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| 1 | Bone marrow mesenchymal stem cell therapy in ischemic stroke: mechanisms of action and treatment optimization strategies显示文摘Animal and clinical studies have confirmed the therapeutic effect of bone marrow mesenchymal stem cells on cerebral ischemia, but their mechanisms of action remain poorly understood. Here, we summarize the transplantation approaches, directional migration, differentiation, replacement, neural circuit reconstruction,angiogenesis, neurotrophic factor secretion, apoptosis, immunomodulation, multiple mechanisms of action,and optimization strategies for bone marrow mesenchymal stem cells in the treatment of ischemic stroke.We also explore the safety of bone marrow mesenchymal stem cell transplantation and conclude that bone marrow mesenchymal stem cell transplantation is an important direction for future treatment of cerebral ischemia. Determining the optimal timing and dose for the transplantation are important directions for future research. | Guihong Li Fengbo Yu Ting Lei Haijun Gao Peiwen Li Yuxue Sun Haiyan Huang Qingchun Mu | 2016 | Neural Regeneration Research2016，11，6： | 22 |
| 2 | Synthesis, bioactivity, action mode and 3D-QSAR of novel anthranilic diamide derivatives显示文摘To study the pesticide effect, action mode, structure-activity relationships (SARs) of anthranilic diamide insecticide and screen highly active pesticides, novel anthranilic diamide derivatives were synthesized.Bioassays indicated that all of the title compounds displayed 100% mortality against diamondback moth and oriental armyworm at 100 mg/L, among which 12 v and 12 w showed 100% insecticidal acitvity at 5 mg/L. Surprisingly compound 12 w exhibited better insecticidal acitvity than commercialized chlorantraniliprole against Pyrausta nubilalis (0.1 mg/L) and Cnaphalocrocis Medinalis (2 mg/L). 3 D-QSAR and SARs statistical analysis revealed that title compounds with R^2 fixed as methoxy had the highest probability possessing high activity. The calcium fluorescence measurements on neurons revealed that E series compounds containing pyrazinyl may have a molecular target different from caffeine on ryanodine receptors rather than the voltage-gated calcium channel present on cytomembran. | Weijie Liu Jiao Li Kai He Fangfang Huang Yi Ma Yuxin Li Qingshan Li Fengbo Xu | 2019 | Chinese Chemical Letters2019，30，2： | 4 |
| 3 | Effects of Rice-Fish Co-culture on Oxygen Consumption in Intensive Aquaculture Pond显示文摘Rice-fish co-culture has gained increasing attention to remediate the negative environmental impacts induced by intensive aquaculture. However, the effect of rice-fish co-culture on oxygen depletion has rarely been investigated. We constructed a rice-fish co-culture system in yellow catfish(Pelteobagrus fulvidraco) and freshwater shrimp(Macrobrachium nipponense) ponds using a new high-stalk rice variety, and conducted a field experiment to investigate the effect of rice-fish co-culture on water parameters and oxygen consumption. The results showed that rice-fish co-culture reduced the nutrients(total nitrogen, ammonia-N, total phosphorous and potassium) and the dissolved oxygen content in fish and shrimp ponds. However, they showed similar seasonal change of dissolved oxygen in the water of fish and shrimp ponds. Rice-fish co-culture reduced the total amount of oxygen consumption and optimized the oxygen consumption structure in pond. The respiration rates in water and sediment were significantly reduced by 66.1% and 31.7% in the catfish pond, and 64.4% and 38.7% in the shrimp pond, respectively, by additional rice cultivation. Rice-fish co-culture decreased the proportions of respiration in sediment and water, and increased the proportion of fish respiration. These results suggest that rice-fish co-culture is an efficient way to reduce hypoxia in intensive culture pond. | LI Fengbo SUN Zhiping QI Hangying ZHOU Xiyue XU Chunchun WU Dianxin FANG Fuping FENG Jinfei ZHANG Ning | 2019 | Rice science2019，26，1： | 4 |
