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| 1 | Impacts of thermodynamic processes over the Tibetan Plateau on the Northern Hemispheric climate显示文摘We here report our recent research results on the climatic features of Tibetan thermodynamic functions and their impacts on the regional climates of the Northern Hemisphere. The results show that the thermodynamic processes over the Tibetan Plateau not only strongly influence the Asian monsoon and precipitation, but also modulate the atmospheric circulation and climate over North America and Europe through stimulating the large-scale teleconnections such as the Asian-Pacific oscillation and affect the atmospheric circulation over the southern Indian Ocean. The Tibetan climate may be affected by sea surface temperatures over the tropical Pacific. On the other hand, the Tibetan climate also affects the atmosphere-ocean interactions in the tropics and mid-latitudes of the Pacific by the atmospheric circulation over the North Pacific. In spring and summer, the thermodynamic anomalies on the plateau affect the subtropical high pressure, the Hadley circulation, and the intertropical convergence zone over the Pacific, and then modulate the development of the El Ni-o/Southern Oscillation (ENSO). It is necessary to study the forecasting methods for the development of ENSO from the Tibetan climate anomaly. This result also embodies the essence of interactions among land, atmosphere, and ocean over the Northern Hemisphere. Since the previous studies focused on impacts of the plateau on climates in the Asian monsoon regions, it is essential to pay more attention to studying the roles of the plateau in the Northern Hemispheric and even global climates. | ZHOU XiuJi ZHAO Ping CHEN JunMing CHEN LongXun LI WeiLiang | 2009 | Science China Earth Sciences2009，52，11： | 42 |
| 2 | Tectonic Evolution of the Meso-Tethys in the Western Segment of Bangonghu-Nujiang Suture Zone: Insights from Geochemistry and Geochronology of the Lagkor Tso Ophiolite显示文摘The subduction of the Bangonghu-Nujiang Meso-Tethys and the collision between the Lhasa and Qiangtang blocks were important events in the growth of the Tibetan crust. However,the timing of collision initiation and closure timing,as well as nature and structure of the Bangonghu ocean basin,are still poorly constrained. The Lagkor Tso ophiolite,located in the south of Gerze County,Tibet,is one of the most completed ophiolites preserved in the southern side of the BangonghuNujiang suture zone. This study discussed the tectonic evolution of the Bangonghu-Nujiang suture zone as revealed by the Lagkor Tso ophiolite investigated by field investigations,petrology,geochemistry,geochronology and tectonic analysis methods. We present new LA-ICP-MS zircon U-Pb and 39Ar/40 Ar ages for the Lagkor Tso ophiolite,in addition to geochemical and platinum-group element(PGE) data presented for the Lagkor Tso ophiolite in Tibet. It is suggested that the ancient Lagkor Tso oceanic basin split in Middle Jurassic(161.2 ± 2.7 Ma – 165.4 ± 3.5 Ma),and experienced a second tectonic emplacement during the Early Cretaceous(137.90 ± 6.39 Ma). The Lagkor Tso ophiolite likely developed in an independent suture zone. The Bangonghu-Nujiang ocean subducted southwards,and the dehydration of the subducting oceanic crust materials caused partial melting of the continental mantle wedge,which formed the second-order expanding center of the obduction dish. This led to inter-arc expansion,followed by the formation of inter-arc and back-arc basins with island arc features,which are represented by ophiolites around the Shiquanhe-Lagkor Tso-Yongzhu region. The tectonic environment presently can be considered to be similar to that of the current Western Pacific,in which a large number of island arc-ocean basin systems are developed. | YUAN Yajuan YIN Zhengxin LIU Weiliang HUANG Qiangtai LI Jianfeng LIU Hongfei WAN Zhifeng CAI Zhourong XIA Bin | 2015 | Acta Geologica Sinica(English Edition)2015，89，2： | 17 |
