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| 1 | Total glucosides of paeony attenuates animal psoriasis induced inflammatory response through inhibiting STAT1 and STAT3 phosphorylation显示文摘OBJECTIVE Psoriasis is an immune system meditated disease,especially T cells.It disturbed many people around the world and hard to therapy.Paeonia lactiflora Pall has been used as a medicine in china for thousands of years.Recent studies has found that the main component of Paeonia lactiflora Pall can alleviates the immune response in many diseases.In this study,we researched the effects and possible mechanisms of total glucosides of paeony(TGP)on animal psoriasis in order to study the therapeutic effects and mechanisms of TGP in 5%propranolol creaminduced psoriasis in guinea pigs and Imiquimod(IMQ)cream-induced psoriasis in mice.METHODS The effect of TGP was evaluated using a psoriasis-like model of guinea pigs and mice.Ear thickness was accessed,and pathology injury was observed by HE staining.The levels of serum IL-1β,IL-6,IL-12,IL-17,IL-23,TNF-α,and IFN-γ,skin IL-17A,IL-22 and orphan nuclear receptor(RORγt)mRNA expression,proliferating cell nuclear antigen(PCNA),total or phosphorylated signal transducers and activators of transcription(STAT1 and STAT3)were determined by ELISA,real time PCR,immu⁃nohistochemical staining,and Western blotting,respectively.RESULTS Compared with model group,TGP treatment decreased the ear thickness,improved pathology of psoriasis,alleviated IMQ-induced keratinocyte proliferation,reduced the inflammatory cytokine,and downregulated IL-17A,IL-22,and RORγt mRNA in mice.Further study indicated that TGP inhibited STAT1 and STAT3 phosphorylation in lesion skins of psoriasis-like mice.CONCLUSION TGP alleviates the symptoms of psoriasis-like guinea pigs and mice,and the possible mechanism may relate to inhibit T helper 17(TH17)cell differentiation and keratinocytes proliferation by inhibiting STAT1 and STAT3 phosphorylation. | LI Bin-bin HE Shu-cheng LIU Rui HUANG Liang-liang LIU Ge WANG Rui-xuan YANG Zhuo-yue LIU Xin-yi LENG Ye LIU Dan YE Cheng-yu LI Yun-man CHEN Yong-jian IN Hong FANG Wei-rong | 2019 | 中国药理学与毒理学杂志2019，33，9： | 21 |
| 2 | Near-diffraction-limited linearly polarized narrow-linewidth random fiber laser with record kilowatt output显示文摘In this paper, we propose and experimentally investigate a linearly polarized narrow-linewidth random fiber laser(RFL) operating at 1080 nm and boost the output power to kilowatt level with near-diffraction-limited beam quality using a master oscillation power amplifier. The RFL based on a half-opened cavity, which is composed of a linearly polarized narrow-linewidth fiber Bragg grating and a 500 m piece of polarization-maintained Ge-doped fiber, generates a 0.71 W seed laser with an 88 pm full width at half-maximum(FWHM) linewidth and a 22.5 dB polarization extinction ratio(PER) for power scaling. A two-stage fiber amplifier enhances the seed laser to the maximal 1.01 k W with a PER value of 17 dB and a beam quality of M_x^2=1.15 and M_y^2=1.13. No stimulated Brillouin scattering effect is observed at the ultimate power level, and the FWHM linewidth of the amplified random laser broadens linearly as a function of the output power with a coefficient of about 0.1237 pm∕W.To the best of our knowledge, this is the first demonstration of a linearly polarized narrow-linewidth RFL with even kilowatt-level near-diffraction-limited output, and further performance scaling is ongoing. | JIANGMING XU LONG HUANG MAN JIANG JUN YE PENGFEI MA JINYONG LENG JIAN WU HANWEI ZHANG PU ZHOU | 2017 | Photonics Research2017，5，4： | 20 |
| 3 | Carbonate-salt-based composite materials for medium- and high-temperature thermal energy storage显示文摘This paper discusses composite materials based on inorganic salts for medium- and high-temperature thermal energy storage application.The composites consist of a phase change material(PCM),a ceramic material,and a high thermal conductivity material.The ceramic material forms a microstructural skeleton for encapsulation of the PCM and structural stability of the composites;the high thermal conductivity material enhances the overall thermal conductivity of the composites.Using a eutectic salt of lithium and sodium carbonates as the PCM,magnesium oxide as the ceramic skeleton,and either graphite flakes or carbon nanotubes as the thermal conductivity enhancer,we produced composites with good physical and chemical stability and high thermal conductivity.We found that the wettability of the molten salt on the ceramic and carbon materials significantly affects the microstructure of the composites. | Zhiwei Ge Feng Ye Hui Cao Guanghui Leng Yue Qin Yulong Ding | 2014 | Particuology2014，12，4： | 19 |
