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| 1 | Whole-genome sequencing of 508 patients identifies key molecular features associated with poor prognosis in esophageal squamous cell carcinoma显示文摘Esophageal squamous cell carcinoma(ESCC)is a poor-prognosis cancer type with limited understanding of its molecular etiology.Using 508 ESCC genomes,we identified five novel significantly mutated genes and uncovered mutational signature clusters associated with metastasis and patients’outcomes.Several functional assays implicated that NFE2L2 may act as a tumor suppressor in ESCC and that mutations in NFE2L2 probably impaired its tumor-suppressive function,or even conferred oncogenic activities.Additionally,we found that the NFE2L2 mutations were significantly associated with worse prognosis of ESCC.We also identified potential noncoding driver mutations including hotspot mutations in the promoter region of SLC35E2 that were correlated with worse survival.Approximately 5.9%and 15.2%of patients had high tumor mutation burden or actionable mutations,respectively,and may benefit from immunotherapy or targeted therapies.We found clinically relevant coding and noncoding genomic alterations and revealed three major subtypes that robustly predicted patients’outcomes.Collectively,we report the largest dataset of genomic profiling of ESCC useful for developing ESCC-specific biomarkers for diagnosis and treatment. | Yongping Cui Hongyan Chen Ruibin Xi Heyang Cui Yahui Zhao Enwei Xu Ting Yan Xiaomei Lu Furong Huang Pengzhou Kong Yang Li Xiaolin Zhu Jiawei Wang Wenjie Zhu Jie Wang Yanchun Ma Yong Zhou Shiping Guo Ling Zhang Yiqian Liu Bin Wang Yanfeng Xi Ruifang Sun Xiao Yu Yuanfang Zhai Fang Wang Jian Yang Bin Yang Caixia Cheng Jing Liu Bin Song Hongyi Li Yi Wang Yingchun Zhang Xiaolong Cheng Qimin Zhan Yanhong Li Zhihua Liu-Show | 2020 | Cell Research2020，30，10： | 19 |
| 2 | Aquaporin JcPIP2 is Involved in Drought Responses in Jatropha curcas显示文摘水隧道蛋白质, aquaporins,在在植物的 transmembranewater 运动的戏基础角色。编码 aquaporin 的新全身的 cDNA 从 Jatropha curcas 的幼苗被孤立。质膜的基因从 J 的内在的蛋白质(果仁) 。curcas (JcPIP2 ) 包含了 843 bp 编码 280 氨基酸的蛋白质的开的读框架。氨基酸顺序与 Ricinus communis 果仁显示出 94% 身份。JcPIP2 互补 RNA intoXenopus 卵母细胞的注射增加了 10 褶层卵母细胞的渗透的水渗透。有 anti-JcPIP2 抗体的 Immunodetection ofJcPIP2 显示这蛋白质无所不在地位于植物的所有测试纸巾。调查在 aquaporins 和干旱抵抗 inJ 之间的关系。curcas,许多 JcPIP2 在二 J 的幼苗被检验。curcas 人口, GaoYouCSC63 和 YanBian S1,在有 PEG6000 的水赤字下面。在地条件下面,那些二张人口, GaoYou CSC63 是抵抗的浇赤字,而是 YanBian S1 是敏感的浇剥夺。与干旱应力的增加的度, JcPIP2 水平在幼苗 ofGaoYou CSC63 增加了,而在 YanBian S1 的幼苗没有重要变化。比较 withYanBian S1, GaoYou CSC63 也显示出更高的根在在水赤字下面的幼苗的水力的电导率和更低的减少趋势。这些结果显示 JcPIP2 可能在 J 在干旱抵抗起了一个作用。curcas。 | Ying ZHANG Yunxiao WANG Luding JIANG Ying XU Yingchun WANG Daihua LU Fang CHEN | 2007 | Acta Biochimica et Biophysica Sinica2007，39，10： | 13 |
| 3 | Investigation on MoS_2 and Graphite Coatings and Their Effects on the Tribological Properties of the Radial Spherical Plain Bearings显示文摘With constant enlargement of the application areas of the spherical plain bearings,higher quality lubrication of the bearings is required.To solve the lubricating problems of spherical plain bearings under high temperature,high vacuum,high speed,heavy loads and strong oxidation conditions,it is urgent for us to develop more excellent self-lubricating technologies.In this paper,the bonded solid lubricant coatings,which use inorganic phosphate as the binder,the mixture of MoS_2 and graphite with two different weight proportions as the solid lubricant,are prepared by spraying under three different spray gun pressures.The bonding strength tests on the coatings show that the best spraying pressure is 0.2 MPa and the better mixing proportion of MoS_2 to Graphite is 3:1.Then for the radial spherical plain bearings with steel/steel friction pair,after the coatings are made on the inner ring outer surfaces,the friction coefficient,the wear loss and the