesostructured functional materials.Organic functionalization is becoming a major topic in this research field,since highly ordered mesostructured organic-inorganic hybrids offer novel functionalities and enhanced performance over their individual components.We begin with a brief overview of the three fundamental methods(post-synthetic grafting technique,co-condensation method,and preparation of periodic mesoporous organosilicas) for the preparation of organically functionalized mesostructured silica,and focus on one of the most promising approaches,which herein was named as functional-template directed self-assembly(FTDSA) approach,and in the eyes of the authors it has a special position in the preparation of this class of hybrid materials.A comprehensive overview of the state of research in the area of FTDSA and its potential applications will be given. | LI LeLe SUN LingDong ZHANG YaWen m YAN ChunHua | 2009 | Science China Chemistry2009，52，11： | 2 |
| 19 | The promises, challenges and pathways to room-temperature sodium-sulfur batteries显示文摘Room-temperature sodium-sulfur batteries(RT-Na-S batteries) are attractive for large-scale energy storage applications owing to their high storage capacity as well as the rich abundance and low cost of the materials.Unfortunately, their practical application is hampered by severe challenges, such as low conductivity of sulfur and its reduced products, volume expansion, polysulfide shuttling effect and Na dendrite formation,which can lead to rapid capacity fading. The review discusses the Na-S-energy-storage chemistry,highlighting its promise, key challenges and potential strategies for large-scale energy storage systems.Specifically, we review the electrochemical principles and the current technical challenges of RT-Na-S batteries, and discuss the strategies to address these obstacles. In particular, we give a comprehensive review of recent progresses in cathodes, anodes, electrolytes, separators and cell configurations, and provide a forward-looking perspective on strategies toward robust high-energy-density RT-Na-S batteries. | Lei Wang Tao Wang Lele Peng Yiliu Wang Meng Zhang Jian Zhou Maoxin Chen Jinhui Cao Huilong Fei Xidong Duan Jian Zhu Xiangfeng Duan | 2022 | National Science Review2022，9，3： | 2 |
| 20 | Controlled synthesis and assembly of ceriabased nanomaterials 显示文摘 | Yuan Quan Duan Haohong Li Lele Sun Lingdong Zhang Yawen Yan Chunhua | 2009 | Journal of Colloid and Interface Science2009，335，2： | 1 |
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