| 4 | Tandem pumping architecture enabled high power random fiberlaser with near-diffraction-limited beam quality显示文摘In this contribution, we present the tandem pumping avenue leveraged performance scaling of random fiber laser to record 3 kW level with inherent temporal stability and near-diffraction-limited beam quality. The high power system employs a four-stage master oscillator power amplifier chain. The master oscillator is a half-opened cavity structured random distributed feedback fiber laser centered at 1080 nm and pumped by incoherent amplified spontaneous emission source. Narrowband random laser seed is selected by employing a spectral filtering module with a maximum output power of 1.08 W, full width at half maximum linewidth of 0.47 nm and spectral optical-signal-to-noise ratio of about 42 dB. As to the main amplification stage, for given 104 W pre-amplified random laser seed and 3.61 kW pump laser, an ultimate output power of 3.03 kW can be obtained,corresponding to an optical-to-optical conversion efficiency of 81.05%. Nearly single-transverse-mode amplified random laser can be achieved even at full power level for inherent high thermal modal instability threshold enabled by tandem pumping and inducing bending loss for high-order transverse-mode. Further performance scaling of this high power random laser system, such as power boosting, operation wavelength tuning and linewidth alteration, is the next goal. | XU JiangMing YE Jun ZHOU Pu LENG JinYong XIAO Hu ZHANG HangWei WU Jian CHEN JinBao | 2019 | Science China(Technological Sciences)2019，62，1： | 8 |
| 5 | Allele-defined genome reveals biallelic differentiation during cassava evolution显示文摘Dear Editor,Generation of heterozygous genomes by hybridization between or within species can help maintain plant diversity and serve as a potential source of new species(Baek et al.,2018).Moreover,genomic heterozygosity is associated with genomic coadaptation,developmental stability,and heterosis.Accurate definition of alleles in haplotypes is necessary to precisely characterize allelic variation controlling agriculturally important traits(Shi et al.,2019).Currently,most released genomes have mosaic assembly of haplotypes due to random selection or collapse of alleles during genome assembly(Shi et al.,2019),which masked allelic variation and functional differentiation of divergent alleles in heterozygous species. | Wei Hu Changmian Ji Haitao shi Zhe Liang Zehong Ding Jianqiu Ye Wenjun Ou Gang Zhou Weiwei Tie Yan Yan Jinghao Yang Xiaoying Yang Yunxie Wei Zhiqiang Jin Jianghui Xie Ming Peng Wenquan Wang Anping Guo Biyu Xu Jianchun Guo Songbi Chen Liming Ma Mingcheng Wang Yang Zhou Xiaolong Li Ruoxi Li Siyi Guo Xinhui Xiao Zhongqing Wan Feifei An Jie Zhang Qingyun Leng Yin Li Ray Ming Kaimian Li | 2021 | Molecular Plant2021，14，6： | 8 |
| 6 | LncRNAs-directed PTEN enzymatic switch governs epithelial–mesenchymal transition显示文摘Despite the structural conservation of PTEN with dual-specificity phosphatases,there have been no reports regarding the regulatory mechanisms that underlie this potential dual-phosphatase activity.Here,we report that K27-linked polyubiquitination of PTEN at lysines 66 and 80 switches its phosphoinositide/protein tyrosine phosphatase activity to protein serine/threonine phosphatase activity.Mechanistically,high glucose,TGF-β,CTGF,SHH,and IL-6 induce the expression of a long non-coding RNA,GAEA(Glucose Aroused for EMT Activation),which associates with an RNA-binding E3 ligase,MEX3C,and enhances its enzymatic activity,leading to the K27-linked polyubiquitination of PTEN.The MEX3C-catalyzed PTEN^K27-polyUb activates its protein serine/threonine phosphatase activity and inhibits its phosphatidylinositol/protein tyrosine phosphatase activity.With this altered enzymatic activity,PTEN^K27-polyUb dephosphorylates the