friction temperature of the bearings under four oscillating frequencies are investigated by a self-made tribo-tester.The test results,SEM of the worn morphologies and EDS of worn areas show that tribological properties of the bearing are obviously improved by the bonded solid lubricant coatings.When sprayed under the spray gun pressure of 0.2 MPa,the bearings have better anti-friction and anti-wear properties than those sprayed under 0.1 MPa and 0.3 MPa.Further as proved from the XPS analysis,between the coating with 3:1 mixing ratio of MoS_2 to Graphite and the coating with 1:1 ratio,the former has less oxidation occurred on the surface and therefore has better tribological characteristics than the latter.This paper provides a reference to developing a new product of the radial spherical plain bearings with high bonding strength,oxidation resistance and abrasion resistance. | QIU Ming LU Jianjun LI Yingchun LV Guisen | 2016 | Chinese Journal of Mechanical Engineering2016，29，4： | 8 |
| 4 | Molecular dynamics simulations of thermal effects in nanometric cutting process显示文摘Understanding the basic action of how material removing in nanoscale is a critical issue of producing well-formed components.In order to clarify thermal effects on material removal at atomic level,molecular dynamics(MD)simulations of nanometric cutting of mono-crystalline copper are performed with Morse,EAM and Tersoff potential.The effects of cutting speed on temperature distribution are investigated.The simulation results demonstrate that the temperature distribution shows a roughly concentric shape around shear zone and a steep temperature gradient lies in diamond tool,a relative high temperature is located in shear zone and machined surface,but the highest temperature is found in chip.At a high cutting speed mode,the atoms in shear zone with high temperature implies a large stress is built up in a local region. | GUO YongBo,LIANG YingChun,CHEN MingJun,BAI QingShun&LU LiHua Precision Research Engineering Institute,Harbin Institute of Technology,Harbin 150001,China | 2010 | Science China(Technological Sciences)2010，53，3： | 7 |
| 5 | Effect of aging on the mechanical properties and corrosion susceptibility of an Al-Cu-Li-Zr alloy containing Sc显示文摘Al-3.5Cu-1.5Li-0.22 (Sc+Zr ) 合金的微观结构,机械性质, intergranular 腐蚀,和脱落腐蚀上的老化的效果被调查了。结果证明合金有年龄变硬,和降水的主要阶段的特性,加强是 T1 阶段。变老的温度和老化时间在 T1 阶段的数量和分发上有重要效果。合金的合适的人工的单个老化的处理在 160r_ | LIANG Wenjie PAN Qinglin HE Yunbin LI Yunchun ZHOU Yingchun LU Congge | 2008 | Rare Metals2008，27，2： | 7 |
| 6 | mTERF5 Acts as a Transcriptional Pausing Factor to Positively Regulate Transcription of Chloroplast psbEFLJ显示文摘RNA polymerase transcriptional pausing represents a major checkpoint in transcription in bacteria and metazoans,but it is unknown whether this phenomenon occurs in plant organelles.Here,we report that transcriptional pausing occurs in chloroplasts.We found that mTERF5 specifically and positively regulates the transcription of chloroplast psbEFLJ in Arabidopsis thaliana that encodes four key subunits of photosystem II.We found that mTERF5 causes the plastid-encoded RNA polymerase(PEP)complex to pause at psbEFLJ by binding to the+30 to+51 region of double-stranded DNA.Moreover,we revealed that mTERF5 interacts with pTAC6,an essential subunit of the PEP complex,although pTAC6 is not involved in the transcriptional pausing at psbEFLJ.We showed that mTERF5 recruits additional pTAC6 to the transcriptionally paused region of psbEFLJ,and the recruited pTAC6 proteins could be assembled into the PEP complex to regulate psbEFLJ transcription.Taken together,our findings shed light on the role of transcriptional pausing in chloroplast transcription in plants. | Shunhua Ding Yi Zhang Zhi Hu Xiahe Huang Bohan Zhang Qingtao Lu Xiaogang Wen Yingchun Wang Congming Lu | 2019 | Molecular Plant2019，12，9： | 6 |
