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| 1 | Identification of long-range transport pathways and potential sources of PM2.5 and PM10 in Beijing from 2014 to 2015显示文摘Trajectory clustering, potential source contribution function(PSCF) and concentration-weighted trajectory(CWT) methods were applied to investigate the transport pathways and identify potential sources of PM_(2.5)and PM_(10) in different seasons from June 2014 to May 2015 in Beijing.The cluster analyses showed that Beijing was affected by trajectories from the south and southeast in summer and autumn. In winter and spring, Beijing was not only affected by the trajectories from the south and southeast, but was also affected by trajectories from the north and northwest. In addition, the analyses of the pressure profile of backward trajectories showed that backward trajectories, which have important influence on Beijing, were mainly distributed above 970 h Pa in summer and autumn and below 950 h Pa in spring and winter. This indicates that PM_(2.5)and PM_(10) were strongly affected by the near surface air masses in summer and autumn and by high altitude air masses in winter and spring. Results of PSCF and CWT analyses showed that the largest potential source areas were identified in spring, followed by winter and autumn,then summer. In addition, potential source regions of PM_(10) were similar to those of PM_(2.5). There were a clear seasonal and spatial variation of the potential source areas of Beijing and the airflow in the horizontal and vertical directions. Therefore, more effective regional emission reduction measures in Beijing's surrounding provinces should be implemented to reduce emissions of regional sources in different seasons. | Deping Li Jianguo Liu Jiaoshi Zhang Huaqiao Gui Peng Du Tongzhu Yu Jie Wang Yihuai Lu Wenqing Liu Yin Cheng | 2017 | Journal of Environmental Sciences2017，29，6： | 22 |
| 2 | Transduction of the Hedgehog signal through the dimerization of Fused and the nuclear translocation of Cubitus interruptus显示文摘分泌蛋白质的刺猬(Hh ) 家庭为在脊椎动物和无脊椎动物的开发是必要的。作为主要 morphogens 之一在后生动物的开发期间,分级的 Hh 信号通过它的细胞质的尾巴的微分 phosphorylation 是越过由 Smoothened (Smo ) 的血浆膜的 transduced,导致小径激活和目标基因的微分表达式。然而,怎么 Smo transduces 经由建筑群糟糕仍然是的 Costal2 (Cos2 )/Fused (Fu ) 的分级的 Hh 信号理解。这里我们在场对由翻译 Smo phosphorylation 信息到 Fu dimerization 和肘脉 interruptus (Ci ) 的一个 Hh 坡度的房间反应的一个模型原子本地化信息。我们的调查结果建议 Smo 的 phosphorylated C 终点招募 Cos2/Fu 建筑群到通过在 Smo 和 Cos2 之间的相互作用的膜,它进一步导致 Fu dimerization。使聚合成二聚物的 Fu 是 phosphorylated 和 transduces 由 phosphorylating Cos2 和 Fu (苏(fu )) 的 Suppressor 的 Hh 信号。我们进一步证明这个过程支持全身的 Ci (Ci155 ) 和 Cos2 或苏(fu ) 的分离,并且导致 Ci155 的 translocation 进原子核,激活目标基因的表示。 | Yanyan Zhang Feifei Mao Yi Lu Wenqing Wu Lei Zhang Yun Zhao | 2011 | Cell Research2011，21，10： | 12 |
| 3 | Data mining-aided materials discovery and optimization显示文摘Recent developments in data mining-aided materials discovery and optimization are reviewed in this paper,and an introduction to the materials data mining(MDM)process is provided using case studies.Both qualitative and quantitative methods in machine learning can be adopted in the MDM process to accomplish different tasks in materials discovery,design,and optimization.State-of-the-art techniques in data mining-aided materials discovery and optimization are demonstrated by reviewing the controllable synthesis of dendritic Co_(3)O_(4) superstructures,materials design of layered double hydroxide,battery materials discovery,and thermoelectric materials design.The results of the case studies indicate that MDM is a powerful approach for use in materials discovery and innovation,and will play an important role in the development of the Materials Genome Initiative and Materials Informatics. | Wencong Lu Ruijuan Xiao Jiong Yang Hong Li Wenqing Zhang | 2017 | Journal of Materiomics2017，3，3： | 11 |
| 4 | Progress and challenges towards additive manufacturing of SiC ceramic显示文摘Silicon carbide(SiC)ceramic and related materials are widely used in various military and engineering fields.The emergence of additive manufacturing(AM)technologies provides a new approach for the fabrication of SiC ceramic products.This article systematically reviews the additive manufacturing technologies of SiC ceramic developed in recent years,including Indirect Additive Manufacturing(Indirect AM)and Direct Additive Manufacturing(Direct AM)technologies.This review also summarizes the key scientific and technological challenges for the additive manufacturing of SiC ceramic,and also forecasts its possible future opportunities.This paper aims to provide a helpful guidance for the additive manufacturing of SiC ceramic and other structural ceramics. | Rujie HE Niping ZHOU Keqiang ZHANG Xueqin ZHANG Lu ZHANG Wenqing WANG Daining FANG | 2021 | Journal of Advanced Ceramics2021，10，4： | 9 |