phosphoserine/threonine residues of TWIST1,SNAI1,and YAP1,leading to accumulation of these master regulators of EMT.Animals with genetic inhibition of PTEN^K27-polyUb,by a single nucleotide mutation generated using CRISPR/Cas9(Pten^K80R/K80R),exhibit inhibition of EMT markers during mammary gland morphogenesis in pregnancy/lactation and during cutaneous wound healing processes.Our findings illustrate an unexpected paradigm in which the lncRNA-dependent switch in PTEN protein serine/threonine phosphatase activity is important for physiological homeostasis and disease development. | Qingsong Hu Chunlai Li Shouyu Wang Yajuan Li Bo Wen Yanyan Zhang Ke Liang Jun Yao Youqiong Ye Heidi Hsiao Tina K.Nguyen Peter K.Park Sergey D.Egranov David H.Hawke Jeffrey R.Marks Leng Han Mien-Chie Hung Bing Zhang Chunru Lin Liuqing Yang | 2019 | Cell Research2019，29，4： | 8 |
| 7 | In-band pumping avenue based high power superfluorescent fiber source with record power and near-diffraction-limited beam quality显示文摘High power superfluorescent fiber sources(SFSs), which could find wide applications in many fields such as middle infrared laser generation, Raman fiber laser pumping and spectral beam combination, have experienced a flourishing time in recent years for its unique properties, such as short coherence length and high temporal stability. The challenge for performance scalability of powerful SFS mainly lies on the physical issues including parasitic laser oscillation and modal instability(MI). In this contribution, by employing in-band pumping avenue and high-order transverse-mode management, we explore a high power SFS with record power, near-diffraction-limited beam quality and spectral manipulation flexibility. An ultimate output power of 3.14 kW can be obtained with high temporal stability and a beam quality of M^2= 1.59 for the amplified light. Furthermore, the dynamics of spectral evolutions, including redshifting of central wavelength and unsymmetrical broadening in spectral wings, of the main amplifier with different seed linewidths are investigated contrastively. Benefiting from the unique high pump brightness and high MI threshold of in-band pumping scheme, the demonstrated system also manifests promising performance scaling potential. | Jiangming Xu Jun Ye Hu Xiao Jinyong Leng Wei Liu Pu Zhou | 2018 | High Power Laser Science and Engineering2018，6，3： | 5 |
| 8 | Integrated System of Solar Cells with Hierarchical NiCo2O4 Battery-Supercapacitor Hybrid Devices for Self-Driving Light-Emitting Diodes显示文摘An integrated system has been provided with a-Si/H solar cells as energy conversion device,NiCo2O4 battery-supercapacitor hybrid(BSH)as energy storage device,and light emitting diodes(LEDs)as energy utilization device.By designing three-dimensional hierarchical NiCo2O4 arrays as faradic electrode,with capacitive electrode of active carbon(AC),BSHs were assembled with energy density of 16.6 Wh kg-1,power density of 7285 W kg-1,long-term stability with 100% retention after 15,000 cycles,and rather low self-discharge.The NiCo2O4//AC BSH was charged to 1.6 V in 1 s by solar cells and acted as reliable sources for powering LEDs.The integrated system is rational for operation,having an overall efficiency of 8.1% with storage efficiency of 74.24%.The integrated system demonstrates a stable solar power conversion,outstanding energy storage behavior,and reliable light emitting.Our study offers a precious strategy to design a self-driven integrated system for highly efficient energy utilization. | Yuliang Yuan Yangdan Lu BeiEr Jia Haichao Tang Lingxiang Chen YuJia Zeng Yang Hou Qinghua Zhang Qinggang He Lei Jiao Jianxing Leng Zhizhen Ye Jianguo Lu | 2019 | Nano-Micro Letters2019，11，3： | 5 |
