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| 1 | Irritable bowel syndrome: Pathogenesis, diagnosis, treatment, and evidence-based medicine显示文摘Irritable bowel syndrome(IBS)is a chronic and debilitating functional gastrointestinal disorder that affects9%-23%of the population across the world.The percentage of patients seeking health care related to IBS approaches 12%in primary care practices and is by far the largest subgroup seen in gastroenterology clinics.It has been well documented that these patients exhibit a poorer quality of life and utilize the health care system to a greater degree than patients without this diagnosis.The pathophysiology of IBS is not clear.Many theories have been put forward,but the exact cause of IBS is still uncertain.According to the updated ROMEⅢcriteria,IBS is a clinical diagnosis and presents as one of the three predominant subtypes:(1)IBS with constipation(IBS-C);(2)IBS with diarrhea(IBS-D);and(3)mixed IBS(IBS-M);former ROME definitions refer to IBS-M as alternating IBS(IBS-A).Across the IBS subtypes,the presentation of symptoms may vary among patients and change over time.Patients report the most distressing symptoms to be abdominal pain,straining,myalgias,urgency,bloating and feelings of serious illness.The complexity and diversity of IBS presentation makes treatment difficult.Although there are reviews and guidelines for treating IBS,they focus on the efficacy of medications for IBS symptoms usinghigh-priority endpoints,leaving those of lower priority largely unreported.Therefore,the aim of this review is to provide a comprehensive evidence-based review of the diagnosis,pathogenesis and treatment to guide clinicians diagnosing and treating their patients. | Lekha Saha | 2014 | World Journal of Gastroenterology2014，20，22： | 65 |
| 2 | 肺结核病人低发现率的社会、经济影响因素研究显示文摘目的 找出重庆地区肺结核病人低发现率的社会经济影响因素,为提出有效的、适合重庆地区的病人发 现模式提供依据,努力提高病人发现水平。方法 本次研究主要采用了个人深入访谈、专题小组讨论、问题分析和矩阵 排序等多种定性研究的方法,对包括结核病现症病人、一般居民、结防专业机构的医护人员等进行了采访。结果 结核 病健康教育和宣传不足、结防专业机构实验室痰涂片检查能力不强、乡村医生业务素质不高等因素影响了肺结核病人的 发现工作。结论 必须采取有效的措施,加大宣传力度,普及防痨知识及落实有关防治政策;增加政府投入,加强结防专 业机构自身的建设;加强对基层医务人员的专业培训,才能够真正提高病人发现率。 | 汪洋 陈静 李颖 胡代玉 Lekha Gurung | 2005 | 中国卫生事业管理2005，21，1： | 22 |
| 3 | Photoanode Activity of ZnO Nanotube Based Dye-Sensitized Solar Cells显示文摘Vertical ZnO nanotube (ZNT) arrays were synthesized onto an indium doped tin oxide (ITO) glass substrate by a simple electrochemical deposition technique followed by a selective etching process. Scanning electron microscopy (SEM) showed formation of well-faceted hexagonal ZNT arrays spreading uniformly over a largearea. X-ray diffraction (XRD) of ZNT layer showed substantially higher intensity for the (0002) diffractionpeak, indicating that the ZnO crystallites were well aligned with their c-axis. Profilometer measurements ofthe ZNT layer showed an average thickness of ~7 μm. Diameter size distribution (DSD) analysis showedthat ZNTs exhibited a narrow diameter size distribution in the range of 65–120 nm and centered at ~75nm. The photoluminescence (PL) spectrum measurement showed violet and blue luminescence peaks thatwere centered at 410 and 480 nm, respectively, indicating the presence of internal defects. Ultra-violet (UV)spectroscopy showed major absorbance peak at ~348 nm, exhibiting an increase in energy gap value of 3.4 eV.By employing the formed ZNTs as the photo-anode for a dye-sensitized solar cell (DSSC), a full-sun conversion efficiency of 1.01% was achieved with a fill factor of 54%. Quantum efficiency studies showed the maximumof incident photon-to-electron conversion efficiency in a visible region located at 520–550 nm range. | R. Ranjusha P. Lekha K.R.V. Subramanian V. Nair Shantikumar A. Balakrishnan | 2011 | Journal of Materials Science & Technology2011，27，11： | 4 |
| 4 | 定性研究方法在肺结核病人发现研究中的应用显示文摘目的:运用定性研究方法找出重庆地区肺结核病人低发现率的主要影响因素,为提出有效的病人发现模式提供依据,提高病人发现率。方法:采用了问题分析和矩阵排序、个人深入访谈、专题小组讨论等多种定性研究的方法,对包括结防专业机构的医护人员、结核病现症病人等进行了采访。结果:政府财政投入不足、高危人群筛查工作开展不足、医疗费用过高、交通不便等因素是制约重庆市结核病人发现工作的主要因素,其中政府财政投入不足影响最大。结论:采用问题分析和矩阵排序的方法明确了不同的因素对病人发现的影响程度。只有更好地落实政府承诺,加强结防机构自身建设,定期开展高危人群的筛查工作及加强归口管理工作,才能够切实地提高病人发现水平。 | 陈静 汪洋 李颖 胡代玉 Lekha Gurung | 2006 | 现代预防医学2006，33，1： | 4 |
