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| 1 | Screening and analysis of the multiple absorbed bioactive components and metabolites of Dangguibuxue decoction by the metabolic fingerprinting technique and liquid chromatography/diode-array detection mass spectrometry显示文摘 | Wang, P Liang, YZ Zhou, N Chen, BM Yi, LZ Yu, Y Yi, ZB | 2007 | 中国生物学文摘2007，21，11： | 31 |
| 2 | Ultra-high pressure metamorphism of granitic gneiss in the Yinggelisayi area, Altun Mountains, NW China显示文摘 | LIU Liang, SUN Yong, LUO Jinhai, WANG Yan, CHEN Danling & ZHANG Anda The Key Laboratory of Continental Dynamics, Ministry of Education,Department of Geology, Northwest University, Xi抋n 710069, China | 2004 | Science China Earth Sciences2004，47，4： | 27 |
| 3 | Cathepsin L upregulation-induced EMT phenotype is associated with the acquisition of cisplatin or paclitaxel resistance in A549 cells显示文摘组织蛋白酶 L (CTSL ) , lysosomal 酸半胱氨酸朊酶,被知道在肿瘤起重要作用转移和化疗抵抗。在这研究,我们调查了在人的肺癌症 cells.Methods 由 CTSL 位于 chemoresistance 的规定下面的分子的机制:人的肺癌症 A549 房间, A549/PTX (paclitaxel 抵抗) 房间和 A549/DDP (cisplatin 抵抗) 房间被测试。到 cisplatin 或 paclitaxel 的抵抗用 MTT 和殖民地形成试金被检测。肌动朊改变与 FITC-Phalloidin 被观察荧光灯的染色或 immunofluorescence。愈合创伤的试金或 Transwell 试金被用来估计迁居或侵略能力。CTSL 和上皮、间充质的标记的表示与西方的弄污和 immunofluorescence 被分析。联系 EMT 的抄写因素的表示与西方的弄污或 q-PCR 被测量。BALB/c 裸体老鼠与 A549 房间 overexpressing CTSL 皮下地被植入,并且老鼠是管理 paclitaxel (10, 15 mg/kg, ip ) 为 5 times.Results 的每 3 d:Cisplatin 或 paclitaxel 治疗(10-80 ng/mL ) 在 A549 房间导致了 CTSL 表示。CTSL 层次比在 A549 房间在 A549/PTX 和 A549/DDP 房间是高得多的。CTSL 的 Silencing 在 A549/DDP 和 A549/TAX 房间颠倒了 chemoresistance,而 CTSL 的 overexpression 稀释了 A549 房间的敏感到 cisplatin 或 paclitaxel。而且, A549/DDP 和 A549/TAX 房间经历了词法并且有增加的房间侵略和迁居能力的细胞骨架变化,由上皮的标记( E-cadherin 和 cytokeratin-18 )的减少的表示伴随了并且增加间充质的标记( N-cadherin 和 vimentin )的表示,以及 联系EMT 的抄写因素的 upregulation 蜗牛,蛞蝓, ZEB1 和 ZEB2 。CTSL 的 Silencing 在 A549/DDP 和 A549/TAX 房间颠倒了 EMT;相反, CTSL 的 overexpression 在 A549 房间导致了 EMT。在异种皮移植裸体人鼠标模型,与 A549 房间 overexpressing CTSL 植入的鼠标展出了显著地减少的敏感到 paclitaxel 处理,并且在肿瘤 tissues.Conclusion 增加了联系 EMT 的蛋白质和抄写因素的表示:Cisplatin 和 paclitaxel 抵抗在 A549 房间与 CTSL 导致 upregulation 的 EMT 被联系。因此,调停 CTSL 的 EMT 可以作为一个目标被利用对肺癌症和恶意的另外的类型提高 cisplatin 或 paclitaxel 的功效。 | Mei-ling HAN Yi-fa n ZHAO Cai-hong TAN Ya-jie XIONG Wen-juan WANG Feng WU Yao FEI Long WANG Zhong-qin LIANG | 2016 | Acta Pharmacologica Sinica2016，37，12： | 15 |
| 4 | Increased nitric oxide inactivation by reactive oxygen species in Lead - induced hypertension 显示文摘 | Vaziri N D Liang KH Ding YX | 1999 | Kidney Int1999，56，： | 3 |
