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| 1 | Study on the creep permeability of mining-cracked N2 laterite as the key aquifuge for preserving water resources in Northwestern China显示文摘 | Wenping Li Qiqing Wang Shiliang Liu Yabing Pei | 2018 | International Journal of Coal Science & Technology2018，5，3： | 22 |
| 2 | Promotion of spinosad biosynthesis by chromosomal integration of the Vitreoscilla hemoglobin gene in Saccharopolyspora spinosa显示文摘To promote spinosad biosynthesis by improving the limited oxygen supply during high-density fermentation of Saccharopolyspora spinosa, the open reading frame of the Vitreoscilla hemoglobin gene was placed under the control of the promoter for the erythromycin resistance gene by splicing using overlapping extension PCR. This was cloned into the integrating vector pSET152, yielding the Vitreoscilla hemoglobin gene expression plasmid pSET152EVHB. This was then introduced into S. spinosa SP06081 by conjugal transfer, and integrated into the chromosome by site-specific recombination at the integration site ΦC31 on pSET152EVHB. The resultant conjugant, S. spinosa S078-1101, was genetically stable. The integration was further confirmed by PCR and Southern blotting analysis. A carbon monoxide differential spectrum assay showed that active Vitreoscilla hemoglobin was successfully expressed in S. spinosa S078-1101. Fermentation results revealed that expression of the Vitreoscilla hemoglobin gene significantly promoted spinosad biosynthesis under normal oxygen and moderately oxygen-limiting conditions (P<0.01). These findings demonstrate that integrating expression of the Vitreoscilla hemoglobin gene improves oxygen uptake and is an effective means for the genetic improvement of S. spinosa fermentation. | LUO YuShuang KOU XiaoXiao DING XueZhi HU ShengBiao TANG Ying LI WenPing HUANG Fan YANG Qi CHEN HanNa XIA LiQiu | 2012 | Science China(Life Sciences)2012，55，2： | 14 |
| 3 | Humoral immune response to circulating SARS-CoV-2 variants elicited by inactivated and RBD-subunit vaccines显示文摘SARS-CoV-2 variants could induce immune escape by mutations on the receptor-binding domain(RBD)and N-terminal domain(NTD).Here we report the humoral immune response to circulating SARS-CoV-2 variants,such as 501Y.V2(B.1.351),of the plasma and neutralizing antibodies(NAbs)elicited by CoronaVac(inactivated vaccine),ZF2001(RBD-subunit vaccine)and natural infection.Among 86 potent NAbs identified by high-throughput single-cell VDJ sequencing of peripheral blood mononuclear cells from vaccinees and convalescents,near half anti-RBD NAbs showed major neutralization reductions against the K417N/E484K/N501Y mutation combination,with E484K being the dominant cause.VH3-53/VH3-66 recurrent antibodies respond differently to RBD variants,and K417N compromises the majority of neutralizing activity through reduced polar contacts with complementarity determining regions.In contrast,the 242–244 deletion(242–244Δ)would abolish most neutralization activity of anti-NTD NAbs by interrupting the conformation of NTD antigenic supersite,indicating a much less diversity of anti-NTD NAbs than anti-RBD NAbs.Plasma of convalescents and CoronaVac vaccinees displayed comparable neutralization reductions against pseudo-and authentic 501Y.V2 variants,mainly caused by E484K/N501Y and 242–244Δ,with the effects being additive.Importantly,RBD-subunit vaccinees exhibit markedly higher tolerance to 501Y.V2 than convalescents,since the elicited anti-RBD NAbs display a high diversity and are unaffected by NTD mutations.Moreover,an extended gap between the third and second doses of ZF2001 leads to better neutralizing activity and tolerance to 501Y.V2 than the standard three-dose administration.Together,these results suggest that the deployment of RBD-vaccines,through a third-dose boost,may be ideal for combating SARS-CoV-2 variants when necessary,especially for those carrying mutations that disrupt the NTD supersite. | Yunlong Cao Ayijiang Yisimayi Yali Bai Weijin Huang Xiaofeng Li Zhiying Zhang Tianjiao Yuan Ran An Jing Wang Tianhe Xiao Shuo Du Wenping Ma Liyang Song Yongzheng Li Xiang Li Weiliang Song Jiajing Wu Shuo Liu Xuemei Li Yonghong Zhang Bin Su Xianghua Guo Yangyang Wei Chuanping Gao Nana Zhang Yifei Zhang Yang Dou Xiaoyu Xu Rui Shi Bai Lu Ronghua Jin Yingmin Ma Chengfeng Qin Youchun Wang Yingmei Feng Junyu Xiao Xiaoliang Sunney Xie | 2021 | Cell Research2021，31，7： | 12 |
