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| 1 | A study of preoperative methionine-depleting parenteral nutrition plus chemotherapy in gastric cancer patients显示文摘AIM To investigate the interference ofmethionine.free parenteral nutrition plus 5-Fu(-MetTPN+5-Fu)in gastric cancer cell kineticsand the side effects of the regimen.METHODS Fifteen patients with advancedgastric cancer were randomly divided into twogroups,7 patients were given preoperatively aseven-day course of standard parenteralnutrition in combination with a five-day courseof chemotherapy(sTPN+5-Fu),while the other8 patients were given methionine-deprivedparenteral nutrition and 5-Fu(-MetTPN+5-Fu).Cell cycles of gastric cancer and normal mucosawere studied by flow cytometry(FCM).Bloodsamples were taken to measure the serumprotein,methionine(Met)and cysteine(Cys)levels,and liver and kidney functions.RESULTS As compared with the resultsobtained before the treatment,the percentage ofG0/G1 tumor cells increased and that of S phasedecreased in the-MetTPN+5-Fu group,while thecontrary was observed in the sTPN+5-Fu group.Except that the ALT,AST and AKP levels wereslightly increased in a few cases receiving-MetTPN+5-Fu,all the other biochemicalparameters were within normal limits.Serum Cys level decreased slightly after the treatmentin both groups.Serum Met level of patientsreceiving sTPN+5-Fu was somewhat higher aftertreatment than that before treatment;however,no significant change occurred in the -MetTPN+5-Fu group,nor operative complications in bothgroups.CONCLUSION -MetTPN+5-Fu exerted asuppressive effect on cancer cell proliferation,probably through a double mechanism ofcreating a state of'Met starvation'adverse tothe tumor cell cycle,and by allowing 5-Fu to killspecifically cells in S phase.Preoperative short-term administration of -MetTPN+5-Fu had littleundesirable effect on host metabolism. | Cao WX Cheng QM Fei XF Li SF Yin HR Lin YZ | 2000 | World Journal of Gastroenterology2000，6，2： | 22 |
| 2 | Identification of tumor associated single-chain Fv by panning and screening antibody phage library using tumor cells显示文摘AIM:To study the feasibility of panning and screeningphage-displaying recombinant single-chain variablefragment (ScFv) of anti-tumor monoclonal antibodiesfor fixed whole cells as the carriers of mAb-bindingantigens.ME,ODS: The recombinant phage displaying librariesfor anti-colorectal tumor mAb MC3Ab, MC5Ab andanti-gastric tumor mAb MGD1 was constructed.Panning and screening were carried outby means ofmodified fixation of colorectal and gastric tumor cellsexpressed the mAb-binding antigens. Concordance ofbinding specificity to tumor cells between phageclones and parent antibodies was analyzed. Thephage of positive clones was identified withcompetitive ELISA, and infected by E.coli HB2151 toexpress soluble ScFv.RESULTS:The ratio of positive clones to MC3-ScF-MC5-ScFv and MGD1-ScFv were 60 %, 24 % and 30 %. MC3-ScFv had Mr 32 000 confirmed by Western blot. Thespecificity to antigen had no difference between 4positive recombinant phage antibodies and MC3Ab.CONCLUSION:The modified process of fixing wholetumor cells is efficient, convenient and feasible to panand screen the phage-displaying ScFv of anti-tumormonoclonal antibodies. | Nie, YZ He, FT Li, ZK Wu, KC Cao, YX Chen, BJ Fan, DM | 2002 | World Journal of Gastroenterology2002，8，4： | 12 |
| 3 | NEW ALDALOIDS TONGOLINE AND TONGOLININE FROMDELPHINIUM TONGOLENSE显示文摘NEWALDALOIDSTONGOLINEANDTONGOLININEFROMDELPHINIUMTONGOLENSELanHE;YaoZuCHEN(TheChemistryDepartmentofLanzhouUniversity,Lanzhou7... | He, L Chen, YZ Ding, LS Li, BG | 1996 | Chinese Chemical Letters1996，7，6： | 4 |