| 7 | Seasonal variations of carboxylic acids and their contributions to the rainwater acidity: A case study of Guiyang and Shangzhong,China显示文摘Low molecule weight carboxylic acids are ubiquitous and important chemical constituents in the troposphere.Seven carboxylic acids in the rainwater of Guiyang and Shangzhong were simultaneously determined by ion chromatography from April 2006 to April 2007.Formic, acetic and oxalic acids were found to be the predominant carboxylic acids.Their volume weighted average concentration (VWA) in the rainwater of Guiyang were 14.24 μmol/L, 9.35 μmol/L and 2.79 μmol/L, respectively;as compared to 4.95 μmol/L, 1.35 μmol/L and 2.31 μmol/L in the rainwater of Shangzhong.In Shangzhong it is witnessed that the concentra-tions of these acids were higher in the summer than in the winter and direct emissions from vegetations or soils may account for the main provenance of the acids.This is, however, not the case in Guiyang, where the concentrations of the carboxylic acids were higher during the non-growing season than during the growing season.The relatively weak scavenging affected by scarce and little rainwater as well as the particles accompanied with the rainfall may have some effect on the carboxylic acids during the wintertime in Guiyang.Carboxylic acids in the rainwater of Guiyang were estimated to account for 18.7% to the free acidity, where formic, acetic and oxalic acids accounted for 7.9%, 4.7%, 6.1%, respectively.In Shangzhong, the 3 primary carboxylic acids represented 58.1% to the free acidity where formic, acetic and oxalic acids represented 25.1%, 7.5%, 25.5%, respectively.Carboxylic anions accounted for 6.6% (1.7%–19.2%) to the total anions in the rainwater of Guiyang.Carboxylic anions repre-sented 13.2% (0.5%–92.2%) to the total anions in the rainwater of Shangzhong.These results indicated that carboxylic acids were the important contributors to the rainwater acidity, especially in remote regions. | XU Gang LEE XinQing LU YingChun CHEN YingJun HUANG DaiKuan | 2010 | Chinese Science Bulletin2010，55，16： | 5 |
| 8 | Engineered Functional Surfaces by Laser Microprocessing for Biomedical Applications显示文摘Metallic biomaterials are increasingly being used in various medical applications due to their high strength,fracture resistance,good electrical conductivity,and biocompatibility.However,their practical applications have been largely limited due to poor surface performance.Laser microprocessing is an advanced method of enhancing the surface-related properties of biomaterials.This work demonstrates the capability of laser microprocessing for biomedical metallic materials including magnesium and titanium alloys,with potential applications in cell adhesion and liquid biopsy.We investigate laser-material interaction,microstructural evolution,and surface performance,and analyze cell behavior and the surface-enhanced Raman scattering(SERS)effect.Furthermore,we explore a theoretical study on the laser microprocessing of metallic alloys that shows interesting results with potential applications.The results show that cells exhibit good adhesion behavior at the surface of the laser-treated surface,with a preferential direction based on the textured structure.A significant SERS enhancement of 6×10^3 can be obtained at the laser-textured surface during Raman measurement. | Guoqing Hu Kai Guan Libin Lu Jiaru Zhang Nie Lu Yingchun Guan | 2018 | Engineering2018，4，6： | 5 |