| 4 | Reproductive management through integration of PGD and MPS-based noninvasive prenatal screening/diagnosis for a family with GJB2-associated hearing impairment显示文摘A couple with a proband child of GJB2(encoding the gap junction protein connexin 26)-associated hearing impairment and a previous pregnancy miscarriage sought for a reproductive solution to bear a healthy child. Our study aimed to develop a customized preconception-to-neonate care trajectory to fulfill this clinical demand by integrating preimplantation genetic diagnosis(PGD), noninvasive prenatal testing(NIPT), and noninvasive prenatal diagnosis(NIPD) into the strategy. Auditory and genetic diagnosis of the proband child was carried out to identify the disease causative mutations. The couple then received in-vitro-fertilization treatment, and eight embryos were obtained for day 5 biopsy. PGD was performed by short-tandem-repeat linkage analysis and Sanger sequencing of GJB2 gene. Transfer of a GJB2 c.235del C heterozygous embryo resulted in a singleton pregnancy. At the 13 th week of gestation, genomic DNA(g DNA) from the trio family and cell-free DNA(cf DNA) from maternal plasma were obtained for assessment of fetal chromosomal aneuploidy and GJB2 mutations. NIPT and NIPD showed the absence of chromosomal aneuploidy and GJB2-associated disease in the fetus, which was later confirmed by invasive procedures and postnatal genetic/auditory diagnosis. This strategy successfully prevented the transmission of hearing impairment in the newborn, thus providing a valuable experience in reproductive management of similar cases and potentially other monogenic disorders. | XIONG WenPing WANG DaYong GAO Yuan GAO Ya WANG HongYang GUAN Jing LAN Lan YAN JunHao ZONG Liang YUAN Yuan DONG Wei HUANG SeXin WU KeLiang WANG YaoShen WANG ZhiLi PENG HongMei LU YanPing XIE LinYi ZHAO Cui WANG Li ZHANG QiuJing GAO Yun LI Na YANG Ju YIN ZiFang HAN Bing WANG Wei CHEN Zi-Jiang WANG QiuJu | 2015 | Science China(Life Sciences)2015，58，9： | 12 |
| 5 | DNA barcoding of 18 species of Bovidae显示文摘Genetic divergences of mitochondrial cytochrome c oxidase subunit I genes,known as DNA barcodes,have been used in species identification in the animal kingdom.Barcodes can assist field workers and taxonomists to determine groups in need of taxa analysis,and facilitate the recognition of appropriate populations and scales for conservation planning.In this study,18 species of Bovidae were selected to evaluate the effectiveness of DNA barcoding for species differentiation.The results showed that all but 2 species had unique DNA barcodes.The mean intraspecific variation was 0.63%,yielding a threshold of 6.3% for flagging putative species.The results supported the inference that barcode variation within species of mammals is somewhat higher than within other animal groups.The present study validated the effectiveness of barcoding for the identification of bovid species. | CAI YanSen ZHANG Liang SHEN FuJun ZHANG WenPing HOU Rong YUE BiSong LI Jing ZHANG ZhiHe | 2011 | Chinese Science Bulletin2011，56，2： | 10 |
