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| 1 | Report of an international workshop to standardize baseline evaluation and response criteria for primary CNS lymphoma.显示文摘 | Abrey LE Batchelor TT Ferreri A J Gospodarowicz M Pulczynski EJ Zucca E Smith JR Korfel A Soussain C DeAngelis LM Neuwelt EA O′Neill BP Thiel E Shenkier T Graus F van den Bent M Seymour JF Poortmans P Armitage JO Cavalli F | 2005 | 中国神经肿瘤杂志2005，3，3： | 53 |
| 2 | A Statistical Study on Seismo-Ionospheric Anomalies of the Total Electron Content for the Period of 56 M≥6.0 Earthquakes Occurring in China During 1998—2012显示文摘This paper reports statistical results of Seismo-Ionospheric Anomalies(SIAs) of the Total Electron Content(TEC) in the Global Ionosphere Map(GIM) associated with 56 M≥6.0 earthquakes in China during 1998—2012.To detect SIA,a quartile-based(i.e.median-based) process is performed.TEC anomalies for the period of earthquakes without being led by magnetic storms about 10 days are further isolated and examined to confirm the SIP existence.Results show that SIA is the TEC significantly decrease in the afternoon period 2—9 days before the earthquakes in China,which is in a good agreement with the SIA appearing before the 12 May 2008 M 8.0 Wenchuan earthquake. | Liu J Y Chen C H Tsai H F Le H | 2013 | 空间科学学报2013，33，3： | 7 |
| 3 | Genetic diversity of the hepatitis C virus: Impact and issues inthe antiviral therapy显示文摘The hepatitis C Virus (HCV) presents a high degree of genetic variability which is explained by the combination of a lack of proof reading by the RNA dependant RNA polymerase and a high level of viral replication. The re- sulting genetic polymorphism defines a classification in clades, genotypes, subtypes, isolates and quasispecies. This diversity is known to reflect the range of responses to Interferon therapy. The genotype is one of the pre- dictive parameters currently used to define the antiviral treatment strategy and the chance of therapeutic suc- cess. Studies have also reported the potential impact of the viral genetic polymorphism in the outcome of antivi- ral therapy in patients infected by the same HCV geno- type. Both structural and non structural genomic regions of HCV have been suggested to be involved in the Inter- feron pathway and the resistance to antiviral therapy. In this review, we first detail the viral basis of HCV diversity. Then, the HCV genetic regions that may be implicated in resistance to therapy are described, with a focus on the structural region encoded by the E2 gene and the non- structural genes NS3, NS5A and NS5B. Both mechanisms of the Interferon resistance and of the new antiviral drugs are described in this review. | H Le Guillou-Guillemette S Vallet C Gaudy-Graffin C Payan A Pivert A Goudeau F Lunel-Fabiani | 2007 | World Journal of Gastroenterology2007，13，17： | 6 |
| 4 | An ORF2 protein-based ELISA for porcine circovirus type 2 antibodies in post-weaning multisystemic wasting syndrome显示文摘 | Ph Blanchard D Mahé R Cariolet C Truong M Le Dimna C Arnauld N Rose E Eveno E Albina F Madec A Jestin | 2003 | Veterinary Microbiology2003，，3： | 2 |
| 5 | A competitive ELISA for the specific diagnosis of contagious bovine pleuropneumonia (CBPP) 显示文摘 | Le Goff C Thiaucourt F | 1998 | Vet Microbiol1998，60，： | 2 |
| 6 | 胚胎巨噬细胞和小胶质细胞消融调控小鼠胚胎背根神经节感觉神经元的发育显示文摘众所周知,小胶质细胞可以调节中枢神经系统发育的一些方面。在第11.5天的小鼠胚胎中的小胶质细胞定殖脊髓时,它们与背根神经节感觉神经元(SN)的生长中心轴突相互作用,这表明它们可能在SN发育中发挥一定功能。为了解决这个问题,我们使用缺乏胚胎巨噬细胞(PU.1敲除小鼠)和免疫细胞消融的小鼠胚胎分析胚胎巨噬细胞消融对SNs早期发育的影响。我们发现,除小胶质细胞外,胚胎巨噬细胞还与来自第11.5天的小鼠胚胎的原肌球蛋白受体激酶(Trk)C+感觉神经元,TrkB+感觉神经元和TrkA+感觉神经元外周神经突产生交联。免疫细胞剥夺会导致第11.5天的小鼠胚胎的TrkC+感觉神经元和TrkB+感觉神经元初始数量的减少,这与其发育细胞死亡(DCD)的改变有关联的可能性较小,因为其后在第12.5天的胚胎中的数量有短暂增加。在分析的发育期(第11.5~15.5天),它也导致TrkA+感觉神经元数量减少,尽管我们没有观察到他们的DCD有任何变化。与神经元祖细胞可能存在一致性的脑脂肪酸结合蛋白(BFABP-)阴性细胞的增殖在第11.5天的胚胎中增加,而它们的增殖在第12.5天的胚胎减少,这可部分解释从11.5 d观察到的SN亚型产生的改变。此外,我们观察到在缺乏胚胎巨噬细胞的情况下神经胶质细胞祖细胞(BFABP+细胞)增殖的改变。我们的数据表明,胚胎巨噬细胞和小胶质细胞消融调控SN的发育。 | Angelim MKSC Maia LMSS Mouffle C Ginhoux F Low D Amancio-Dos-Santos A Makhoul J Le Corronc H Mangin JM Legendre P 聂昊(编译) | 2018 | 神经损伤与功能重建2018，13，9： | 2 |