| 3 | Evaluation of the Trend Uncertainty in Summer Ozone Valley over the Tibetan Plateau in Three Reanalysis Datasets显示文摘Trend uncertainty in the ozone valley over the Tibetan Plateau(OVTP)and the South Asian high(SAH)during1979–2009 in ERA-Interim(interim reanalysis data from the ECMWF),JRA-55(55-yr reanalysis data from the Japan Meteorological Agency),and NCEP-CFSR(Climate Forecast System Reanalysis)datasets was evaluated.The results showed that the NCEP-CFSR OVTP became strong in the summers of 1979–2009,whereas it became weak according to ERA-Interim and JRA-55.Satellite data merged with TOMS(Total Ozone Mapping Spectrometer)and OMI(Ozone Monitoring Instrument)agreed with the OVTP trend of NCEP-CFSR.The OVTP strengthening in NCEP-CFSR may have been caused by SAH intensification,a rising tropopause,and increasing ozone over non-TP(non-Tibetan Plateau)areas(27°–37°N,<75°E and>105°E).Analogously,the OVTP weakening in ERA-Interim and JRA-55 may have been affected by weakening SAH,descending tropopause,and decreasing non-TP ozone. | Dong GUO Yucheng SU Xiuji ZHOU Jianjun XU Chunhua SHI Yu LIU Weiliang LI Zhenkun LI | 2017 | Journal of Meteorological Research2017，31，2： | 13 |
| 4 | Humoral immune response to circulating SARS-CoV-2 variants elicited by inactivated and RBD-subunit vaccines显示文摘SARS-CoV-2 variants could induce immune escape by mutations on the receptor-binding domain(RBD)and N-terminal domain(NTD).Here we report the humoral immune response to circulating SARS-CoV-2 variants,such as 501Y.V2(B.1.351),of the plasma and neutralizing antibodies(NAbs)elicited by CoronaVac(inactivated vaccine),ZF2001(RBD-subunit vaccine)and natural infection.Among 86 potent NAbs identified by high-throughput single-cell VDJ sequencing of peripheral blood mononuclear cells from vaccinees and convalescents,near half anti-RBD NAbs showed major neutralization reductions against the K417N/E484K/N501Y mutation combination,with E484K being the dominant cause.VH3-53/VH3-66 recurrent antibodies respond differently to RBD variants,and K417N compromises the majority of neutralizing activity through reduced polar contacts with complementarity determining regions.In contrast,the 242–244 deletion(242–244Δ)would abolish most neutralization activity of anti-NTD NAbs by interrupting the conformation of NTD antigenic supersite,indicating a much less diversity of anti-NTD NAbs than anti-RBD NAbs.Plasma of convalescents and CoronaVac vaccinees displayed comparable neutralization reductions against pseudo-and authentic 501Y.V2 variants,mainly caused by E484K/N501Y and 242–244Δ,with the effects being additive.Importantly,RBD-subunit vaccinees exhibit markedly higher tolerance to 501Y.V2 than convalescents,since the elicited anti-RBD NAbs display a high diversity and are unaffected by NTD mutations.Moreover,an extended gap between the third and second doses of ZF2001 leads to better neutralizing activity and tolerance to 501Y.V2 than the standard three-dose administration.Together,these results suggest that the deployment of RBD-vaccines,through a third-dose boost,may be ideal for combating SARS-CoV-2 variants when necessary,especially for those carrying mutations that disrupt the NTD supersite. | Yunlong Cao Ayijiang Yisimayi Yali Bai Weijin Huang Xiaofeng Li Zhiying Zhang Tianjiao Yuan Ran An Jing Wang Tianhe Xiao Shuo Du Wenping Ma Liyang Song Yongzheng Li Xiang Li Weiliang Song Jiajing Wu Shuo Liu Xuemei Li Yonghong Zhang Bin Su Xianghua Guo Yangyang Wei Chuanping Gao Nana Zhang Yifei Zhang Yang Dou Xiaoyu Xu Rui Shi Bai Lu Ronghua Jin Yingmin Ma Chengfeng Qin Youchun Wang Yingmei Feng Junyu Xiao Xiaoliang Sunney Xie | 2021 | Cell Research2021，31，7： | 12 |
