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3篇 您的检索式：作者名="LEO M.Lee"

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		题名	作者	年代	出处	被引量
	1	Heterodimer formation between c-Jun and Jun B proteins mediated by Epstein Barr virus encoded latent membrane protein 1显示文摘Epstein-Barr virus (EBV) encoded latent membrane protein 1 (LMP1) may trigger the transcription factor AP-1 including c-Jun and c-fos. In this report, using a Tet-on LMP1 HNE2 cell line which is a dual-stable LMP1 integrated nasopharyngeal carcinoma (NPC) cell line and the expression of LMP1 in which could be regulated by the Tet-on system, we show that Jun B can efficiently form a new heterodimeric complex with the c-Jun protein under the regulation of LMP1, phosphorylation of c-Jun (ser 63, ser 73) and Jun B is involved in the process of the new heterodimeric formation. We also find that this heterodimeric form can bind to the AP-1 consensus sequence. Transfection studies suggest that JNK interaction protein (JIP) could inhibit the heterodimer formation of c-Jun and Jun B through blocking the AP-1 signaling pathway triggered by LMP1. The interaction and function between c-Jun protein and Jun B protein increase the repertoire of possible regulatory complexes by LMP1 that could play an important role in the regulation of transcription of specific cellular genes in the process of genesis of nasopharyngeal carcinoma.	Leo M.Lee	2005	Science China(Life Sciences)2005，48，1：	2
	2	EBV-LMP1通过NF-κB介导的信号传导途径活化cyclin D1机制初探显示文摘	赵晓荣殷莉群邓琳唐敏 LEO M.Lee 邓锡云陶德定龚建平曹亚	2000	中国病理生理杂志2000，16，10：	1
	3	中国人鼻咽癌恶性转化基因的克隆及其生物物理性状研究显示文摘鼻咽癌是我国南方及东南亚一些国家和地区的高发肿瘤,其病因发病机理一直是国内外研究的热门课题。利用小鼠JB6细胞和分子克隆技术,我们成功地从中国人鼻咽癌细胞株CNE2中克隆出恶性转化基因Tx。鼻咽癌恶性转化基因Tx全长16kb,其3’端含人Alu重复序列。Tx基因在DNA杂交水平与ras、myc等瘤基因以及EB病毒基因无同源性。	曹亚邓锡云胡维新 Leo M.Lee 陈孝光贺红李晓艳姚开泰	1996	医学研究杂志1996，30，2：	0

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