| 4 | Impact of Rice-Catfish/Shrimp Co-culture on Nutrients Fluxes Across Sediment-Water Interface in Intensive Aquaculture Ponds显示文摘Exchange of nitrogen and phosphorus across sediment-water interface plays an important role in the management of nutrient recycling in the aquaculture pond. In this study, a plot experiment was conducted to study the effect of rice-catfish/shrimp co-culture on the micro-profile of oxygen (O2), pH and nutrient exchange across sediment-water interface in the intensive culture ponds. The results showed that rice-catfish co-culture increased the concentration and penetrating depth of O2, but decreased the pH value across the sediment-water interface, compared with catfish monoculture. Additional rice cultivation significantly reduced the flux rates of ammonium (NH4+) and nitrate (NO3-) across sediment-water interface in the catfish and shrimp ponds. The flux rates of NO2 - and soluble phosphorus (PO43-) showed no significant difference between rice-catfish/shrimp co-culture ponds and catfish/shrimp monoculture ponds. Rice only affected the dissolved inorganic nitrogen and phosphorus fractions in the sediment. The concentrations of NH4 + were significantly lower in the sediment of co-culture ponds than in the monoculture ponds. Additional rice cultivation also significantly reduced the content and percentage of dissolved inorganic phosphorus in the sediment of catfish ponds. | LIU Yaobin QIN Lin LI Fengbo ZHOU Xiyue XU Chunchun JI Long CHEN Zhongdu FENG Jinfei FANG Fuping | 2019 | Rice science2019，26，6： | 4 |
| 5 | Atomic and electronic basis for the serrations of refractory high-entropy alloys显示文摘Refractory high-entropy alloys present attractive mechanical properties,i.e.,high yield strength and fracture toughness,making them potential candidates for structural applications.Understandings of atomic and electronic interactions are important to reveal the origins for the formation of high-entropy alloys and their structure−dominated mechanical properties,thus enabling the development of a predictive approach for rapidly designing advanced materials.Here,we report the atomic and electronic basis for the valence−electron-concentration-categorized principles and the observed serration behavior in high-entropy alloys and highentropy metallic glass,including MoNbTaW,MoNbVW,MoTaVW,HfNbTiZr,and Vitreloy-1 MG(Zr_(41)Ti_(14)Cu_(12.5)Ni_(10)Be_(22.5)).We find that the yield strengths of high-entropy alloys and high-entropy metallic glass are a power-law function of the electron-work function,which is dominated by local atomic arrangements.Further,a reliance on the bonding-charge density provides a groundbreaking insight into the nature of loosely bonded spots in materials.The presence of strongly bonded clusters and weakly bonded glue atoms imply a serrated deformation of high-entropy alloys,resulting in intermittent avalanches of defects movement. | William Yi Wang Shun Li Shang Yi Wang Fengbo Han Kristopher A.Darling Yidong Wu Xie Xie Oleg N.Senkov Jinshan Li Xi Dong Hui Karin A.Dahmen Peter K.Liaw Laszlo J.Kecskes Zi-Kui Liu | 2017 | npj Computational Materials2017，，1： | 3 |
| 6 | Synthesis,bioactivities and 3D-QSAR of novel avermectin B2a aglycon derivatives显示文摘Fourteen avermectin B2 a aglycon derivatives were designed and synthesized after removing the oleandrose disaccharide of avermectin B2 a.Their structures were characterized by’H NMR,13 C NMR,HMRS.Preliminary bioassays indicated that these compounds exhibited good insecticidal activity against diamondback moth at 200 mg/L,with mortality no less than 90%.Compounds 10 b,12 a,12 c,17 demonstrated good acaricidal activity against the adult mites,larvae,and good inhibition rate of hatching to mite eggs of Tetranychus cinnabarinus.Compounds 5,10 b,10 c exhibited excellent fungicidal activity against fourteen fungal pathogens in vitro.3 D-QSAR analysis showed that the fungicidal activity of avermectin B2 a aglycon derivatives would be increased when a negatively charged and bulky group was introduced at 13-position,which will be instructive for the further modification of avermectin B2 aaglycon. | Fangfang Huang Huan Ling Jiao Li Sen Lu Weijie Liu Qingshan Li Fengbo Xu | 2020 | Chinese Chemical Letters2020，31，1： | 2 |
| 7 | Nanoporous photocatalysts developed through heat-driven stacking of graphitic carbon nitride nanosheets 显示文摘 | Huang Zhijun Li Fengbo Chen Bingfeng | 2015 | The Royal Society of Chemistry2015，5，14： | 1 |
