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| 1 | Intestinal lysozyme liberates Nod1 ligands from microbes to direct insulin trafficking in pancreatic beta cells显示文摘Long-range communication between intestinal symbiotic bacteria and extra-intestinal organs can occur through circulating bacterial signal molecules, through neural circuits, or through cytokines or hormones from host cells. Here we report that Nod1 ligands derived from intestinal bacteria act as signal molecules and directly modulate insulin trafficking in pancreatic beta cells. The cytosolic peptidoglycan receptor Nod1 and its downstream adapter Rip2 are required for insulin trafficking in beta cells in a cell-autonomous manner. Mechanistically, upon recognizing cognate ligands, Nod1 and Rip2 localize to insulin vesicles, recruiting Rab1a to direct insulin trafficking through the cytoplasm. Importantly, intestinal lysozyme liberates Nod1 ligands into the circulation, thus enabling long-range communication between intestinal microbes and islets. The intestine-islet crosstalk bridged by Nod1 ligands modulates host glucose tolerance. Our study defines a new type of inter-organ communication based on circulating bacterial signal molecules, which has broad implications for understanding the mutualistic relationship between microbes and host. | Qin Zhang Ying Pan Benhua Zeng Xiaojiao Zheng Haifang Wang Xueying Shen Hui Li Qian Jiang Jiaxu Zhao Zhuo-Xian Meng Pingping Li Zhengjun Chen Hong Wei Zhihua Liu | 2019 | Cell Research2019，29，7： | 11 |
| 2 | Directly patterned substrate-free plasmonic “nanograter” structures with unusual Fano resonances显示文摘The application of three-dimensional(3D)plasmonic nanostructures as metamaterials(MMs),nano-antennas,and other devices faces challenges in producing metallic nanostructures with easily definable orientations,sophisticated shapes,and smooth surfaces that are operational in the optical regime and beyond.Here,we demonstrate that complex 3D nanostructures can be readily achieved with focused-ion-beam irradiation-induced folding and examine the optical characteristics of plasmonic“nanograter”structures that are composed of free-standing Au films.These 3D nanostructures exhibit interesting 3D hybridization in current flows and exhibit unusual and well-scalable Fano resonances at wavelengths ranging from 1.6 to 6.4 mm.Upon the introduction of liquids of various refractive indices to the structures,a strong dependence of the Fano resonance is observed,with spectral sensitivities of 1400 nm and 2040 nm per refractive index unit under figures of merit of 35.0 and 12.5,respectively,for low-order and high-order resonance in the near-infrared region.This work indicates the exciting,increasing relevance of similarly constructed 3D free-standing nanostructures in the research and development of photonics and MMs. | Ajuan Cui Zhe Liu Jiafang Li Tiehan H Shen Xiaoxiang Xia Zhiyuan Li Zhijie Gong Hongqiang Li Benli Wang Junjie Li Haifang Yang Wuxia Li Changzhi Gu | 2015 | Light(Science & Applications)2015，4，1： | 8 |
| 3 | Genomic insights into the fast growth of paulownias and the formation of Paulownia witches' broom显示文摘Paulownias are among the fastest growing trees in the world,but they often suffer tremendous loss of wood production due to infection by Paulownia witches'broom(PaWB)phytoplasmas.In this study,we have sequenced and assembled a high-quality nuclear genome of Paulownia fortunei,a commonly cultivated paulownia species.The assembled genome of P.fortunei is 511.6 Mb in size,with 93.2%of its sequences anchored to 20 pseudo-chromosomes,and it contains 31985 protein-coding genes.Phylogenomic analyses show that the family Paulowniaceae is sister to a clade composed of Phrymaceae and Orobanchaceae.Higher photosynthetic efficiency is achieved by integrating C3 photosynthesis and the crassulacean acid metabolism pathway,which may contribute to the extremely fast growth habit of paulownia trees.Comparative transcriptome analyses reveal modules related to cambial growth and development,photosynthesis,and defense responses.Additional genome sequencing of PaWB phytoplasma,combined with functional analyses,indicates that the effector PaWB-SAP54 interacts directly with Paulownia PfSPLa,which in turn causes the degradation of PfSPLa by the ubiquitin-mediated pathway and leads to the formation of witches'broom.Taken together,these results provide significant insights into the biology of paulownias and the regulatory mechanism for the formation of PaWB. | Yabing Cao Guiling Sun Xiaoqiao Zhai Pingluo Xu Liming Ma Minjie Deng Zhenli Zhao Haibo Yang Yanpeng Dong Zhonghai Shang Yujie Lv Lijun Yan Haifang Liu Xibing Cao Bingbing Li Zhe Wang Xiaogai Zhao Haiyan Yu Fan Wang Wen Ma Jinling Huang Guoqiang Fan | 2021 | Molecular Plant2021，14，10： | 7 |