| 5 | Optimal Energy-Efficient Transmission for Hybrid Spectrum Sharing in Cooperative Cognitive Radio Networks显示文摘In order to improve the energy efficiency(EE)in cognitive radio(CR),this paper investigates the joint design of cooperative spectrum sensing time and the power control optimization problem for the secondary user systems to achieve the maximum energy efficiency in a cognitive network based on hybrid spectrum sharing,meanwhile considering the maximum transmit power,user quality of service(QoS)requirements,interference limitations,and primary user protection.The optimization of energy efficient sensing time and power allocation is formulated as a non-convex optimization problem.The Dinkelbach’s method is adopted to solve this problem and to transform the non-convex optimization problem in fractional form into an equivalent optimization problem in the form of subtraction.Then,an iterative power allocation algorithm is proposed to solve the optimization problem.The simulation results show the effectiveness of the proposed algorithms for energy-efficient resource allocation in the cognitive network. | Linna Hu Rui Shi Minghe Mao Zhiyu Chen Hongxi Zhou Weiliang Li | 2019 | China Communications2019，16，6： | 9 |
| 6 | Simulation of secondary aerosols over North China in summer显示文摘The comparisons of observed and simulated NOx, CO, O3, NH3, HNO3, SO2 and PM2.5 indicate that CMAQ model can simulate variations of pollutants over North China well.Moreover, the model results show that high NH3 is in Hebei, Henan and Shandong provinces,with average concentration of (30-35)×10-9. The results of the sensitive experiment indicate that high concentration of NH3 has the efficiency of the production of secondary sulfate aerosol increase by more than 30%, especially at the juncture of Handan, Anyang and Changzhi that increased by 50%. In addition, NH3 also produces secondary ammonia and nitrate aerosol, and the sum of them is approximately equal to sulfate aerosol. The height of planetary boundary layer (PBL) in Beijing is higher in daytime, with average height of 1500 m at noon. This makes SO2,NH3 and HNO3 transported into upper PBL of 850 hPa. The high secondary sulfate, and ammonia and nitrate aerosol happen in the upper and lower PBL, respectively. Because PM2.5 lifetime is relatively long, it can be transported into the middle troposphere to form a thick aerosol layer,which is the arched roof of aerosol. The model result suggests that if the aerosol concentration in North China would be controlled, the reduction of NH3 emission is one of efficient ways besides the reduction of primary SO2, NOx and aerosol emission. | LIU Yu LI Weiliang ZHOU Xiuji | 2005 | Science China Earth Sciences2005，48，z2： | 8 |
| 7 | Mass exchange between stratosphere and trotosphere over the Tibetan Plateau and its surroundings显示文摘Using NCEP dataset we calculate the exchange of mass across the thermal tropopause by the Wei’s method from 1978 to 1997 over the Tibetan Plateau and its surroundings. We also calculate the annual variation of aerosol and ozone of 100 hPa level with the monthly SAGE dataset from July 1988 to December 1993. Results indicate that (i) the mass from troposphere to stratosphere is magistral station in summer over the Tibetan Plateau and its surroundings. The air transport reaches the summit in midsummer with two large value centers, which lie in the north of Bengal Bay and southeastern Tibetan Plateau, respectively. A large value center, which lies over the Tibetan Plateau, is smaller than that aforementioned. In winter, the mass transport is from stratosphere to troposphere, and reaches the minimum in January. (ii) As far as the 19-year mean cross-tropopause mass exchange from June to September is concerned, the net mass transport is 14.84×l018 kg from troposphere to stratosphere. So the area from the | Chunhua Cong Weiliang Li Xiuji Zhou | 2002 | Chinese Science Bulletin2002，47，6： | 8 |