| 7 | Competition between fusion-evaporation and multifragmentation in central collisions in ^(58)Ni+^(48)Ca at 25A MeV显示文摘The experimental data concerning the58Ni+48Ca reaction at Elab(Ni)=25A MeV,collected by using the CHIMERA 4π device,have been analyzed in order to investigate the competition among different reaction mechanisms for central collisions in the Fermi energy domain.As a main criterion for centrality selection we have chosen the flow angle(flow) method,making an event-by-event analysis that considers the shape of events,as it is determined by the eigenvectors of the experimental kinetic-energy tensor.For the selected central events(flow >60°) some global variables,good to characterize the pattern of central collisions have been constructed.The main features of the reaction products were explored by using different constraints on some of the relevant observables,like mass and velocity distributions and their correlations.Much emphasis was devoted,for central collisions,to the competition between fusion-evaporation processes with subsequent identification of a heavy residue and a possible multifragmentation mechanism of a well defined(if any) transient nuclear system.Dynamical evolution of the system and pre-equilibrium emission were taken into account by simulating the reactions in the framework of transport theories.Different approaches have been envisaged(dynamical stochastic BNV calculations + sequential SIMON code,QMD,CoMD,etc.).Preliminary comparison of the experimental data with BNV calculations shows reasonable agreement with the assumption of sequential multifragmentation emission in the mass region of IMFs close to the heavy residues.Possible deviations from sequential processes were found for those IMFs in the region of masses intermediate between the mass of heavy residues and the mass of light IMFs.Further simulations are in progress.The experimental analysis will be enriched also by information obtained inspecting the IMF-IMF correlation function,in order to elucidated the nature of space-time decay property of the emitting source associated with events having the largest IMF multiplicity. | FRANCALANZA L ABBONDANNO U AMORINI F BARLINI S BINI M BOUGAULT R BRUNO M CARDELLA G CASINI G AGOSTINO M D' De FILIPPO V De SANCTIS J GERACI E GIUSSANI A GRAMEGNA F GUIOT B KRAVCHUK V La GUIDARA E LANZALONE G Le NEINDRE N MAIOLINO C MARINI P MORELLI L OLMI A PAGANO A PAPA M PIANTELLI S PIRRONE S POLITI G POGGI G PORTO F RUSSOTTO P RIZZO F VANNINI G VANNUCCI L | 2013 | Nuclear Science and Techniques2013，24，5： | 2 |
| 8 | Diffusion tensor imaging:concepts and applications 显示文摘 | Le Bihan D Mangin J F Poupon C | 2001 | J Magn Reson Imaging2001，13，4： | 1 |
| 9 | Proteomics-based identification of RS/DJ-1 as a novel circulating tumor antigen in breast cancer显示文摘 | le NAOUR F MISEK D E KRAUSE M C | 2001 | Clin Cancer Res2001，7，11： | 1 |
| 10 | Endurance and strength training effects on physiological and muscular parameters during prolonged cycling显示文摘 | HAUSSWIRTH C ARGENTIN F LE M | | 0，，： | 1 |
| 11 | FES99: A global tide finite element solution assimilating tide gauge and altimetric information 显示文摘 | Lefevre F Lyard F H Le Provost C | 2002 | Journal of Atmospheric and Oceanic Technology2002，19，9： | 1 |
| 12 | Behavioral and neuroendocrine effects of the exposure to chronic restraint or variable stress in early adolescent rats显示文摘 | CRUZ F C MARIN M T LE ~O R M | 2012 | International Journal of Developmental Neuroscience2012，30，1： | 1 |
| 13 | Causes and mechanisms of cerebellar infarction in young patients显示文摘 | Barinagarrementeria F Amaya LE Cantu C | 1997 | Stroke1997，28，12： | 1 |
| 14 | Mechanism of actin-based motility 显示文摘 | Pantaloni D Le Clainche C Carlier M F | 2001 | Science2001，292，5521： | 1 |
| 15 | Capacity of myeloid and plasmacytoid dendritic cells especially at mature stage to express and secrete HLA - G molecules 显示文摘 | Le Friec G Gins F Sebti Y Guilloux V Panganlt C Fauchet R Amiot L | 2004 | J Leukoc Biol2004，76，6： | 1 |
| 16 | Comparison between different LiFePO4 synthesis routes and their influence on its physico-chemical properties 显示文摘 | Franger S Le C F Bourgbon C | 2003 | Joumal Power Sources2003，119，： | 1 |
| 17 | Copy number variations in chronic pancreatitis显示文摘 | Chen J M Masson E Le Maréchal C Férec C | 2009 | Cytogenetic and Genome Research (-)2009，，1： | 1 |
| 18 | High speed train noise emission: latest investigation of the aerodynamic/ rolling noise contribution显示文摘 | Mellet C Le tourneaux F Poisson F | 2006 | Journal of Sound and Vibration2006，293，55： | 1 |
| 19 | Antitumor effects of clinical dosing regimens of bisphosphonates in experimental breast cancer bone metastasis显示文摘 | Daubiné F Le Gall C Gasser J | 2007 | J Natl Cancer Inst2007，99，4： | 1 |
| 20 | DDT-induced oxidative damage in human blood mononuclear cells 显示文摘 | Pérez-Maldonado IN Herrera C Batres LE González-Amaro R Díaz-Barriga F Yá?ez L | 2005 | Environ Res2005，98，2： | 1 |
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