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| 1 | Experimental study of“Tong Xia”purgative method in ameliorating lung injury in acute necrotizing pancreatitis显示文摘AIM To investigate the role of tumor necrosisfactor(TNF)in lung injury during acutenecrotizing pancreatitis(ANP),and thetherapeutic effect of'Tong Xia'purgativemethod in minimizing the severity of lung injury.METHODS Fourteen canines were randomlydivided into 3 groups:the'Tong Xia'treatmentgroup(n = 5)using Dachengqitang;salinecontrol group(n = 5),and the sham operationgroup(n = 4).TNF activity in serum and inbronchoalveolar lavage fluid(BALF),the serumendotoxin levels were measured,and theseverity of lung injury evaluated.RESULTS Elevation of TNF activity was moreprominent in BALF than in serum.TNF activity inserum at 6 and 12 hours and in BALI:wassignificantly decreased in the'Tong Xia'treatment group than in the saline control one(q=21.11,q=12.07,q=9.03,respectively,P<0.01)and the lung injury was significantlyalleviated at 12 hours as compared with that inthe saline group,manifested as amelioration otthe lung wet/ dry weight ratio,decrease inprotein concentration and neutrophils count inBALF,and improvement of pulmonaryinflammatory changes.A positive correlationwas demonstrated between serum TNF activity and endotoxin level.CONCLUSION Hypersecretion of TNF is shownto be one of the major causes of lung injuryduring ANP;'Tong Xia'purgative method couldalleviate the degree of lung injury mediated byTNF. | Xia Q Jiang JM Gong X Chen GY Li L Huang ZW | 2000 | World Journal of Gastroenterology2000，6，1： | 31 |
| 2 | 药物开发中与草药相互作用药物的鉴定显示文摘迄今为止,几种临床上重要的药物已被鉴定与常用的草药相互作用。这些药物包括华法林、咪达唑仑、地高辛、阿米替林、茚地那韦、环孢素A、他克莫司、伊立替康。重要的是这些药物大多治疗指数极窄,大部分是细胞色素P450(CYP)和(或)P糖-蛋白(P-gp)的底物。由于药物-草药相互作用能显著地影响药物的循环浓度,改变临床结果,因此与常用的草药相互作用的药物的鉴定在药物开发中具重要的意义。计算机模拟、体外、动物和人体研究经常用于鉴定药物和草药的相互作用。建议将药物-草药和草药-CYP相互作用研究纳入药物开发中。 | Zhou SF Zhou ZW Li CG 贾秀虹 | 2008 | 国际药学研究杂志2008，35，3： | 2 |
| 3 | Evaluation of various solutions for small bowel graft preservation显示文摘EvaluationofvarioussolutionsforsmalbowelgraftpreservationLIYouSheng1,LIJieShou1,LINing1,JIANGZhiWei1,ZHAOYunZhao1,LINan?.. | Li YS Li JS Li N Jiang ZW Zhao YZ Li NY Liu FN | 1998 | World Journal of Gastroenterology1998，4，2： | 2 |
| 4 | Tumor microenvironment and drug resistancein hematologic malignancies显示文摘 | Li ZW Dalton WS | 2006 | Blood Rev2006，20，： | 1 |
| 5 | Modulation effects of hexamethylene bisacetamide on growth and differentiation of cultured human malignant glioma cells 显示文摘 | Li XN Du ZW Huang Q | 1996 | J Neurosurg1996，84，： | 1 |
| 6 | A DNA vaccine against chimeric AFP enhanced by HSP70 suppresses growth of hepatocellular carcinoma 显示文摘 | Lan YH Li YG Liang ZW | 2007 | Cancer Immunol Immunother2007，56，7： | 1 |
| 7 | Inhibiting epi-dermal growth factor receptor attenuates reactive as-trogliosis and improves ftinctional outcome after spinalcord injury in rats 显示文摘 | Li ZW Tang RH Zhang JP | 2011 | Neurochem Int2011，58，： | 1 |
| 8 | Induction of apoptosis and autophagy via sirtuin1-and PI3K/Akt/mTOR-mediated pathways by plumbagin in human prostate cancer cells显示文摘 | Zhou ZW Li XX He ZX | 2015 | Drug Des DevelTher2015，12，9： | 1 |
| 9 | Somatostatin elevates topoisomerase II alpha and enhances the cytotoxic effect of doxorubicin on gallhladder cancer cells 显示文摘 | Quan ZW Yue JN Li JY | 2008 | Chemotherapy2008，54，6： | 1 |
| 10 | Molecular epidemiology of humanBlastocystis in a village in Yunnan Province,China显示文摘 | Li LH Zhou XN Du ZW | 2007 | ParasitolInt2007，56，4： | 1 |
| 11 | Sustained potentiation by substance P of NMDA-activated current in rat primary neurons显示文摘 | Wu ZZ Guan BC Li ZW | 2004 | Brain Res2004，1010，12： | 1 |
| 12 | Specification of motoneuronsfrom human embryonic stem cells显示文摘 | Li XJ Du ZW Zamowska ED | 2005 | Nat Biotechnol2005，23，2： | 1 |
| 13 | One stage surgical correction of congenital cardiac disease and congenital tracheal stenosis in infants and children显示文摘 | Xu ZW Li WH | 2009 | Card Surg2009，24，5： | 1 |
| 14 | Modulation effects of hexamethylene bisacetamide on growth and differentiation of cultured human malignant glioma cells 显示文摘 | Li XN Du ZW Huang Q | 1996 | J Neurosurg1996，84，5： | 1 |
| 15 | Growth-inhibitory and differentiation-inducing activity of dimethylformamide in cultured human malignant glioma cells 显示文摘 | Li XN Du ZW Huang Q | 1997 | Neuosurgery1997，40，6： | 1 |
| 16 | Growth-inhibitory and differentiation-inducing activity of dimethylformamide in cultured human malignant glioma cells显示文摘 | Li XN Du ZW Huang Q | 1997 | Neurosurgery1997，40，6： | 1 |
| 17 | Acquisition of epithelial-mesenchymal transition phenotype of gemcitabine-resistant pancreatic cancer cells is linked with activation of the notch signaling pathway 显示文摘 | Wang ZW Li YW Kong D | 2009 | Cancer Res2009，69，6： | 1 |
| 18 | Sustained potentiation by substance P of NMDA - activated current in rat primary sensory neurons 显示文摘 | Wu ZZ Guan BC Li ZW | 2004 | Brain Res2004，1010，12： | 1 |
| 19 | Growth-inhibitory and differentiation-inducing activity of dimethylformamide in cultured human malignant glioma cells 显示文摘 | Li XN Du ZW Huang Q | 1997 | Neurosurg1997，40，6： | 1 |
| 20 | Helicobacter pylori infection contributes to high risk of ischemic stroke: evidence from a meta - analysis 显示文摘 | Wang ZW Li Y Huang LY | 2012 | J Neurol2012，259，12： | 1 |
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