| 5 | Spatial-resolved metabolomics reveals tissue-specific metabolic reprogramming in diabetic nephropathy by using mass spectrometry imaging显示文摘Detailed knowledge on tissue-specific metabolic reprogramming in diabetic nephropathy(DN)is vital for more accurate understanding the molecular pathological signature and developing novel therapeutic strategies.In the present study,a spatial-resolved metabolomics approach based on air flowassisted desorption electrospray ionization(AFADESI)and matrix-assisted laser desorption ionization(MALDI)integrated mass spectrometry imaging(MSI)was proposed to investigate tissue-specific metabolic alterations in the kidneys of high-fat diet-fed and streptozotocin(STZ)-treated DN rats and the therapeutic effect of astragalosideⅣ,a potential anti-diabetic drug,against DN.As a result,a wide range of functional metabolites including sugars,amino acids,nucleotides and their derivatives,fatty acids,phospholipids,sphingolipids,glycerides,carnitine and its derivatives,vitamins,peptides,and metal ions associated with DN were identified and their unique distribution patterns in the rat kidney were visualized with high chemical specificity and high spatial resolution.These region-specific metabolic disturbances were ameliorated by repeated oral administration of astragaloside Ⅳ(100 mg/kg)for 12 weeks.This study provided more comprehensive and detailed information about the tissue-specific metabolic reprogramming and molecular pathological signature in the kidney of diabetic rats.These findings highlighted the promising potential of AFADESI and MALDI integrated MSI based metabolomics approach for application in metabolic kidney diseases. | Zhonghua Wang Wenqing Fu Meiling Huo Bingshu He Yaqi Liu Lu Tian Wanfang Li Zhi Zhou Baili Wang Jianzhen Xia Yanhua Chen Jinfeng Wei Zeper Abliz | 2021 | Acta Pharmaceutica Sinica B2021，11，11： | 7 |
| 6 | Generation of obese rat model by transcription activator-like effector nucleases targeting the leptin receptor gene显示文摘The laboratory rat is a valuable mammalian model organism for basic research and drug discovery. Here we demonstrate an efficient methodology by applying transcription activator-like effector nucleases(TALENs) technology to generate Leptin receptor(Lepr) knockout rats on the Sprague Dawley(SD) genetic background. Through direct injection of in vitro transcribed m RNA of TALEN pairs into SD rat zygotes, somatic mutations were induced in two of three resulting pups. One of the founders carrying bi-allelic mutation exhibited early onset of obesity and infertility. The other founder carried a chimeric mutation which was efficiently transmitted to the progenies. Through phenotyping of the resulting three lines of rats bearing distinct mutations in the Lepr locus, we found that the strains with a frame-shifted or premature stop codon mutation led to obesity and metabolic disorders. However, no obvious defect was observed in a strain with an in-frame 57 bp deletion in the extracellular domain of Lepr. This suggests the deleted amino acids do not significantly affect Lepr structure and function. This is the first report of generating the Lepr mutant obese rat model in SD strain through a reverse genetic approach. This suggests that TALEN is an efficient and powerful gene editing technology for the generation of disease models. | Yuting Chen Wenqing Lu Na Gao Yi Long Yanjiao Shao Meizhen Liu Huaqing Chen Shixin Ye Xueyun Ma Mingyao Liu Dali Li | 2017 | Science China(Life Sciences)2017，60，2： | 4 |
| 7 | Distinct functions of polycomb group proteins in regulating Ci transcription in developing Drosophila显示文摘 | Xiangdong Lv Hao Chen Shuo Zhang Zhao Zhang Chenyu Pan Yuanxin Xia Jialin Fan Wenqing Wu Yi Lu Lei Zhang Hailong Wu Yun Zhao | 2018 | Journal of Molecular Cell Biology2018，10，5： | 3 |
