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| 1 | LORELEI-LIKE GPI-ANCHORED PROTEINS 2/3 Regulate Pollen Tube Growth as Chaperones and Coreceptors for ANXUR/BUPS Receptor Kinases in Arabidopsis显示文摘Pollen tube growth is crucial for successful fertilization.In Arabidopsis thaliana,the ANXUR(ANX)/BUPS receptor kinase complex controls and maintains pollen tube growth in response to autocrine rapid alkalin-ization factor 4/19(RALF4/19)signaling;however,the molecular and cellular mechanisms underlying the ANX/BUPS-mediated regulation of pollen tube growth remain unclear.In this study,we found that pollen-specific LORELEI-like GPI-anchored proteins 2 and 3(LLG2/3)promote pollen tube growth in vitro and in vivo.LLG2/3 interacte with ANX/BUPS in a RALF4-concentration-dependent manner,suggesting that ANX/BUPS and LLG2/3 might form a receptor-coreceptor complex for perceiving RALF peptide signals.Disruption of the ANX/BUPS-LLG2/3 interaction led to the cytoplasmic retention of ANX1/2,in either llg2/3 knockdown mutants or in anx1/2 mutants lacking the J region,which mediates the ANX/BUPS-LLG2/3 interaction.Moreover,we found that RALF4 induced the production of reactive oxygen species(ROS),which stimulate pollen tube growth and reduce pollen burst rate.ROS levels are reduced in the pollen tubes of LLG2/3 RNAi lines,and application of exogenous H2O2 could partially rescue the defective pollen tube growth of LLG2/3 RNAi lines.Taken together,our study identifies LLG2/3 as novel regulatory components of pollen tube growth,and shows that they chaperone ANX/BUPS for secretion to the apical plasma membrane of pollen tube and act as coreceptors of ANX/BUPS in the acti-vation of ROS production for promoting pollen tube growth. | Hanqian Feng Chen Liu Rong Fu Minmin Zhang Hui Li Lianping Shen Qiqi Wei Xiang Sun Lin Xu Bin Ni Chao Li | 2019 | Molecular Plant2019，12，12： | 10 |
| 2 | Current understanding of osteoarthritis pathogenesis and relevant new approaches显示文摘Osteoarthritis(OA)is the most common degenerative joint disease that causes painful swelling and permanent damage to the joints in the body.The molecular mechanisms of OA are currently unknown.OA is a heterogeneous disease that affects the entire joint,and multiple tissues are altered during OA development.To better understand the pathological mechanisms of OA,new approaches,methods,and techniques need to be used to understand OA pathogenesis.In this review,we first focus on the epigenetic regulation of OA,with a particular focus on DNA methylation,histone modification,and microRNA regulation,followed by a summary of several key mediators in OA-associated pain.We then introduce several innovative techniques that have been and will continue to be used in the fields of OA and OA-associated pain,such as CRISPR,scRNA sequencing,and lineage tracing.Next,we discuss the timely updates concerning cell death regulation in OA pathology,including pyroptosis,ferroptosis,and autophagy,as well as their individual roles in OA and potential molecular targets in treating OA.Finally,our review highlights new directions on the role of the synovial lymphatic system in OA.An improved understanding of OA pathogenesis will aid in the development of more specific and effective therapeutic interventions for OA. | Liping Tong Huan Yu Xingyun Huang Jie Shen Guozhi Xiao Lin Chen Huaiyu Wang Lianping Xing Di Chen | 2022 | Bone Research2022，10，4： | 4 |
| 3 | Mice Deficient in NF-κB p50 and p52 or RANK Have Defective Growth Plate Formation and Post-natal Dwarfism显示文摘NF-κBp50/p52 double knockout(dKO)and RANK KO mice have no osteoclasts and develop severe osteopetrosis associated with dwarfism.In contrast,Op/Op mice,which form few osteoclasts,and Src KO mice,which have osteoclasts with defective resorptive function,are osteopetrotic,but they are not dwarfed.Here,we compared the morphologic features of long bones from p50/p52 dKO,RANK KO,Op/Op and Src KO mice to attempt to explain the differences in their long bone lengths.We found that growth plates in p50/p52 dKO and RANK KO mice are significantly thicker than those in WT mice due to a 2-3-fold increase in the hypertrophic chondrocyte zone associated with normal a proliferative chondrocyte zone.This growth plate abnormality disappears when animals become older,but their dwarfism persists.Op/Op or Src KO mice have relatively normal growth plate morphology.In-situ hybridization study of long bones from p50/p52 dKO mice showed marked thickening of the growth plate region containing type 10 collagen-expressing chondrocytes.Treatment of micro-mass chondrocyte cultures with RANKL did not affect expression levels of type 2 collagen and Sox9,markers for proliferative chondrocytes,but RANKL reduced the number of type 10collagen-expressing hypertrophic chondrocytes.Thus,RANK/NF-κB signaling plays a regulatory role in post-natal endochondral ossification that maintains hypertrophic conversion and prevents dwarfism in normal mice. | Lianping Xing Di Chen Brendan F.Boyce | 2013 | Bone Research2013，1，4： | 2 |
