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| 1 | Sensory-motor responses to mechanical stimulation of the esophagus after sensitization with acid显示文摘AIM: Sensitization most likely plays an important role in chronic pain disorders, and such sensitization can be mimicked by experimental acid perfusion of the esophagus.The current study systematically investigated the sensory and motor responses of the esophagus to controlled mechanical stimuli before and after sensitization.METHODS: Thirty healthy subjects were included.Distension of the distal esophagus with a balloon was performed before and after perfusion with 0.1 mol/L hydrochloric acid for 30 min. An impedance planimetry system was used to measure cross-sectional area,volume, pressure, and tension during the distensions. A new model allowed evaluation of the phasic contractions by the tension during contractions as a function of the initial muscle length before the contraction (comparable to the Frank-Starling law for the heart). Length-tension diagrams were used to evaluate the muscle tone before and after relaxation of the smooth muscle with butylscopolamine.RESULTS: The sensitization resulted in allodynia and hyperalgesia to the distension volumes, and the degree of sensitization was related to the infused volume of acid. Furthermore, a nearly 50% increase in the evoked referred pain was seen after sensitization. The mechanical analysis demonstrated hyper-reactivity of the esophagus following acid perfusion, with an increased number and force of the phasic contractions, but the muscle tone did not change.CONCLUSION: Acid perfusion of the esophagus sensitizes the sensory pathways and facilitates secondary contractions.The new model can be used to study abnormal sensorymotor mechanisms in visceral organs. | Asbjφrn Mohr Drewes Hariprasad Reddy Camilla Staahl Jan Pedersen Peter Funch-Jensen Lars Arendt-Nielsen Hans Gregersen | 2005 | World Journal of Gastroenterology2005，11，28： | 3 |
| 2 | Different effects of morphine and oxycodone in experimentally evoked hyperalgesia: a human translational study 显示文摘 | Olesen AE Staahl C Arendt-Nielsen L | 2010 | Br J Clio Pharmacol2010，70，2： | 1 |
| 3 | Buyer power and exclusion in vertically related markets显示文摘 | Tommy Staahl Gabrielsen Bj?rn Olav Johansen | 2014 | International Journal of Industrial Organization2014，，： | 1 |
| 4 | A comparative study of oxycodone and morphine in a multi-modal,tissue-differentiated experimental pain model显示文摘 | Staahl C Christrup LL Andersen SD | 2006 | Pain2006，123，12： | 1 |
| 5 | MicroRNA-mediated switching of chromatin-remodelling complexes in neural development 显示文摘 | Yoo AS Staahl BT Chen L | 2009 | Nature2009，460，7255： | 1 |
| 6 | MicroRNA-mediated switching of chromatin-remodelling complexes in neural development显示文摘 | Yoo A S Staahl B T Chen L | 2009 | Nature2009，460，7255： | 1 |
| 7 | Gender Differences in Pain and Biomechanical Responses After Acid Sensitization of the Human Esophagus显示文摘 | Hariprasad Reddy MD Lars Arendt-Nielsen PhD Camilla Staahl MScPharm Jan Pedersen MD PhD Peter Funch-Jensen MD PhD Hans Gregersen MD PhD Asbj?rn Mohr Drewes MD PhD | 2005 | Digestive Diseases and Sciences2005，，11： | 1 |
| 8 | Induced stereo- and substrate selectivity of bioimprinted alpha-chymotrypsin in anhydrous organic media显示文摘 | Staahl M Jeppsson-Wistrand U Maamsson M O | 1991 | Journal of the American Chemical Society1991，113，24： | 1 |
| 9 | Different effect oi opioids in patients with chronic pancrdatitis: an experimental pain study 显示文摘 | Staahl C Dimcevski G Andersen SD | 2007 | Scand J Ganstroenterol2007，42，3： | 1 |
| 10 | Analgesic Efficacy of Peripheral κ-Opioid Receptor Agonist CR665 Compared to Oxycodone in a Multi-modal, Multi-tissue Experimental Human Pain Model: Selective Effect on Visceral Pain显示文摘 | Lars Arendt-Nielsen Anne E. Olesen Camilla Staahl Frédérique Menzaghi Sherron Kell Gilbert Y. Wong Asbj?rn M. Drewes | 2009 | Anesthesiology2009，，3： | 1 |
| 11 | Gender Differences in Pain and Biomechanical Responses After Acid Sensitization of the Human Esophagus显示文摘 | Hariprasad Reddy MD Lars Arendt-Nielsen PhD Camilla Staahl MScPharm Jan Pedersen MD PhD Peter Funch-Jensen MD PhD Hans Gregersen MD PhD Asbj?rn Mohr Drewes MD PhD | 2005 | Digestive Diseases and Sciences2005，，11： | 1 |
| 12 | Different effect of opioids in patients with chronic pancreatitis: an experimental pain study 显示文摘 | Staahl C Dimcevski G Andersen SD | 2007 | Scand Canstroenterol2007，42，3： | 1 |
| 13 | A comparative study of oxycodone and morphine in a multi-modal,tissue-differentiated,experimental pain model显示文摘 | Staahl C Christrup LL Andersen SD | 2006 | Pain2006，2，6： | 1 |
| 14 | A population pharmacokinetic and pharmacodynamic study of a peripheralκ-opioid receptor agonist CR665 and oxycodone显示文摘 | OLESEN AE KRISTENSEN K STAAHL C | 2013 | Clin Pharmacokinet2013，52，2： | 1 |
| 15 | A transla- tional study of the effects of ketamine and pregabalin on temporal summation of experimental pain显示文摘 | Arendt-Nielsen L Mansikka H Staahl C | 2011 | Reg Anesth Pain Med2011，36，6： | 1 |
| 16 | Analgesic efficacy of peripheral kappa-opioid receptor agonist CR665 compared to oxy- codone in a multi-modal,multi-tissue experimental human pain model:selective effect on visceral pain 显示文摘 | Arendt-Nielsen L Olesen AE Staahl C | 2009 | Anesthesiology2009，111，3： | 1 |
| 17 | Differential effect of opioids in patients with chronic pancreatitis:an experimental pain study显示文摘 | Staahl C Dimcevski G Due Andersen S | 2007 | Scandinavian J Gastroenterology2007，42，3： | 1 |
| 18 | Differential effect of opioids in patients with chronic pancreatitis: an experi- mental pain study显示文摘 | Staahl C Dimcevski G Andersen SD | 2007 | Stand J Gastroenterol2007，42，3： | 1 |
| 19 | A comparativestuy of oxycodone and morphine in a multl-modal, tissue-differ- entiated experimental pain model显示文摘 | Staahl C Christrup LL Andersen SD | 2006 | Pain2006，123，12： | 1 |
| 20 | Analgesic effica- cy of peripheral kappa - opioid receptor agonist CR665 compared to oxycodone in a multi - modal, multi - tissue experimental hu- man pain model : selective effect on visceral pain 显示文摘 | Arendt - Nielsen L Olesen AE Staahl C | 2009 | Anesthesiol- ogy2009，111，3： | 1 |
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