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| 1 | Adjuvant radiotherapy in central hepatocellular carcinoma after narrow-margin hepatectomy:A 10-year real-world evidence显示文摘Objective:A prospective randomized control study investigated the feasibility and efficacy of adjuvant radiotherapy on patients with central hepatocellular carcinoma(HCC)after narrow-margin hepatectomy(<1 cm).This study presents an updated 10-year real-world evidence to further characterize the role of adjuvant radiotherapy.Methods:Patients with central HCC after narrow-margin hepatectomy(<1 cm)were prospectively assigned to adjuvant radiotherapy group and control group.Patients'outcome,adverse events,long-term recurrence and survival rates were investigated.Results:The 1-,5-,and 10-year recurrence-free survival(RFS)rates were 81.0%,43.9%,and 38.7%,respectively in adjuvant radiotherapy group and 71.7%,35.8%,and 24.2%,respectively in control group(log-rank test,P=0.09).The 1-,5-,and 10-year overall survival(OS)rates were 96.6%,54.7%,and 42.8%,respectively in adjuvant radiotherapy group and 90.2%,55.1%,and 30.0%,respectively in control group(log-rank test,P=0.20).The 1-,5-,and 10-year RFS rates for patients with small HCC(≤5 cm)were 91.1%,51.6%,and 48.4%,respectively in adjuvant radiotherapy group and 80.0%,36.6%,and 26.6%,respectively in control group(log-rank test,P=0.03).Landmark analysis demonstrated that patients with small HCC in adjuvant radiotherapy group had a significantly improved OS in second five years after treatment in comparison to patients in control group(log-rank test,P=0.05).Conclusions:Our updated results showed a sustained clinical benefit on reducing recurrence,improving longterm survival for small central HCC by adjuvant radiotherapy after narrow-margin hepatectomy.Long-term survival data also indicated that hepatectomy is an optimal treatment for selected patients with central HCC. | Weiqi Rong Weibo Yu Liming Wang Fan Wu Kai Zhang Bo Chen Chengli Miao Liguo Liu Songlin An Changcheng Tao Weihu Wang Jianxiong Wu | 2020 | Chinese Journal of Cancer Research2020，32，5： | 6 |
| 2 | Biofilm from a clinical strain of Cryptococcus neoformans activates the NLRP3 inflammasome显示文摘 | Guowei Lei Mingkuan Chen Hua Li Jun-Ling Niu Shuxian Wu Liming Mao Ailing Lu Hongbin Wang Wei Chen Bin Xu Qibin-Leng Cunshuan Xu Guiwen Yang Liguo An Li-Ping Zhu Guangxun Meng | 2013 | Cell Research2013，23，7： | 5 |
| 3 | Bacterial and cyanobacterial diversities determined by T-RFLP analyses in the Jiaozhou Bay显示文摘染色 epifluorescence 显微镜学和 T-RFLP 分析的 DAPI 的方法被用来在在 12 上在调查期间从 12stations 取样在内并且在 Jiaozhou 海湾外面的表面海水和 2004 年 9 月 13 日分析微生物引起的丰富和差异。全部的微生物的 Theabundance 在 10 ~ 的范围是 6 ~ 10 ~ 7 cells/cm~3,类似于那些在在世界上的适度的区域的围住 mostsemi 的海湾。最高微生物引起的密度发生在 Jiaozhou 海湾的东北部分,绕 Loushan 和 Licun 河的嘴,建议并且 theHongdao 水文化耕作区域污染的度和特征,与一起地理并且水文学效果,可以是在 Jiaozhou 海湾影响细菌的丰富和分发的重要决定因素。细菌的社区在内并且在 Jiaozhou 海湾外面能基于 T-RFLP 模式和簇分析被组织进三个班。在海湾嘴和外面的水隧道驻扎,例如 D1, D3, D5, D6 andD7,一起被组织代表在 Jiaozhou 海湾外面与环境交往的在外面细菌的社区。Jiaozhou 海湾,如此的 asA3, A5, B2 和 Y1 的最深处的方面的车站,一起被组织代表居住细菌社区。StationsC1, C3 和 C4 一起被组织并且可以代表在居住社区和外面的社区之间的过渡细菌的集合。然而,为 cyanobacterial 差异的盒子没有如此的一种定义关系,显示 cyanobacteria 对各种条件更灵活、能适应的事实。 | REN Jing DANG Hongyue SONG Linsheng SUN Song AN Liguo | 2006 | Acta Oceanologica Sinica2006，25，4： | 4 |