| 8 | polymer-derived carbon-supported group ⅤⅢ metals catalysts for vapor phase carbonylation显示文摘 | Fengbo Li jun Huang jin Zou | 2003 | Applied Catalysis A:General2003，251，： | 1 |
| 9 | An efficient chemical reduction-induced assembly of Fe_(3)O_(4)@graphene fiber for wire-shaped supercapacitors with ultrahigh volumetric energy density显示文摘Benefiting from high flexibility and weavability,the wire-shaped supercapacitors(SCs)arouse tremendous interests for the applications in wearable/portable electronics.Graphene fiber(GF)is considered as a promising linear electrode for wire-shaped SCs.However,the bottleneck is how to develop the GF-based linear electrode with facile fabrication process while wellmaintaining satisfactory electrochemical performance.Herein,a novel Fe_(3)O_(4)@GF composite linear electrode is proposed via a chemical reduction-induced assembly approach,in which the GO and Fe_(3)O_(4) nanoparticles(NPs)realize the efficient selfassembly owing to the electrostatic and van der Waals interactions,as well as the sufficient reduction of GO during the preparation process.The resultant fiber-shaped architecture shows boosted charge-transfer kinetics,high flexibility and structural integrity.Such Fe_(3)O_(4)@GF linear electrode exhibits excellent electrochemical behaviors including a large volumetric specific capacitance(~250.75 F cm^(−3)),remarkable rate capability and favorable electrochemical kinetics in aqueous electrolyte,superior than previously reported GF-based linear electrodes.For real application,a high-performance wire-shaped SC with excellent flexibility and weavability is fabricated based on such Fe_(3)O_(4)@GF linear electrode and gel electrolyte,demonstrating ultrahigh volumetric energy density(18.8 mWh cm^(−3)),power density(4000 mW cm^(−3))and strong durability(~93.5%retention after 10000 cycles).Prospectively,the fabricated wire-shaped SC can maintain reliable electrochemical behaviors in various deformation states,showing its potentials in future portable and wearable devices. | XIAO Peng SHI MinJie XU Li TAO FengBo LI Yu ZHU HangTian LIU YuTing LI ZhiMin ZHOU YunPeng FENG Wei | 2021 | Science China(Technological Sciences)2021，64，10： | 1 |
| 10 | Polymer-derived carbon-supported Ⅷ group metals catalysts for vapor phase carbonylation of methanol显示文摘 | Li Fengbo Huang Jun Zou Jin | 2003 | Applied Catalysis A:General2003，251，： | 1 |
| 11 | Hydrophobic aerogel-modified hemostatic gauze with thermal management performance显示文摘Current hemostatic agents or dressings are not efficient under extremely hot and cold environments due to deterioration of active ingredients,water evaporation and ice crystal growth.To address these challenges,we engineered a biocompatible hemostatic system with thermoregulatory properties for harsh conditions by combining the asymmetric wetting nano-silica aerogel coated-gauze(AWNSA@G)with a layer-by-layer(LBL)structure.Our AWNSA@G was a dressing with a tunable wettability prepared by spraying the hydrophobic nano-silica aerogel onto the gauze from different distances.The hemostatic time and blood loss of the AWNSA@G were 5.1 and 6.9 times lower than normal gauze in rat’s injured femoral artery model.Moreover,the modified gauze was torn off after hemostasis without rebleeding,approximately 23.8 times of peak peeling force lower than normal gauze.For the LBL structure,consisting of the nano-silica aerogel layer and a n-octadecane phase change material layer,in both hot(70℃)and cold(-27℃)environments,exhibited dual-functional thermal management and maintained a stable internal temperature.We further verified our composite presented superior blood coagulation effect in extreme environments due to the LBL structure,the pro-coagulant properties of nano-silica aerogel and unidirectional fluid pumping of AWNSA@G.Our work,therefore,shows great hemostasis potential under normal and extreme temperature environments. | Xiaoli Jia Chao Hua Fengbo Yang Xiaoxiao Li Peng Zhao Feifan Zhou Yichi Lu Hao Liang Malcolm Xing Guozhong Lyu | 2023 | Bioactive Materials2023，，8： | 1 |
| 12 | Static recrystallization simulations by coupling cellular automata and crystal plasticity finite element method using a physically based model for nucleation显示文摘 | Fengbo Han Bin Tang Hongchao Kou Liang Cheng Jinshan Li Yong Feng | 2014 | Journal of Materials Science2014，，8： | 1 |
