|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Computational methods and engineering applications of static/dynamic aeroelasticity based on CFD/CSD coupling solution显示文摘The CFD/CSD coupling method is turning into the main research direction for the static/dynamic aeroelastic analyses.If one wants to use the method for the complex engineering aeroelastic problems,he needs to investigate the relative aeroelastic algorithms,such as the numerical computational method of unsteady aerodynamic forces,equivalent low-dimensional structural finite element model and the solution method of structural dynamic equations,data transfer technique between fluid and structure,the moving grid method,etc.Besides,he also needs to improve the computational efficiency by such as massive parallel CFD algorithm,reduced-order model(ROM) of unsteady aerodynamic forces,etc.In this paper,based on the authors' recent investigations,the research progresses in computational aeroelastic methods and their applications to engineering problem are summarized. | YANG GuoWei ZHENG GuanNan LI GuiBo | 2012 | Science China(Technological Sciences)2012，55，9： | 6 |
| 2 | An application of interacting shear flows theory: exact solution for unsteady oblique stagnation point flow显示文摘交往的管理方程的一个分析答案砍为不稳定的倾斜的停滞点流动的流动被获得。它把从完全的 NS 方程和物理分析和相关讨论获得的准确答案的当时是的一样的形式介绍。 | Guibo Li Minguo Dai Z. Gao | 2006 | Acta Mechanica Sinica2006，22，5： | 4 |
| 3 | microRNA-128 plays a critical role in human non-small cell lung cancer tumourigenesis, angiogenesis and lymphangiogenesis by directly targeting vascular endothelial growth factor-C显示文摘 | Jing Hu Yongxia Cheng Yuezhen Li Zaishun Jin Yanming Pan Guibo Liu Songbin Fu Yafang Zhang Kejian Feng Yukuan Feng | 2014 | European Journal of Cancer2014，，13： | 1 |
| 4 | In-situ growth of CNTs encapsulating P-doped NiSe_(2) nanoparticles on carbon framework as efficient bifunctional electrocatalyst for overall water splitting显示文摘Nickel diselenide(NiSe_(2)) is a promising low-cost catalyst for both hydrogen evolution reaction(HER) and oxygen evolution reaction(OER),due to its suitable d-electron configuration and high electrical conductivity.Several representative elements,e.g.,Co,Fe and P,have been utilized as cation or anion to promote the electrocatalytic activity of NiSe_(2) by modulating the interaction with Se element,whilst the catalyst stability is less concerned.In this work,the catalytic Ni nanoparticles were in-situ encapsulated in carbon nanotubes grown on three-dimensional conducting carbon framework.Subsequent phosphorization and selenization yield dispersed P-doped NiSe_(2) nanoparticles protected by carbon shell with highly exposed yet stable active sides,resulting in significantly promoted HER and OER activities as well as accelerated kinetics.In detail,the P-NiSe_(2)@N-CNTs/NC hybrid catalyst deliver low overpotentials of 95 and 306 mV at10 mA cm^(-2) for HER and OER in alkaline media,respectively.DFT calculations reveal that P doping reduces the electron density surrounding Ni atoms while accumulates the charges to Se, respectively,which in turn reduces the energy barriers for both water dissociation and intermediates adsorption for both HER and OER.As a concept of proof,a cell assembled by P-NiSe_(2)@N-CNTs/NC hybrid catalystbased anode and cathode performs a low applied voltage of 1.609 V to reach 10 mA cm^(-2),and outstanding long-term stability. | Jing Yu Wei-Jian Li Guibo Kao Cheng-Yan Xu Rongrong Chen Qi Liu Jingyuan Liu Hongsen Zhang Jun Wang | 2021 | Journal of Energy Chemistry2021，30，9： | 1 |
| 5 | Temporal-spatial Generation of Astrocytes in the Developing Diencephalon显示文摘tAstrocytes are the largest glial population in the mammalian brain.However,we have a minimal understanding of astrocyte development,especially fate specification in different regions of the brain.Through lineage tracing of the progenitors of the third ventricle(3V)wall via in-utero electroporation in the embryonic mouse brain,we show the fate specification and migration pattern of astrocytes derived from radial glia along the 3V wall.Unexpectedly,radial glia located in different regions along the 3V wall of the diencephalon produce distinct cell types:radial glia in the upper region produce astrocytes and those in the lower region produce neurons in the diencephalon.With genetic fate mapping analysis,we reveal that the first population of astrocytes appears along the zona incerta in the diencephalon.Astrogenesis occurs at an early time point in the dorsal region relative to that in the ventral region of the developing diencephalon.With transcriptomic analysis of the region-specific 3V wall and lateral ventricle(LV)wall,we identified cohorts of differentially-expressed genes in the dorsal 3V wall compared to the ventral 3V wall and LV wall that may regulate astrogenesis in the dorsal diencephalon.Together,these results demonstrate that the generation of astrocytes shows a spatiotemporal pattern in the developing mouse diencephalon. | Wentong Hong Pifang Gong Xinjie Pan Zhonggan Ren Yitong Liu Guibo Qi Jun-Liszt Li Wenzhi Sun Woo-Ping Ge Chun-Li Zhang Shumin Duan Song Qin | 2024 | Neuroscience Bulletin2024，40，1： | 0 |
| 6 | Effect of surface tension and viscosity on bubble growth of single mode Rayleigh-Taylor instability显示文摘Based on the Zufiria theoretical model,a new model regarding the asymptotic bubble velocity for the Rayleigh-Taylor(RT) instability is presented by use of the complex velocity potential proposed by Sohn.The proposed model is an extension of the ordinary Zufiria model and can deal with non-ideal fluids.With the control variable method,the effect of the viscosity and surface tension on the bubble growth rate of the RT instability is studied.The result is consistent with Cao's result if we only consider the viscous effect and with Xia's result if we only consider the surface tension effect.The asymptotic bubble velocity predicted by the Zufiria model is smaller than that predicted by the Layzer model,and the result from the Zufiria model is much closer to White's experimental data. | Mingjun LI Qiaofeng ZHU Guibo LI | 2016 | Applied Mathematics and Mechanics(English Edition)2016，37，12： | 0 |