| 8 | Autotuning algorithm of particle swarm PID parameter based on D-Tent chaotic model显示文摘An improved particle swarm algorithm based on the D-Tent chaotic model is put forward aiming at the standard particle swarm algorithm. The convergence rate of the late of proposed algorithm is improved by revising the inertia weight of global optimal particles and the introduction of D-Tent chaotic sequence. Through the test of typical function and the autotuning test of proportionalintegral-derivative(PID) parameter, finally a simulation is made to the servo control system of a permanent magnet synchronous motor(PMSM) under double-loop control of rotating speed and current by utilizing the chaotic particle swarm algorithm. Studies show that the proposed algorithm can reduce the iterative times and improve the convergence rate under the condition that the global optimal solution can be got. | Min Zhu Chunling Yang Weiliang Li | 2013 | Journal of Systems Engineering and Electronics2013，24，5： | 7 |
| 9 | Effects of redox-active interlayer anions on the oxygen evolution reactivity of NiFe-layered double hydroxide nanosheets显示文摘镍铁分层的双氢氧化物(NiFe-LDH ) nanosheets 显示出最佳的氧进化反应(OER ) 性能;然而,在 OER 活动的设置的离子的角色仍然保持不清楚。在这个工作,我们证明 NiFe-LDHs 的活动能被设置的阴离子与不同氧化还原作用潜力定制。而 NiFe-LDHs 与高氧化还原作用潜力(低减少能力)的阴离子设置了,有低氧化还原作用潜力(高减少能力)的阴离子的置闰例如次磷酸盐,与 240 mV 的低 OER 过电位和 36.9 mV/dec 的一个小 Tafel 斜坡导致 NiFe-LDHs ,例如 fluorion ,显示出 370 mV 的高过电位和 80.8 mV/dec 的一个 Tafel 斜坡。OER 活动与标准氧化还原作用潜力显示出令人吃惊的线性关联。密度功能的理论计算和 X 光检查光电子光谱学分析显示设置的阴离子改变在表面暴露了的金属原子的电子结构。有低标准氧化还原作用潜力和强壮的减少能力的阴离子把更多的电子转移到氢氧化物层。这增加表面金属地点的电子密度并且稳定他们的高原子价的状态,其形成在 OER 过程以前作为关键步被知道。 | Daojin Zhou Zhao Cai Yongmin Bi Weiliang Tian Ma Luo Qian Zhang Qixian Xie Jindi Wang Yaping Li Yun Kuang Xue Duan Michal Bajdich Samira Siahrostami Xiaoming Sun | 2018 | Nano Research2018，11，3： | 6 |
| 10 | Vacancy formation enthalpies of high-entropy FeCoCrNi alloy via first-principles calculations and possible implications to its superior radiation tolerance显示文摘Because atoms in high-entropy alloys(HEAs) coordinate in very different and distorted local environments in the lattice sites, even for the same type of constituent, their point defects could highly vary.Therefore, theoretical determination of the thermodynamic quantities(i.e., defect formation enthalpies)of various point defects is rather challenging because each corresponding thermodynamic quantity of all involve constituents is not unique. The knowledge of these thermodynamic quantities is prerequisite for designing novel HEAs and understanding the mechanical and physical behaviors of HEAs. However,to date there has not been a good method to theoretically derive the defect formation enthalpies of HEAs. Here, using first-principles calculations within the density functional theory(DFT) in combination of special quasi-random structure models(SQSs), we have developed a general method to derive corresponding formation enthalpies of point defects in HEAs, using vacancy formation enthalpies of a four-component equiatomic fcc-type FeCoCrNi HEA as prototypical and benchmark examples. In difference from traditional ordered alloys, the vacancy formation enthalpies of FeCoCrNi HEA vary in a highly wide range from 0.72 to 2.89 eV for Fe, 0.88–2.90 eV for Co, 0.78–3.09 eV for Cr, and 0.91–2.95 eV for Ni due to high-level site-to-site lattice distortions and compositional complexities. On