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| 1 | Structure-based Comparative Analysis and Prediction of N-linked Glycosylation Sites in Evolutionarily Distant Eukaryotes显示文摘The asparagine-X-serine/threonine (NXS/T) motif, where X is any amino acid except proline, is the consensus motif for N-linked glycosylation. Significant numbers of high-resolution crystal structures of glycosylated proteins allow us to carry out structural analysis of the N-linked glycosylation sites (NGS). Our analysis shows that there is enough structural information from diverse glycoproteins to allow the development of rules which can be used to predict NGS. A Python-based tool was developed to investigate asparagines implicated in N-glycosylation in five species: Homo sapiens, Mus musculus, Drosophila melanogaster, Arabidopsis thaliana and Saccharomyces cerevisiae. Our analysis shows that 78% of all asparagines of NXS/T motif involved in N-glycosylation are localized in the loop/turn conformation in the human proteome. Similar distribution was revealed for all the other species examined. Comparative analysis of the occurrence of NXS/T motifs not known to be glycosylated and their reverse sequence (S/TXN) shows a similar distribution across the secondary structural elements, indicating that the NXS/T motif in itself is not biologically relevant. Based on our analysis, we have defined rules to determine NGS. Using machine learning methods based on these rules we can predict with 93% accuracy if a particular site will be glycosylated. If structural information is not available the tool uses structural prediction results resulting in 74% accuracy. The tool was used to identify glycosylation sites in 108 human proteins with structures and 2247 proteins without structures that have acquired NXS/T site/s due to non-synonymous variation. The tool, Structure Feature Analysis Tool (SFAT), is freely available to the public at http://gffzzd6cb8b41b64c4e07hknufkuxuwkx565u5.ffgz.tsg.suse.edu.cn/tools/sfat. | Phuc Vinh Nguyen Lam Radoslav Goldman Konstantinos Karagiannis Tejas Narsule Vahan Simonyan Valerii Soika Raja Mazumder | 2013 | Genomics, Proteomics & Bioinformatics2013，11，2： | 8 |
| 2 | Extremely high prevalence of Helicobacter pylori infection in Bhutan显示文摘AIM: To revealed the prevalence of Helicobacter pylori (H. pylori ) infection in the Bhutanese population. METHODS: We recruited a total of 372 volunteers (214 females and 158 males; mean age of 39.6 ± 14.9 years) from three Bhutanese cities (Thimphu, Punaka, and Wangdue). The status of H. pylori infection was determined based on five different tests: the rapid urease test (CLO test), culture, histology, immunohistochemistry (IHC), and serum anti H. pylori -antibody. RESULTS: The serological test showed a significantly higher positive rate compared with the CLO test, culture, histology and IHC (P < 0.001, P < 0.001, P=0.01, and P=0.01, respectively). When the subjects were considered to be H. pylori positive in the case of at least one test showing a positive result, the overall prevalence of H. pylori infection in Bhutan was 73.4%. The prevalence of H. pylori infection significantly decreased with age (P < 0.01). The prevalence of H. pylori infection was lower in Thimphu than in Punakha and Wangdue (P=0.001 and 0.06, respectively). The prevalence of H. pylori infection was significantly higher in patients with peptic ulcers than in those with gastritis (91.4% vs 71.3%, P=0.003). CONCLUSION: The high incidence of gastric cancer in Bhutan may be attributed to the high prevalence of H. pylori infection. | Ratha-korn Vilaichone Varocha Mahachai Seiji Shiota Tomohisa Uchida Thawee Ratanachu-ek Lotay Tshering Nguyen Lam Tung Toshio Fujioka Masatsugu Moriyama Yoshio Yamaoka | 2013 | World Journal of Gastroenterology2013，19，18： | 8 |