| 8 | Fsh-Pc-Sce complex mediates active transcription of Cubitus interruptus (Ci)显示文摘表明小径的刺猬(Hh ) 在胚胎的开发和成年织物动态平衡起重要作用。如此的生物功能被抄写因素肘脉 interruptus (Ci ) 调停。然而,受动器 Ci 本身的 transcriptional 规定糟糕被调查。通过一幅基于 RNAi 的基因屏幕,我们识别了那女性无菌(1 ) homeotic (Fsh ) ,抄写激活剂,直接激活 Ci 抄写。生物化学试金在 Fsh 之中表明了物理相互作用,性梳子额外(Sce ) ,并且 Polycomb (Pc ) 。功能的试金进一步证明 Pc 和 Sce 为 Ci 被要求表示,没被 Engrailed 的 derepression 多半调停,) , Ci 的一个抑压者,在 Pc 或 Sce 异种房间。最后,我们提供证明 Pc/Sce 在 Ci 地点便于 Fsh 的绑定并且在 Fsh 和 Pc 之间的物理相互作用为调停 Fsh 的 Ci 抄写是必要的证据。一起拿,我们不仅揭开那 Ci 被复杂的 Fsh-Pc-Sce transcriptionally 调整而且在 transcriptional 为在 Fsh 和 PcG 蛋白质之间的协作提供证据规定。 | Xiangdong Lv Hao Chen Shuo Zhang Zhao Zhang Chenyu Pan Yuanxin Xia Jialin Fan Wenqing Wu Yi Lu Lei Zhang Hailong Wu Yun Zhao | 2018 | Journal of Molecular Cell Biology2018，10，5： | 2 |
| 9 | Nlrc3-like is required for microglia maintenance in zebrafish显示文摘Microglia are tissue-resident macrophages residing in the central nervous system (CNS) and play critical roles in removing cellular debris and infectious agents as well as regulating neurogenesis and neuronal activities. Yet, the molecular basis underlying the establishment of microglia pool and the maintenance of their homeostasis in the CNS remain largely undefined. Here we report the identification and characterization of a mutant zebrafish, which harbors a point mutation in the nucleotide-binding oligomerization domain (NOD) like receptor gene nlrc3-like, resulting in the loss of microglia in a temperature sensitive manner. Temperature shift assay reveals that the late onset of nlrc3-like deficiency leads to excessive microglia cell death. Further analysis shows that the excessive microglia death in nlrc3-like deficient mutants is attributed, at least in part, to aberrant activation of canonical inflammasome pathway. Our study indicates that proper regulation of inflammasome cascade is critical for the maintenance of microglia homeostasis. | Tienan Wang Bo Yan Liang Lou Xi Lin Tao Yu Shuting Wu Qing Lu Wei Liu Zhibin Huang Mingjie Zhang Wenqing Zhang Zilong Wen | 2019 | Journal of Genetics and Genomics2019，46，6： | 2 |
| 10 | HBeAg induces liver sinusoidal endothelial cell activation to promote intrahepatic CD8 T cell immunity and HBV clearance显示文摘To the Editor It is believed that the inherent tolerogenic property of the liver is involved in the chronicity of hepatitis B virus(HBV)infection[1].However,exposure to HBV in adults usually leads to spontaneous clearance of the virus and the induction of potent and effective anti-HBV T cell immunity in the liver[2],suggesting that the immune microenvironment of the liver switches from limiting to allowing effector T cell responses during acute resolution of HBV infection. | Xiaohong Xie Jinzhuo Luo Ruth Broering Dan Zhu Wenqing Zhou Mengji Lu Xin Zheng Ulf Dittmer Dongliang Yang Jia Liu | 2021 | Cellular & Molecular Immunology2021，18，11： | 1 |
| 11 | Classification of rice seed variety using point cloud data combined with deep learning显示文摘Rice variety selection and quality inspection are key links in rice planting.Compared with two-dimensional images,three-dimensional information on rice seeds shows the appearance characteristics of rice seeds more comprehensively and accurately.This study proposed a rice variety classification method using three-dimensional point cloud data of the surface of rice seeds combined with a deep learning network to achieve the rapid and accurate identification of rice varieties.First,a point cloud collection platform was set up with a Raytrix light field camera as the core to collect three-dimensional point cloud data on the surface of rice seeds;then,the collected point cloud was filled,filtered and smoothed;after that,the point cloud segmentation is based on the RANSAC algorithm,and the point cloud downsampling is based on a combination of random sampling algorithm and voxel grid filtering algorithm.Finally,the processed point cloud was input to the improved PointNet network for feature extraction and species classification.The improved PointNet network added a cross-level feature connection structure,made full use of features at different levels,and better extracted the surface structure features of rice seeds.After testing,the improved PointNet model had an average classification accuracy of 89.4%for eight varieties of rice,which was 1.2%higher than that of the PointNet model.The method proposed in this study combined deep learning and point cloud data to achieve the efficient classification of rice varieties. | Yan Qian Qianjin Xu Yingying Yang Hu Lu Hua Li Xuebin Feng Wenqing Yin | 2021 | International Journal of Agricultural and Biological Engineering2021，14，5： | 1 |
| 12 | Early diagnosis of novel SFTS bunyavirus infection by quantitative real-time RT-PCR assay显示文摘 | Yulan Sun Mifang Liang Jing Qu Cong Jin QuanFu Zhang Jiandong Li Xiaolin Jiang Qin Wang Jing Lu Wen Gu Shuo Zhang Chuan Li XianJun Wang Faxian Zhan Wenqing Yao Zhenqiang Bi Shiwen Wang Dexin Li | 2011 | Journal of Clinical Virology2011，，1： | 1 |