| 4 | The EGFR-P38 MAPK axis up-regulates PD-L1 through miR-675-5p and down-regulates HLA-ABC via hexokinase-2 in hepatocellular carcinoma cells显示文摘Background:Immunotherapy has been shown to be a promising strategy against human cancers.A better understanding of the immune regulation in hepatocellular carcinoma(HCC)could help the development of immunotherapy against HCC.The epidermal growth factor receptor(EGFR)signaling is frequently activated in HCC and plays important roles in tumorigenesis.However,its role in HCC immunity is still largely unknown.This study aimed to investigate the impact of EGFR signaling on programmed death-ligand 1(PD-L1)and human leukocyte antigen class-I(HLA-I)expression in HCC cells and its underlying mechanisms.Methods:The expression of phosphorylated EGFR(p-EGFR),PD-L1,and HLAI(HLA-ABC)in HCC specimens was detected by immunohistochemistry,and their correlations were analyzed.PD-L1 and HLA-ABC expression in EGFRactivated HCC cells were detected by quantitative real-time PCR,Western blotting,and flow cytometry,and T cell-mediated lysis was performed to test the immunosuppressive effects of PD-L1 and HLA-ABC alterations in HCC cells.Furthermore,the underlying mechanisms of EGFR activation-induced PD-L1 up-regulation and HLA-ABC down-regulation were explored by animal experiments,luciferase reporter assay,and gene gain-and loss-of-function studies.Results:p-EGFR was positively correlated with PD-L1 and negatively correlated with HLA-ABC expression in HCCs.EGFR activation by its ligand EGF up-regulated PD-L1 and down-regulated HLA-ABC in HCC cells,which was functionally important and could be abolished by the EGFR inhibitor,gefitinib,both in vitro and in vivo.Mechanistically,enhanced P38 mitogenactivated protein kinase(MAPK)activation down-regulated microRNA-675-5p(miR-675-5p)and up-regulated glycolysis-related enzyme hexokinase 2(HK2);miR-675-5p down-regulation enhanced the stability of PD-L1 mRNA probably via the 3’-untranslated region(3’-UTR)of PD-L1 and thereby caused PD-L1 accumulation,and HK2 up-regulation enhanced aerobic glycolysis and mediated a decrease in HLA-ABC.Conclusions:The EGFR-P38 MAPK axis could up-regulate PD-L1 through miR-675-5p and down-regulate HLA-ABC via HK2 in HCC cells.Our study reveals a novel signaling network that may cause immune suppression in HCC and suggests that EGFR signaling can be targeted for HCC immunotherapy. | Zongcai Liu Fen Ning Yanna Cai Huiying Sheng Ruidan Zheng Xi Yin Zhikun Lu Ling Su Xiaodan Chen Chunhua Zeng Haifang Wang Li Liu | 2021 | Cancer Communications2021，41，1： | 5 |
| 5 | Link Prediction in Brain Networks Based on a Hierarchical Random Graph Model显示文摘Link prediction attempts to estimate the likelihood of the existence of links between nodes based on available brain network information, such as node attributes and observed links. In response to the problem of the poor efficiency of general link prediction methods applied to brain networks, this paper proposes a hierarchical random graph model based on maximum likelihood estimation. This algorithm uses brain network data to create a hierarchical random graph model. Then, it samples the space of all possible dendrograms using a Markov-chain Monte Carlo algorithm. Finally, it calculates the average connection probability. It also employs an evaluation index.Comparing link prediction in a brain network with link prediction in three different networks(Treponemapallidum metabolic network, terrorist networks, and grassland species food webs) using the hierarchical random graph model, experimental results show that the algorithm applied to the brain network has the highest prediction accuracy in terms of AUC scores. With the increase of network scale, AUC scores of the brain network reach 0.8 before gradually leveling off. In addition, the results show AUC scores of various algorithms computed in networks of eight different scales in 28 normal people. They show that the HRG algorithm is far better than random prediction and the ACT global index, and slightly inferior to local indexes CN and LP. Although the HRG algorithm does not produce the best results, its forecast effect is obvious, and shows good time complexity. | Yanli Yang Hao Guo Tian Tian Haifang Li | 2015 | Tsinghua Science and Technology2015，20，3： | 4 |
