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| 1 | Colonoscopy surveillance for high risk polyps does not always prevent colorectal cancer显示文摘AIM To determine the frequency and risk factors for colorectal cancer(CRC) development among individuals with resected advanced adenoma(AA)/traditional serrated adenoma(TSA)/advanced sessile serrated adenoma(ASSA). METHODS Data was collected from medical records of 14663 subjects found to have AA, TSA, or ASSA at screening or surveillance colonoscopy. Patients with inflammatory bowel disease or known genetic predisposition for CRC were excluded from the study. Factors associated with CRC developing after endoscopic management of high risk polyps were calculated in 4610 such patients who had at least one surveillance colonoscopy within 10 years following the original polypectomy of the incident advanced polyp. RESULTS84/4610(1.8%) patients developed CRC at the polypectomy site within a median of 4.2 years(mean 4.89 years), and 1.2%(54/4610) developed CRC in a region distinct from the AA/TSA/ASSA resection site within a median of 5.1 years(mean 6.67 years). Approximately, 30%(25/84) of patients who developed CRC at the AA/TSA/ASSA site and 27.8%(15/54) of patients who developed CRC at another site had colonoscopy at recommended surveillance intervals. Increasing age; polyp size; male sex; right-sided location; high degree of dysplasia; higher number of polyps resected; and piecemeal removal were associated with an increased risk for CRC developmentat the same site as the index polyp. Increasing age; right-sided location; higher number of polyps resected and sessile endoscopic appearance of the index AA/TSA/ASSA were significantly associated with an increased risk for CRC development at a different site. CONCLUSION Recognition that CRC may develop following AA/TSA/ASSA removal is one step toward improving our practice efficiency and preventing a portion of CRC related morbidity and mortality. | Mohamad A Mouchli Lidia Ouk Marianne R Scheitel Alisha P Chaudhry Donna Felmlee-Devine Diane E Grill Shahrooz Rashtak Panwen Wang Junwen Wang Rajeev Chaudhry Thomas C Smyrk Ann L Oberg Brooke R Druliner Lisa A Boardman | 2018 | World Journal of Gastroenterology2018，24，8： | 5 |
| 2 | Fatty acid intake in relation to reproductive hormones and testicular volume among young healthy men显示文摘新兴的证据建议饮食的脂肪可以影响阴囊的功能。然而,大多数这域上的出版文学为阴囊的功能把精液质量参数用作唯一的代理。我们在健康的年轻西班牙的人之中与传播繁殖荷尔蒙层次和阴囊的体积检验了胖吸入的协会。这是在在西班牙的 Murcia 区域在 2010 年 10 月和 2011 年 11 月之间进行的 209 个健康男志愿者之中的代表性的研究。参加者在生活方式上完成了问询表,饮食,并且吸烟,并且各经历了物理考试,并且提供了一件血样品。线性回归被用来检验在每种丰满的酸类型和繁殖荷尔蒙层次和阴囊的体积之间的协会。Monounsaturated 丰满的酸吸入相反地与计算免费睾丸激素,全部的睾丸激素,和 inhibin B 的浆液血层次被联系。一个积极协会在多元不堡和的吸入之间被观察丰满的酸,特别地 omega-6 多元不堡和丰满的酸,和 luteinizing 荷尔蒙集中。另外, trans 的吸入丰满的酸与更低的全部的睾丸激素和计算免费睾丸激素集中被联系(P 趋势 = 0.01 和 0.02,分别地) 。omega-3 多元不堡和的吸入丰满的酸断然与阴囊的体积有关当时 omega-6 多元不堡和的吸入丰满的酸和 trans 丰满的酸相反地与阴囊的体积有关。这些数据建议那胖吸入,并且特别地终止 3 的吸入,终止 6,并且 trans 丰满的酸,可以影响阴囊的功能。 | Lidia Minguez-Alarcon Jorge E Chavarro JJaime Mendiola Manuela Roca Cigdem Tanrikut Jesus Vioque Niels Jorgensen Alberto M Torres-Cantero | 2017 | Asian Journal of Andrology2017，19，2： | 5 |
| 3 | A high-density, multi-parental SNP genetic map on apple validates a new mapping approach for outcrossing species显示文摘Quantitative trait loci(QTL)mapping approaches rely on the correct ordering of molecular markers along the chromosomes,which can be obtained from genetic linkage maps or a reference genome sequence.For apple(Malus domestica Borkh),the genome sequence v1 and v2 could not meet this need;therefore,a novel approach was devised to develop a dense genetic linkage map,providing the most reliable marker-loci order for the highest possible number of markers.The approach was based on four strategies:(i)the use of multiple full-sib families,(ii)the reduction of missing information through the use of HaploBlocks and alternative calling procedures for single-nucleotide polymorphism(SNP)markers,(iii)the construction of a single backcross-type data set including all families,and(iv)a two-step map generation procedure based on the sequential inclusion of markers.The map comprises 15417 SNP markers,clustered in 3 K HaploBlock markers spanning 1267 cM,with an average distance between adjacent markers of 0.37 cM and a maximum distance of 