| 5 | Laser-induced oxidation assisted micro milling of high aspect ratio microgroove on WC-Co cemented carbide显示文摘Severe tool wear and poor surface quality are the main problems during micro machining of cemented carbide.In this work,an innovative hybrid process of laser-induced oxidation assisted micro milling(LOMM)was proposed to solve the problems.A nanosecond laser was utilized to induce oxidation of the WC-20%Co material,producing loose oxide which was easy to remove.The micro machinability of the material was improved by laser-induced oxidation.The oxidation mechanisms of cemented carbide were studied.A microgroove with a depth of 2.5 mm and aspect ratio of 5 was fabricated successfully.The milling force,surface quality and tool wear mechanisms were investigated.For comparison,a microgroove was also fabricated with conventional micro milling(COMM)using identical milling parameters.Results revealed that in LOMM the milling force and tool wear rate were extremely low during removing the oxide.The machined surface quality and dimensional accuracy achieved by LOMM were superior to those obtained by COMM.The surface roughness Saof the microgroove bottom reached 88 nm in LOMM,while the cross-sectional geometry of the microgroove was a trapezoid.Perpendicularity of the microgroove sidewall machined by LOMM was better than that by COMM.The tool wear forms in LOMM were coating spalling and slight tool nose breakage.Compared with COMM,the tool life in LOMM was prolonged significantly.It indicates that the proposed hybrid process is an effective and efficient way to fabricate high aspect ratio micro-features with high dimensional accuracy. | Guolong ZHAO Hongjun XIA Yang ZHANG Liang LI Ning HE Hans Nφrgaard HANSEN | 2021 | Chinese Journal of Aeronautics2021，34，4： | 3 |
| 6 | 中国荷斯坦奶牛跛行和飞节损伤的风险因素分析显示文摘为了评估散栏牧场高产奶牛跛行率、飞节损伤与饲养管理、牧场设计之间的相关性,收集了中国34个大中型牧场高产牛群管理和卧床设计数据,如卧床设计、垫料类型和挤奶程序等。对每个圈的所有奶牛进行行走评分(1~5分)和飞节评分(1~3分)。其中行走评分大于等于3分定义为临床跛行,大于等于4分定义为严重跛行;飞节损伤大于等于2分为轻微损伤,3分为严重损伤。中国大中型牧场临床跛行率和严重跛行率分别为(31±12)%(分布于7%~51%)和(10±6)%(分布于0%~27%)。飞节轻微损伤率和严重损伤率分别为(40±20)%(分布于6%~95%)和(5±9)%(分布于0%~50%)。临床跛行率和严重跛行率与牧场的规模有显著相关性。随着牧场规模的增大,临床跛行和严重跛行有降低的趋势,每增加100头牛,临床跛行率降低(0.35±0.09)%,严重跛行率降低(0.15±0.06)%。牧场的新旧程度也显著影响跛行率,尤其是大于9年的牧场跛行率和严重跛行率明显升高。牧场的规模和新旧程度在引起临床跛行和严重跛行的因素中占49%和30%的作用。深槽卧床可降低轻微飞节损伤和严重飞节损伤的发生率(分别降低20.9%和3.65%)。大于9年的牧场飞节轻微损伤率和严重损伤率分别提高16.68%和7.17%。这2个变量可影响飞节轻微损伤和飞节严重损伤的52%和58%。总之,牧场之间的跛行率和飞节损伤率变异很大。良好的卧床设计和管理有助于降低跛行率和飞节损伤率。 | 王艳明 Chapinal N Liang Y Weary D M Wang Y | 2015 | 中国乳业2015，0，7： | 3 |
| 7 | Stem cell differentiation and human liver disease显示文摘Human stem cells are scalable cell populations capable of cellular differentiation.This makes them a very attractive in vitro cellular resource and in theory provides unlimited amounts of primary cells.Such an approach has the potential to improve our understanding of human biology and treating disease.In the future it may be possible to deploy novel stem