| 6 | An on-chip intestine-liver model for multiple drugs absorption and metabolism behavior simulation显示文摘A double-layer microfluidic chip integrated with a hollow fiber(HF)was developed to reconstitute the intestine-liver functionality for studying the absorption and metabolism of combination drugs.Caco-2 cells were inoculated in the HF cavity at the top of the serpentine channel to simulate the intestinal tissue for drug absorption and transport studied,and Hep G2 cells,seeded in the bottom chamber,were used to mimic the liver for metabolism-related studies.Genistein and dacarbazine were selected for combination drug therapy and its effects on cell viability,hepatotoxicity,and cell cycle arrest under drug-conditioned culture were investigated.The results suggested that the combined concentration below-100μg/m L had no significant inhibitory effect on Hep G2 cell viability,and therefore Hep G2 cells maintained their drug metabolism ability.When the drug concentration was increased above 250μg/m L,Hep G2 cells underwent apoptosis.Detection of metabolites by mass spectrometry proved the effective metabolism in the microchip model.This dynamic,co-culture microchip successfully provided a podium for long-term observation of absorption,transport,and metabolism of combination drugs,and could be an effective in vitro simulation model for further clinical research. | Mingsha Jie Haifeng Lin Ziyi He Hanyang Liu Haifang Li Jin-Ming Lin | 2018 | Science China Chemistry2018，61，2： | 3 |
| 7 | SciFinder-guided rational design of fluorescent carbon dots for ratiometric monitoring intracellular pH fluctuations under heat shock显示文摘Intracellular pH plays a significant role in various biological processes, including cell proliferation,apoptosis, metabolism, enzyme activity and homeostasis. In this work, a novel design strategy for the preparation of pH responsive carbon dots(CDs-pH) for ratiometric intracellular imaging was reported. By using SciFinder database, fluorescent CDs-pH with the required p Kavalue of 6.84 were rationally designed, which is vital important for precise sensing of intracellular pH. As a result, the synthesized CDspH demonstrated robust ability to test pH fluctuations within the physiological range of 5.4-7.4. The CDspH was further utilized for fluorescent ratiometric imaging of pH in living HeLa cells, effectively avoided the influence of autofluorescence from native cellular species. Moreover, real-time monitoring of intracellular pH fluctuation under heat shock was successfully realized. This SciFinder-guided design strategy is simple and flexible, which has a great potential to be used for the development of other types of CDs for various applications. | Haifang Liu Yuanqiang Sun Zhaohui Li Ran Yang Jie Yang Aaron Albert Aryee Xiaoge Zhang Jia Ge Lingbo Qu Yuehe Lin | 2019 | Chinese Chemical Letters2019，30，9： | 3 |
| 8 | Mobile platform of rocker-type coal mine rescue robot显示文摘After a coal mine disaster,especially a gas and coal dust explosion,the space-restricted and unstructured underground terrain and explosive gas require coal mine rescue robots with good obstacle-surmounting performance and explosion-proof capability. For this type of environment,we designed a mobile platform for a rocker-type coal mine rescue robot with four independent drive wheels.The composition and operational principles of the mobile platform are introduced,we discuss the flameproof design of the rocker assembly,as well as the operational principles and mechanical structure of the bevel gear differential and the main parameters are provided.Motion simulation of the differential function and condition of the robot running on virtual,uneven terrain is carried out with ADAMS.The simulation results show that the differential device can maintain the main body of the robot at an average angle between two rockers.The robot model has good operating performance.Experiments on terrain adaptability and surmounting obstacle performance of the robot prototype have been carried out.The results indicate that the prototype has good terrain adaptability and strong obstacle-surmounting performance. | LI Yunwang GE Shirong ZHU Hua FANG Haifang GAO Jinke | 2010 | Mining Science and Technology2010，20，3： | 3 |
