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| 1 | Dysfunctional stem and progenitor cells impair fracture healing with age显示文摘Successful fracture healing requires the simultaneous regeneration of both the bone and vasculature;mesenchymal stem cells (MSCs) are directed to replace the bone tissue, while endothelial progenitor cells (EPCs) form the new vasculature that supplies blood to the fracture site. In the elderly, the healing process is slowed, partly due to decreased regenerative function of these stem and progenitor cells. MSCs from older individuals are impaired with regard to cell number, proliferative capacity, ability to migrate, and osteochondrogenic differentiation potential. The proliferation, migration and function of EPCs are also compromised with advanced age. Although the reasons for cellular dysfunction with age are complex and multidimensional, reduced expression of growth factors, accumulation of oxidative damage from reactive oxygen species, and altered signaling of the Sirtuin-1 pathway are contributing factors to aging at the cellular level of both MSCs and EPCs. Because of these geriatric-specific issues, effective treatment for fracture repair may require new therapeutic techniques to restore cellular function. Some suggested directions for potential treatments include cellular therapies, pharmacological agents, treatments targeting age-related molecular mechanisms, and physical therapeutics. Advanced age is the primary risk factor for a fracture, due to the low bone mass and inferior bone quality associated with aging;a better understanding of the dysfunctional behavior of the aging cell will provide a foundation for new treatments to decrease healing time and reduce the development of complications during the extended recovery from fracture healing in the elderly. | Diane R Wagner Sonali Karnik Zachary J Gunderson Jeffery J Nielsen Alanna Fennimore Hunter J Promer Jonathan W Lowery M Terry Loghmani Philip S Low Todd O McKinley Melissa A Kacena Matthias Clauss Jiliang Li | 2019 | World Journal of Stem Cells2019，11，6： | 3 |
| 2 | Performance of optical OFDM in ultralong-haul WDM lightwave systems显示文摘 | LOWERY J DU L ARMSTRONG J | 2007 | J of Lightwave Technol2007，25，1： | 1 |
| 3 | Immunotargeted nanoshells for Integrated cancer imaging and therapy 显示文摘 | Loo C Lowery A Halas N J | 2005 | Nano Lett2005，5，： | 1 |
| 4 | Experi- mental Demonstrations of Electronic Dispersion Com- pensation for Long-Haul Transmission Using Direct- Detection Optical OFDM 显示文摘 | Schmidt B J C Lowery A J Armstrong J | 2008 | Journal of Lightwave Technology2008，26，1： | 1 |
| 5 | Dysregulated miRNA- 183 inhibits migration in breast cancer cells显示文摘 | Lowery A J Miller N Dwyer RM | 2010 | BMC Cancer2010，10，： | 1 |
| 6 | physical properties of selected soil by erosion clss显示文摘 | Lowery B Swan J Schumacher T | 1995 | Soil and Water Cons1995，50，3： | 1 |
| 7 | circulating microRNAs as novel minimal y invasive biomarkers for breast cancer显示文摘 | Heneghan H M Mil er N Lowery A J | | 0，，03： | 1 |
| 8 | The future of professional development: a vision and a roadmap 显示文摘 | Lowery J | 2004 | Information Outlook2004，8，2： | 1 |
| 9 | Physical properties of selected soils by ero- sion class 显示文摘 | Lowery B Swan J | 1995 | Soil Water Conservation1995，50，2： | 1 |
| 10 | The role of BMP-2 signaling in the skeleton显示文摘 | Lowery J W Pazin D Intini G | | 0，，02： | 1 |
| 11 | Protein measurement with the folin phenol reagent显示文摘 | Lowery O H Rosebrough N J Farr A L | 1951 | J Biol Chem1951，193，1： | 1 |
| 12 | Soil physical properties and crop productivity of an eroded soil amended with cattle manure显示文摘 | Arriaga F J Lowery B | 2003 | Soil Science2003，168，12： | 1 |
| 13 | Power Efficient Optical OFDM 显示文摘 | Armstrong J Lowery A J | 2006 | Electronics Letters2006，42，6： | 1 |
| 14 | A biomechanical evaluation of an interspinous device (Coflex) used to stabilize the lumbar spine 显示文摘 | Tsai K J Murakami H Lowery GL | 2006 | J-Surg-Orthop-Adv2006，15，3： | 1 |
| 15 | Physical properties of selected soils by erosion class显示文摘 | Lowery B Swan J | 1995 | Soil Water Conserv1995，50，： | 1 |
| 16 | Revisiting AI-2 quorum sensing inhibitors: direct comparison of alkyl-DPD analogues and a natural product fimbrolide显示文摘 | Lowery C A Abe T Park J | 2009 | J Am Chem Soc2009，131，15： | 1 |
| 17 | Power efficient optical OFDM 显示文摘 | Armstrong J Lowery A J | 2006 | Electronics Letters2006，42，6： | 1 |
| 18 | lOGbit/s multimode fiber link u- sing power-efficient orthogonal-frequeney-division multi- plexing 显示文摘 | Lowery A J Armstrong J | 2005 | Optics Express2005，13，10： | 1 |
| 19 | A biomechanical evaluation of aninterspinous device (Coflex) used to stabilize the lumbar spine显示文摘 | Tsai K J Murakami H Lowery GL | 2006 | J Surg Orlhop Adv2006，15，3： | 1 |
| 20 | Electrospun poly(styrene- block-dimethylsiloxane) block copolymer fibers exhibiting superhydrophobicity显示文摘 | Ma M L Hill R M Lowery J L | 2005 | Langmuir2005，21，： | 1 |
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