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| 1 | Ten years of sorafenib in hepatocellular carcinoma: Are there any predictive and/or prognostic markers?显示文摘Sorafenib has been considered the standard of care for patients with advanced unresectable hepatocellular carcinoma(HCC) since 2007 and numerous studieshave investigated the role of markers involved in the angiogenesis process at both the expression and genetic level and clinical aspect. What results have ten years of research produced? Several clinical and biological markers are associated with prognosis. The most interesting clinical parameters are adverse events, Barcelona Clinic Liver Cancer stage, and macroscopic vascular invasion, while several single nucleotide polymorphisms and plasma angiopoietin-2 levels represent the most promising biological biomarkers. A recent pooled analysis of two phase III randomized trials showed that the neutrophil-to-lymphocyte ratio, etiology and extra-hepatic spread are predictive factors of response to sorafenib, but did not identify any predictive biological markers. After 10 years of research into sorafenib there are still no validated prognostic or predictive factors of response to the drug in HCC. The aim of the present review was to summarize 10 years of research into sorafenib, looking in particular at the potential of associated clinical and biological markers to predict its efficacy in patients with advanced HCC. | Giorgia Marisi Alessandro Cucchetti Paola Ulivi Matteo Canale Giuseppe Cabibbo Leonardo Solaini Francesco G Foschi Serena De Matteis Giorgio Ercolani Martina Valgiusti Giovanni L Frassineti Mario Scartozzi Andrea Casadei Gardini | 2018 | World Journal of Gastroenterology2018，24，36： | 14 |
| 2 | Sonohysterography: Principles, technique and role in diagnosis of endometrial pathology显示文摘Sonohysterography (SHG), which provides enhanced endometrial visualization during standard transvaginal ultrasonography, is a relatively safe procedure for the evaluation of endometrial pathology. It can be used to evaluate patients with abnormal vaginal bleeding or infertility. This modality offers real time imaging of the endometrium without exposure to ionizing radiation. SHG is typically used in patients for whom standard transvaginal ultrasonography does not show the endometrium well, show a potential abnormality for which further imaging is required, or in patients without endometrial pathology defined on routine transvaginal imaging but in whom there is a strong clinical suspicion of an abnormality. This article will discuss the utility of the sonohysterogram in evaluation of various endometrial pathologies. Imaging examples of these pathological entities will be illustrated as well. | Thomas Yang Amit Pandya Leonardo Marcal Ronald O Bude Joel F Platt Deepak G Bedi Khaled M Elsayes | 2013 | World Journal of Radiology2013，5，3： | 5 |
| 3 | Effect of electrical stimulation of the lower esophageal sphincter in gastroesophageal reflux disease patients refractory to proton pump inhibitors显示文摘AIM: To evaluate the efficacy of lower esophageal sphincter(LES)-electrical stimulation therapy(EST) in a subgroup of patients that reported only partial response to proton pump inhibitors(PPIs) therapy, compared to a group of patient with complete response.METHODS: Bipolar stitch electrodes were laparoscopically placed in the LES and connected to an implantable pulse generator(EndoS tim BV, the Hague, the Netherlands), placed subcutaneously in the anterior abdominal wall. Stimulation at 20 Hz, 215 μsec, 3-8 m Amp in 30 min sessions was delivered starting on day 1 post-implant. Patients were evaluated using gastroesophageal reflux disease(GERD)-HRQL, symptom diaries; esophageal p H and esophageal manometry before and up to 24 mo after therapy and results were compared between partial and complete responders.RESULTS: Twenty-three patients with GERD on LESEST were enrolled and received continuous per-protocol stimulation through 12 mo and 21 patients completed 24 mo of therapy. Of the 23 patients, 16(8 male, mean age 52.1 ± 12 years) had incomplete response to PPIs prior to LES-EST, while 7 patients(5 male, mean age 52.7 ± 4.7) had complete response to PPIs. In the sub-group with incomplete response to PPIs, median(IQR) composite GERD-HRQL score improved significantly from 9.5(9.0-10.0) at baseline on-PPI and 24.0(20.8-26.3) at baseline off-PPI to 2.5(0.0-4.0) at 12-mo and 0.0(0.0-2.5) at 24-mo follow-up(P < 0.05 compared to on-and off-PPI at baseline). Median(IQR) % 24-h esophageal pH < 4.0 at baseline in this sub-group improved significantly from 9.8%(7.8-11.5) at baseline to 3.0%(1.9-6.3) at 12 mo(P < 0.001) and 4.6%(2.0-5.8) at 24 mo follow-up(P < 0.01). At their 24-mo follow-up, 9/11 patients in this sub-group were completely free of PPI use. These results were comparable to the sub-group that reported complete response to PPI therapy at baseline. No unanticipated implantation or stimulation-related adverse events, or any untoward sensation due to stimulation were reported in either group and LES-EST was safely tolerated by both groups. CONCLUSION: LES-EST is safe and effective in controlling symptoms and esophageal acid exposure in GERD patients with incomplete response to PPIs. These results were comparable to those observed PPI responders. | Edy Soffer Leonardo Rodríguez Patricia Rodriguez Beatriz Gómez Manoel G Neto Michael D Crowell | 2016 | World Journal of Gastrointestinal Pharmacology and Therapeutics2016，7，1： | 4 |
