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| 1 | New advances in targeted gastric cancer treatment显示文摘Despite a decrease in incidence over past decades,gastric cancer remains a major global health problem. In the more recent period, survival has shown only minor improvement, despite significant advances in diagnostic techniques, surgical and chemotherapeutic approaches, the development of novel therapeutic agents and treatment by multidisciplinary teams. Because multiple genetic mutations, epigenetic alterations, and aberrant molecular signalling pathways are involved in the development of gastric cancers, recent research has attempted to determine the molecular heterogeneity responsible for the processes of carcinogenesis, spread and metastasis. Currently, some novel agents targeting a part of these dysfunctional molecular signalling pathways have already been integrated into the standard treatment of gastric cancer, whereas others remain in phases of investigation within clinical trials. It is essential to identify the unique molecular patterns of tumours and specific biomarkers to develop treatments targeted to the individual tumour behaviour. This review analyses the global impact of gastric cancer, as well as the role of Helicobacter pylori infection and the efficacy of bacterial eradication in preventing gastric cancer development. Furthermore, the paper discusses the currently available targeted treatments and future directions of research using promising novel classes of molecular agents for advanced tumours. | Daniela Cornelia Lazar Sorina Taban Marioara Cornianu Alexandra Faur Adrian Goldis | 2016 | World Journal of Gastroenterology2016，22，30： | 15 |
| 2 | Stem cell-derived exosomes-an emerging tool for myocardial regeneration显示文摘Cardiovascular diseases(CVDs) continue to represent the number one cause of death and disability in industrialized countries. The most severe form of CVD is acute myocardial infarction(AMI), a devastating disease associated with high mortality and disability. In a substantial proportion of patients who survive AMI, loss of functional cardiomyocytes as a result of ischaemic injury leads to ventricular failure, resulting in significant alteration to quality of life and increased mortality. Therefore, many attempts have been made in recent years to identify new tools for the regeneration of functional cardiomyocytes. Regenerative therapy currently represents the ultimate goal for restoring the function of damaged myocardium by stimulating the regeneration of the infarcted tissue or by providing cellsthat can generate new myocardial tissue to replace the damaged tissue. Stem cells(SCs) have been proposed as a viable therapy option in these cases. However, despite the great enthusiasm at the beginning of the SC era, justified by promising initial results, this therapy has failed to demonstrate a significant benefit in large clinical trials. One interesting finding of SC studies is that exosomes released by mesenchymal SCs(MSCs) are able to enhance the viability of cardiomyocytes after ischaemia/reperfusion injury, suggesting that the beneficial effects of MSCs in the recovery of functional myocardium could be related to their capacity to secrete exosomes. Ten years ago, it was discovered that exosomes have the unique property of transferring miRNA between cells, acting as miRNA nanocarriers. Therefore, exosomebased therapy has recently been proposed as an emerging tool for cardiac regeneration as an alternative to SC therapy in the post-infarction period. This review aims to discuss the emerging role of exosomes in developing innovative therapies for cardiac regeneration as well as their potential role as candidate biomarkers or for developing new diagnostic tools. | Erzsebet Lazar Theodora Benedek Szilamer Korodi Nora Rat Jocelyn Lo Imre Benedek | 2018 | World Journal of Stem Cells2018，10，8： | 12 |
| 3 | Adalimumab Induces and Maintains Clinical Remission in Patients With Moderate-to-Severe Ulcerative Colitis显示文摘 | William J. Sandborn Gert van Assche Walter Reinisch Jean–Frederic Colombel Geert D’Haens Douglas C. Wolf Martina Kron Mary Beth Tighe Andreas Lazar Roopal B. Thakkar | 2012 | Gastroenterology2012，，2： | 9 |