average, the vacancy formation enthalpies of 1.58 eV for Fe, 1.61 eV for Cr, 1.70 eV for Co and 1.89 eV for Ni are all larger than that(1.41 eV) of pure fcc nickel. This fact implies that the vacancies are much more difficult to be created than in nickel, indicating a reasonable agreement with the recent experimental observation that FeCoCrNi exhibits two orders of amplitudes enhancement of radiation tolerance with the suppression of void formation at elevated temperatures than in pure nickel. | Weiliang Chen Xueyong Ding Yuchao Feng Xiongjun Liu Kui Liu Z.P. Lu Dianzhong Li Yiyi Li C.T. Liu Xing-Qiu Chen | 2018 | Journal of Materials Science & Technology2018，34，2： | 6 |
| 11 | Why are oseltamivir and zanamivir effective against the newly emerged influenza A virus (A/HIN1)?显示文摘 | Kunqian Yu Cheng Luo Guangrong Qin Zhijian Xu Ning Li Hong Liu Xu Shen Jianpeng Ma Qinghua Wang Caiguang Yang Weiliang Zhu Hualiang Jiang | 2009 | Cell Research2009，19，10： | 6 |
| 12 | An overview of the development history and technical progress of China's coal-fired power industry显示文摘As the main power source of China, coalfired power industry has achieved a great progress in installed capacity, manufacturing technologies, thermal efficiency, as well as pollutant control during the past century. With the fast development of renewable energies, coal-fired power industry is experiencing a strategic transformation. To specify the development of coal-fired power industry, its development history is reviewed and the technical progresses on aspects of thermal efficiency, pollutants control and peaking shaving capacity are discussed. It is concluded that the role of China's coal-fired power source would be transformed from the dominant position to a base position in power source structure. Considering the sustainable development of coal-fired power industry in energy conservation, emission control, and utilization of renewable energies, it is suggested that the national average thermal efficiency should be improved by continual up-gradation of units by using advanced technologies and eliminating outdated capacity. Moreover, the emission standard of air pollutants should not be stricter any more in coal-fired power industry. Furthermore, the huge amount of combined heat and power (CHP) coal-fired units should be operated in a decoupled way, so as to release more than 350 GW regulation capacity for the grid to accept more renewable energy power. | Weiliang WANG Zheng LI Junfu LYU Hai ZHANG Guangxi YUE Weidou NI | 2019 | Frontiers in Energy2019，13，3： | 6 |
| 13 | Characteristics of atmospheric aerosol optical depth variation over China in recent 30 years显示文摘This note retrieves the annual and monthly mean 0.75 urn aerosol optical depth (AOD) by using the daily direct solar radiation and sunshine duration data of 47 solar stations from 1961 to 1990. The characteristic of AOD variation over China in recent 30 years was analyzed. The results indicate that AOD increased obviously over China from 1961 to 1990. AOD increased most rapidly over the east part of Southwest China, the middle-and-lower reaches of the Yangtze River and the Tibetan Plateau. The increasing trend of AOD is also relatively distinct in North China, the Shandong Peninsula, east part of Qinghai Province, and coastal areas of Guangdong Province. However, in most parts of Northwest China and Northeast China, the increase of AOD is less significant, while in the west part of the Xinjiang Uygur Autonomous Region and some parts of Yunnan Province, AOD shows decreasing tendency. Generally, AOD reaches its maximum in spring and the minimum appears in summer. As to the linear trend, the maximum | LUO Yunfeng LU Daren HE Qing LI Weiliang ZHOU Xiuji | 2000 | Chinese Science Bulletin2000，45，14： | 6 |