| 4 | Intraoperative abdominal ultrasound in oncologic imaging显示文摘Significant advances in ultrasound technology have created new opportunities for its use in oncologic imaging. The advent of new transducers with focal beam technology and higher frequency has solidified the role of intraoperative sonography (IOUS) as an invaluable imaging modality in oncologic surgery of the liver, kidneys and pancreas. The ability to detect and characterize small lesions and the precise intraoperative localization of such tumors is essential for adequate surgical planning in segmental or lobar hepatic resections, metastasectomy, nephron-sparing surgery, and partial pancreatectomy. Also, diagnostic characterization of small equivocal lesions deemed indeterminate by conventional preoperative imaging such as multidetector computed tomography or magnetic resonance imaging, has become an important application of IOUS. This article will review the current applications of IOUS in the liver, kidneys and pancreas. | Leonardo P Marcal Madhavi Patnana Priya Bhosale Deepak G Bedi | 2013 | World Journal of Radiology2013，5，3： | 3 |
| 5 | Central nervous system vasculitis and polyneuropathy as first manifestations of hepatitis C显示文摘Sensory or motor peripheral neuropathy may be observed in a significant proportion of hepatitis C virus (HCV)-infected patients.However,central nervous system (CNS) involvement is uncommon,especially in cryoglobulin-negative subjects.We describe a case of peripheral neuropathy combined with an ischemic CNS event as primary manifestations of chronic HCV infection without cryoglobulinemia.Significant improvement was observed after antiviral therapy.We discuss the spectrum of neurological manifestations of HCV infection and review the literature. | Roberto J Carvalho-Filho Janaína Luz Narciso-Schiavon Luciano HL Tolentino Leonardo L Schiavon Maria Lucia G Ferraz Antonio Eduardo B Silva | 2012 | World Journal of Gastroenterology2012，18，2： | 3 |
| 6 | Unpacking the challenge of gastric varices: A review on indication, timing and modality of therapy显示文摘Upper gastrointestinal bleeding from oesophageal or gastric varices is an important medical condition in patients with portal hypertension.Despite the emergence of a number of novel endoscopic and radiologic therapies for oesophagogastric varices,controversy exists regarding the indication,timing and modality of therapy.The aim of this review is to provide a concise and practical evidence-based overview of these issues. | Karl Vaz Marios Efthymiou Rhys Vaughan Adam G Testro Hin-Boon Lew Leonardo Zorron Cheng Tao Pu Sujievvan Chandran | 2021 | World Journal of Hepatology2021，13，8： | 2 |
| 7 | Electrical stimulation therapy of the lower esophageal sphincter is successful in treating GERD: final results of open-label prospective trial显示文摘 | Leonardo Rodríguez Patricia Rodriguez Beatriz Gómez Juan C. Ayala Jorge Saba Alberto Perez-Castilla Manoel Galvao Neto Michael D. Crowell | 2013 | Surgical Endoscopy2013，，4： | 2 |
| 8 | Bipolar transurethral resection of prostate: clinical and urodynamic evaluation显示文摘 | Iori F Franco G Leonardo C Laurenti C Tubaro A D-Amico F | 2008 | Urology2008，71，： | 1 |
| 9 | Bipolar transurethral resection of prostate: clinical and urodynamic evaluation 显示文摘 | IORI F FRANCO G LEONARDO C | 2008 | Urology2008，71，2： | 1 |
| 10 | Anisotropic polyvinyl alcohol-Bacerial cellulose nanocomposite for biomedical applications显示文摘 | Leonardo E Millon Guhados G | | 0，，： | 1 |
| 11 | Bipolar transurethral resection of prostate : clinical and urodynamic evaluation 显示文摘 | IORI F FRANCO G LEONARDO C | 2008 | J Urol2008，71，2： | 1 |
| 12 | Vaccine-linked chemotherapy : can schistosomiasis control benefit from an integrated approach 显示文摘 | Bergquist N R Leonardo L R Mitchell G F | 2005 | Trends Parasitol2005，21，： | 1 |
| 13 | Video-assisted thoracic surgery versus pleural drainage in the management of the first episode of primary spontaneous pneumothorax显示文摘 | Divisi D Di Leonardo G Crisci R | 2015 | American journal of surgery2015，210，1： | 1 |
| 14 | The complete nucleotide sequence and development of a diferential detection assay for a Pepper mild mottle virus(PMMoV) isolate that overcomes L3 resistance in pepper显示文摘 | LEONARDO V DIRK J LETICIA R G | 2002 | Journal of Virological Methods2002，106，： | 1 |
| 15 | A numerical model for gas flow and droplet motion in wave-plate mist eliminators with drainage channels显示文摘 | Chiara G Elisabetta B Leonardo T | | 0，，23： | 1 |
| 16 | Immunohistochemical evaluation of P-glycoprotein in human malignancies by monoclonal antibody MC57显示文摘 | Leonardo E Valente G Cappia S | 1994 | IntJ Cancer1994，57，6： | 1 |
| 17 | Prostatic capsule and seminal vesicle-sparing cystectomy: im- proved functional results, inferior oncologic outcome 显示文摘 | Simone G Papalia R Leonardo C | 2008 | Urology2008，72，1： | 1 |
| 18 | SPH simulation of time-dependent Poiseuille flow at low Reynolds numbers显示文摘 | Sigalotti Leonardo Di G | 2003 | J Computational Physics2003，191，： | 1 |
| 19 | Optimization of the operating conditions using factorial designs for determination of uranium by inductively coupled plasma optical emission spectrometry显示文摘 | Juracir S Santos Leonardo S G Teixeira Rennan G O Ara6jo | 2011 | Microchemical Journal2011，97，： | 1 |
| 20 | Odor threshold determination of 53 odorant chemicals显示文摘 | LEONARDOS G KENDALL D BARNARD N | 1969 | Journal of the Air Pollution Control Association1969，19，2： | 1 |
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