3.29 cM.Moreover,chromosome 5 was oriented according to its homoeologous chromosome 10.This map was useful to improve the apple genome sequence,design the Axiom Apple 480 K SNP array and perform multifamily-based QTL studies.Its collinearity with the genome sequences v1 and v3 are reported.To our knowledge,this is the shortest published SNP map in apple,while including the largest number of markers,families and individuals.This result validates our methodology,proving its value for the construction of integrated linkage maps for any outbreeding species. | Erica A Di Pierro Luca Gianfranceschi Mario Di Guardo Herma JJ Koehorst-van Putten Johannes W Kruisselbrink Sara Longhi Michela Troggio Luca Bianco Hélène Muranty Giulia Pagliarani Stefano Tartarini Thomas Letschka Lidia Lozano Luis Larisa Garkava-Gustavsson Diego Micheletti Marco CAM Bink Roeland E Voorrips Ebrahimi Aziz Riccardo Velasco François Laurens W Eric van de Weg | 2016 | Horticulture Research2016，3，1： | 3 |
| 4 | Measurement of intracellular triglyceride stores by 1H spectroscopy: validation in vivo显示文摘 | Szczepaniak Lidia S Babcock Evelyn E Schick Fritz | 1999 | Am J Physiol1999，276，1： | 1 |
| 5 | Zeta chain expression in T and NK cells in peripheral tlood of children with nephrotic syndrome 显示文摘 | Kinga M Lidia E Agata Kosmaczewska | 2010 | Pediatr Nephrol2010，25，1： | 1 |
| 6 | Recrystallization of waxy maize starch during manufacturing of starch micro- spheres for drug delivery:influence of excipients显示文摘 | Lidia E Ann-Charlotte E Monica J | 2007 | Carbo- hydrate Polymers2007，69，4： | 1 |
| 7 | Structural characterization of a new binding Motif and a novel binding mode in group 2 WW domains显示文摘 | XIMENA R E LIDIA R PAU M M | 2008 | Journal of Molecular Biology2008，373，5： | 1 |
| 8 | Feasibility of near infrared spectroscopy for analyzing corn kernel damage and viability of soybean and corn kernels 显示文摘 | Lidia E A Ellis D D Duvick S | 2012 | Journal of Cereal Science2012，55，2： | 1 |
| 9 | Recrystalliza- tion of waxy maize starch during manufacturing of starch microspheres for drug delivery: Influence of excipients 显示文摘 | Lidia E Ann-Charlotte E Monica J | 2007 | Carbohydrate Polymers2007，69，4： | 1 |
| 10 | Review of Methods for Increasing discrimination in data envelopment analysis显示文摘 | Lidia A Marcos P E | 2002 | Annals of Operations Research2002，，116： | 1 |
| 11 | Review of method for increasing discrimination in data envelopment analysis显示文摘 | Lidia M P E | 2002 | Annals of Operations Research2002，116，14： | 1 |
| 12 | A spectrophotometric method for estimating hemin in biological system显示文摘 | MARIA E L LIDIA S A ALCIRA B et a1 | 2005 | Analytical Biochemistry2005，341，： | 1 |
| 13 | Evaluacion bacteriologica de semen de verracos usados como reproductores en granjas porcinas de la zone de lurtn, lima显示文摘 | Lidia Conza Bl Sonia Calle E Luisa Echevarria C | 2004 | Rev Inv Vet Peru2004，15，2： | 1 |
| 14 | Immunoglbulins,growth factors and growth hormone in bovine colostrum and the effects of processing显示文摘 | Lidia E | 2002 | International Dairy Journal2002，12，： | 1 |
| 15 | Metal-chelating chitin derivatives via reaction of chitosan with nitrilotriacetic acid显示文摘 | Vladimir E Lidia A Ygor A | 1996 | Carbohydrate Research1996，290，1： | 1 |
| 16 | The effect of starch material, encapsulated protein and production conditions on the protein release from starch microspheres显示文摘 | Lidia E Ann-Charlotte E Marie W | | 0，，10： | 1 |
| 17 | Immunoglbulins,growth factors and growth hormone in bovine colostrum and the effects of processing显示文摘 | Lidia E | 2002 | International Dairy Journal2002，12，： | 1 |
| 18 | Recrystallization of waxy maize starch during manufacturing of starch mierospheres for drug delivery: Influence of excipients显示文摘 | Lidia E Ann-Charlotte E Monica J | 2007 | Carbohydrate Pol- ymers2007，69，4： | 1 |
| 19 | Immunoglobulins, growth factors and growth hormone in bovine colostrum and the effects of processing 显示文摘 | LIDIA E HELENA L M MARIE P | 2002 | International Dairy Journal2002，12，： | 1 |
| 20 | Response of soil microbial biomass and community composition to chronic nitrogen additions at Harvard forest显示文摘 | COMPTON J E LIDIA S W ARLENE L P | 2004 | Forest Ecology and Management2004，196，： | 1 |
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