| 4 | Evaluation of various solutions for small bowel graft preservation显示文摘EvaluationofvarioussolutionsforsmalbowelgraftpreservationLIYouSheng1,LIJieShou1,LINing1,JIANGZhiWei1,ZHAOYunZhao1,LINan?.. | Li YS Li JS Li N Jiang ZW Zhao YZ Li NY Liu FN | 1998 | World Journal of Gastroenterology1998，4，2： | 2 |
| 5 | Effet of Maotai liguor in inducing metallothioneins and on hepatic stellate cells显示文摘 | Cheng ML Wu J Wang HQ Xue LM Tan YZ Liu P Li CX Huang NH Yao YM Ren LZ Ye L Li L Jia ML | 2001 | Shijie Huaren Xiaohua Zazhi2001，9，12： | 2 |
| 6 | Treatment of pancreatic carcinoma by adenoviral mediated gene transfer of vasostatin in mice显示文摘 | Li L Yuan YZ Lu J | 2006 | Gut2006，55，2： | 1 |
| 7 | Endothelial progenitor cells (EPCs) mobilized and activated by neurotrophic factors may contribute to pathologic neovascularization in diabetic retinopa-thy显示文摘 | Liu XL Li YJ Liu YZ | 2010 | Am J Pathol2010，176，1： | 1 |
| 8 | The construction of siRNA plasmid targeting mouse HIF-la and in vitro study of its inhi- bition effect显示文摘 | Ding ZY Li ZG Xing YZ | 2010 | Neurosci Bu112010，25，3： | 1 |
| 9 | Simultaneous quantification of loureirin A and loureirin B in rat urine,feces,and bile by HPLC-MS/MS method and its application to excretion study显示文摘 | Zhang YS Li YZ Chen B | 2011 | Analytical and Bioanalytical Chemistry2011，400，： | 1 |
| 10 | Determinants and prognostic implications of reperfusion injury during primary percutaueous coronary intervention in Chinese patients with acute myocardial infarction 显示文摘 | Luo Y Li GL Pan YZ | 2009 | Clin Cardiol2009，32，3： | 1 |
| 11 | Banana polyphenol oxidase: occurrence and change of polypheno| o~idase activity in some banana cultivars during fruit development 显示文摘 | YangC P NongZR LuJL LU L Xu J S Han YZ Li Y J Fujita S | 2004 | Food Science Technology2004，10，1： | 1 |
| 12 | Nuclephosmin mutations in Chinese adults with acute myelogenous leukemia 显示文摘 | Ruan GR Li JL Qin YZ | 2009 | Ann Hematol2009，88，： | 1 |
| 13 | Effect of time factors on the mortality in brittle hip fracture 显示文摘 | Li YZ Lin JK Wang PW | 2014 | J Orthop Surg Res2014，9，： | 1 |
| 14 | Uhrastructural pathology' of rat lung injury induced by ischemic acute kidney injury显示文摘 | Zang DY Shao YZ Li XM | 2013 | Uhrastruct Pathol2013，37，6： | 1 |
| 15 | Effects of losartan on haemodynamic parameters and angiotensin receptor mRNA levels in rat heart after myocardial infarction显示文摘 | Zhu YZ Zhu YC Li J | 2000 | JRAAS2000，1，3： | 1 |
| 16 | Long-term effects of aniotensin Ⅱ type 2(AT2) receptor null mutation on renal fibronectin deposition and PA/PAI regulation显示文摘 | Li W Chen XM Ye YZ | 1998 | J American Soc Nephrol1998，9，： | 1 |
| 17 | Iron homeo- stasis in osteoporosis and its clinical impli- cations 显示文摘 | Li GF Pan YZ Sirois P | 2012 | Osteoporos Int2012，23，10： | 1 |
| 18 | Hydrogen sulfide is a novel mediator of lipopolysaccharide-induced inflammation in the mouse显示文摘 | Bhatia M Zhu YZ | 2005 | FASEB J2005，19，： | 1 |
| 19 | Three-dimensional digitalized virtual planning for retrograde sural neurovascular island flaps:a comparative study显示文摘 | Li YG Chen XJ Zhang YZ | 2014 | Bums2014，40，5： | 1 |
| 20 | The efficacy of Combizym in the treatment of Chinese patients with dyspepsia:a multicenter,randomized,placebo-controlled and cross-over study:Shanghai Combizym Clinical Cooperative Group显示文摘 | Ran ZH Yuan YZ Li ZS | 2009 | J Dig Dis2009，10，1： | 1 |
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