| 14 | Dihydrocelastrol inhibits multiple myeloma cell proliferation and promotes apoptosis through ERK1/2 and IL-6/STAT3 pathways in vitro and in vivo显示文摘多重骨髓瘤(公里) 是第二很经常的恶意的 hematological 疾病。Dihydrocelastrol (DHCE ) 被 hydrogenated celastrol 综合,从中国药用的植物 Tripterygium regelii 孤立的 treterpene。在这研究,我们首先在公里房间上报导了 DHCE 的反肿瘤活动。我们发现 DHCE 能禁止房间增长并且在 vitro 通过 caspase 依赖的方法支持 apoptosis。另外, DHCE 能使 interleukin (IL ) 的表达式失去活性 -6 和 downregulate 细胞外的调整蛋白质 kinases (ERK1/2 ) 和信号变换器和在公里的抄写 3 的使活跃之物(STAT3 ) 的 phosphorylation。它也面对 IL-6 对公里房间线保留了它的活动。而且,有 DHCE 的公里房间的处理在房间周期的 G 0/G1 阶段导致了房间的累积。尤其是, DHCE 减少了 4 和 6 在公里房间衬里的 cyclin D1 和 cyclin 依赖的 kinases 的表示。另外,它向 MM 房间线的功效能与 histone deacetylase 禁止者 panobinostat (LBH589 ) 在联合被提高,它在公里作为潜在的治疗学的策略暗示了 DHCE 和 LBH589 的联合处理的可能性。另外,有 DHCE 的 NCI-H929 忍受肿瘤的裸体老鼠的处理(10 mg/kg/d, i.p, 1-14 天) 在 vivo 导致了肿瘤生长的 73% 抑制。一起拿,我们的现在的学习的结果显示 DHCE 能禁止细胞的增长并且在骨髓瘤房间导致房间 apoptosis 通过不同机制调停了,可能通过禁止 IL-6/STAT3 和 ERK1/2 小径。并且它可以为公里病人提供一种新治疗学的选择。 | Liangning Hu Huiqun Wu Bo Li Dongliang Song Guang Yang Gege Chen Bingqian Xie Zhijian Xu Yong Zhang Dandan Yu Jun Hou Wenqin Xiao Xi Sun Gaomei Chang Yiwen Zhang Lu Gao Bojie Dai Yi Tao Jumei Shi Weiliang Zhu | 2017 | Acta Biochimica et Biophysica Sinica2017，49，5： | 5 |
| 15 | Response of Soil Moisture to Rainfall Event in Black Locust Plantations at Different Stages of Restoration in Hilly-gully Area of the Loess Plateau, China显示文摘Precipitation plays an important role in the water supplies that support ecological restoration by sustaining large-scale artificial plantations in arid and semiarid regions, especially black locust(Robinia pseudoacacia) plantations(RP plantations), which are widely planted due to R. pseudoacacia being an excellent pioneer species. Characterizing the response of soil moisture to rainfall events at different stages of restoration is important for assessing the sustainability of restoration in RP plantations. In this study, we quantified the response of soil moisture to rainfall events at different years of restoration(15, 20 and 30 yr) representing different restoration stages in RP plantations in a typical hilly-gully area, i.e., the Yangjuangou Catchment, of the Loess Plateau, China. Over the growing season(June to September) of 2017, smart probes were placed at nine depths(10, 20, 40, 60, 80, 100, 120, 150, and 180 cm below the soil surface) to obtain volumetric soil water information at 30-min intervals in the three RP plantations. The advance of the wetting front was depicted, and the total cumulative water infiltration was measured. Soil moisture was mainly replenished by eight heavy rainfall events(mean rainfall amount = 46.3 mm), accounting for 88.7% of the rainfall during the growing season. The mean soil moisture content profiles of RP plantations at the three restoration stages were ordered as 30-yr(14.07%) > 20-yr(10.12%) > 15-yr(8.03%), and this relationship displayed temporal stability. Soil moisture was primarily replenished by rainfall at the 0-60 cm soil depth, and soil moisture remained stable below the 100-cm soil depth. The rainfall regime influenced the advancement of the wetting front. Here, a single rainfall event of 30 mm was the rainfall threshold for infiltration into the 60-cm soil layer. The total infiltration time ranged from 310.5-322.0 h, but no significant differences were found among RP plantations at different restoration stages. Young and old RP plantations had more total infiltration(more than 228.2 mm) and deeper infiltration depths(80-100 cm) than middle-aged plantations. The RP plantation at the intermediate restoration stage exhibited minimal total infiltration(174.2 mm) and a shallow infiltration depth(60 cm) due to the soil physical structure of the plot, which may have limited rain infiltration. More stand conditions that may affect infiltration should be considered for priority afforestation areas. | CHEN Weiliang LI Zongshan JIAO Lei WANG Cong GAO Guangyao FU Bojie | 2020 | Chinese Geographical Science2020，30，3： | 5 |