| 6 | Recent Advances in Interface Engineering for Electrocatalytic CO_(2) Reduction Reaction显示文摘Electrocatalytic CO_(2) reduction reaction(CO_(2) RR) can store and transform the intermittent renewable energy in the form of chemical energy for industrial production of chemicals and fuels,which can dramatically reduce CO_(2) emission and contribute to carbon-neutral cycle. E cient electrocatalytic reduction of chemically inert CO_(2) is challenging from thermodynamic and kinetic points of view. Therefore,low-cost,highly e cient,and readily available electrocatalysts have been the focus for promoting the conversion of CO_(2). Very recently,interface engineering has been considered as a highly e ective strategy to modulate the electrocatalytic performance through electronic and/or structural modulation,regulations of electron/proton/mass/intermediates,and the control of local reactant concentration,thereby achieving desirable reaction pathway,inhibiting competing hydrogen generation,breaking binding-energy scaling relations of intermediates,and promoting CO_(2) mass transfer. In this review,we aim to provide a comprehensive overview of current developments in interface engineering for CO_(2) RR from both a theoretical and experimental stand-point,involving interfaces between metal and metal,metal and metal oxide,metal and nonmetal,metal oxide and metal oxide,organic molecules and inorganic materials,electrode and electrolyte,molecular catalysts and electrode,etc. Finally,the opportunities and challenges of interface engineering for CO_(2) RR are proposed. | Junjun Li Sulaiman Umar Abbas Haiqing Wang Zhicheng Zhang Wenping Hu | 2021 | Nano-Micro Letters2021，13，12： | 9 |
| 7 | Recent Progress in Distributed Optical Fiber Raman Photon Sensors at China Jiliang University显示文摘在在中国 Jiliang 大学(CJLU ) 的完整的分布式的纤维拉曼光子传感器的研究,生产和应用的最近的进步的简短评论被介绍。以便改进测量距离,精确性,空间分辨率,多参数大小的能力,和完整的分布式的纤维传感器系统的智力,一种新一代纤维传感器技术基于光纤维,非线性的散布熔化原则被建议。一系列新一代完整的分布式的纤维传感器被调查并且设计,它由新产生组成极端长的距离散布与一个纤维拉曼放大器综合的光子传感器的完整的分布式的纤维拉曼和瑞利,汽车修正完整的分布式的纤维拉曼光子温度传感器基于拉曼关联双来源,完整的分布式的纤维拉曼光子温度传感器基于编码的脉搏采购原料,完整的分布式的纤维拉曼光子温度传感器 | Zaixuan ZHANG | 2012 | Photonic Sensors2012，2，2： | 8 |
| 8 | Vertical‐organic‐nanocrystal‐arrays for crossbar memristors with tuning switching dynamics toward neuromorphic computing显示文摘Memristors proposed by Leon Chua provide a new type of memory device for novel neuromorphic computing applications.However,the approaching of distinct multi‐intermediate states for tunable switching dynamics,the con-trolling of conducting filaments(CFs)toward high device repeatability and reproducibility,and the ability for large‐scale preparation devices,remain full of challenges.Here,we show that vertical‐organic‐nanocrystal‐arrays(VONAs)could make a way toward the challenges.The perfect one‐dimensional structure of the VONAs could confine the CFs accurately with fine‐tune resistance states in a broad range of 103 ratios.The availability of large‐area VONAs makes the fabrication of large‐area crossbar memristor arrays facilely,and the analog switching characteristic of the memristors is to effectively imitate different kinds of synaptic plasticity,indicating their great potential in future applications. | Fangxu Yang Lingjie Sun Qingxi Duan Huanli Dong Zhaokun Jing Yuchao Yang Rongjin Li Xiaotao Zhang Wenping Hu Leon Chua | 2021 | SmartMat2021，2，1： | 5 |
| 9 | Research on Radiation Characteristics of Polymeric Plastic Fiber显示文摘The anti-radiation mechanism of polymeric plastic fiber is analyzed. The radiation characteristic of this type fiber is studied. Our experimental results indicate that under the low radiation dosage (below 1 kGy) the plastic optical fiber’s transmission rate rises instead of descends while this type of fiber is radiated by γ ray, electron beam and proton beam respectively. After a period of time, it gradually reaches a constant value. But under the high radiation dosage (above 1 kGy) the fiber’s transmission rate descends after radiation. Later, it gradually goes up to a constant value. | 殷宗敏 Li Rongyu Ge Wenping Liu Rui | 2001 | High Technology Letters2001，7，2： | 5 |