| 13 | Cellular automata modeling of static recrystallization based on the curvature driven subgrain growth mechanism显示文摘 | Fengbo Han Bin Tang Hongchao Kou Jinshan Li Yong Feng | 2013 | Journal of Materials Science2013，，20： | 1 |
| 14 | Early Enteral Nutrition within 24 Hours or between 24 and 72 Hours for Acute Pan- creatitis :Evidence Based on 12 RCTs 显示文摘 | Xueping Li Fengbo Ma Kezhi Jia | 2014 | Med Sci Monit2014，，20： | 1 |
| 15 | Ultrasound-driven BaTiO_(3) nanorobots patching immunologic barrier to cure chronic rheumatoid arthritis显示文摘The disruption and reconstruction of the TREM2^(+) tissue resident macrophage(TRM)barrier on the surface of synovial lining play a key role in the activation and'remission'of rheumatoid arthritis(RA),which engender the prediction of this immunologic barrier as a potential driver for the achievement of'cure'in RA.However,strategies to promote the reconstruction of this barrier have not been reported,and the effect of patching this barrier remains unidentified.On the other hand,appropriate piezoelectric stimulation can reprogram macrophages,which has never been exerted on this barrier TRM yet.Herein,we design piezoelectric tetragonal BaTiO_(3)(BTO)ultrasound-driven nanorobots(USNRs)by the solvothermal synthesis method,which demonstrates satisfactory electro-mechanical conversion effects,paving the way to generate controllable electrical stimulation under ultrasound to reprogram the barrier TRM by minimally invasive injection into joint cavity.It is demonstrated that the immunologic barrier could be patched by this USNR effectively,thereby eliminating the hyperplasia of vessels and nerves(HVN)and synovitis.Additionally,TREM2 deficiency serum-transfected arthritis(STA)mice models are applied and proved the indispensable role of TREM2 in RA curing mediated by USNR.In all,our work is an interesting and important exploration to expand the classical tetragonal BTO nanoparticles in the treatment of autoimmune diseases,providing a new idea and direction for the biomedical application of piezoelectric ceramics. | Le Jiang Yifan Wang Chunlin Liu Nan Xu Wenshuo Li Lei Wang Yixian Wu Jingyun Wang Zhijun He Fengbo Sun Lingyun Zhao Qiong Wu Xiumei Wang Huihui Yuan Xiaohui Wang Xiaodan Sun | 2023 | Journal of Advanced Ceramics2023，12，5： | 0 |
| 16 | Venetoclax and Azacitidine in Chinese patients with untreated acute myeloid leukemia ineligible for intensive chemotherapy显示文摘Dear Editor,Acute Myeloid Leukemia(AML)patients are often found ineligible for aggressive standard chemotherapy in clinic because of old age and poor conditions.Current evidences suggest that targeted combination therapy might help these patients achieve a higher response rate with acceptable adverse events(AEs).^(1)Venetoclax(VEN),a selective small-molecule BCL2 inhibitor,combined with hypomethylating agent(HMA),such as azacytidine(AZA). | Leiming Xia Wanlu Tian Yiming Zhao Lingling Jiang Wei Qian Lei Jiang Ling Ge Jianjun Li Fengbo Jin Mingzhen Yang | 2023 | Signal Transduction and Targeted Therapy2023，8，6： | 0 |
| 17 | Network Invulnerability Enhancement Algorithm Based on WSN Closeness Centrality显示文摘Wireless Sensor Network(WSN)is an important part of the Internet of Things(IoT),which are used for information exchange and communication between smart objects.In practical applications,WSN lifecycle can be influenced by the unbalanced distribution of node centrality and excessive energy consumption,etc.In order to overcome these problems,a heterogeneous wireless sensor network model with small world characteristics is constructed to balance the centrality and enhance the invulnerability of the network.Also,a new WSN centrality measurement method and a new invulnerability measurement model are proposed based on the WSN data transmission characteristics.Simulation results show that the life cycle and data transmission volume of the network can be improved with a lower network construction cost,and the invulnerability of the network is effectively enhanced. | Qian Sun Fengbo Yang Xiaoyi Wang Jing Li Jiping Xu Huiyan Zhang Li Wang Jiabin Yu Xiao Peng Ruichao Wang | 2022 | Computers, Materials & Continua2022，，11： | 0 |