| 3 | Characterizations of Sobolev spaces in Euclidean spaces and Heisenberg groups显示文摘Recently,many new features of Sobolev spaces Wk,pRNwere studied in[4–6,32].This paper is devoted to giving a brief review of some known characterizations of Sobolev spaces in Euclidean spaces and describing our recent study of new characterizations of Sobolev spaces on both Heisenberg groups and Euclidean spaces obtained in[12]and[13]and outlining their proofs.Our results extend those characterizations of frst order Sobolev spaces in[32]to the Heisenberg group setting.Moreover,our theorems also provide diferent characterizations for the second order Sobolev spaces in Euclidean spaces from those in[4,5]. | CUI Xiao-yue LAM Nguyen LU Guo-zhen | 2013 | Applied Mathematics(A Journal of Chinese Universities)2013，28，4： | 3 |
| 4 | The Incidence of Primary Antibiotic Resistance of Helicobacter pylori in Vietnam显示文摘 | Tran T. Binh Seiji Shiota Lam T. Nguyen Dung D.Q. Ho Hai H. Hoang Long Ta Dung T. Trinh Toshio Fujioka Yoshio Yamaoka | 2013 | Journal of Clinical Gastroenterology2013，，3： | 2 |
| 5 | 反思金融深化:新兴市场的稳定与发展显示文摘有深度和流动性良好的金融系统,加上有丰富的金融工具可抵御金融冲击,还可以增加一国金融的稳定性。但是金融发展或许存在一个边界,越过此边界进一步发展其收益或将下降。本文通过研究新兴市场发现:一、大部分新兴市场金融进一步发展仍然对经济的增长和稳定有利。二、金融发展对经济增长的促进作用是倒U型的,在越过高点之后金融深化对要素生产率的促进作用将下降。三、如果金融发展过快,快速深化的金融产业可能引发经济和金融动荡。四、提升金融稳定与金融发展之间没有太大冲突,更好的金融监管有助于提升金融稳定,促进金融发展。五、发展金融机构或金融市场不存在通用的顺序,尽管前者对经济的作用在下降而后者在上升。 | IMF课题组 Ratna Sahay Martin Cihak Papa N’Diaye Adolfo Barajas Ran Bi Diana Ayala Yuan Gao Annette Kyobe Lam Nguyen Christian Saborowski Katsiaryna Svirydzenka Seyed Reza Yousefi 胡妍斌 王辰 | 2015 | 新金融2015，0，10： | 2 |
| 6 | Functional analysis of a NAC‐type transcription factor OsNAC6 involved in abiotic and biotic stress‐responsive gene expression in rice显示文摘 | KazuoNakashima Lam‐Son P.Tran DongVan Nguyen MikiFujita KyonoshinMaruyama DaisukeTodaka YusukeIto NagaoHayashi KazuoShinozaki KazukoYamaguchi‐Shinozaki | 2007 | The Plant Journal2007，，： | 2 |
| 7 | Fracture mechanisms in soft rock: Identification and quantification of evolving displacement discontinuities by extended digital image correlation显示文摘 | Tuong Lam Nguyen Stephen A. Hall Pierre Vacher Gioacchino Viggiani | 2010 | Tectonophysics2010，，1： | 2 |
| 8 | Adherence to Screening for Hepatocellular Carcinoma Among Patients with Cirrhosis or Chronic Hepatitis B in a Community Setting显示文摘 | Carrie R. Wong Ruel T. Garcia Huy N. Trinh Khoa D. Lam Nghi B. Ha Huy A. Nguyen Khanh K. Nguyen Brian S. Levitt Mindie H. Nguyen | 2009 | Digestive Diseases and Sciences2009，，12： | 2 |
| 9 | Ecoregional variations of aboveground biomass and stand structure in evergreen broadleaved forests显示文摘Biotic and abiotic factors control aboveground biomass(AGB)and the structure of forest ecosystems.This study analyses the variation of AGB and stand structure of evergreen broadleaved forests among six ecoregions of Vietnam.A data set of 1731-ha plots from 52 locations in undisturbed old-growth forests was developed.The results indicate that basal area and AGB are closely correlated with annual precipitation,but not with annual temperature,evaporation or hours of sunshine.Basal area and AGB are positively correlated with trees>30 cm DBH.Most areas surveyed(52.6%)in these old-growth forests had AGB of 100–200 Mg ha^-1;5.2%had AGB of 400–500 Mg ha^-1,and 0.6%had AGB of>800 Mg ha^-1.Seventy percent of the areas surveyed had stand densities of 300–600 ind.ha^-1,and 64%had basal areas of 20–40 m^2 ha^-1.Precipitation