| 4 | Malignant hepatic vascular tumors in adults: Characteristics,diagnostic difficulties and current management显示文摘Malignant vascular tumors of the liver include rare primary hepatic mesenchymal tumors developed in the background of a normal liver parenchyma. Most of them are detected incidentally by the increased use of performing imaging techniques. Their diagnosis is challenging, involving clinical and imaging criteria, with final confirmation by histology and immunohistochemistry. Surgery represents the mainstay of treatment. Liver transplantation(LT) has improved substantially the prognosis of hepatic epithelioid hemangioendothelioma(HEHE), with 5-year patient survival rates of up to 81%, based on the European Liver Intestine Transplantation AssociationEuropean Liver Transplant Registry study. Unfortunately, the results of surgery and LT are dismal in cases of hepatic angiosarcoma(HAS). Due to the disappointing results of very short survival periods of approximately 6-7 mo after LT, because of tumor recurrence and rapid progression of the disease, HAS is considered an absolute contraindication to LT. Recurrences after surgical resection are high in cases of HEHE and invariably present in cases of HAS. The discovery of reliable prognostic markers and the elaboration of prognostic scores following LT are needed to provide the best therapeutic choice for each patient.Studies on a few patients have demonstrated the stabilization of the disease in a proportion of patients with hepatic vascular tumors using novel targeted antiangiogenic agents, cytokines or immunotherapy. These new approaches,alone or in combination with other therapeutic modalities, such as surgery and classical chemotherapy, need further investigation to assess their role in prolonging patient survival. Personalized therapeutic algorithms according to the histopathological features, behavior, molecular biology and genetics of the tumors should be elaborated in the near future for the management of patients diagnosed with primary malignant vascular tumors of the liver. | Daniela Cornelia Lazar Mihaela Flavia Avram Ioan Romosan Violetta Vacariu Adrian Goldis Marioara Cornianu | 2019 | World Journal of Clinical Oncology2019，10，3： | 7 |
| 5 | The hormone resistin links obesity to diabetes显示文摘 | Steppan CM Bailey ST Bhat S Brown EJ Banerjee RR Wright CM Patel HR Ahima RS Lazar MA | | 0，，： | 6 |
| 6 | Adalimumab Induces and Maintains Mucosal Healing in Patients With Crohn’s Disease: Data From the EXTEND Trial显示文摘 | Paul Rutgeerts Gert Van Assche William J. Sandborn Douglas C. Wolf Karel Geboes Jean–Frédéric Colombel Walter Reinisch Ashish Kumar Andreas Lazar Anne Camez Kathleen G. Lomax Paul F. Pollack Geert D’Haens | 2012 | Gastroenterology2012，，5： | 4 |
| 7 | A resilience-based approach in managing the closure and abandonment of large mine tailing ponds显示文摘Mining tailing ponds are large infrastructure objects whose life cycle spans over several decades.They are indispensable for certain types of mines where technological process produces and rejects mud.They also have potential to generate risks for human life,property and environment.For that reason,it is essential to adequately manage them throughout all the stages of their life cycle.The phase of their closure and abandonment is less studied and understood.The paper proposes a holistic resilience-based approach for analyzing this phase of their life cycle.The proposed methodology is validated through a case study at an actual surface iron ore mine in Bosnia and Herzegovina. | Dragan Komljenovic Lazar Stojanovic Vladimir Malbasic Aleksandar Lukic | 2020 | International Journal of Mining Science and Technology2020，30，5： | 4 |
| 8 | Therapeutic Potentials of Oroxylum indicum Bark Extracts显示文摘AIM:Diverse therapeutic potentials of methanolic and aqueous extracts of Oroxylum indicum(L.)Vent.bark,includ- ing antioxidant property,cytotoxicity and protection against oxidative DNA damage were investigated in this study.METHODS:Total phenolics in the extracts were determined by spectrophotometric method.Ferric reducing antioxidant property(FRAP),free radical (DPPH·and ·OH)scavenging activities,as well as inhibitory effect on lipid peroxidation have been investigated.Cytotoxicity of the extracts was investigated by XTT assay in MDA-MB-435S and Hep3B cell lines.Protection of DNA by the extracts against oxidative damage by UV-photolysis of H2O2 was studied.RESULTS:Total phenolic content and inhibition of lipid peroxidation in both extracts were found to be