| 9 | Hepatic perivascular epithelioid cell tumor in three patients显示文摘Perivascular epithelioid cell tumor(PEComa) is a rare, soft tissue tumor that can occur in various locations. The present report included three patients(one male and two females; age range, 25-51 years) with hepatic PEComas. The collected data included the clinical manifestations, diagnosis, management, treatment, and prognosis. Since it is difficult to diagnose hepatic PEComas by imaging, the patients were diagnosed by tumor tissue examination such as immunohistochemistry, which was positive for HMB-45, Melan-A, and SMA on all slides. The tumor was composed of diverse tissues including smooth muscle, adipose tissue, and thick-walled blood vessels. During the follow-up period, one of the tumors was malignant(double-positive for CD34 and Ki-67) and recurred 3 months after surgery. In addition, malignant hepatic PEComas were reviewed in the literature, indicating that the majority of hepatic PEComas are benign, but few hepatic PEComas exhibit malignant behaviors in older female patients(>50 years of age) with abdominal discomfort and pain, larger tumor size(>10 cm), or positive staining for CD34 and Ki-67. In conclusion, there is no effective method to diagnose PEComas. Currently, the diagnosis of PEComas depends on immunohistochemical staining. Tumor resection and close follow-up are the principal methods for the management of PEComas. | Bao-Bin Hao Jian-Hua Rao Ye Fan Chuang-Yong Zhang Xin-Zheng Dai Xiao Li Yan Leng Feng Zhang | 2016 | Hepatobiliary & Pancreatic Diseases International2016，15，6： | 4 |
| 10 | Passively spatiotemporal gain-modulation-induced stable pulsing operation of a random fiber laser显示文摘Unlike a traditional fiber laser with a defined resonant cavity, a random fiber laser(RFL), whose operation is based on distributed feedback and gain via Rayleigh scattering(RS) and stimulated Raman scattering in a long passive fiber, has fundamental scientific challenges in pulsing operation for its remarkable cavity-free feature. For the time being, stable pulsed RFL utilizing a passive method has not been reported. Here, we propose and experimentally realize the passive spatiotemporal gain-modulation-induced stable pulsing operation of counterpumped RFL. Thanks to the good temporal stability of an employed pumping amplified spontaneous emission source and the superiority of this pulse generation scheme, a stable and regular pulse train can be obtained.Furthermore, the pump hysteresis and bistability phenomena with the generation of high-order Stokes light is presented, and the dynamics of pulsing operation is discussed after the theoretical investigation of the counterpumped RFL. This work extends our comprehension of temporal property of RFL and paves an effective novel avenue for the exploration of pulsed RFL with structural simplicity, low cost, and stable output. | JIANGMING XU JUN YE WEI LIU JIAN WU HANWEI ZHANG JINYONG LENG PU ZHOU | 2017 | Photonics Research2017，5，6： | 4 |
| 11 | Vortex random fiber laser with controllable orbital angular momentum mode显示文摘In this paper, we propose and experimentally demonstrate a vortex random fiber laser(RFL) with a controllable orbital angular momentum(OAM) mode. The topological charge of the vortex RFL can range from-50 to 50 with nearly watt-level output power. A triangular toroidal interferometer is constructed to verify the spiral phase structure of the generated vortex random laser with a special coherence property. Vortex RFLs with fractional topological charge are also performed in this work. As the first demonstration of a vortex RFL with a controllable OAM mode(to the best of our knowledge), this work may not only offer a valuable reference on temporal modulation of a vortex beam and optical field control of an RFL but also provide a potential vortex laser source for applications in imaging, sensing, and communication. | XIAOYA MA JUN YE YANG ZHANG JIANGMING XU JIAN WU TIANFU YAO JINYONG LENG PU ZHOU | 2021 | Photonics Research2021，9，2： | 4 |
| 12 | Pump scheme optimization of an incoherently pumped high-power random fiber laser显示文摘Optical signal-to-noise ratio(OSNR) is one of the most significant parameters for the performance characterization of random fiber lasers(RFLs) and their application potentiality in sensing and telecommunication. An effective way to improve the OSNR of RFLs is pump scheme optimization, for example, employing a temporally stable source as the pump. In this paper, the output performance of an incoherently pumped RFL dependence on the pump bandwidth has been investigated both in experiment and theory. It is found that a high-OSNR RFL can be achieved with broadband amplified spontaneous emission(ASE) source pumping, and a relatively broad pump bandwidth can also help suppress the spectral broadening while maintaining an ultra-high