| 10 | Natural Climate Solutions for China:The Last Mile to Carbon Neutrality显示文摘“I call on all leaders worldwide to declare a State of Climate Emergency in their own countries until carbon neutrality is reached.”–António GUTERRES(United Nations Secretary General),12 December,2020 There is no shortcut to a carbon neutral society;solutions are urgently required from both energy&industrial sectors and global ecosystems.While the former is often held accountable and emphasized in terms of its emissions reduction capability,the latter(recently termed natural climate solutions)should also be assessed for potential and limitations by the scientific community,the public,and policy makers. | Zhangcai QIN Xi DENG Bronson GRISCOM Yao HUANG Tingting LI Pete SMITH Wenping YUAN Wen ZHANG | 2021 | Advances in Atmospheric Sciences2021，38，6： | 5 |
| 11 | CMTM4 inhibits cell proliferation and migration via AKT, ERK1/2,and STAT3 pathway in colorectal cancer显示文摘CMTM4(CKLF-like MARVEL transmembrane domain containing 4),a potential tumor suppressor gene,is involved in several types of malignancies.It has been reported to be downregulated and exhibit anti-tumorigenic activities by regulating cell growth and cell cycle in clear cell renal cell carcinoma.It has also been identified as a tumor suppressor in hepatocellular carcinoma(HCC),and its negative expression is a risk factor for poor prognosis of HCC patients.In the present study,an integrated bioinformatics analysis based on The Cancer Genome Atlas(TCGA)database showed that CMTM4 was frequently reduced in colorectal cancer(CRC)and high expression of CMTM4 was associated with increased overall survival rates.Based on these findings,we adopted gain-of-function and lost-of-function strategies using SW480 and HT29 CRC cell lines which have relatively low and high endogenous CMTM4 levels,respectively.We observed impeded cell proliferation and migration upon overexpression of CMTM4 in SW480 cells,and the opposite effects were observed upon knockdown of CMTM4 in HT-29 cells.Cell signaling pathways essential for CRC progression were then examined,and the phosphorylation levels of AKT,ERK1/2,and STAT3 were found to be decreased by CMTM4 overexpression in SW480 cells and elevated by CMTM4 silencing in HT29 cells.Their inhibitors were used to validate that the three signaling pathways contributed to the inhibitory effects of CMTM4 on CRC cells.Taken together,our results suggest that CMTM4 plays a tumor suppressive role in CRC. | Hui Xue Ting Li Pingzhang Wang Xiaoning Mo Hejun Zhang Shigang Ding Dalong Ma Wenping Lv Jing Zhang Wenling Han | 2019 | Acta Biochimica et Biophysica Sinica2019，51，9： | 5 |
| 12 | Interaction mechanism of the interface between a deep buried sand and a paleo-weathered rock mass using a high normal stress direct shear apparatus显示文摘In order to evaluate the feasibility of safe mining close to the contact zone under reduced security coal pillar conditions at a coal mine in eastern China, the interaction mechanism of the interface between deep buried sand and a paleo-weathered rock mass was investigated in the laboratory by direct shear testing. A DRS-1 high pressure soil shear testing machine and orthogonal design method were used in the direct shear tests. Variance and range methods were applied to analyze the sensitivity of each factor that has an influence on the mechanical characters of the interface. The test results show that the normal pressure is the main influencing factor for mechanical characteristics of the interface, while the lithological characters and roughness are minor factors; the shear stress against shear displacement curve for the interface shows an overall hyperbola relationship, no obvious peak stress and dilatancy was observed.When the normal pressure is 6 MPa, the shear strengths of interfaces with different roughness are basically the same, and when the normal pressure is more than 8 MPa, the larger the roughness of the interface, the larger will be the shear strength; the shear strength has a better linear relationship with the normal pressure, which can be described by a linear Mohr–Coulomb criterion. | Bai Hanying Li Wenping Ding Qingfeng Wang Qiqing Yang Dongdong | 2015 | International Journal of Mining Science and Technology2015，25，4： | 4 |
