4篇
您的检索式：作者名="LUO Huangda"
|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | ADS Venus-Ⅱ Subcritical Reactivity and Dynamic Characteristic Experiment显示文摘The source-jerk method is a classical method of measuring sub-criticality on reactor.The experiment was carried out on Venus-Ⅱ.Three sub-critical levels(keffare 0.99,0.98,0.97)are chosen to carry out the measurements by different loading of nuclear fuel rods in reactor core.The result comparing with experimental meas- | LIANG Shuhong ZHU Qingfu ZHOU Qi LUO Huangda | 2017 | Annual Report of China Institute of Atomic Energy2017，，1： | 0 |
| 2 | ADS Venus-Ⅱ Critical Extrapolation Experiment显示文摘Venus-ⅡADS zero power experiment assembly which is based on the original heavy water zero power reactor has been designed and built in two reactor core structure—A water core and a solid lead core,and the debugging has been completed by the end of December 2016.Then the two core both reached to critical respectively for the first time,and a series of reactor | ZHU Qingfu ZHOU Qi ZHANG Wei LIANG Shuhong LUO Huangda LIU Yang LIU Donghai LIU Feng | 2017 | Annual Report of China Institute of Atomic Energy2017，，1： | 0 |
| 3 | Identification of heptapeptides targeting a lethal bacterial strain in septic mice through an integrative approach显示文摘Effectively killing pathogenic bacteria is key for the treatment of sepsis.Although various anti-infective drugs have been used for the treatment of sepsis,the therapeutic effect is largely limited by the lack of a specific bacterium-targeting delivery system.This study aimed to develop antibacterial peptides that specifically target pathogenic bacteria for the treatment of sepsis.The lethal bacterial strain Escherichia coli MSI001 was isolated from mice of a cecal ligation and puncture(CLP)model and was used as a target to screen bacterial binding heptapeptides through an integrative bioinformatics approach based on phage display technology and high-throughput sequencing(HTS).Heptapeptides binding to E.coli MSI001 with high affinity were acquired after normalization by the heptapeptide frequency of the library.A representative heptapeptide VTKLGSL(VTK)was selected for fusion with the antibacterial peptide LL-37 to construct the specific-targeting antibacterial peptide VTK-LL37.We found that,in comparison with LL37,VTK-LL37 showed prominent bacteriostatic activity and an inhibitive effect on biofilm formation in vitro.In vivo experiments demonstrated that VTK-LL37 significantly inhibited bacterial growth,reduced HMGB1 expression,alleviated lesions of vital organs and improved the survival of mice subjected to CLP modeling.Furthermore,membrane DEGP and DEGQ were identified as VTKbinding proteins by proteomic methods.This study provides a novel strategy for targeted pathogen killing,which is helpful for the treatment of sepsis in the era of precise medicine. | Xiaoyan Zhang Shan Li Haihua Luo Shuyue He Huangda Yang Lei Li Tian Tian Qizheng Han Jiacong Ye Chenyang Huang Aihua Liu Yong Jiang | 2022 | Signal Transduction and Targeted Therapy2022，7，8： | 0 |
| 4 | Reactivity Meter for CENTER Project显示文摘A reactivity meter for the CENTER project was developed.The reactivity meter was tested on the reactor in the Nuclear Power Institute of China.The testing result was very satisfying,and the all parameters were accepted.The testing contents include self-testing of device,the accuracy of reactivity,measuring the reactivity value of control rod,the reliability of long-time running,etc. | LUO Huangda CHEN Xiaoliang ZHU Qingfu CHEN Xiaoxian LIANG Song ZHANG Zhifeng HU Xiao | 2018 | 中国原子能科学研究院年报2018，，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员