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| 1 | Endoscopic mucosal resection for high-grade dysplasia and intramucosal carcinoma in Barrett's esophagus: An Italian experience显示文摘AIM: To evaluate endoscopic mucosal resection (EMR)in patients with high-grade dysplasia (HGD) and/or intramucosal cancer (IMC) in Barrett's esophagus (BE).METHODS: Between June 2000 and December 2003,39 consecutive patients with HGD (35) and/or IMC (4)underwent EMR. BE >30 mm was present in 27 patients.In three patients with short segment BE (25.0%), HGDwas detected in a normal appearing BE. Lesions had a mean diameter of 14.8±10.3 mm. Mucosal resection was carried out using the cap method.RESULTS: The average size of resections was 19.7±9.4×14.6±8.2 mm. Histopathologic assessment postresection revealed 5 low-grade dysplasia (LGD) (12.8%),27 HGD (69.2%), 2 IMC (5.1%), and 5 SMC (-12.8%).EMR changed the pre-treatment diagnosis in 10 patients (25.6%). Three patients with SMC underwehtsurgery.Histology of the surgical specimen revealed 1 T0N0 and 2 T1N0 lesions. The remaining two patients were cancer free at 32.5 and 45.6 mo, respectively. A metachronous lesion was detected after 25 mo in one patient with HGD. Intra-procedural bleeding, controlled at endoscopy,occurred in four patients (10.3%). After a median followup of 34.9 mo, all patients remained in remission.CONCLUSION: In the medium term, EMR is effective and safe to treat HGD and/or IMC within BE and is a valuable staging method. It could become an alternative to surgery. | Massimo Conio Alessandro Repici Renzo Cestari Sabrina Blanchi Gabriella Lapertosa Guido Missale Domenico Della Casa Vincenzo Villanacci Pier Gigi Calandri Rosangela Filiberti | 2005 | World Journal of Gastroenterology2005，11，42： | 6 |
| 2 | Prevalence and prognostic significance of endocrine cells in colorectal adenocarcinoma显示文摘 | Lapertosa G Baracchini P Dlucchi F | 1994 | Patholgica1994，86，2： | 1 |
| 3 | Prevalence and Prognostic Significance of Endocrine Cells in Colorectal Adenocarcinomas显示文摘 | LAPERTOSA G BARACCHINI P DELUCCHI F | 1994 | Pathology1994，86，： | 1 |
| 4 | Barrett' s esophagus: an update 显示文摘 | Conio M Lapertosa G Blanehi S | 2003 | Crit Rev oneol Hematol2003，46，： | 1 |
| 5 | Prevalence and prognostic significance of endocrine cells in colorectal adenocarcinoma显示文摘 | Lapertosa G Baracchini P Dlucchi F | 1994 | Pathologica1994，86，2： | 1 |
| 6 | Barrett's esophagus:An update显示文摘 | Conio M Lapertosa G Blanchi S | 2003 | Crit Rev Oncol Hematol2003，46，2： | 1 |
| 7 | Long-term endoscopic surveillance of patients with Barrett’s esophagus. incidence of dysplasia and adenocarcinoma: a prospective study显示文摘 | Massimo Conio Sabrina Blanchi Gabriella Lapertosa Roberto Ferraris Renato Sablich Santino Marchi Vittorio D’Onofrio Teresa Lacchin Gaetano Iaquinto Guido Missale Paolo Ravelli Renzo Cestari Giorgio Benedetti Giuseppe Macrì Roberto Fiocca Francesco Munizzi | 2003 | The American Journal of Gastroenterology2003，，9： | 1 |
| 8 | Histogenetic considerations on mucinous cystomas of the ovary based on histochemical and immunohistochemical findings显示文摘 | Lapertosa G | 1989 | Pathologica1989，81，1074： | 1 |
| 9 | Long-term endoscopic surveillance of patients with Barrett’s esophagus. incidence of dysplasia and adenocarcinoma: a prospective study显示文摘 | Massimo Conio Sabrina Blanchi Gabriella Lapertosa Roberto Ferraris Renato Sablich Santino Marchi Vittorio D’Onofrio Teresa Lacchin Gaetano Iaquinto Guido Missale Paolo Ravelli Renzo Cestari Giorgio Benedetti Giuseppe Macrì Roberto Fiocca Francesco Munizzi | 2003 | The American Journal of Gastroenterology2003，，： | 1 |
| 10 | Prevalance and prognostic significance of endocrine cells in colorectal adenocarcinomas显示文摘 | Lapertosa G Baracchini P Delucchi F | 1994 | Pathology1994，86，： | 1 |
| 11 | Endoscopic mucosal resection of large hyperplastic polyps in 3 patients with Barrett’s esophagus显示文摘AIM: To report the endoscopic treatment of large hyperplastic polyps of the esophagus and esophago- gastric junction (EGJ) associated with Barrett’s esophagus (BE) with low-grade dysplasia (LGD), by endoscopic mucosal resection (EMR). METHODS: Cap fitted EMR (EMR-C) was performed in 3 patients with hyperplastic-inflammatory polyps (HIPs) and BE. RESULTS: The polyps were successfully removed in the 3 patients. In two patients, with short segment BE (SSBE) (≤ 3 cm), the metaplastic tissue was completely excised. A 2 cm circumferential EMR was performed in one patient with a polyp involving the whole EGJ. A simultaneous EMR-C of a BE-associated polypoid dysplastic lesion measuring 1 cm x 10 cm, was also carried out. In the two patients, histologic assessment detected LGD in BE. No complications occurred. Complete neosquamous re- epithelialization occurred in the two patients with SSBE. An esophageal recurrence occurred in the remaining one and was successfully retreated by EMR. CONCLUSION: EMR-C appears to be a safe and effective method for treating benign esophageal mucosal lesions, allowing also the complete removal of SSBE. | Antonella De Ceglie Gabriella Lapertosa Sabrina Blanchi Marcello Di Muzio Massimo Picasso Rosangela Filiberti Francesco Scotto Massimo Conio | 2006 | World Journal of Gastroenterology2006，12，35： | 0 |
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