dosage-dependent.Moreover,both extracts exhibited considerable free radical scavenging and ferric reducing abili- ties.The extracts demonstrated extensive cytotoxicity in both tested cell lines,with the methanolic extract showing greater cytotoxic potential.Both extracts exhibited moderate levels of DNA protection against oxidative stress.Total phenolic content was noted to have significant positive correlations with free radical scavenging and reducing power,as well as lipid peroxidation inhibition(P<0.05). CONCLUSIONS:These results indicate that O.indicum bark extracts possess diverse biological activities in vitro and could render itself as a prospective candidate for drug research. | R.Ashok Kumar V.Rajkumar Gunjan Guha Lazar Mathew | 2010 | 中国天然药物2010，8，2： | 4 |
| 9 | 中国和南斯拉夫异地育种对南斯拉夫玉米群体改良的效果显示文摘198 5~ 1997年对南斯拉夫玉米群体SYN1/9C0 进行半同胞轮回选择。 1998年在唐山对C1~C6和在贝尔格莱德对C4~C6等共计 10个轮回群体与 4个标准自交系进行半双列杂交研究。两年的试验结果表明 ,群体产量和杂交组合产量以及杂种优势、配合力和田间部分性状一般配合力均存在显著差异 ,南斯拉夫和唐山两地改良效果极具互补性。实验还表明 ,中国、南斯拉夫异地育种在提高南斯拉夫玉米群体自身产量、杂交组合产量的同时 ,能更为有效地提升群体杂种优势 ,使产量特殊配合力、一般配合力同时提高。 | 谢振江 张锦芬 Lazar Kojic | 2001 | 南京农业大学学报2001，24，3： | 4 |
| 10 | Restless legs syndrome is contributing to fatigue and low quality of life levels in hemodialysis patients显示文摘AIM To examine whether hemodialysis(HD) patients with restless legs syndrome(RLS) are subjects of greater fatigue and impaired quality of life(QoL) compared to HD patients without RLS.METHODS Eighty five stable HD patients participated in this study. According to their RLS status, the patients were dividedinto the RLS group(n = 23) and the non-RLS group(n = 62). QoL, fatigue, sleep quality, daily sleepiness and depression symptoms were assessed by using various questionnaires. Finally, biochemical parameters including iron, ferritin, hemoglobin, hematocrit and parathormone were assessed. RESULTS The HD patients with RLS scored worse in all the questionnaires used in the study(P < 0.05). The patients with RLS were more likely to receive the HD therapy on the morning shift, whilst 43.5% of the RLS patients reported to experience the RLS symptoms also during HD. The severity of RLS was correlated with fatigue, depression score and sleep quality(P < 0.05). CONCLUSION HD patients with RLS are subject to lower QoL related parameters and greater fatigue compared to HD patients without RLS. RLS should be successfully managed in order to improve the QoL of the sufferers. | Christoforos D Giannaki Michael Hadjigavriel Akis Lazarou Aristos Michael Loukas Damianou Efthimios Atmatzidis Ioannis Stefanidis Georgios M Hadjigeorgiou Giorgos K Sakkas Marios Pantzaris | 2017 | World Journal of Nephrology2017，6，5： | 3 |
| 11 | Wavelet-based video coder via bit allocation显示文摘 | LAZAR D AVERBUCH A | 2001 | IEEE Transactions on Circuits and Systems for Video Technology2001，11，7： | 2 |
| 12 | Predictors of rebleeding and in-hospital mortality in patients with nonvariceal upper digestive bleeding显示文摘BACKGROUND Nonvariceal upper digestive bleeding (NVUDB) represents a severe emergency condition and is associated with significant morbidity and mortality. Despite a decrease in the incidence due to the widespread use of potent therapy with proton pump inhibitors as well as the implementation of modern endoscopic techniques, the mortality rate associated with NVUDB is still high. AIM To identify the clinical, biological, and endoscopic parameters associated with a poor outcome in patients with NVUDB to allow the stratification of risk, which will lead to the implementation of the most accurate management. METHODS We performed a retrospective study including patients who were admitted to the Gastroenterology Department of Clinical Emergency County Hospital Timisoara, Romania, with a diagnosis of NVUDB between 1 January 2008 and 31 December 2016. All the data were collected from the patient’s records, including demographic data, medication history, hemodynamic status, paraclinical tests, and endoscopic features as well as the methods of hemostasis, rate of rebleeding, need for surgery and death;we also assessed the Rockall score of the patients, length of hospitalization and associated comorbidities. All these parameters were evaluated as potential risk factors associated with rebleeding and death in patients with NVUDB.RESULTS We included a batch of 1581 patients with NVUDB, including 523 (33%) females and 1058 (67%) males with a median age of 