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| 1 | Combined carriership of TLR9 -1237C and CD14 -260T alleles enhances the risk of developing chronic relapsing pouchitis显示文摘AIM: To investigate the single nucleotide polymorphisms (SNPs) in genes involved in bacterial recognition and the susceptibility to pouchitis or pouchitis severity.METHODS: Analyses of CD14 -260C>T, CARD15/NOD2 3020insC, Toll-like receptor (TLR)4 +896A>G,TLR9 -1237T>C, TLR9+ 2848G>A, and IRAKM +22148G>A SNPs were performed in 157 ileal-pouch anal anastomosis (IPAA) patients (79 patients who did not develop pouchitis, 43 infrequent pouchitis patients,35 chronic relapsing pouchitis patients) and 224 Italian Caucasian healthy controls.RESULTS: No significant differences were found in SNP frequencies between controls and IPAA patients.However, a significant difference in carriership frequency of the TLR9-1237C allele was found between the infrequent pouchitis and chronic relapsing pouchitis groups [P = 0.028, odd's ratio (OR) = 3.2, 95%CI = 1.2-8.6].This allele uniquely represented a 4-locus TLR9 haplotype comprising both studied TLR9 SNPs in Caucasians.Carrier trait analysis revealed an enhanced combined carriership of the alleles TLR9 -1237C and CD14 -260T in the chronic relapsing pouchitis and infrequent pouchitis group (P = 0.018, OR = 4.1, 95%CI = 1.4 -12.3).CONCLUSION: There is no evidence that the SNPs predispose to the need for IPAA surgery. The significant increase of the combined carriership of the CD14 -260T and TLR9 -1237C alleles in the chronic relapsing pouchitis group suggests that these markers identify a subgroup of IPAA patients with a risk of developing chronic or refractory pouchitis. | KM Lammers S Ouburg SA Morré JBA Crusius P Gionchetti F Rizzello C Morselli E Caramelli R Conte G Poggioli M Campieri AS Pea | 2005 | World Journal of Gastroenterology2005，11，46： | 7 |
| 2 | Dynamic simulation of dispersed gas-liquid two-phase flow using a discrete bubble model显示文摘 | Delnoij E Lammers F A Kuipers J A M | 1997 | Chem Eng Sci1997，52，9： | 1 |
| 3 | Modeling of complex premixed burner systems by using flamelet-generated manifolds 显示文摘 | VAN OIJEN J A LAMMERS F A DE GOEY I P H | 2001 | Combustion and Flame2001，127，： | 1 |
| 4 | Conjuncti- va-associated lymphoid tissue in avian mucosal immunity显示文摘 | Van Ginkel F W Gulley S L Lammers A | 2012 | Devel Comp Immunol2012，36，2： | 1 |
| 5 | Dynamic simulation of dispersed gas-liquid two-phase flow using a discrete bubble model 显示文摘 | DELNOIJ E LAMMERS F A KUIPERS J A M | 1997 | Chemical Engineering Science1997，52，9： | 1 |
| 6 | Dynamic simulation of dispersed gas-liquid two-phaseflow using a discrete bubble model 显示文摘 | DELNOU E LAMMERS F A KUIPERS J A M | 1997 | ChemicalEngineering Science1997，52，9： | 1 |
| 7 | Model- ing of Complex Premixed Burner Systems by Using Flamelet-Generated Manifolds 显示文摘 | Van Oijen J A Lammers F A De Goey L P H | 2001 | Combustion and Flame2001，127，3： | 1 |
| 8 | A numerical study of flash back of laminar premixed flames in ceramic-foam surface burners 显示文摘 | Lammers F A Goey L P H | 2003 | Combustion and Flame2003，133，12： | 1 |
| 9 | Dynamic Simulation of Dispersed Gas-Liquid Two-Phase Model显示文摘 | Delnoij E Lammers F A Kuipers J A M | 1997 | Chemical Engineering Science1997，52，： | 1 |
| 10 | Conjunctiva-as- sociated lymphoid tissue in avian mucosal immunity 显示文摘 | Van Ginkel F W Gulley S L Lammers A | 2012 | Develop- mental and comparative immunology2012，36，2： | 1 |
| 11 | Common bile duct obstruction due to malignancy: treatment with plastic versus metal stents 显示文摘 | LAMMER J HAUSEGTGER K A FLUCKIGER F | 1996 | Radiology1996，201，1： | 1 |
| 12 | Modelling of Complex Premixed Burner Systems by Using Flamelet- Generated Manifolds 显示文摘 | Van Oijen J A Lammers F A De Goey L P H | 2001 | Combust Flame2001，127，3： | 1 |
| 13 | 显示文摘 | Lammer J Hausegger K A Fluckiger F | 1996 | Radiology1996，201，： | 1 |
| 14 | Dynamic simulation of dispersed gas -liquid two- phase flow using a discrete bubble model显示文摘 | Delnoij E Lammers F A Kuipers J A M | 1997 | Chemical Engineering Science1997，52，9： | 1 |
| 15 | Conjunctiva-associated lymphoid tissue in avian mucosal im-munity显示文摘 | VAN GINKEL F W GULLEY S L LAMMERS A | 2012 | Del Comp Immunol2012，36，2： | 1 |
| 16 | The major bovine mastitis pathogens have different cell tropisms in cultures of bovine mammary gland cells 显示文摘 | Lammers A Vorstenbosch V C J Erkens J H F | 2001 | Vet Microbiol2001，80，3： | 1 |
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