spectral purity.By optimizing the pump bandwidth to ~10 nm, maximum OSNR of ~39 dB(corresponding to a spectral purity of ~99.96%) with more than 99 W output power can be obtained. Moreover, for the pump bandwidth of 0.6–40 nm, the spectral purity can reach as high as >99% with the pump power ranging from ~85 to ~117 W.In addition, with the aid of theoretical simulation based on a modified power balance model, we find that the increment of pump bandwidth can decrease the effective Raman gain coefficient, further influencing the gain characteristics, nonlinear effects, and eventually the output performance. This work provides new insight into the influence of the pump characteristics on the output performance of incoherently pumped RFLs. | JUN YE JIANGMING XU JIAXIN SONG ANG ZHANG HANWEI ZHANG HU XIAO JINYONG LENG PU ZHOU | 2019 | Photonics Research2019，7，9： | 4 |
| 13 | Optical rogue wave in random fiber laser显示文摘The famous demonstration of optical rogue waves(RWs),a powerful tool to reveal the fundamental physics in different laser scenarios,opened a flourishing time for temporal statistics.Random fiber laser(RFL)has likewise attracted wide attention due to its great potential in multidisciplinary demonstrations and promising applications.However,owing to the distinctive cavity-free structure,it is a scientific challenge to achieve temporal localized RWs in RFLs,whose feedback arises from multiple scattering in disordered medium.Here,we report the exploration of RW in the highly skewed,transient intensity of an incoherently pumped RFL for the first time,to our knowledge,and unfold the involved kinetics successfully.The corresponding frequency domain measurements demonstrate that the RW event arises from a crucial sustained stimulated Brillouin scattering process with intrinsic stochastic nature.This investigation highlights a novel path to fully understanding the complex physics,such as photon propagation and localization,in disordered media. | JIANGMING XU JIAN WU JUN YE JIAXIN SONG BAICHENG YAO HANWEI ZHANG JINYONG LENG WEILI ZHANG PU ZHOU YUNJIANG RAO | 2020 | Photonics Research2020，8，1： | 4 |
| 14 | The Pathogenesis and Treatment of COVID-19:A System Review显示文摘INTRODUCTION After the outbreak of severe acute respiratory syndrome(SARS)and Middle East respiratory syndrome(MERS),it was difficult to imagine the recurrence of a virus that can spread worldwide in less than two decades.However,it did.In December of 2019,this virus called severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)was associated with the emergence of pneumonia cases of unknown etiology in Wuhan,Hubei Province. | JI Ye Long WU Yang QIU Zhen MING Hao ZHANG Yi ZHANG Ai Ning LENG Yan XIA Zhong Yuan | 2021 | Biomedical and Environmental Sciences2021，34，1： | 3 |
| 15 | Industrial TiO2 based nacreous pigments as functional building materials:Photocatalytic removal of NO显示文摘In this paper,the photocatalytic activity of industrial titanium dioxide(TiO2)based nacreous pigments was researched as functional building materials for photocatalytic NO remove.Three industrial TiO2 based nacreous pigments were selected to estimate the photocatalytic activity for NO remove.This study is a good proof that pearlescent pigments can eliminate NO,and its performance is positively correlated with its titanium dioxide content.And this research will widen the application of nacreous pigments in functional building materials,and provide a new way to eliminate in door nitric oxide pollution. | Jue Li Li Wang Chunqiu Han Fengyun Su Yumin Leng Liqun Ye | 2020 | Chinese Journal of Chemical Engineering2020，28，10： | 3 |
| 16 | Enzymatically-degradable hydrogel coatings on titanium for bacterial infection inhibition and enhanced soft tissue compatibility via a self-adaptive strategy显示文摘Ideal percutaneous titanium implants request both antibacterial ability and soft tissue compatibility.ZnO structure constructed on titanium has been widely proved to be helpful to combat pathogen contamination,but the biosafety of ZnO is always questioned.How to maintain the remarkable antibacterial ability of ZnO and efficiently reduce the corresponding toxicity is still challenging.Herein,a hybrid hydrogel coating was constructed on the fabricated ZnO structure of titanium,and the coating was