| 9 | Forest soil CO_2 fluxes as a function of understory removal and N-fixing species addition显示文摘We report on the effects of forest management practices of understory removal and N-fixing species(Cassia alata) addition on soil CO2 fluxes in an Eucalyptus urophylla plantation(EUp),Acacia crassicarpa plantation(ACp),10-species-mixed plantation(Tp),and 30-species-mixed plantation(THp) using the static chamber method in southern China.Four forest management treatments,including(1) understory removal(UR);(2) C.alata addition(CA);(3) understory removal and replacement with C.alata(UR+CA);and(4) control without any disturbances(CK),were applied in the above four forest plantations with three replications for each treatment.The results showed that soil CO2 fluxes rates remained at a high level during the rainy season(from April to September),followed by a rapid decrease after October reaching a minimum in February.Soil CO2 fluxes were significantly higher(P < 0.01) in EUp(132.6 mg/(m2.hr)) and ACp(139.8 mg/(m2.hr)) than in Tp(94.0 mg/(m2.hr)) and THp(102.9 mg/(m2.hr)).Soil CO2 fluxes in UR and CA were significantly higher(P < 0.01) among the four treatments,with values of 105.7,120.4,133.6 and 112.2 mg/(m2.hr) for UR+CA,UR,CA and CK,respectively.Soil CO2 fluxes were positively correlated with soil temperature(P < 0.01),soil moisture(P < 0.01),NO3?-N(P < 0.05),and litterfall(P < 0.01),indicating that all these factors might be important controlling variables for soil CO2 fluxes.This study sheds some light on our understanding of soil CO2 flux dynamics in forest plantations under various management practices. | Haifang Li Shenglei Fu Hongting Zhao Hanping Xia | 2011 | Journal of Environmental Sciences2011，23，6： | 3 |
| 10 | Multi-channel microfluidic chip-mass spectrometry platform for cell analysis显示文摘In this review, we highlight the latest development of multi-channel microfluidic chip-mass spectrometry(chip-MS) in cell analysis and metabolite detection. Following a brief introduction about history and development of multi-channel microchip and MS combination, we will elaborate the key issues of constructing chip-MS platform interface. Then exciting progresses made in this field should be reviewed with well exemplified works, including chip-MS technology for cell introduction, pretreatment of cell secretions and cell metabolite analysis. We will also describe the development of integrated total analysis systems proposed by our group. We hope this brief review will inspire interested readers and provide knowledge about chip-MS platform in the bioanalysis field, particularly in cell analysis and metabolite identifying applications. | Mingsha Jie Sifeng Mao Haifang Li Jin-Ming Lin | 2017 | Chinese Chemical Letters2017，28，8： | 2 |
| 11 | Novel Model Using Kernel Function and Local Intensity Information for Noise Image Segmentation显示文摘It remains a challenging task to segment images that are distorted by noise and intensity inhomogeneity.To overcome these problems, in this paper, we present a novel region-based active contour model based on local intensity information and a kernel metric. By introducing intensity information about the local region, the proposed model can accurately segment images with intensity inhomogeneity. To enhance the model's robustness to noise and outliers, we introduce a kernel metric as its objective functional. To more accurately detect boundaries, we apply convex optimization to this new model, which uses a weighted total-variation norm given by an edge indicator function. Lastly, we use the split Bregman iteration method to obtain the numerical solution. We conducted an extensive series of experiments on both synthetic and real images to evaluate our proposed method, and the results demonstrate significant improvements in terms of efficiency and accuracy, compared with the performance of currently popular methods. | Gang Li Haifang Li Ling Zhang | 2018 | Tsinghua Science and Technology2018，23，3： | 2 |
| 12 | Magic of hydrogen spillover: Understanding and application显示文摘The hydrogen spillover effect(HSPE)plays an important role in heterogeneous catalysis and hydrogen storage as an interfacial phenomenon,which facilitates the improvement of hydrogen storage properties of porous nanomaterials and indirectly or directly affects the reaction performance of multiphase catalytic reactions.The setting-up of the word“hydrogen spillover”opened up a new area to gain insight into the dynamic behavior of migrating hydrogen atoms on a catalyst surface.However,a comprehensive understanding of the HSPE is still lacking.Today,the development of advanced characterization techniques provides increasingly valuable information to further our understanding of the HSPE.Based on these considerations,in this review,we hope to provide some answers to the question“What is hydrogen spillover and how do we recognize it?”.To do this,we will rely on advanced characterization techniques as well as experimental and theoretical studies.Then,we discuss in detail the influences of the HSPE on hydrogen storage performance and the important catalytic effects of the HSPE in catalysis.These effects will be reviewed by looking through the catalytic results obtained in many reactions in thermal catalysis,electrocatalysis,and photocatalysis.Furthermore,based on the application potential of hydrogen spillover,we present some preliminary research proposals and discuss the opportunities and challenges that remain to be faced in this research area. | Haifang Shen Hao Li Zhensheng Yang Chunli Li | 2022 | Green Energy & Environment2022，7，6： | 2 |
