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| 1 | 帕博利珠单抗联合以铂类为基础的化疗治疗非小细胞肺癌合并稳定性脑转移患者的结局:KEYNOTE-021、-189和-407研究的汇总分析显示文摘背景与目的此项探索性分析回顾评价了晚期非小细胞肺癌(non-small cell lung cancer,NSCLC)患者的结局,旨在确定基线时合并脑转移是否会影响一线应用帕博利珠单抗联合化疗(pembrolizumab plus chemotherapy,PC)比对单用化疗的疗效。患者和方法对KEYNOTE-021队列G(非鳞癌)、KEYNOTE-189(非鳞癌)和KEYNOTE-407(鳞癌)三项研究晚期NSCLC患者的数据进行汇总分析。患者接受含铂两药化疗和/或35个周期帕博利珠单抗治疗(每3周200 mg)。所有研究均纳入了经治或初治的稳定性脑转移患者(KEYNOTE-189与KEYNOTE-407研究纳入初治脑转移患者)。经治的脑转移患者已处于病情稳定的状态≥2周(KEYNOTE-021队列G患者≥4周),无新发或脑转移病灶扩大的证据且入组前至少3天以上未使用激素。初治的无症状脑转移患者需定期接受脑部影像学检查。结果共纳入1298例患者,其中171例有基线脑转移,1127例无脑转移。两组的中位随访时间(范围)在数据截止时分别为10.9(0.1-35.1)个月和11.0(0.1-34.9)个月。合并脑转移和无脑转移患者的总生存期[0.48(95%CI:0.32-0.70)和0.63(95%CI:0.53-0.75)]和无进展生存期[0.44(95%CI:0.31-0.62)和0.55(95%CI:0.48-0.63)]的风险比(PC/化疗)相似。合并脑转移的患者中,PC组和单用化疗组患者的中位总生存期分别为18.8个月和7.6个月,中位无进展生存期分别为6.9个月和4.1个月。无论是否合并脑转移,PC组患者的客观缓解率都高于单用化疗组,且缓解持续时间有显著延长。合并脑转移的患者中,PC组与单用化疗组的治疗相关不良事件发生率分别为88.2%和82.8%;而无脑转移的患者中,两组治疗相关不良事件的发生率分别为94.5%和90.6%。结论无论是否合并脑转移,与单用化疗相比,帕博利珠单抗联合以铂类为基础的组织学特异性化疗可改善所有PD-L1亚组的临床结局,其中包括PD-L1肿瘤比例评分<1%的患者,并且在晚期NSCLC患者中安全性良好。该方案是晚期NSCLC初治患者的标准方案,并可用于合并稳定性脑转移的患者。 | 周清(翻译校对) Steven F Powell Delvys Rodríguez-Abreu Corey J Langer Ali Tafreshi Luis Paz-Ares Hans-Georg Kopp Jeronimo Rodríguez-Cid Dariusz M Kowalski Ying Cheng Takayasu Kurata Mark M Awad Jinaxin Lin Bin Zhao M Catherine Pietanza Bilal Piperdi Marina C Garassino | 2022 | 中国肺癌杂志2022，25，1： | 6 |
| 2 | Modeling and Managing Student Loyalty An Ap- proach Based on the Concept of Relationship Quali- ty显示文摘 | Hennig-Thurau T Langer M F and Hansen U | 2001 | Journal of Service Research2001，3，4： | 1 |
| 3 | Cytokine response to pulmonary thromboendarterectomy 显示文摘 | Langer F Schramm R Bauer M | 2004 | Chest2004，126，1： | 1 |
| 4 | Sleeve Gastrectomy and Gastric Banding: Effects on Plasma Ghrelin Levels显示文摘 | F B Langer M A Reza Hoda A Bohdjalian F X Felberbauer J Zacherl E Wenzl K Schindler A Luger B Ludvik G Prager | 2005 | Obesity Surgery2005，，7： | 1 |
| 5 | Modelling and managing studenl loyalty:An approach based on the concept of relationship quality显示文摘 | Hennig-Thurau T Langer M F Hansen U | 2001 | Journal of Service Research2001，3，4： | 1 |
| 6 | A novel biotinylated degradable polymer for cell - interactive applications 显示文摘 | Cannizzaro S M Padera R F Langer R | 1998 | Biotechnol & Bioengeng1998，58，5： | 1 |
| 7 | High - resolution computerized tomography of the petrous bone with two - dimensional and three - dimensiona显示文摘 | Astinet F Langer M Keske U | 1990 | Rofo1990，153，1： | 1 |
| 8 | Cytokine re- sponse to pulmonary thromboendarterectomy 显示文摘 | Langer F Schramm R Bauer M | 2004 | Chest2004，126，1： | 1 |
| 9 | Platelet -vessel wall interactions in atherosclerotic disease 显示文摘 | LANGER H F GAWAZ M | 2008 | Thromb Haemost2008，99，3： | 1 |
| 10 | No wilderness for immigrants:Cultural differences in images of nature and landscape preferences显示文摘 | Buijs A E Elands B H M Langers F | 2009 | Landscape and Urban Planning2009，，03： | 1 |
| 11 | Assessing quality of rural areas in the Netherlands: Ending the most important indicators for recreation 显示文摘 | Goossen M Langers F | 2000 | Landscape and Urban Planning2000，46，4： | 1 |
| 12 | Modeling and Managing Student Loyalty An Approach Based on the Concept of Relationship Quality 显示文摘 | Hennig--Thurau T Langer M F Hansen U | 2001 | Journal of Service Research2001，3，4： | 1 |
| 13 | Influence of solvent,matrix dielectric properties,and applied poweron the liquid-phase microwave-assisted processes extraction of ginger显示文摘 | Alfaro M J Bélanger J M R Padilla F C | 2003 | Food Research International2003，36，2： | 1 |
| 14 | High pretherapeutic thymidylate synthetase and MRP--1 protein levels are associated with nonresponse to neoadjuvant chemotherapy in oesophageal adenocarcinoma patients显示文摘 | J Langer R Ott K Feith M Lordick F | 2010 | J Surg Oncol2010，102，5： | 1 |
| 15 | 显示文摘 | Stevens M M Qanadilo H F Langer R | 2004 | Biomaterials2004，25，： | 1 |
| 16 | The role of complex hepatic artery reconstruction in orthotopic liver transplantation显示文摘 | Soliman T Bodingbauer M Langer F | 2003 | Liver Transpl2003，9，9： | 1 |
| 17 | Cytokine response to pulmonary thromboendarterectomy显示文摘 | LANGER F SCHRAMM R BAUER M | 2004 | Chest2004，126，1： | 1 |
| 18 | Cytokine response to pulmonary thromboendarterectomy 显示文摘 | Langer F Schramm R Bauer M | 2004 | Chest2004，126，1： | 1 |
| 19 | Intermittent PTH (1-84) is osteoanabolic but not osteoangiogenic and relocates bone marrow blood vessels closer to bone-forming sites显示文摘 | Prisby R Guignandon A Vanden-Bossche A Mac-Way F Lino-ssier MT Thomas M Laroche N Malaval L Langer M Peter ZA Peyrin F Vico L Lafage-Proust MH | | 0，，： | 1 |
| 20 | Successive action of DnaK,DnaJ and GroEL along the pathway of chaperone-mediated protein folding 显示文摘 | Langer T Lu C Echols H Flanagan J Hayer M K Hartl F U | 1992 | Nature1992，356，6371： | 1 |
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