| 16 | Effects of dietary ratio of n-6 to n-3 polyunsaturated fatty acids on immunoglobulins, cytokines, fatty acid composition, and performance of lactating sows and suckling piglets显示文摘This experiment was conducted to investigate the effects of dietary ratios of n-6:n-3 polyunsaturated fatty acids (PUFA) on the performance of lactating sows and their piglets. Thirty pregnant Landrace sows were assigned to one of three treatments from d 108 of gestation until weaning (26-29 d) and were fed diets containing different ratios of n-6:n-3 PUFA including 3:1, 9:1 and 13:1. The effects on sow and litter production traits were examined together with an assessment of sow body condition. No differences were detected among the treatments for the daily feed intake of sows or changes in sow weight and back-fat levels during lactation (P > 0.05). Litter size at d 14 and d 21 were tended to increase in 3:1 treatment compared with 9:1 and 13:1 treatments (P < 0.10). Litter weight gain (1.77 kg/d) from d 0 to d 14 was tended to increase in 9:1 groups compared with the other two treatments (P < 0.10). A significant difference was observed for the content of α -linolenic acid, total n-3 PUFA, and the ratio of n-6:n-3 PUFA in the colostrum, milk, and piglets plasma (P < 0.01). The effects of different ratios of n-6:n-3 PUFA in sow diets on colostrum, milk, and piglet plasma immunoglobulin concentrations are studied. No difference was observed among treatments in the concentrations of IgM, and IgA in colostrum (P > 0.05). A great significant difference for IgG concentration was observed among 3 group in colostrum. A great significant difference for IgA, and IgM (P < 0.01) concentrations in piglet plasma at d14 and a significant difference for IgG(P < 0.05) was observed at d14. Furthermore, at d 21 of lactation, piglet plasma IgG and IgA concentration were greater in 3:1 compared with 13:1 group (P < 0.01). In summary, the current study demonstrated that altering the ratio of n-6:n-3 PUFA in lactating sow diet had an effect on the immune component including immunoglobulin and cytokines, and it tended to increase the litter average daily gain and improve the immune status of piglets when dietary ratio of n-6:n-3 PUFA was 9:1. | Wei Yao Jie Li Jun jun Wang Weiliang Zhou Qingbo Wang Rongchang Zhu Fenglai Wang Phil Thacker | 2013 | Journal of Animal Science and Biotechnology2013，4，2： | 4 |
| 17 | Targeting the PI3K/Akt/mTOR signaling pathway by pterostilbene attenuates mantle cell lymphoma progression显示文摘 | Dandan Yu Yong Zhang Gege Chen Yongsheng Xie Zhijian Xu Shuaikang Chang Liangning Hu Bo Li Wenxuan Bu Yingcong Wang Wenqin Xiao Xi Sun Gaomei Chang Lu Gao Sujing Qiang Xiaosong Wu Weiliang Zhu Jumei Shi | 2018 | Acta Biochimica et Biophysica Sinica2018，50，8： | 4 |
| 18 | p-RWBO:a novel low-collision and QoS-supported MAC for wireless ad hoc networks显示文摘QoS supported MAC mechanism is a key issue for supporting QoS in wireless ad hoc networks. A new backoff algorithm,named RWBO+BEB,was proposed previously to decrease the packet collision probability significantly. In this paper,it is explored how to make RWBO+BEB support service differentiation in wireless ad hoc networks,and a novel proportional service differentiation algorithm,named p-RWBO,is proposed to allocate the wireless bandwidth according to the bandwidth ratio of each station. In p-RWBO,station n's walking probability(pw,n) is selected according to its allocated bandwidth ratio. An analytical model is proposed to analyze how to choose pw,n according to the bandwidth ratios of station n. The simulation results indicate that p-RWBO can differentiate services in terms of both bandwidth and delay. | LONG KePing LI Yun ZHAO WeiLiang WANG ChongGang Kazem SOHRABY | 2008 | Science in China(Series F)2008，51，9： | 4 |