| 13 | Analysis of cDNA sequence,protein structure and expression of parotid secretory protein in pig显示文摘Parotid secretory protein (PSP) secreted abundantly in saliva, whose function is related with the anti-bacterial effect. The PSP cDNA has been isolated from pig parotid glands by 3′ and 5′ rapid amplification of cDNA end (RACE), based on the conserved signal peptide region among the known mammalian PSP. The result of homologous comparison shows that pig PSP and human PSP shares the high identity at the level of the primary, secondary and tertiary protein structure. A search for functionally significant protein motifs revealed a unique amino acid sequence pattern consisting of the residues Leu-X(6)-Leu-X(6)-Leu- X(7)-Leu-X(6)-Leu-X(6)-Leu near the amino-terminal portion of the protein, which is important to its function. RT-PCR, Dot blot and Northern blot analysis demonstrated that PSP was strongly expressed in parotid glands, but not in other tissues. | YIN Haifang, FAN Baoliang, ZHAO Zhihui, LIU Zhaoliang, FEI Jing & LI Ning State Key Laboratory for Agrobiotechnology, China Agricultural University, Beijing 100094, China Correspondence should be addressed to Li Ning (e-mail: ninglbau@ public3.bta.net.cn) | 2003 | Chinese Science Bulletin2003，48，13： | 2 |
| 14 | On-chip solid phase extraction coupled with electrophoresis using modified magnetic microspheres as stationary phase显示文摘A poly(dimethylsiloxane)(PDMS)/glass hybrid microchip for on-line solid phase extraction (SPE) and electrophoresis separation has been developed and evaluated. The SPE microchannel was crossed to the electrophoresis microchannel. All the microfluidic channels were etched on the glass substrate. The magnetic microspheres were coated with hydroxyl-terminated poly-dimethylsiloxane (PDMS-OH) serving as extraction phase,which could be conveniently immobilized into the sample pretreatment channel by magnetic field. The PDMS-OH microspheres were mobilized into and out of the pretreatment channel by injection flow. The 0.1 μmol/L solution of fluorescence isothiocyanate (FITC)-labeled phenylalanine (Phe) was electrically injected into the SPE channel and extracted onto the PDMS-OH microspheres bed. The enriched FITC-labeled Phe was electrically eluted by 9 mmol/L sodium acetate containing 10% acetonitrile and electrically driven into the electrophoresis channel and then separated. The preconcentration factor could reach 87.5 after sufficient extraction. A linear preconcentration curve was obtained with the initial FITC-labeled Phe concentration ranging from 6 nmol/L to 300 nmol/L (R2=0.9922) with 200 s loading time. The detection limit (S/N=3) for the FITC-labeled Phe was 3 nmol/L. | LI Hong LI HaiFang CHEN ZhiFeng LIN JinMing | 2009 | Science China Chemistry2009，52，12： | 2 |
| 15 | Combination of dynamic hollow fiber liquid-phase microextraction with HPLC analysis for the determination of UV filters in cosmetic products显示文摘A simple method based on hollow fiber liquid-phase microextraction (HF-LPME) followed by high performance liquid chro-matography (HPLC) analysis was successfully developed for the determination of UV filters in cosmetic products. A canular extractor was assembled by mounting a hollow fiber inside an external tube with a tee-connector. The organic solvent was immobilized into the fiber to form a liquid membrane as the acceptor phase. The sample was continuously injected into the extractor and the UV filters were extracted from the aqueous sample into organic acceptor phase. The main parameters affecting HF-LPME including extraction solvent, sample volume, sample flow rate, pH values and ionic strength were investigated. Toluene has been verified to be suitable as the acceptor phase. Under the optimized HF-LPME conditions, the enrichment factors of five UV filters varying from 24 to 57 were achieved. The limits of detection for the five UV filters were in the range of 1-100 μg L-1 .The relative standard deviations (RSDs) of HF-LPME and HPLC analysis were lower than 5.2%. The proposed method has been successfully applied to the analysis of the varied cosmetic products. | YANG HongYun LI HaiFang Masahito Ito LIN Jin-Ming GUO GuangSheng DING MingYu | 2011 | Science China Chemistry2011，54，10： | 2 |