| 4 | A systematic review of evaluation of variability management approaches in software product lines显示文摘 | Lianping Chen Muhammad Ali Babar | 2011 | Information and Software Technology2011，53，4： | 1 |
| 5 | Managing Variability in Software Product Lines 显示文摘 | Babar Muhammad Ali Chen Lianping Shull Forrest | 2010 | IEEE Software2010，27，3： | 1 |
| 6 | NOTCH inhibits osteoblast formation in inflammatory arthritis via noncanonical NF-[Kappa]B显示文摘 | Zhang Hengwei Hilton Matthew J Anolik Jennifer H Welle Stephen L Zhao Chen Yao Zhenqiang Li Xing Wang Zhiyu Boyce Brendan F Xing Lianping | 2014 | Journal of Clinical Investigation2014，，： | 1 |
| 7 | Fabrication of luminescent SrWO4 thin films by a novel electrochemical method显示文摘 | Chen Lianping Gao Yuanhong | 2007 | Materials Research Bulletin2007，42，： | 1 |
| 8 | Mechanisms and applications of cell electrochemical technique to prepare luminescent SrMoO4 thin films显示文摘 | Chen Lianping Gao Yuanhong | 2007 | Chemical Engineering Journal2007，131，： | 1 |
| 9 | Mechanisms and applications of cell electrochemical technique to prepare luminescent SrMoO4 thin films显示文摘 | Lianping Chen Yuanhong Gao | 2007 | Chemical Engineering Journal2007，131，： | 1 |
| 10 | Large-Area Gravure-Printed AgNWs Electrode on Water/Oxygen Barrier Substrate for Long-Term Stable Large-Area Flexible Organic Solar Cells显示文摘Large-area AgNWs electrodes(25 cm×10 cm)were fabricated through roll-to-roll printing on the polyvinyl alcohol(PVA)modified water and oxygen barrier substrate.The modification of the barrier film with PVA improved the wettability of silver nanowires on the barrier films and led to the formation of homogenous large-area AgNWs networks.The mechanical flexibility,especially the adhesion force between the silver electrode and the barrier film substrate was dramatically improved through PVA modification.The efficiency of 13.51%for the flexible OSCs with an area of 0.64 cm2 was achieved based on the PET/barrier film/PVA/AgNWs electrode.The long-term stability showed the flexible OSCs based on the PET/barrier film/PVA/AgNWs electrode have a significantly improved stability relative to the device on PET/AgNWs electrode,and comparable air stability as the rigid device with glass/ITO device.The unencapsulated devices maintained nearly 50%of the original efficiency after storage for 600 h in air.After a simple top encapsulation,the flexible devices remained at 60%of the initial efficiency after 2000 h in the air.Therefore,the flexible AgNWs electrode based on the barrier film would have the potential to improve the air storage stability of organic flexible solar cells. | Hao Wang Yaqin Pan Yunfei Han Zhuo Chen Tianyu Liu Lianping Zhang Qun Luo Chang-Qi Ma | 2024 | Chinese Journal of Chemistry2024，42，5： | 0 |
| 11 | Thermoplastic elastomer enhanced interface adhesion and bending durability for flexible organic solar cells显示文摘Stable interface adhesion and bending durability of flexible organic solar cells(FOSCs)is a basic requirement for its real application in wearable electronics.Unfortunately,the device performance always degraded during continuous bending.Here,we revealed the weak interface adhesion force between MoO_(3) hole transporting layer(HTL)and the organic photoactive layer was the main reason of poor bending durability.The insertion of an interface bonding layer with a thermoplastic elastomer,polystyrene-blockpoly(ethylene-ran-butylene)-block-polystyrene(SEBS)effectively improved the interface adhesion force of MoO_(3) HTL and the active layer and decreased the modulus,which ensured higher than 90%of the initial efficiency remaining after 10000 bending.Meanwhile,the FOSCs gave an efficiency of 14.18%and 16.15%for the PM6:Y6 and PM6:L8-BO devices,which was among the highest performance of FOSCs.These results demonstrated the potential of improving the mechanical durability of FOSCs through thermoplastic elastomer interface modification. | Zihan Xu Yunfei Han Yuanyuan Bai Xingze Chen Jingbo Guo Lianping Zhang Chao Gong Qun Luo Ting Zhang Chang-Qi Ma | 2022 | npj Flexible Electronics2022，6，1： | 0 |
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