| 9 | A novel BIST scheme for circuit aging measurement of aerospace chips显示文摘The avionics working environment is bad, easy to accelerate aging of circuits. Circuit aging is one of the important factors that influence the reliability of avionics, so circuit aging testing is of great significance to improve the reliability of avionics. As continuing aging would degrade circuit performance, aging can be monitored through precise measurement of performance degradation. However, previous methods for predicting circuit performance have limited prediction accuracy. In this paper, we propose a novel Built-In Self-Test(BIST) scheme for circuit aging measurement, which constructs self-oscillation loops employing parts of critical paths and activates oscillations by specific test patterns. An aging signature counter is then used to capture the oscillation frequency and in turn measure the aging state of the circuit. We propose to implement this measurement process by BIST. Experimental results show that the proposed in-field aging measurement is robust with respect to process variations and can achieve a precision of about 90%. The application of this scheme has a certain value to improve the reliability of avionics systems. | Huaguo LIANG Xiangsheng FANG Maoxiang YI Zhengfeng HUANG Yingchun LU | 2018 | Chinese Journal of Aeronautics2018，31，7： | 3 |
| 10 | Identification of ancient ceramics by digital shape characterization显示文摘Shapes are important clues for the identification of ancient ceramics.In this study,digital extraction methods of shape characterization were discussed,using samples of flared mouthed porcelain bowls produced in Jingdezhen Hutian Kiln from the Five Dynasties to the Song and Yuan period.By employing the techniques of image enhancement,edge detection and curve fitting of Matlab,the method using digital shape characterization has advanced accuracy and effectiveness of traditional identification which is based on visual and tactual inspections.Together with the increasingly applied compositional data analysis and thermoluminescence dating technique,the method will further improve and upgrade the scientific identification system for ancient ceramics. | WU Juan LIU YingChun XIONG Lu TANG Min ZHANG MaoLin WU JunMing LI QiJiang HUANG MengXuan LI JiaZhi | 2012 | Science China(Technological Sciences)2012，55，9： | 3 |
| 11 | Genotypic variation in spatiotemporal distribution of canopy light interception in relation to yield formation in cotton显示文摘Background: Within-canopy interception of photosynthetically active radiation(PAR) impacts yield and other agronomic traits in cotton(Gossypium hirsutum L.). Field experiments were conducted to investigate the influence of 6 cotton varieties(they belong to 3 different plant types) on yield, yield distribution, light interception(LI), LI distribution and the relationship between yield formation and LI in Anyang, Henan, in 2014 and 2015.Result: The results showed that cotton cultivars with long branches(loose-type) intercepted more LI than did cultivars with short branches(compact-type), due to increased LI in the middle and upper canopy. Although loose-type varieties had greater LI, they did not yield significantly higher than compact-type varieties, due to decreased harvest index. Therefore, improving the harvest index by adjusting the source-to-sink relationship may further increase cotton yield for loose-type cotton. In addition, there was a positive relationship between reproductive organ biomass accumulation and canopy-accumulated LI, indicating that enhancing LI is important for yield improvement for each cultivar. Furthermore, yield distribution within the canopy was significantly linearly related to vertical LI distribution.Conclusion: Therefore, optimizing canopy structure of different plant type and subsequently optimizing LI distribution within the cotton canopy can effectively enhance the yield. | XING Fangfang HAN Yingchun FENG Lu ZHI Xiaoyu WANG Guoping YANG Beifang FAN Zhengyi LEI Yaping DU Wenli WANG Zhanbiao XIONG Shiwu LI Xiaofei Ll Yabing | 2018 | Journal of Cotton Research2018，1，3： | 3 |