cell-based approaches to treat human liver diseases.In recent years,eff icient hepatic differentiation from human stem cells has been achieved by several research groups including our own.In this review we provide an overview of the f ield and discuss the future potential and limitations of stem cell technology. | Wen-Li Zhou Claire N Medine Liang Zhu David C Hay | 2012 | World Journal of Gastroenterology2012，18，17： | 3 |
| 8 | Influence of Eutrophication on the Distribution of Total Mercury and Methylmercury in Hydroelectric Reservoirs显示文摘 | Meng Bo Feng X B Chen C X Qiu G L Sommar J Guo Y N Liang P Wan Q | 2010 | EN2010，，5： | 2 |
| 9 | Taxuchin B,a New Chlorine-Containing Taxoid显示文摘A new taxoid, taxuchin B[1], has been isolated from twigs and needles of Taxus chinensis. It is the first chlorine-containing taxoid reported to | Fang, WS Fang, QC Liang, XT Lu, Y Wu, N Zheng, QT | 1997 | Chinese Chemical Letters1997，8，3： | 2 |
| 10 | Adsorption study of copper(Ⅱ) by chemically modified orange peel显示文摘 | FENG N GUO X LIANG S | 2009 | J Hazard Mater2009，164，： | 1 |
| 11 | Assimilation of enterprise systems : The effect of institutional pressures and the mediating role of top management显示文摘 | Liang H G Saraf N Hu Q | 2007 | MIS Quarterly2007，31，1： | 1 |
| 12 | A Laplacian spectral method for stereo correspondence显示文摘 | Tang J Liang D Wang N | 2007 | Pattern Recognition Letters Elsevier2007，28，12： | 1 |
| 13 | Kinetic and thermodynamic studies on biosorption of Cu (II) by chemically modified orange peel 显示文摘 | Liang S Guo X Y Feng N C | 2009 | Trans Nonferrous Met Soc China2009，19，： | 1 |
| 14 | Evaluation of abradability of porous seal materials in a single-pendulum scratch device显示文摘 | Liang Y N Li S Li S Z | 1994 | Wear1994，177，： | 1 |
| 15 | Comparison of one -dimensional and two- dimensional models for wet surface fin efficiency of a plate - fin - tube heat exchanger 显示文摘 | Liang S Y Wong T N Nathan G K | 2000 | Applied Thermal Engineering2000，20，10： | 1 |
| 16 | Type-2 fuzzy logic systems显示文摘 | Karnik N Mendel J Liang Q | 1999 | IEEE Transactions on Fuzzy Systems1999，7，6： | 1 |
| 17 | A fast and accurate online sequential learning algorithm for feed- forward networks 显示文摘 | Liang N Y Huang G B Saratchandran P | 2006 | Neural Networks IEEE Transac- tions on2006，17，6： | 1 |
| 18 | Anal Chim Acta显示文摘 | Cao D S Hu Q N Xu Q S Yang Y N Zhao J C Lu H M Zhang L X Liang Y Z | 2011 | 692(1-2):502011，692，12： | 1 |
| 19 | Resveratrol inhibits β-amyloid- induced neuronal apoptosis through regulation of SIRT1-ROCK1 signaling pathway显示文摘 | Feng X Liang N Zhu D | 2013 | PLoS One2013，8，59： | 1 |
| 20 | 查看详情显示文摘 | Liang Y. N Wang F Guo J | | 0，，： | 1 |
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