| 7 | Application of Traditional Chinese Veterinary Medicine in Sheep Green Breeding显示文摘Disease control and health care with traditional Chinese veterinary medicine( TCVM) has attracted more and more attention in sheep green breeding. To promote healthy and smooth development of the work,the relationships between TCVM and antibiotics,and between TCVM and vaccines,were reviewed and analyzed. It was thought that TCVM and western medicine,such as antibiotics and vaccines,etc.,have their own characteristics and advantages,and should be mutually complemented rather than replaced. We should pay attention to the characteristics and advantages of the wholism concept and syndrome differentiation and treatment( diagnosis and treatment based on an overall analysis of the illness and the patient's condition) of TCVM,to develop and use TCVM health care agent or vaccine adjuvant,and their pertinence was improved according to different growth stages and physiological and pathological characteristics. Diagnosis and treatment based on an overall analysis of the illness and the population patient's condition must be attached importance to optimize the mode of administration,in order to adapt to disease prevention and control requirements in intensive and scale breeding of sheep. | Luo Chaoying Li Jinyu Wang Guibo | 2017 | Animal Husbandry and Feed Science2017，9，5： | 0 |
| 8 | Self-adjuvant Astragalus polysaccharide-based nanovaccines for enhanced tumor immunotherapy:a novel delivery system candidate for tumor vaccines显示文摘The study of tumor nanovaccines(NVs)has gained interest because they specifically recognize and eliminate tumor cells.However,the poor recognition and internalization by dendritic cells(DCs)and insufficient immunogenicity restricted the vaccine efficacy.Herein,we extracted two molecular-weight Astragalus polysaccharides(APS,12.19 k D;APSHMw,135.67 k D)from Radix Astragali and made them self-assemble with OVA257–264directly forming OVA/APS integrated nanocomplexes through the microfluidic method.The nanocomplexes were wrapped with a sheddable calcium phosphate layer to improve stability.APS in the formed nanocomplexes served as drug carriers and immune adjuvants for potent tumor immunotherapy.The optimal APS-NVs were approximately 160 nm with uniform size distribution and could remain stable in physiological saline solution.The FITC-OVA in APS-NVs could be effectively taken up by DCs,and APS-NVs could stimulate the maturation of DCs,improving the antigen cross-presentation efficiency in vitro.The possible mechanism was that APS can induce DC activation via multiple receptors such as dectin-1 and Toll-like receptors 2 and 4.Enhanced accumulation of APS-NVs both in draining and distal lymph nodes were observed following s.c.injection.Smaller APS-NVs could easily access the lymph nodes.Furthermore,APS-NVs could markedly promote antigen delivery efficiency to DCs and activate cytotoxic T cells.In addition,APS-NVs achieve a better antitumor effect in established B16-OVA melanoma tumors compared with the OVA+Alum treatment group.The antitumor mechanism correlated with the increase in cytotoxic T cells in the tumor region.Subsequently,the poor tumor inhibitory effect of APS-NVs on the nude mouse model of melanoma also confirmed the participation of antitumor adaptive immune response induced by NVs.Therefore,this study developed a promising APS-based tumor NV that is an efficient tumor immunotherapy without systemic side effects. | Nan Li Yun Zhang Miaomiao Han Tian Liu Jinjia Wu Yingxia Xiong Yikai Fan Fan Ye Bing Jin Yinghua Zhang Guibo Sun Xiaobo Sun Zhengqi Dong | 2024 | Science China(Life Sciences)2024，67，4： | 0 |
| 9 | 低氧条件下γ射线对Hep-2细胞周期、凋亡的影响(英文)显示文摘Objective: The aim of the study was to investigate the impact of 60Co γ-ray on apoptosis, cell cycles and the expression of protein hypoxia-inducible factor-1α (HIF-1α) to Hep-2 cell line in the conditions of normoxia and hypoxia. Methods: Hep-2 cell were divided into 2 groups: group A (normoxia) and group B (hypoxia). All of the cells were exposed to γ-ray with dosage being 0, 1, 3, 5, 10, 20, and 40 Gy. Flow cytometry was used to measure the protein level of HIF-1α and to detect apoptosis and cell cycles. The protein level of HIF-1α was also determined by immunohistochemistry and Western blotting. Results: The protein level of HIF-1α in group B was significantly higher than that in group A. In group A, low doses (1-5 Gy) of γ-ray had caused G0/G1 cell cycle arrest and high doses (10-40 Gy) had caused G2/M cell cycle arrest. In group B, without exposure of γ-ray (0 Gy) had caused G0/G1 cell cycle arrest, all of the different dosage of γ-ray could cause G2/M cell cycle arrest. The curve of apoptosis rate in group A was a parabola, the apoptotic rate was related to the dosage of γ-ray in a dosage dependent manner. The peak was at the point of 5 Gy. The apoptosis rate in group A was significantly higher than that in group B. Conclusion: Different doses of γ-ray could cause different cell cycles arrest then make different impact on apoptosis to Hep-2 cell. The lower apoptosis rate in condition of hypoxia maybe has a relationship with G2/M cell cycle arrest. Up-regulated HIF-1α protein may be one of the reasons for G2/M cell cycle arrest. | Baoshan Wang Guibo Li Dongmei Song Jihua Zhang | 2010 | The Chinese-German Journal of Clinical Oncology2010，9，7： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员