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| 1 | Contribution of functional KIR3DL1 to ankylosing spondylitis显示文摘Increasing evidence points to a role for killer immunoglobulin-like receptors(KIRs)in the development of autoimmune diseases.In particular,a positive association of KIR3DS1(activating receptor)and a negative association of KIR3DL1(inhibitory receptor)alleles with ankylosing spondylitis(AS)have been reported by several groups.However,none of the studies analyzed these associations in the context of functionality of polymorphic KIR3DL1.To better understand how the KIR3DL1/3DS1 genes determine susceptibility to AS,we analyzed the frequencies of alleles and genotypes encoding functional(KIR3DL1*F)and non-functional(KIR3DL1*004)receptors.We genotyped 83 AS patients and 107 human leukocyte antigen(HLA)-B27-positive healthy controls from the Russian Caucasian population using a two-stage sequence-specific primer PCR,which distinguishes KIR3DS1,KIR3DL1*F and KIR3DL1*004 alleles.For the patients carrying two functional KIR3DL1 alleles,those alleles were additionally genotyped to identify KIR3DL1*005 and KIR3DL1*007 alleles,which are functional but are expressed at low levels.KIR3DL1 was negatively associated with AS at the expense of KIR3DL1*F but not of KIR3DL1*004.This finding indicates that the inhibitory KIR3DL1 receptor protects against the development of AS and is not simply a passive counterpart of the segregating KIR3DS1 allele encoding the activating receptor.However,analysis of genotype frequencies indicates that the presence of KIR3DS1 is a more important factor for AS susceptibility than the absence of KIR3DL1*F.The activation of either natural killer(NK)or T cells via the KIR3DS1 receptor can be one of the critical events in AS development,while the presence of the functional KIR3DL1 receptor has a protective effect.Nevertheless,even individuals with a genotype that carried two inhibitory KIR3DL1 alleles expressed at high levels could develop AS. | Ivan V Zvyagin Ilgar Z Mamedov Olga V Britanova Dmitriy B Staroverov Evgeni L Nasonov Anna G Bochkova Anna V Chkalina Alexei A Kotlobay Dmitriy O Korostin Denis V Rebrikov Sergey Lukyanov Yuri B Lebedev Dmitriy M Chudakov | 2010 | Cellular & Molecular Immunology2010，7，6： | 5 |
| 2 | Transesterification of rapeseed oil under fiow conditions catalyzed by basic solids: M - AI(La) -O (M =Sr, Ba), M-Mg-O (M=Y, La) 显示文摘 | SHERSTYUK O V IVANOVA A S LEBEDEV M Y | 2012 | Appl Catal A- Gen2012，，： | 1 |
| 3 | Chronic asympto-matic hyperuricemia as a marker of atherogenic risk in children 显示文摘 | Maliavskaia S I Lebedev A V Temovskaia V A | 2007 | Kardiologiia2007，47，3： | 1 |
| 4 | The phylogeny and systematics of the endemic Ethiopian Lophuromys flavopunctatus species complex based upon random amplified polymorphic DNA (RAPD) analysis显示文摘 | Lavrenchenko L A Potapov S G Lebedev V S | 2001 | Bioch Syst Ecol2001，29，11： | 1 |
| 5 | Cold Crucible Inductive Melting Technology Application to Vitrification and Ceramization of High Level and Actinide Wastes显示文摘 | Stefanovsky S V Lebedev V V Ptashkin A G | 2010 | Advances in Science and Technology2010，73，： | 1 |
| 6 | Plasma formation and implosion structure in wire array Z pinches显示文摘 | Chittenden J P LebedevS V Bell A R | 1999 | PhysRev Lett1999，83，： | 1 |
| 7 | Crossed products by endomorphisms and reduction of relations in relative Cuntz-Pimsner algebras显示文摘 | Kwasniewski B K Lebedev A V | 2013 | J Func Anal2013，264，： | 1 |
| 8 | OXYS rats as a model of senile cataract显示文摘 | KOLOSOVA N G LEBEDEV P A AIDAGULOVA S V | 2003 | Bull Exp Biol Med2003，136，41： | 1 |
| 9 | DLTS study of defects in 6H- and 4H-SiC created by proton irradiation显示文摘 | Davedov D V Lebedev A A Kozlovski V V | 2001 | Physica2001，13，308： | 1 |
| 10 | Reaction of hexamethyldisilthiane with inorganic and carboxylic acids显示文摘 | LEBEDEV E P REISFELD V O BABURINA V A | | 0，，04： | 1 |
| 11 | Effect of trailing mass on scaling of X-ray power in wire array Z-pinches显示文摘 | Lebedev S V Hammer D A Cuneo M E | 2006 | AIP Conf Proc2006，808，： | 1 |
| 12 | Single-phase Weld-ing Current Power Sources for Mechanised Carbon Dioxide Welding显示文摘 | Lebedev V A Romanyuk V S | 2004 | Welding International2004，18，6： | 1 |
| 13 | X-ray generation mechanisms in three-dimensional simulations of wire array Z-pinches显示文摘 | Chittenden J P Lebedev S V Jennings C A | 2004 | Plasma Phys Control Fusion2004，46，12： | 1 |
| 14 | Synthesis and N-alkylation of 2-alkyl- and 2-arylimidazole-4,5-dicarbox- ylic acid esters 显示文摘 | Lebedev A V Lebedeva A B Sheludyakov V D | 2007 | Russ J Gen Chem2007，77，5： | 1 |
| 15 | Classification and control of the origin of photoluminescence from Si nanocrystals显示文摘 | Godefroo S Hayne M Jivanescu M Stesmans A Zacharias M Lebedev O I Van Yendeloo G Moshchalkov V V | | 0，，03： | 1 |
| 16 | Self-organization of sulfonated polystyrene ionomers in low-polarity solvents显示文摘 | LEBEDEV V T MEL' NIKOV A B VINOGRADOVA L V | 2010 | Polymer Science Series C2010，52，1： | 1 |
| 17 | Seasonal variability of physical-mechanlcal characteristics of sea ice显示文摘 | GAVRILO V P LEBEDEV G A FEDOTOV V I | 1991 | International Journal of Offshore and Polar Engineering1991，1，1： | 1 |
| 18 | Genetic divergence and phylogeny of the Salmoninae based on allozyme data显示文摘 | Osinov A G Lebedev V S | 2000 | Fish Biol2000，57，： | 1 |
| 19 | Trends in increasing gas-turbine units efficiency 显示文摘 | Lebedev A S Kostennikov S V | 2008 | Thermal Engineering2008，55，6： | 1 |
| 20 | X-ray generation mechanisms in three-dimensional simulations of wire array Z-pinches显示文摘 | CHITTENDEN J P LEBEDEV S V JENNINGS C A | 2004 | Plasma Phys Control Fusion2004，46，12： | 1 |
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