| 13 | Soil erosion affects variations of soil organic carbon and soil respiration along a slope in Northeast China显示文摘Background:Although soil erosion plays a key role in the carbon cycle,a holistic and mechanistic understanding of the soil erosion process within the cycle is still lacking.The aim of this study was therefore to improve our mechanistic understanding of soil organic carbon(SOC)and soil respiration dynamics through an experiment conducted in an eroding black soil farmland landscape in Northeast China.Results:The depositional profiles store 5.9 times more SOC than the eroding profiles and 3.3 times more SOC than the non-eroding profiles.A linear correlation between the SOC and 137Cs(Caesium-137)was observed in our study,suggesting that the SOC decreased with increased soil erosion.Furthermore,the fractions of intermediate C and the microaggregate C were lowest at the eroding position and highest at the depositional position.In the depositional topsoil,the input of labile materials plays a promotional role in soil respiration.Conversely,in the subsoil(i.e.,below 10 cm),the potential mineralization rates were lowest at the depositional position—due to effective stabilization by physical protection within soil microaggregates.The field results of soil surface respiration also suggest that the depositional topsoil SOC is prone to be mineralized and that SOC at this depositional context is stabilized at subsoil depth.In addition,the high water contents at the depositional position can limit the decomposition rates and stabilize the SOC at the same time.Conclusions:The findings from this study support that a majority of the SOC at footslope is stored within most of the soil profile(i.e.,below 10 cm)and submitted to long-term stabilization,and meanwhile support that the depositional profile emits more CO2 than the summit due to its high amount and quality of SOC. | Tong Li Haicheng Zhang Xiaoyuan Wang Shulan Cheng Huajun Fang Gang Liu Wenping Yuan | 2019 | Ecological Processes2019，8，1： | 4 |
| 14 | Molecular-scale integrated multi-functions for organic lightemitting transistors显示文摘Organic light-mitting transistors(OLETs)integrate the functions of light-emitting diodes and field-effect transistors into a unique device,opening a new door for optoelectronics.However,there is still a challenge due to the absence of high quality organic semiconductors for OLETs.Herein,we reported a novel molecule 2,6-di(anthracen-2-yl)naphthalene(2,6-DAN),which exhibited mobility of up to 19 cm2:V'-s'and an absolute fluorescence quantum yield of 37.09%,which are good values for organic semiconductors.Moreover,OLETs based on 2,6-DAN single crystals showed bright yellowish-green emission and well-balanced ambipolar charge transport.The excellent ratio of hole to electron mobilty can reach up to 0.86,which is superior to most single component OL ETs in typical device configurations reported so far. | Lei Zheng Jinfeng Li Ke Zhou Xixia Yu Xiaotao Zhang Huanli Dong Wenping Hu | 2020 | Nano Research2020，13，7： | 4 |
| 15 | Recent advances in carbon-based materials for electrochemical CO_(2) reduction reaction显示文摘The increase of atmospheric CO_(2)concentration has caused many environmental issues.Electrochemi-cal CO_(2)reduction reaction(CO_(2)RR)has been considered as a promising strategy to mitigate these chal-lenges.The electrocatalysts with a low overpotential,high Faradaic efficiency,and excellent selectivity are of great significance for the CO_(2)RR.Carbon-based materials including metal-free carbon catalysts and metal-based carbon catalysts have shown great potential in the CO_(2)RR,owing to the tailorable porous structures,abundant natural resources,resistance to acids and bases,high-temperature stability,and en-vironmental friendliness.In this review,various carbon materials including graphene,carbon nanotubes,quantum dots,porous carbon,and MOF-derived catalysts,etc.,for the CO_(2)RR have been summarized.Particularly,recent progress in terms of the mechanism and pathway of CO_(2)conversion has been com-prehensively reviewed.Finally,the opportunities and challenges of carbon-based electrocatalysts for the CO_(2)RR are proposed. | Zengqiang Gao Junjun Li Zhicheng Zhang Wenping Hu | 2022 | Chinese Chemical Letters2022，33，5： | 4 |