is an important factor influencing the AGB of old-growth,evergreen broadleaved forests in Vietnam.Disturbances causing the loss of large-diameter trees(e.g.,>100 cm DBH)affects AGB but may not seriously affect stand density. | Tran Van Do Mamoru Yamamoto Osamu Kozan Vo Dai Hai Phung Dinh Trung Nguyen Toan Thang Lai Thanh Hai Vu Thanh Nam Trieu Thai Hung Hoang Van Thang Tran Duc Manh Cao Chi Khiem Vu Tien Lam Nguyen Quang Hung Tran Hoang Quy Pham Quang Tuyen Trinh Ngoc Bon Nguyen Thi Thu Phuong Ninh Viet Khuong Nguyen Van Tuan Dang Thi Hai Ha Tran Hai Long Dang Van Thuyet Dang Thinh Trieu Nguyen Van Thinh Tran Anh Hai Duong Quang Trung Nguyen Van Bich Dinh Hai Dang Pham Tien Dung Nguyen Huy Hoang Le Thi Hanh Phan Minh Quang Nguyen Thi Thuy Huong Hoang Thanh Son Nguyen Thanh Son Nguyen Thi Van Anh Nguyen Thi Hoai Anh Pham Dinh Sam Hoang Thi Nhung Hoang Van Thanh Nguyen Huu Thinh Tran Hong Van Ho Trung Luong Bui Kieu Hung | 2020 | Journal of Forestry Research2020，31，5： | 1 |
| 10 | A serotonin receptor gene (5HT1A) variant found in a Tourette's syndrome patient显示文摘 | Lam S Shen Y Nguyen T | | 0，，： | 1 |
| 11 | An edge-based smoothed finite element method (ES-FEM) for static, free and forced vibration analyses of solids 显示文摘 | LIU G R NGUYEN T T LAM K Y | 2009 | Sound and Vibration2009，320，4： | 1 |
| 12 | Gastric feed intolerance is not increased in critically ill patients with type II diabetes mellitus显示文摘 | Nguyen NO Lam SW Ching K | 2007 | Intensive Care Med2007，33，10： | 1 |
| 13 | The effect of Hispanic accents on employment decisions显示文摘 | Megumi Hosoda Lam T. Nguyen Eugene F. Stone-Romero | 2012 | Journal of Managerial Psychology2012，，4： | 1 |
| 14 | Swidden Change in Southeast Asia: Understanding Causes and Consequences显示文摘 | Ole Mertz Christine Padoch Jefferson Fox R. A. Cramb Stephen J. Leisz Nguyen Thanh Lam Tran Duc Vien | 2009 | Human Ecology2009，，3： | 1 |
| 15 | 超级高铁显示文摘BIG的创始合伙人比亚克评价说:'通过超级高铁,我们定义了一个由客舱和站门组成的交通出行生态系统。人们不必等车,也不再需要候车厅,超级高铁用接近超音速的速度将集体社会和个人自由联系在一起。在未来,这种崭新的出行方式将改变我们对时空的习惯认知,我们脑海中对城市版图的理解也将随之改变。' | Erik Berg Kreider Adi Krainer Ashton Stare Cheyenne Vandevoorde Cristian Lera Daniele Pronesti Derek Wong Domenic Schmid Evan Wiskup Francesca Portesine Hugo Soo Kristian Hindsberg Lam Le Nguyen Lasse Kristensen Linda Halim Maureen Rahman Ovidiu Munteanu Pei Pei Yang Ryan Duval Stephen Steckel Terrence Chew Thomas Christoffersen Tore Banke Veronica Moretti Yehezkiel Wiliardy 曲鸿(译) | 2019 | 城市环境设计2019，0，2： | 1 |
| 16 | Evaluation of Rapid Urine Test for the Detection of He- licobacter pylori infection in the Vietnamese population 显示文摘 | Lam Tung Nguyen Tomohisa Uchida Yoshiyuki Tsukamoto | 2010 | Digestive Diseases and Sciences2010，55，1： | 1 |
| 17 | A generalized empirical description for particle slip velocities in liquid fluidized beds显示文摘 | K.P. Galvin S. Pratten G. Nguyen Tran Lam | 1999 | Chemical Engineering Science1999，，8： | 1 |
| 18 | An edge based smoothed finite element method (ES FEM) for static, free and forced vibration analyses of solids 显示文摘 | LIU G R NGUYEN THOI T LAM K Y | 2009 | Journal of Sound and Vibration2009，320，4： | 1 |
| 19 | Prevalence of Colorectal Neoplasms in Asian Americans显示文摘 | Khoa D. Lam Ruel T. Garcia Long H. Nguyen Huy Trinh George Triadafilopoulos Jeanine T. Phan Khanh Nguyen Huy Nguyen Aijaz Ahmed Mindie H. Nguyen | 2009 | Digestive Diseases and Sciences2009，，1： | 1 |
| 20 | ChoIera epidemicassociated with consumption of unsafe drinking water andstreet-vended water-Eastern Freetown,Sierra Leone,2012显示文摘 | Nguyen VD Sreenivasan N Lam E | 2014 | Am J Trop Med Hyg2014，90，3： | 1 |
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