| 13 | Screening of Bacillus strains as potential probiotics and subsequent confirmation of the in vivo effectiveness of Bacillus subtilis MA139 in pigs显示文摘 | Xiaohua Guo Defa Li Wenqing Lu Xiangshu Piao Xiaoling Chen | 2006 | Antonie van Leeuwenhoek2006，，2： | 1 |
| 14 | Elevated levels of urinary 8-hydroxy-2 -deoxyguanosine, lymphocytic micronuclei, and serum glutathione S-transferase in workers exposed to coke oven emissions 显示文摘 | LIU Ailin LU Wenqing WANG Zengzhen | 2006 | Environ Health Perspect2006，114，5： | 1 |
| 15 | Prevalence of Diabetes among Men and Women in China显示文摘 | Yang W Lu J Wenq J | 2010 | N Engl J Med2010，362，12： | 1 |
| 16 | Active learning for the power factor prediction in diamond-like thermoelectric materials显示文摘The Materials Genome Initiative requires the crossing of material calculations,machine learning,and experiments to accelerate the material development process.In recent years,data-based methods have been applied to the thermoelectric field,mostly on the transport properties.In this work,we combined data-driven machine learning and first-principles automated calculations into an active learning loop,in order to predict the p-type power factors(PFs)of diamond-like pnictides and chalcogenides.Our active learning loop contains two procedures(1)based on a high-throughput theoretical database,machine learning methods are employed to select potential candidates and(2)computational verification is applied to these candidates about their transport properties.The verification data will be added into the database to improve the extrapolation abilities of the machine learning models.Different strategies of selecting candidates have been tested,finally the Gradient Boosting Regression model of Query by Committee strategy has the highest extrapolation accuracy(the Pearson R=0.95 on untrained systems).Based on the prediction from the machine learning models,binary pnictides,vacancy,and small atom-containing chalcogenides are predicted to have large PFs.The bonding analysis reveals that the alterations of anionic bonding networks due to small atoms are beneficial to the PFs in these compounds. | Sheng Yasong Wu Jiong Yang Wencong Lu Pierre Villars Wenqing Zhang | 2020 | npj Computational Materials2020，，1： | 1 |
| 17 | Endogenous amino acid loss at the terminal ileum of rats fed water-extractable or alkali-extractable soluble non-starch polysaccharides obtained from wheat bran when fed with and without xylanase显示文摘 | He Yonghui Lu Wenqing Piao Xiangshu | 2006 | Journal of Animal and Veterinary Advances2006，5，： | 1 |
| 18 | Ultrahigh Thermoelectric Performance by Electron and Phonon Critical Scattering in Cu2Se1‐xIx显示文摘 | Huili Liu Xun Yuan Ping Lu Xun Shi Fangfang Xu Ying He Yunshan Tang Shengqiang Bai Wenqing Zhang Lidong Chen Yue Lin Lei Shi He Lin Xingyu Gao Xingmin Zhang Hang Chi Ctirad Uher | 2013 | Mater2013，，45： | 1 |
| 19 | SVM for Constellation Shaped 8QAM PON System显示文摘Nonlinearity impairments and distortions have been bothering the bandwidth constrained passive optical network(PON)system for a long time and limiting the develop-ment of capacity in the PON system.Unlike other works concentrating on the exploration of the complex equalization algorithm,we investigate the potential of constellation shap-ing joint support vector machine(SVM)classification scheme.At the transmitter side,the 8 quadrature amplitude modulation(8QAM)constellation is shaped into three designs to mitigate the influence of noise and distortions in the PON channel.On the receiver side,simple multi-class linear SVM classifiers are utilized to replace complex equalization methods.Simulation results show that with the bandwidth of 25 GHz and overall bitrate of 50 Gbit/s,at 10 dBm input optical power of a 20 km standard single mode fiber(SSMF),and under a hard-decision forward error correction(FEC)threshold,transmission can be realized by employing Circular(4,4)shaped 8QAM joint SVM classifier at the maximal power budget of 37.5 dB. | LI Zhongya CHEN Rui HUANG Xingang ZHANG Junwen NIU Wenqing LU Qiuyi CHI Nan | 2022 | ZTE Communications2022，20，S01： | 1 |
| 20 | Screening and characterization of astaxanthin-hyperproducing mutants of Haematococcus pluvialis显示文摘 | Yong Chen Defa Li Wenqing Lu Jianjun Xing Bodi Hui Yashan Han | 2003 | Biotechnology Letters2003，，7： | 1 |
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