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| 1 | Glypican-3和CD34免疫组化染色在肝细胞癌与良性肝细胞性病变鉴别诊断中的价值显示文摘 | Coston W M P Loera S Lau S K 黄文斌(摘译) | 2008 | 临床与实验病理学杂志2008，24，3： | 31 |
| 2 | Elevated blood pressure: Our family's fault?The genetics of essential hypertension显示文摘AIM: To provide an updated review on current genetic aspects possibly affecting essential hypertension(EH), and to further elucidate their role in EH. METHODS: We searched for genetic and epigenetic factors in major studies associated with EH between Jan 2008-Oct 2013 using PubMed. We limited our search to reviews that discussed mostly human studies, and were accessible through the university online re-source. We found 11 genome wide association studies(GWAS), as well as five methylation and three miRNA studies that fit our search criteria. A distinction was not made between genes with protective effects or nega-tive effects, as this article is only meant to be a sum-mary of genes associated with any aspect of EH.RESULTS: We found 130 genes from the studies that met our inclusion/exclusion criteria. Of note, genes withmultiple study references include: STK39, CYP17A1, MTHFR-NPPA, MTHFR-NPPB, ATP2B1, CSK, ZNF652, UMOD, CACNB2, PLEKHA7, SH2B3, TBX3-TBX5, ULK4, CSK-ULK3, CYP1A2, NT5C2, CYP171A, PLCD3, SH2B3, ATXN2, CACNB2, PLEKHA7, SH2B3, TBX3-TBX5, ULK4, and HFE. The following genes overlapped between the genetic studies and epigenetic studies: WNK4 and BDKRB2. Several of the identified genes were found to have functions associated with EH. Many epigenetic factors were also correlated with EH. Of the epigenetic factors, there were no articles discussing siRNA and its effects on EH that met the search criteria, thus the topic was not included in this review. Among the miRNA tar-gets found to be associated with EH, many of the genes involved were also identified in the GWAS studies.CONCLUSION: Genetic hypertension risk algorithms could be developed in the future but may be of limited benefit due to the multi-factorial nature of EH. With emerging technologies, like next-generation sequenc-ing, more direct causal relationships between genetic and epigenetic factors affecting EH will likely be discov-ered creating a tremendous potential for personalized medicine using pharmacogenomics. | Aniket Natekar Randi L Olds Meghann W Lau Kathleen Min Karra Imoto Thomas P Slavin | 2014 | World Journal of Cardiology2014，6，5： | 7 |
| 3 | Frequent amplification of a chr19q13.41 microRNA polycistron in aggressive primitive neuroectodermal brain tumors显示文摘 | Li M Lee KF Lu Y Clarke I Shih D Eberhart C Collins VP Van Meter T Picard D Zhou L Boutros PC Modena P Liang ML Scherer SW Bouffet E Rutka JT Pomeroy SL Lau CC Taylor MD Gajjar A Dirks PB Hawkins CE Huang A. | 2009 | 中国神经肿瘤杂志2009，7，4： | 3 |
| 4 | Tumor necrosis factor-α-induced protein 1 and immunity to hepatitis B virus显示文摘AIM: To compare the gene expression profile in a pair of HBV-infected twins.METHODS: The gene expression profile was compared in a pair of HBV-infected twins.RESULTS: The twins displayed different disease outcomes. One acquired natural immunity against HBV,whereas the other became a chronic HBV carrier. Eightyeight and forty-six genes were found to be up- or downregulated in their PBMCs, respectively. Tumor necrosis factor-alpha-induced protein 1 (TNF-αIP1) that expressed at a higher level in the HBV-immune twins was identified and four pairs of siblings with HBV immunity by RTPCR. However, upon HBV core antigen stimulation,TNF-αIP1 was downregulated in PBMCs from subjects with immunity, whereas it was slightly upregulated in HBV carriers. Bioinformatics analysis revealed a K+channel tetramerization domain in TNF-αIP1 that shares a significant homology with some human, mouse, and C elegan proteins.CONCLUSION: TNF-αIP1 may play a role in the innate immunity against HBV. | Marie C Lin Nikki P Lee Ning Zheng Pai-Hao Yang Oscar G Wong Hsiang-Fu Kung Chee-Kin Hui John M Luk George Ka-Kit Lau | 2005 | World Journal of Gastroenterology2005，11，48： | 3 |