| 12 | Influence of post-grown treatments on CuInS_2 thin films prepared by sulphurization of Cu-In films显示文摘Polycrystalline CuInS2 (CIS) films were prepared by sulphurization of Cu-In films. The surface morphology and phase composition of the as-grown film, the KCN-etched film, and the annealed KCN-etched film were investigated. During the sulphurization, the secondary CuxS phase segregated on the surface of the as-grown films. To improve the crystalline quality of CuInS2 films, a series of post-grown treatments, such as KCN-etching and vacuum annealing KCN-etched films, were performed on the as-grown films. Both as-grown and post-treated films were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), and energy dispersive spectroscopy (EDS). The results indicated that a CuxS secondary phase segregated on the surface of the as-grown film, which could be removed effectively by KCN etching. After the vacuum annealing treatment, the KCN-etched film had a sphalerite structure with (112) preferred orientation. Meanwhile, the crystalline quality of the CIS film was significantly improved, which provided a novel method to improve the performance of thin film solar cells. | YAN Youhua LIU Yingchun FANG Ling ZHAO Haihua LI Deren LU Zhichao ZHOU Shaoxiong | 2008 | Rare Metals2008，27，5： | 2 |
| 13 | Dexmedetomidine Inhibits Inflammatory Reaction in Lung Tissues of Septic Rats by Suppressing TLR4/NF- κ B Pathway显示文摘 | Yuqing Wu Yingchun Liu He Huang Yangzi Zhu Yong Zhang Fuzhao Lu Ce Zhou Li Huang Xin Li Chenghua Zhou Celeste C. Finnerty | 2013 | Mediators of Inflammation2013，，： | 2 |
| 14 | Cryptococcus neoformans,a global threat to human health显示文摘Background Emerging fungal pathogens pose important threats to global public health. The World Health Organization has responded to the rising threat of traditionally neglected fungal infections by developing a Fungal Priority Pathogens List (FPPL). Taking the highest-ranked fungal pathogen in the FPPL,Cryptococcus neoformans, as a paradigm, we review progress made over the past two decades on its global burden, its clinical manifestation and management of cryptococcal infection, and its antifungal resistance. The purpose of this review is to drive research efforts to improve future diagnoses, therapies, and interventions associated with fungal infections.Methods We first reviewed trends in the global burden of HIV-associated cryptococcal infection, mainly based on a series of systematic studies. We next conducted scoping reviews in accordance with the guidelines described in the Preferred Reporting Items for Systematic Reviews and Meta-analyses extension for Scoping Reviews using PubMed and ScienceDirect with the keywordCryptococcus neoformans to identify case reports of cryptococcal infections published since 2000. We then reviewed recent updates on the diagnosis and antifungal treatment of cryptococcal infections. Finally, we summarized knowledge regarding the resistance and tolerance ofC. neoformans to approved antifungal drugs.Results There has been a general reduction in the estimated global burden of HIV-associated cryptococcal meningitis since 2009, probably due to improvements in highly active antiretroviral therapies. However, cryptococcal meningitis still accounts for 19% of AIDS-related deaths annually. The incidences of CM in Europe and North America and the Latin America region have increased by approximately two-fold since 2009, while other regions showed either reduced or stable numbers of cases. Unfortunately, diagnostic and treatment options for cryptococcal infections are limited, and emerging antifungal resistance exacerbates the public health burden.Conclusions The rising threat ofC. neoformans is compounded by accumulating evidence for its ability to infect immunocompetent individuals and the emergence of antifungal-resistant variants. Emphasis should be placed on further understanding the mechanisms of pathogenicity and of antifungal resistance and tolerance. The development of novel management strategies through the identification of new drug targets and the discovery and optimization of new and existing diagnostics and therapeutics are key to reducing the health burden. | Youbao Zhao Leixin Ye Fujie Zhao Lanyue Zhang Zhenguo Lu Tianxin Chu Siyu Wang Zhanxiang Liu Yukai Sun Min Chen Guojian Liao Chen Ding Yingchun Xu Wanqing Liao Linqi Wang | 2023 | Infectious Diseases of Poverty2023，12，2： | 2 |