proved to be enzymatically-degradable when bacteria exist.Then the antibacterial activity of ZnO was presented.When under the normal condition(no bacteria),the hydrogel coating was stable and tightly adhered to titanium.The toxicity of ZnO was reduced,and the viability of fibroblasts was largely improved.More importantly,the hydrogel coating provided a good buffer zone for cell ingrowth and soft tissue integration.The curbed Zn ion release was also proved to be useful to regulate fibroblast responses such as the expression of CTGF and COL-I.These results were also validated by in vivo studies.Therefore,this study proposed a valid self-adaptive strategy for ZnO improvement.Under different conditions,the sample could present different functions,and both the antibacterial ability and soft tissue compatibility were finely preserved. | Jin Leng Ye He Zhang Yuan Bailong Tao Ke Li Chuanchuan Lin Kun Xu Maowen Chen Liangliang Dai Xuemin Li Tony Jun Huang Kaiyong Cai | 2021 | Bioactive Materials2021，6，12： | 2 |
| 17 | Characterization of two newly emerged iso- lates of porcine reproductive and respiratory syndrome virus from Northeast China in 2013显示文摘 | Leng C L Tian Z J Zhang W C Zhang H L Zhai H Y An T Q Peng J M Ye C Sun L Wang Q Sun Y Li L Zhao HY Chang D Cai XH Zhang GH Tong GZ | 2014 | Vet Microbiol2014，171，12： | 1 |
| 18 | Revealing the dynamics of intensity fluctuation transfer in a random Raman fiber laser显示文摘Temporal intensity fluctuation is one of the inherent features of fiber lasers.When utilizing the fiber lasers to pump a random Raman fiber laser(RRFL),the intensity fluctuation transfer from the pump to the random lasing could affect the output performance significantly.In this paper,we comprehensively compared the spectral,temporal,and power characteristics of an RRFL pumped by two different fiber lasers—a temporally unstable fiber oscillator and a temporally stable amplified spontaneous emission(ASE)source.Owing to less impact of the intensity fluctuation transfer,the ASE source-pumped RRFL shows∼45.3%higher maximum output power,higher spectral purity(>99.9%)and optical signal-to-noise ratio(>40dB),weaker spectral broadening,and more stable temporal behavior compared to the fiber oscillator-pumped RRFL.Furthermore,based on the temporal-spatial-coupled Raman equations and the generalized nonlinear Schrödinger equations,we numerically revealed the impact of the pump intensity fluctuations on the output characteristics of RRFLs,and found that the temporal walk-off effect played an important role in the dynamics of intensity fluctuation transfer.This work may provide a reference for designing and implementing high-performance RRFLs and promote their practicability in sensing,telecommunications,and high-power applications. | Jun Ye Xiaoya Ma Yang Zhang Jiangming Xu Hanwei Zhang Tianfu Yao Jinyong Leng Pu Zhou | 2022 | Photonics Research2022，10，3： | 1 |
| 19 | Potential roles of IL-9 in the pathogenesis of systemic lupus erythematosus 显示文摘 | Leng RX Pan HF Ye DQ | 2012 | Am J Clin Exp Immunol2012，1，1： | 1 |
| 20 | 2-kW-level superfluorescent fiber source with flexible wavelength and linewidth tunable characteristics显示文摘The superfluorescent fiber source(SFS)with tunable optical spectrum has shown great application potential in the sensing,imaging,and spectral combination.Here,we demonstrate for the first time a 2-kW-level wavelength and linewidth tunable SFS.Based on a flexible filtered SFS seed and three stages of fiber amplifiers,the output power can be scaled from the milliwatt level to about 2 kW,with a wavelength tuning range of 1068–1092 nm and a linewidth tuning range of 2.5–9.7 nm.Moreover,a numerical simulation is conducted based on the generalized nonlinear Schr?dinger equation,and the results reveal that the wavelength tuning range is limited by the decrease of seed power and the growth of amplified spontaneous emission,whereas the linewidth tuning range is determined by the gain competition and nonlinear Kerr effects.The developed wavelength and linewidth tunable SFS may be applied to scientific research and industrial processing. | Jun Ye Chenchen Fan Jiangming Xu Hu Xiao Jinyong Leng Pu Zhou | 2021 | High Power Laser Science and Engineering2021，9，4： | 1 |
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