| 5 | Percutaneous balloon mitral valvuloplasty in patients with mitral restenosis after previous surgical commissurotomy: a matched comparative study显示文摘 | LAU K W DING Z P GAO W | 1996 | Eur Heart J1996，17，9： | 2 |
| 6 | The 40-50 day oscillation and El Nino/Southern Oscillation:A new perspective显示文摘 | Lau K M Chan P H | 1986 | Bull Amer Meteor Soc1986，67，5： | 2 |
| 7 | Cholesteryl ester transfer protein (CETP) expression protects against diet induced atherosclerosis in SR-BI deficient mice显示文摘 | HARDER C LAU P MENG A | 2007 | Arterioscler Thromb Vasc Biol2007，27，4： | 1 |
| 8 | Suppression subtractive hy+bridization: a method for generating differentially regulated or tissue-specific cDNA probes and libraries显示文摘 | Lau Y F Campbell A P | 1996 | Proc Natl Acad Sci U S A1996，93，12： | 1 |
| 9 | Catheter-related microbacterium bacteremia identified by 16 S rRNA gene sequencing显示文摘 | Lau K P Woo C Y Moo M Y et a1 | 2002 | Clin Microbiol2002，40，7： | 1 |
| 10 | Carbon Nanotube Films Prepared by Thermal Chemical Vapor Deposition at Low Temperature for Field Emission Applications显示文摘 | Li Y J Sun Z Lau S P | 2001 | Appl Phys Lett2001，79，11： | 1 |
| 11 | Probucol promotes func- tional reendothelialization in balloon-injured rabbit aortas 显示文摘 | Lau AK Leichtweis SB Hume P | 2003 | Cir- culation2003，107，15： | 1 |
| 12 | Suppression subtractive hybridization:a method for generating differentially regulated or tissue specific cDNA probes and libraries显示文摘 | Diatchenko L Lau Y F Campbell A P | 1996 | Proc Natl Acad Sci U S A1996，93，12： | 1 |
| 13 | Enhancement of nearband-edge photoluminescence from ZnO films by face-to-face annealing显示文摘 | Wang Y G Lau S P Zhang X H | 2003 | J Crystal Gruth2003，259，： | 1 |
| 14 | Suppression subtractive hybridization:A method for generating differentially regulated or tissue-specific cDNA probes and libraries显示文摘 | Diatchenko L Lau Y F C Campbell A P | 1996 | Proc Natl Acad Sci USA1996，93，12： | 1 |
| 15 | Suppression subtractive hybridization:A method for generating differentially regulated or tissue-specific cDNA probes and libraries显示文摘 | Diatchenko L Lau Y-F C Campbell A P | 1996 | Proc Natl Acad Sci USA1996，93，12： | 1 |
| 16 | Hot-wire chemical vapor deposition (HWCVD) of fluorocarbon and organosilicon thin films显示文摘 | Lau K K S Lewis H G P Limb S J | 2001 | Thin Solid Films2001，395，12： | 1 |
| 17 | Polycrystalline ZnO thin films on Si (100) deposited by filtered cathodic vacuum arc 显示文摘 | XU X L LAU S P CHEN J S CHEN G Y TAY B K | 2001 | Journal of Crystal Growth2001，223，12： | 1 |
| 18 | A comparative study on catalyst deactivation of nickel and cobalt incorporated MCM-41 catalysts modified by platinum in methane reforming with carbon dioxide 显示文摘 | LIU D P CHEO W N E LIM Y W Y BORGN A LAU R YANG Y H | 2010 | Catalysis Today2010，154，34： | 1 |
| 19 | Synchronized formation rota- tion and attitude control of multiple free-flying spacecraft 显示文摘 | WANG P K HADAEGH F Y LAU K | 1999 | Journal of Guidance Control and Dynamic1999，22，1： | 1 |
| 20 | Molecular characterization of fluoroquinolone resistance in Mycobacterium tuberculosis: functional analysis of gyrA mutation at position 74 显示文摘 | Lau R W Ho P L Kao R Y | 2011 | Antimicrob Agents Chemother2011，55，2： | 1 |
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