| 19 | DCZ0801,a novel compound,induces cell apoptosis and cell cycle arrest via MAPK pathway in multiple myeloma显示文摘Multiple myeloma(MM)is a refractory malignant hematological malignancy,and many therapeutic strategies have been developed to cure patients with MM.DCZ0801 is a compound that consists of oxophenamide and pterostilbene.The role of these compounds in hematological cancers such as MM has yet to be studied.In this study,we explored the potential mechanism of DCZ0801 action,its anti-tumor activity both in vitro and in vivo on MM.This study was carried out via cell cycle proliferation assay,apoptotic analysis,western blot analysis,and examination of xenotransplantation model of tumors.The in vitro studies revealed that DCZ0801 could inhibit cell proliferation and induce apoptosis by regulating both caspase-dependent and mitogen-activated protein kinase signaling pathways,inducing S-phase arrest of the cell cycle related to downregulation of CDK2,cyclin-A2,and CDC25A protein expression.The in vivo studies showed that DCZ0801 could significantly reduce the size of the tumors in nude mice.Our results demonstrated that DCZ0801 may emerge as the new therapeutic option for the patient with MM. | Ting Zhang Bo Li Qilin Feng Zhijian Xu Cheng Huang Huiqun Wu Zhangbo Chen Liangning Hu Lu Gao Peng Liu Guang Yang Hui Zhang Kang Lu Tingye Li Yi Tao Xiaosong Wu Jumei Shi Weiliang Zhu | 2019 | Acta Biochimica et Biophysica Sinica2019，51，5： | 3 |
| 20 | ETCM v2.0:An update with comprehensive resource and rich annotations for traditional Chinese medicine显示文摘Existing traditional Chinese medicine(TCM)-related databases are still insufficient in data standardization,integrity and precision,and need to be updated urgently.Herein,an Encyclopedia of Traditional Chinese Medicine version 2.0(ETCM v2.0,http://gffzz3ff3e9d9e9f64aa3hqw9fvf6xcc606k06.ffgz.tsg.suse.edu.cn/ETCM2/front/#/)was constructed as the latest curated database hosting 48,442 TCM formulas recorded by ancient Chinese medical books,9872 Chinese patent drugs,2079 Chinese medicinal materials and 38,298 ingredients.To facilitate the mechanistic research and new drug discovery,we improved the target identification method based on a two-dimensional ligand similarity search module,which provides the confirmed and/or potential targets of each ingredient,as well as their binding activities.Importantly,five TCM formulas/Chinese patent drugs/herbs/ingredients with the highest Jaccard similarity scores to the submitted drugs are offered in ETCM v2.0,which may be of significance to identify prescriptions/herbs/ingredients with similar clinical efficacy,to summarize the rules of prescription use,and to find alternative drugs for endangered Chinese medicinal materials.Moreover,ETCM v2.0 provides an enhanced Java Script-based network visualization tool for creating,modifying and exploring multi-scale biological networks.ETCM v2.0 may be a major data warehouse for the quality marker identification of TCMs,the TCM-derived drug discovery and repurposing,and the pharmacological mechanism investigation of TCMs against various human diseases. | Yanqiong Zhang Xin Li Yulong Shi Tong Chen Zhijian Xu Ping Wang Meng Yu Wenjia Chen Bing Li Zhiwei Jing Hong Jiang Lu Fu Wenjing Gao Yanhua Jiang Xia Du Zipeng Gong Weiliang Zhu Hongjun Yang Haiyu Xu | 2023 | Acta Pharmaceutica Sinica B2023，13，6： | 3 |
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