| 16 | Boosting polysulfide redox conversion of Li-S batteries by one-step-synthesized Co-Mo bimetallic nitride显示文摘Lithium-sulfur(Li-S)batteries are considered as one of the most promising next generation energy storage systems due to the high theoretical specific capacity,low cost,and environmental benignity.However,the notorious shuttle effect of polysulfides hinders the practical application of Li-S batteries.Herein,we have rationally designed and synthesized sea urchin-like Co-Mo bimetallic nitride(Co_(3) MO_(3) N)in the absence of additional nitrogen sources with only one step,which was applied as the sulfur host materials for Li-S batteries.The results indicate that Co_(3) Mo_(3) N can efficiently anchor and catalyze the conversion of polysulfides,thus accelerating the electrochemical reaction kinetics and enabling prominent electrochemical properties.As a consequence,the S@Co_(3) Mo_(3) N cathode exhibits a high rate performance of 705 mAh g^(-1) at 3 C rate and an excellent cycling stability with a low capacity fading rate of 0.08%per cycle at 1 C over 600 cycles.Even at a high sulfur loading of 5.4 cmg cm^(-2),it delivers a high initial areal capacity of 4.50 mAh cm^(-2) which is still retained at 3.64 mAh cm^(-2) after 120 cycles.Furthermore,the catalytic mechanism and structural stability of Co_(3) Mo_(3) N during cycling were elucidated by a combination of X-ray photoelectron spectroscopy and X-ray absorption fine structure.This work highlights the strategy of structure-catalysis engineering of bimetallic nitride,which is expected to have a wide application in Li-S batteries. | Yingying Yan Hongtai Li Chen Cheng Tianran Yan Wenping Gao Jing Mao Kehua Dai Liang Zhang | 2021 | Journal of Energy Chemistry2021，30，10： | 3 |
| 17 | Partitioning root and microbial contributions to soil respiration in Leymus chinensis populations显示文摘 | Bingrui Jia Guangsheng Zhou Fengyu Wang Yuhui Wang Wenping Yuan Li Zhou | 2005 | Soil Biology and Biochemistry2005，，4： | 3 |
| 18 | Regional Guanxi Culture and Entrepreneurs' Action Logic: A Multilevel Analysis显示文摘 | Xinchun Li Wenping Ye Pengxiang Zhang Xiao Xiao | 2016 | Frontiers of Business Research in China2016，10，1： | 3 |
| 19 | Features of the Excess Adsorption Isotherms of High-Pressure Methane Adsorption on Coal and Simulation Model显示文摘不同等级的四件煤样品被选择执行高压的甲烷(CH4 ) 的吸附测量。测量的最高的平衡压力超过 20 MPa。与测量结果和理论分析结合了,为山峰的原因或出现在过量吸附等温线的最大的吸附能力被解释。山峰出现的规则被总结。然后基于煤毛孔结构的特征,吸附高压的气体,煤表面的小宇宙的相互作用关系和 CH4 分子展示,并且 coalbed 甲烷水库在煤吸附上调节三个理论假设高压的 CH4 被建议。根据这些理论假设,此后, Ono-Kondo 格子模型为简化和变丑被处理。随后,在煤上为高压的 CH4 吸附的过量吸附等温线建模的方程被获得。通过测量数据上的确认,恰当的结果显示使用 Ono-Kondo 格子模式在煤上为高压的 CH4 吸附的过量吸附等温线建模是可行的。 | CUI Yongjun ZHANG Dengfeng ZHANG Qun LIN Weigang SONG Wenli LI Yuhui JIANG Wenping | 2010 | Acta Geologica Sinica(English Edition)2010，84，6： | 3 |
| 20 | Stem cell-derived exosomes repair ischemic muscle injury by inhibiting the tumor suppressor Rbl-mediated NLRP3 inflammasome pathway显示文摘Dear Editor,Lower-limb ischemia is a serious clinical condition affecting many patients world-wide and there is no effective therapy.Ischemia activates the NLRP3 inflammasome,which triggers tissue damage by releasing inflammatory cytokines including IL-1β and IL-18.1 However,the molecular mechanisms underlying activation of the NLRP3 inflammasome remain largely unknown. | Yanli Wang Wenping Xie Bin Liu Hui Huang Wei Luo Yu Zhang Xiangbin Pan Xi-Yong Yu Zhenya Shen Yangxin Li | 2021 | Signal Transduction and Targeted Therapy2021，6，4： | 3 |
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