| 15 | Ultraefficient thermoacoustic conversion through a split ring resonator显示文摘Microwaves,which have a∼10-cm wavelength,can penetrate deeper into tissue than photons,heralding exciting deep tissue applications such as modulation or imaging via the thermoacoustic effect.Thermoacoustic conversion efficiency is however very low,even with an exogenous contrast agent.We break this low-conversion limit,using a split ring resonator to effectively collect and confine the microwaves into a submillimeter hot spot for ultrasound emission and achieve a conversion efficiency over 2000 times higher than other reported thermoacoustic contrast agents.Importantly,the frequency of emitted ultrasound can be precisely tuned and multiplexed by modulation of the microwave pulses.Such performance is inaccessible by a piezoelectric-based transducer or a photoacoustic emitter and,therefore,split ring resonators open up new opportunities to study the frequency response of cells in ultrasonic biomodulation.For applications in deep tissue localization,a split ring resonator can be used as a wireless,battery-free ultrasound beacon placed under a breast phantom. | Lu Lan Yueming Li Tiffany Yang-Tran Ying Jiang Yingchun Cao Ji-Xin Cheng | 2020 | Advanced Photonics2020，2，3： | 1 |
| 16 | Research on static stiffness of hydrostatic bearing using fluid-structure interaction analysis 显示文摘 | Lu Lihua Su Hao Liang Yingchun | 2012 | Procedia Engineering2012，29，： | 1 |
| 17 | A Kinase-Phosphatase-Transcription Factor Module Regulates Adventitious Root Emergence in Arabidopsis Root-Hypocotyl Junctions显示文摘Adventitious roots form from non-root tissues as part of normal development or in response to stress or wounding.The root primordia form in the source tissue,and during emergence the adventitious roots penetrate the inner cell layers and the epidermis;however,the mechanisms underlying this emergence remain largely unexplored.Here,we report that a regulatory module composed of the AP2/ERF transcription factor ABSCISIC ACID INSENSITIVE 4(ABI4),the MAP kinases MPK3 and MPK6,and the phosphatase PP2C12 plays an important role in the emergence of junction adventitious roots(J-ARs)from the root-hypocotyl junctions in Arabidopsis thaliana.ABI4 negatively regulates J-AR emergence,preventing the accumulation of reactive oxygen species and death of epidermal cells,which would otherwise facilitate J-AR emergence.Phosphorylation by MPK3/MPK6 activates ABI4 and dephosphorylation by PP2C12 inactivates ABI4.MPK3/MPK6 also directly phosphorylate and inactivate PP2C12 during J-AR emergence.We propose that this'double-check'mechanism increases the robustness of MAP kinase signaling and finely regulates the local programmed cell death required for J-AR emergence. | Zechen Bai Jing Zhang Xin Ning Hailong Guo Xiumei Xu Xiahe Huang Yingchun Wang Zhubing Hu Congming Lu Lixin Zhang Wei Chi | 2020 | Molecular Plant2020，13，8： | 1 |
| 18 | Remediation of petroleum-contaminated soil after composting by sequential treatment with Fenton-like oxidation and biodegradation显示文摘 | Mang Lu Zhongzhi Zhang Wei Qiao Xiaofang Wei Yueming Guan Qingxia Ma Yingchun Guan | 2009 | Bioresource Technology2009，，7： | 1 |
| 19 | Towards energy-efficient storage placement in large scale sensor networks显示文摘 | Lei XIE Sanglu LU Yingchun CAO Daoxu CHEN | 2014 | Frontiers of Computer Science2014，8，3： | 1 |
| 20 | An efficient method of all-optical buffering with ultra-small core photonic crystal fibers显示文摘 | CAO Yingchun LU Peixiang | | 0，，： | 1 |
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