| 18 | Optimal Deployment of Heterogeneous Nodes to Enhance Network Invulnerability显示文摘Wireless sensor networks(WSN)can be used in many fields.In wireless sensor networks,sensor nodes transmit data in multi hop mode.The large number of hops required by data transmission will lead to unbalanced energy consumption and large data transmission delay of the whole network,which greatly affects the invulnerability of the network.Therefore,an optimal deployment of heterogeneous nodes(ODHN)algorithm is proposed to enhance the invulnerability of the wireless sensor networks.The algorithm combines the advantages of DEEC(design of distributed energy efficient clustering)clustering algorithm and BAS(beetle antenna search)optimization algorithm to find the globally optimal deployment locations of heterogeneous nodes.Then,establish a shortcut to communicate with sink nodes through heterogeneous nodes.Besides,considering the practical deployment operation,we set the threshold of the mobile location of heterogeneous nodes,which greatly simplifies the deployment difficulty.Simulation results show that compared with traditional routing protocols,the proposed algorithm can make the network load more evenly,and effectively improve energy-utilization and the fault tolerance of the whole network,which can greatly improve the invulnerability of the wireless sensor networks. | Qian Sun Fengbo Yang Xiaoyi Wang Jiping Xu Huiyan Zhang Li Wang Jiabin Yu Xiao Peng Ruichao Wang | 2022 | Computers, Materials & Continua2022，，11： | 0 |
| 19 | Composite B-cell and T-cell lymphomas:clinical,pathological,and molecular features of three cases and literature review显示文摘Composite lymphoma(CL)involving B-cell lymphoma and T-cell lymphoma is extremely rare.Herein,we report three such cases using immunohistochemistry,flow cytometry,and the next-generation sequencing(NGS)to identify the pathological and molecular characteristics of CL.In the first case,the patient was admitted to hospital for generalized pruritic maculopapular rash over the whole body.An excisional biopsy of the skin lesions showed T-cell lymphoma.At the same time,the staging bone marrow(BM)biopsy revealed a diffuse large B-cell lymphoma(DLBCL).After R-CHOP(rituximab,cyclophosphamide,doxorubicin,vincristine,and prednisone)therapies,the patient produced a good response with substantial dissipation of the rashes and relief of skin.The other two patients were admitted to hospital due to lymphadenopathy and were diagnosed with DLBCL and follicular lymphoma(FL)after core needle biopsy of lymph nodes,BM biopsy,BM aspiration,and flow cytometry.Following R-CHOP and R-COP(rituximab,cyclophosphamide,vincristine,and prednisone)therapies,they achieved complete remission unconfirmed(CRu)and complete remission(CR).However,one or two years later,they suffered a relapse of lymphadenopathy.The shocking fact was that re-biopsy of lymphadenopathy revealed peripheral T-cell lymphoma(PTCL)and angioimmunoblastic T-cell lymphoma(AITL).NGS findings identified DNA methyltransferase 3a(DNMT3a),isocitrate dehydrogenase 2(IDH2),Ras homolog gene family,member A(RHOA),splicing factor 3B subunit 1(SF3B1),and tumor protein p53(TP53)mutations.After immunochemotherapy,these patients achieved CRu and CR again.Nevertheless,they suffered a second relapse of T-cell lymphoma.Finally,they died due to progression of disease.We found that the occurrence of CL is associated with Epstein-Barr virus infection and DNMT3a,IDH2,and TP53 mutations,and the prognosis of the disease is closely related to the T-cell lymphoma components. | Xueli JIN Hui LIU Jing LI Xibin XIAO Xianggui YUAN Panpan CHEN Boxiao CHEN Yun LIANG Fengbo HUANG | 2023 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2023，24，8： | 0 |
| 20 | Porous Silicon Carbide/Carbon Composite Microspherules for Methane Storage显示文摘多孔的硅碳化物 / 碳(SiC/C ) 微小球体被聚合物和硅石混血儿的控制加热处理准备在在 Ar/H2 的 1000 ° C 上的先锋流。结果的 SiC/C 合成表演改进了象优秀机械力量,常规物理形式,和高收拾行李密度那样的物理性质。当没有牺牲孔性质,把激活的碳用作吸收剂时,如此的改进克服遇到的主要固有的问题。N2 吸着分析表演 SiC/C 合成有 1793 m2/g 和 0.92 ml/g 的毛孔体积的一个赌注表面区域。甲烷吸附等温线被常规容量的方法在 25 ° C andupto7.0MPa 决定。在容量的基础上, SiC/C 合成微小球体在 3.5 MPa 和 25 ° C 显示出 145 的甲烷存储(V/V ) 。在这 SiC/C 的优秀物理性质和孔性质的联合合成借大可能性为天然气开发一个竞争存储系统。 | Fengbo Li Qingli Qian Shufeng Zhang Fang Yan Guoqing Yuan | 2007 | Journal of Natural Gas Chemistry2007，16，4： | 0 |
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