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| 1 | Sensory-motor responses to mechanical stimulation of the esophagus after sensitization with acid显示文摘AIM: Sensitization most likely plays an important role in chronic pain disorders, and such sensitization can be mimicked by experimental acid perfusion of the esophagus.The current study systematically investigated the sensory and motor responses of the esophagus to controlled mechanical stimuli before and after sensitization.METHODS: Thirty healthy subjects were included.Distension of the distal esophagus with a balloon was performed before and after perfusion with 0.1 mol/L hydrochloric acid for 30 min. An impedance planimetry system was used to measure cross-sectional area,volume, pressure, and tension during the distensions. A new model allowed evaluation of the phasic contractions by the tension during contractions as a function of the initial muscle length before the contraction (comparable to the Frank-Starling law for the heart). Length-tension diagrams were used to evaluate the muscle tone before and after relaxation of the smooth muscle with butylscopolamine.RESULTS: The sensitization resulted in allodynia and hyperalgesia to the distension volumes, and the degree of sensitization was related to the infused volume of acid. Furthermore, a nearly 50% increase in the evoked referred pain was seen after sensitization. The mechanical analysis demonstrated hyper-reactivity of the esophagus following acid perfusion, with an increased number and force of the phasic contractions, but the muscle tone did not change.CONCLUSION: Acid perfusion of the esophagus sensitizes the sensory pathways and facilitates secondary contractions.The new model can be used to study abnormal sensorymotor mechanisms in visceral organs. | Asbjφrn Mohr Drewes Hariprasad Reddy Camilla Staahl Jan Pedersen Peter Funch-Jensen Lars Arendt-Nielsen Hans Gregersen | 2005 | World Journal of Gastroenterology2005，11，28： | 3 |
| 2 | Relationship among flavor, volatile compounds, chemical changes and microflora in Italian-type dry-cured ham during processing显示文摘 | Lars L Hinrichsen Susanne B Pedersen | 1995 | J Agric Food Chem1995，，43： | 1 |
| 3 | 显示文摘 | Ojamae Lars Aulin Christian Pedersen Henrik | 2006 | Journal of Colloid and Interface Science2006，296，： | 1 |
| 4 | Enhanced aut:o adhesion of wood fibers using phenol oxidases显示文摘 | ClAus Felby Lars Saaby Pedersen Bo Bud Nielsen | 1997 | Holzforschung1997，51，： | 1 |
| 5 | Gender Differences in Pain and Biomechanical Responses After Acid Sensitization of the Human Esophagus显示文摘 | Hariprasad Reddy MD Lars Arendt-Nielsen PhD Camilla Staahl MScPharm Jan Pedersen MD PhD Peter Funch-Jensen MD PhD Hans Gregersen MD PhD Asbj?rn Mohr Drewes MD PhD | 2005 | Digestive Diseases and Sciences2005，，11： | 1 |
| 6 | Control of GDI engines using torque feedback exemplified by simulations 显示文摘 | Magnus Gafverta Karl-Erik Arzen Lars Malcolm Pedersen | 2004 | Control Engineering Practice2004，12，2： | 1 |
| 7 | Differences Between Male and Female Responses to Painful Thermal and Mechanical Stimulation of the Human Esophagus显示文摘 | Jan Pedersen Hariprasad Reddy Peter Funch-Jensen Lars Arendt-Nielsen Hans Gregersen Asbj?rn Mohr Drewes | 2004 | Digestive Diseases and Sciences (-)2004，，7： | 1 |
| 8 | Fiber reinforced crack resistant epoxy paint for ballast tanks coating显示文摘 | | 2006 | Double Liaison2006，4，552： | 1 |
| 9 | Full-scale co-firing of straw and coal显示文摘 | Lars Storm Pedersen Hanne Philbert Nielsen Wren Kiil | 1996 | Fuel1996，75，13： | 1 |
| 10 | Fiber-reinforced zinc silicate coatings显示文摘 | Juhl Mads Pedersen Lars | 2010 | Materials Performance2010，49，11： | 1 |
| 11 | Gender Differences in Pain and Biomechanical Responses After Acid Sensitization of the Human Esophagus显示文摘 | Hariprasad Reddy MD Lars Arendt-Nielsen PhD Camilla Staahl MScPharm Jan Pedersen MD PhD Peter Funch-Jensen MD PhD Hans Gregersen MD PhD Asbj?rn Mohr Drewes MD PhD | 2005 | Digestive Diseases and Sciences2005，，11： | 1 |
| 12 | Low-field 1H nuclear magnetic resonance and chemometrics combined for simultaneous determination of water, oil, and protein contents in oilseeds显示文摘 | Henrik Toft Pedersen Lars Munck Siren Balling Engelsen | 2000 | Journal of the American Oil Chemists’ Society2000，，10： | 1 |
| 13 | Soluble α-Klotho and Its Relation to Kidney Function and Fibroblast Growth Factor-23显示文摘 | Alexandra Scholze Ying Liu Lise Pedersen Shengqiang Xia Heinz J. Roth Berthold Hocher Lars Melholt Rasmussen Martin Tepel | 2014 | The Journal of Clinical Endocrinology & Metabolism2014，，5： | 1 |
| 14 | Hyperalgesia and temporal summation of pain after heat injury in man显示文摘 | Juri L Pedersen Ole K Andersen Lars Arendt-Nielsen Henrik Kehlet | 1998 | Pain1998，，2： | 1 |
| 15 | Enhanced auto adhesion of wood fibers using phenol oxidases 显示文摘 | Claus Felby Lars Saaby Pedersen Bo Rud Nielsen | 1997 | Holzforschung1997，51，3： | 1 |
| 16 | Neither Long-Term Statin Use nor Atherosclerotic Disease Is Associated With Risk of Colorectal Cancer显示文摘 | Douglas J. Robertson Anders Hammerich Riis S?ren Friis Lars Pedersen John A. Baron Henrik Toft S?rensen | 2010 | Clinical Gastroenterology and Hepatology2010，，12： | 1 |
| 17 | Control of GDI engines using torque feedback exemplified by simulations显示文摘 | Magnus Gafvert Karl-Erik A rzen Lars Malcolm Pedersen | 2004 | Control Engineering Practice2004，，12： | 1 |
| 18 | Trandolapril re-duces the incidence of aterial fibrillation after acute myocardial infarc-tion in patients with left ventricular dysfunction显示文摘 | Ole Dyg Pedersen Henning Bagger Lars Kober | 1999 | Circulation1999，100，2： | 1 |
| 19 | Dickkopf-1 Enhances Inflammatory Interaction Between Platelets and Endothelial Cells and Shows Increased Expression in Atherosclerosis显示文摘 | Thor Ueland Kari Otterdal Tove Lekva Bente Halvorsen Anders Gabrielsen Wiggo J. Sandberg Gabrielle Paulsson-Berne Turid M. Pedersen Lasse Folkersen Lars Gullestad Erik ?ie G?ran K. Hansson P?l Aukrust | 2009 | Arteriosclerosis, Thrombosis, and Vascular Biology2009，，： | 1 |
| 20 | Soluble serum Klotho levels in healthy subjects. Comparison of two different immunoassays显示文摘 | Lise Pedersen Susanne M?ller Pedersen Claus Lohman Brasen Lars Melholt Rasmussen | 2013 | Clinical Biochemistry2013，，12： | 1 |
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