| 5 | Augmenting MNK1/2 activation by c-FMS proteolysis promotes osteoclastogenesis and arthritic bone erosion显示文摘Osteoclasts are bone-resorbing cells that play an essential role in homeostatic bone remodeling and pathological bone erosion.Macrophage colony stimulating factor(M-CSF)is abundant in rheumatoid arthritis(RA).However,the role of M-CSF in arthritic bone erosion is not completely understood.Here,we show that M-CSF can promote osteoclastogenesis by triggering the proteolysis of c-FMS,a receptor for M-CSF,leading to the generation of FMS intracellular domain(FICD)fragments.Increased levels of FICD fragments positively regulated osteoclastogenesis but had no effect on inflammatory responses.Moreover,myeloid cell-specific FICD expression in mice resulted in significantly increased osteoclast-mediated bone resorption in an inflammatory arthritis model.The FICD formed a complex with DAP5,and the FICD/DAP5 axis promoted osteoclast differentiation by activating the MNK1/2/EIF4E pathway and enhancing NFATcl protein expression.Moreover,targeting the MNK1/2 pathway diminished arthritic bone erosion.These results identified a novel role of c-FMS proteolysis in osteoclastogenesis and the pathogenesis of arthritic bone erosion. | Se Hwan Mun Seyeon Bae Steven Zeng Brian Oh Carmen Chai Matthew Jundong Kim Haemin Kim George Kalliolias Chitra Lekha Dahia Younseo Oh Tae-Hwan Kim Jong Dae Ji Kyung-Hyun Park-Min | 2021 | Bone Research2021，9，4： | 2 |
| 6 | Production and application of tanninacyl hydrolase:state of the art显示文摘 | Lekha PK Lonsane BK | 1997 | Advances in Applied Microbiology1997，44，： | 1 |
| 7 | Consolidation of Clays for Variable Permeability and Compressibility显示文摘 | LEKHA K R KRISHNASWAMY N R BASAK P | 2003 | Journal of Geotechnical and Geoenvironmental Engineering2003，129，11： | 1 |
| 8 | DNA profiling of disputed chilli samples (Capsicum annum )using ISSR-PCR and FISSR-PCR marker assays 显示文摘 | Lekha D Kurnar Kathirvel M Rao G V | 2001 | Forensic Science International2001，116，： | 1 |
| 9 | Production and application oftannin acyl hydrolase: state of the art显示文摘 | Lekha P K Lonsane B K | 1997 | Adv Appl Biochem Microbiol1997，44，： | 1 |
| 10 | Consolidation of clays for variable permeability and compressibility显示文摘 | LEKHA K KRISHNASWAMY N BASAK P | 2003 | Journal of Geotechnical and Geoenvironmental Engineering2003，129，11： | 1 |
| 11 | Co-overexperssion of p53 and bcl-2 proteins in HPV-induced squamous cell carcinoma of the uterine cervix 显示文摘 | Grace VM Shalini JV Lekha TT | 2003 | Gynecol Oncol2003，91，1： | 1 |
| 12 | Solid acid catalyzed biodiesel production from waste cooking oil显示文摘 | Kathlene Jacobson Rajesh Gopinath Lekha Charan Meher | 2008 | Environmental2008，85，12： | 1 |
| 13 | Consolidation of clays for variable permeability and compressibility显示文摘 | LEKHA K R KRISHNASWAMY N R BASAK P | 2003 | Journal of Geotechnical and Geoenvironmental Engineering ASCE2003，129，11： | 1 |
| 14 | Two-dimensional finite ele- ment analysis of stresses developed in the supporting tissues under complete dentures using teeth with different cusp angulations显示文摘 | Chowdhary R Lekha K Patil NP | 2008 | Gerodontology2008，25，3： | 1 |
| 15 | Field instrumentation and monitor- ing of soil erosion in coir geotextile stabilised slopes-A case study显示文摘 | Lekha K R | 2004 | Geotextiles and Geomem- branes2004，22，5： | 1 |
| 16 | Consolidation of clay by sand drain under time-dependent loading显示文摘 | LEKHA K R KRISHNASWAMY N R BASAK P | 1998 | Journal of Geotechnical and Geo-environmental Engineering ASCE1998，124，1： | 1 |
| 17 | Differential floral development and gene expression in grapevines during long and short photoperiods suggests a role for floral genes in dormancy transitioning显示文摘 | Lekha Sreekantan Kathy Mathiason Jér?me Grimplet Karen Schlauch Julie A. Dickerson Anne Y. Fennell | 2010 | Plant Molecular Biology2010，，1： | 1 |
| 18 | Synthesis,spectroscopic characterization and antibacterial studies oflanthanide(III) Schiff base complexes containing N, O donoratoms显示文摘 | Lekha L Kanmani Raja K Rajagopal G | 2014 | Journal of Molecular Structure2014，，： | 1 |
| 19 | DNA profiling of disputed chilli samples (Capsicum annum) using ISSR - PCR and FISSR- PCR marker assays 显示文摘 | Lekha D Kathirvel KM Rao GV | 2001 | Foren Sci Int2001，116，： | 1 |
| 20 | Ductal drainage with head coring in chronic pancreatitis with small-duct disease显示文摘 | Hariharan Ramesh George Jacob Vijayalakshmi Lekha Ambadi Venugopal | 2003 | Journal of Hepato - Biliary - Pancreatic Surgery2003，，5： | 1 |
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