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| 1 | Immunization with chlamydial plasmid protein pORF5 DNA vaccine induces protective immunity against genital chlamydial infection in mice显示文摘To validate the immune protective efficacy of pORF5 DNA vaccine and to analyze potential mechanisms related to this protection. In this study, pORF5 DNA vaccine was constructed and evaluated for its protective immunity in a mouse model of genital chlamydial infection. Groups of BALB/c mice were immunized intranasally with pORF5 DNA vaccine. Humoral and cell mediated immune responses were evaluated. The clearance ability of chlamydial challenge from the genital tract and the chlamy- dia-induced upper genital tract gross pathology and histopathological characterization were also de- tected. The results showed that the total and the IgG2a anti-pORF5 antibody levels in serum were sig- nificantly elevated after pcDNA3.1-pORF5 vaccination, as were the total antibody and IgA levels in vaginal fluids. pcDNA3.1-pORF5 induced a significantly high level of Th1 response as measured by robust gamma interferon (IFN-γ). Minimal IL-4 was produced by immune T cells in response to the re-stimulation with pORF5 protein or the inactive elementary body in vitro. pcDNA3.1-pORF5-vacci- nated mice displayed significantly reduced bacterial shedding upon a chlamydial challenge and an accelerated resolution of infection. 100% of pcDNA3.1-pORF5 vaccinated mice successfully resolved the infection by day 24. pcDNA3.1-pORF5-immunized mice also exhibited protection against patho- logical consequences of chlamydial infection. The stimulated index was significantly higher than that of mice immunized with pcDNA3.1 and PBS (P<0.05). Together, these results demonstrated that immu- nization with pORF5 DNA vaccine is a promising approach for eliciting a protective immunity against a genital chlamydial challenge. | LI ZhongYu1,2, WANG ShiPing1, Wu YiMou2, ZHONG GuangMing3 & CHEN Ding3 1 Xiangya School of Medicine, Central South University, Changsha 410078, China 2 Department of Microbiology and Immunology, University of South China, Hengyang 421001, China 3 University of Texas Health Science Center at San Antonio, TX 78229, USA | 2008 | Science China(Life Sciences)2008，51，11： | 16 |
| 2 | The Asymptotic Behavior of a Class of Second Order Differential Equation显示文摘In the paper the asympotic behavior of the solution of the following second order differential equation y+ q(t)f(y) =0 is investigated. Some results for asymptotic behavior of the nonoscillation solution are obtained. | FENG Zhao-sheng, WANC Xiao-hui, LI Jin-cheng ( Dept. of Math., Texas A&M University, College Station, TX 77843, USA Dept. of Stat., Texas A&M University, College Station, TX 77843, USA Basic Dep., Tianjin Vocational Tech. & Teaching College, Tianjin 3 | 2001 | Journal of Mathematical Research and Exposition2001，21，3： | 6 |
| 3 | Mechanisms of inactivation of Hepatitis A Virus by chlorine 显示文摘 | Li JW Zhong TX Wang XW | 2002 | Applied and Environmental Microbiology2002，68，10： | 1 |
| 4 | Self-assembly of gold nanoparticles to carbon nanotubes using a thiol-terminated pyrene as interlin- ker显示文摘 | Liu L Wang TX Li JX | 2003 | Chemical Physics Letters2003，367，56： | 1 |
| 5 | Effect of azelnidipine on angiotensin II-mediated growth-promoting signaling in vascular smooth muscle ceils显示文摘 | Li JM Iwai M Cui TX | 2005 | Mol Pharmacol2005，67，5： | 1 |
| 6 | Instability of the Marangoni convection in a liquid bridge with liquid encapsulation under microgravity condition 显示文摘 | LI MW ZENG DL ZHU TX | 2002 | International Journal of Heat and Mass Transfer2002，45，1： | 1 |
| 7 | Many paths to alopeeia via compro- mised regeneration of hair follicle stem cells 显示文摘 | Li J Jiang TX Chuong CM | 2013 | J Invest Derma- tol2013，133，6： | 1 |
| 8 | Symptomatic intracranial vertebral ar- tery atherosclerotic stenosis ( ≥70% ) with concurrent contralateral ver- tebral atherosclerotic diseases in 88 patients treated with the intracranial stenting 显示文摘 | Wang ZL Gao BL Li TX | 2015 | Eur J Radio12015，84，9： | 1 |
| 9 | Antitumor and immunomodulatory activity of arabinoxylans : A major constituent of wheat bran 显示文摘 | Li C Liu XZ Qian TX | 2011 | Iut J Biol Maeromol2011，48，： | 1 |
| 10 | Fluvastatin enhances the inhibitory effects of a selective angiotensin Ⅱ type 1 receptor blocker,valsartan,on vascular neointimal formation显示文摘 | Cui TX Li Z | 2003 | Circulation2003，107，1： | 1 |
| 11 | Fluvasta- tin enhances the inhibitory effects of a selective angiotensin II type 1 receptor blocker ,valsartan, on vascular neointimal forma- tion显示文摘 | Horiuchi M Cui TX Li Z Li JM Nakagami H Iwai M | 2003 | Circulation2003，107，1： | 1 |
| 12 | Roles of mTOR and p-mTOR in gastro- intestinal stromal tumors显示文摘 | Li JC Zhu HY Chen TX | 2013 | Asian Pac J Cancer Prev2013，14，10： | 1 |
| 13 | The results of stent graft versusmedication therapy for chronic type B dissection显示文摘 | Jia X Guo W Li TX | 2013 | J Vase Surg2013，57，2： | 1 |
| 14 | Fluvastatin enhances the inhibitory effects of a selective angiotensin Ⅱ type 1 receptor blocker,valsartan,on vascular neointimal formation显示文摘 | Cui TX Li Z | 2003 | Circulation2003，107，： | 1 |
| 15 | Clinical characteristics of recurrent nasopharyngeal carcinoma in high-incidence area 显示文摘 | Li JX Lu TX Huang Y | 2012 | Sci W J2012，2012，71： | 1 |
| 16 | Remarks on the paper 显示文摘 | HAN ZL LI TX SUN S R etal | 2010 | Applied Mathematics and Computation2010，215，： | 1 |
| 17 | Accurate identification of closely related Dendrobium species with multiple species-specific gDNA probes 显示文摘 | Li TX Wang JK Lu ZH 2005 | 2005 | Journal of Biochemical and Biophysical Methods2005，62，2： | 1 |
| 18 | CTLA4Ig inhibits airway eosinorhilia and hynervesponsineness by regulating the deuelopment of Th1/Th2 sulsets is a nature model of asthma 显示文摘 | Padrid PA Mathur M Li TX | 1998 | Am J Respir Cell Mol Boil1998，18，： | 1 |
| 19 | RNA interference-mediated silencing of the HSP70 gene inhibits human gastric cancer cell growth and induces apoptosis in vitro and in vivo显示文摘 | Xiang TX Li Y Jiang Z | | 0，，04： | 1 |
| 20 | Short-term simulated nitrogen deposition increases carbon sequestration in a Pleioblastus amarus plantation 显示文摘 | Tu LH Hu TX Zhang J Li RH Dai HZ Luo SH | 2011 | Plant Soil2011，340，12： | 1 |
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