| 16 | Construction of on-line supercritical fluid extraction with reverse phase liquid chromatography–tandem mass spectrometry for the determination of capsaicin显示文摘A novel on-line system composed of supercritical fluid extraction(SFE), dilution line and reverse phase liquid chromatography/mass spectrometry(RPLC/MS) was constructed for on-line extraction and reverse phase separation of some fat-soluble components in foods. Three columns including a trap column,concentration column and analytical column were used for trapping the fat-soluble components, on-line enrichment and reverse phase separation, respectively. Capsaicinoids were on-line extracted by a CO_2 supercritical fluid, then concentrated and separated by using the C_(18) columns, finally detected by mass spectrometry(MS). Capsaicin eluted at 10.1 min and limit of detection(LOD, S/N=3) for the standard solution is 0.55pg. The linearity was calculated with a value of coefficient of determination(R^2)≥0.998 in the range of 1.1–8.5 ng. Concentrations of capsaicin in the green, yellow, and red bell peppers were determined to be 60.33 ng/g, 31.79 ng/g, 35.38ng/g, respectively. | Naoki Hamada Yuki Hashi Satoshi Yamaki Yanli Guo Lin Zhang Haifang Li Jin-Ming Lin | 2019 | Chinese Chemical Letters2019，30，1： | 2 |
| 17 | Lipid profiling of mammalian cells with in situ matrix-assisted laser desorption ionization-mass spectrometry显示文摘The analysis of cellular lipids and phospholipids has been of continuously increasing research interest due to the importance of these molecules in psychological process.In this work,a mass spectrometry-based method for direct,in situ analysis of lipids in cells was reported.Mammalian cells were directly cultured on ITO-coated glass and then analyzed by matrix-assisted laser desorption ionization-mass spectrometry(MALDI-MS).The matrix application process was achieved by electrospray coating,which produced a homogenous layer of matrix crystal on the sample.The detection results and reproducibility are satisfactory.With this method,a profile of abundant membrane lipids is generated,which is characteristic of cell type.In conclusion,this in situ MALDI-MS cellular lipid analysis method provides a platform for sensitive and robust molecular profiling of mammalian cells. | ZHANG YanDong LI HaiFang MA Yuan LIN JinMing | 2014 | Science China Chemistry2014，57，3： | 1 |
| 18 | Determination of chromium (Ⅲ) and total chromium using dual channels on glass chip with chemiluminescence detection显示文摘 | Warapom Som - Aum Jirasak Threeprom Haifang Li | 2007 | Talanta2007，，71： | 1 |
| 19 | Combining Residual Attention Mechanisms and Generative Adversarial Networks for Hippocampus Segmentation显示文摘This research discussed a deep learning method based on an improved generative adversarial network to segment the hippocampus.Different convolutional configurations were proposed to capture information obtained by a segmentation network.In addition,a generative adversarial network based on Pixel2Pixel was proposed.The generator was a codec structure combining a residual network and an attention mechanism to capture detailed information.The discriminator used a convolutional neural network to discriminate the segmentation results of the generated model and that of the expert.Through the continuously transmitted losses of the generator and discriminator,the generator reached the optimal state of hippocampus segmentation.T1-weighted magnetic resonance imaging scans and related hippocampus labels of 130 healthy subjects from the Alzheimer’s disease Neuroimaging Initiative dataset were used as training and test data;similarity coefficient,sensitivity,and positive predictive value were used as evaluation indicators.Results showed that the network model could achieve an efficient automatic segmentation of the hippocampus and thus has practical relevance for the correct diagnosis of diseases,such as Alzheimer’s disease. | Hongxia Deng Yuefang Zhang Ran Li Chunxiang Hu Zijian Feng Haifang Li | 2022 | Tsinghua Science and Technology2022，27，1： | 1 |
| 20 | Neurotoxicity of low-dose repeatedly intranasal instillation of nano- and submicron-sized ferric oxide particles in mice显示文摘 | Bing Wang Weiyue Feng Motao Zhu Yun Wang Meng Wang Yiqun Gu Hong Ouyang Huajian Wang Ming Li Yuliang Zhao Zhifang Chai Haifang Wang | 2009 | Journal of Nanoparticle Research2009，，1： | 1 |
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