66 years. The main cause of NVUDB was peptic ulcer (73% of patients). More than one-third of the patients needed endoscopic treatment. Rebleeding rate was 7.72%;surgery due to failure of endoscopic hemostasis was needed in 3.22% of cases;the in-hospital mortality rate was 8.09%, and the bleeding-episode-related mortality rate was 2.97%. Although our predictive models for rebleeding and death had a low sensitivity, the specificity was very high, suggesting a better discriminative capacity for identifying patients with better outcomes. Our results showed that the Rockall score was associated with both rebleeding and death;comorbidities such as respiratory conditions, liver cirrhosis and sepsis increased significantly the risk of in-hospital mortality (OR of 3.29, 2.91 and 8.03). CONCLUSION Our study revealed that the Rockall score, need for endoscopic therapy, necessity of transfusion and sepsis were risk factors for rebleeding. Moreover, an increased Rockall score and the presence of comorbidities were predictive factors for inhospital mortality. | Daniela Cornelia Lazar Sorin Ursoniu Adrian Goldis | 2019 | World Journal of Clinical Cases2019，7，18： | 2 |
| 13 | New developments in adipogenesis显示文摘 | Martina I. Lefterova Mitchell A. Lazar | 2009 | Trends in Endocrinology & Metabolism2009，，3： | 2 |
| 14 | Thyroid hormone stimulates hepatic lipid catabolism via activation of autophagy显示文摘 | Sinha Rohit Anthony You Seo-Hee Zhou Jin Siddique Mobin M Bay Boon-Huat Zhu Xuguang Privalsky Martin L Cheng Sheue-Yann Stevens Robert D Summers Scott A Newgard Christopher B Lazar Mitchell A Yen Paul M | 2012 | EN2012，，7： | 2 |
| 15 | Dendritic Cell-Based Vaccines Positively Impact Natural Killer and Regulatory T Cells in Hepatocellular Carcinoma Patients显示文摘 | Sarah M. Bray Lazar Vujanovic Lisa H. Butterfield E. Shevach | 2011 | Clinical and Developmental Immunology2011，，： | 2 |
| 16 | Aqueous extract of Phyllanthus amarus inhibits chromium(VI)-induced toxicity in MDA-MB-435S cells显示文摘 | Gunjan Guha V. Rajkumar R. Ashok Kumar Lazar Mathew | 2009 | Food and Chemical Toxicology2009，，1： | 2 |
| 17 | Resistin Is an Inflammatory Marker of Atherosclerosis in Humans显示文摘 | Muredach P. Reilly Michael Lehrke Megan L. Wolfe Anand Rohatgi Mitchell A. Lazar Daniel J. Rader | 2005 | Circulation2005，，7： | 2 |
| 18 | Resistin Is an Inflammatory Marker of Atherosclerosis in Humans显示文摘 | Muredach P. Reilly Michael Lehrke Megan L. Wolfe Anand Rohatgi Mitchell A. Lazar Daniel J. Rader | 2005 | Circulation2005，，7： | 2 |
| 19 | Exosomal microRNAs from mesenchymal stem/stromal cells: Biology and applications in neuroprotection显示文摘Mesenchymal stem/stromal cells(MSCs)are extensively studied as cell-therapy agents for neurological diseases.Recent studies consider exosomes secreted by MSCs as important mediators for MSCs’neuroprotective functions.Exosomes transfer functional molecules including proteins,lipids,metabolites,DNAs,and coding and non-coding RNAs from MSCs to their target cells.Emerging evidence shows that exosomal microRNAs(miRNAs)play a key role in the neuroprotective properties of these exosomes by targeting several genes and regulating various biological processes.Multiple exosomal miRNAs have been identified to have neuroprotective effects by promoting neurogenesis,neurite remodeling and survival,and neuroplasticity.Thus,exosomal miRNAs have significant therapeutic potential for neurological disorders such as stroke,traumatic brain injury,and neuroinflammatory or neurodegenerative diseases and disorders.This review discusses the neuroprotective effects of selected miRNAs(miR-21,miR-17-92,miR-133,miR-138,miR-124,miR-30,miR146a,and miR-29b)and explores their mechanisms of action and applications for the treatment of various neurological disease and disorders.It also provides an overview of state-of-the-art bioengineering approaches for isolating exosomes,optimizing their yield and manipulating the miRNA content of their cargo to improve their therapeutic potential. | Aida Nasirishargh Priyadarsini Kumar Lalithasri Ramasubramanian Kaitlin Clark Dake Hao Sabrina V Lazar Aijun Wang | 2021 | World Journal of Stem Cells2021，13，7： | 2 |
| 20 | A cluster-based power-efficient MAC protocol for event-driven sensing applications显示文摘 | LAZAROU G Y LI Jing PICONE J | 2007 | Ad hoc Networks2007，5，7： | 1 |
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