| 4 | Human pathogenic fungus Trichophyton schoenleinii activates the NLRP3 inflammasome显示文摘The fungus Trichophyton schoenleinii(T.schoenleinii)is the causative agent of Trichophytosis and Tinea favosa of the scalp in certain regions of Eurasia and Africa.Hu-man innate immune system plays an important role in combating with various pathogens including fungi.The inflammasome is one of the most critical arms of host innate immunity,which is a protein complex controlling maturation of IL-1β.To clarify whether T.schoenleinii is able to activate the infl ammasome,we analyzed human monocytic cell line THP-1 for IL-1βproduction upon infec-tion with T.schoenleinii strain isolated from Tinea favosa patients,and rapid IL-1βsecretion from THP-1 cells was observed.Moreover,applying competitive inhibitors and gene specifi c silencing with shRNA,we found that T.sch-oenleinii induced IL-1βsecretion,ASC pyroptosome for-mation as well as caspase-1 activation were all dependent on NLRP3.Cathepsin B activity,ROS production and K+effl ux were required for the infl ammasome activation by T.schoenleinii.Our data thus reveal that the NLRP3 infl am-masome plays an important role in host defense against T.schoenleinii,and suggest that manipulating NLRP3 signaling can be a novel approach for control of diseases caused by T.schoenleinii infection. | Hua Li Shuxian Wu Liming Mao Guowei Lei Liping Zhang Ailing Lu Liguo An Guiwen Yang Paride Abliz Guangxun Meng | 2013 | Protein & Cell2013，4，7： | 3 |
| 5 | Blue revolution for food security under carbon neutrality: A case from the water-saving and drought-resistance rice显示文摘The increasing concentration of greenhouse gases(GHGs)in Earth's atmosphere leads to global warming,which further causes a series of climate changes and does great harm to both human society and natural ecosystems.Agricultural GHG emissions,mainly in theform of methane(CH4)and nitrous oxide(N2O),areasignificantsourceofGHGs,accountingfor~14%total global GHGs(Zhang et al.,2022).One major source of agricultural GHGs is CH4 emissions from rice paddies,which is responsiblefor~10%-12%ofhuman-inducedCH4emissions(van Groenigen et al.,2013)and contributes~2.40%to the enhanced global warming effect(Zhang et al.,2022).The global warming potential of GHGs emissions from rice systems is roughly four times higher than either wheat or maize(Linquist et al.,2012). | Hui Xia Xianxian Zhang Yi Liu Junguo Bi Xiaosong Ma Anning Zhang Hongyan Liu Liang Chen Sheng Zhou Huan Gao Kai Xu Haibin Wei Guolan Liu Feiming Wang Hongyang Zhao Xingxing Luo Danping Hou Qiaojun Lou Fangjun Feng Liguo Zhou Shoujun Chen Ming Yan Tianfei Li Mingshou Li LeiWang Zaochang Liu Xinqiao Yu HanweiMei Lijun Luo | 2022 | Molecular Plant2022，15，9： | 3 |
| 6 | CUTTING TEMPERATURE OF TEMPERING BEARING STEEL GCr15 CUT BY PCBN CUTTER显示文摘A thermoelectric curve of GCr15 BN500 is acquired by rapid label way. The study on measuring the cutting temperature with PCBN cutter is done and the calculation formula is achieved. A series of experiments about cutting temperature are made for different hardness tempering bearing steel at the same time. The rule that cutting temperature increases with increasing of the cutting speed, feed, back engagement of the cutting edge is gained. It is known that the cutting temperature is highest under the condition that back engagement of the cutting edge a p≥2.5 mm and the machined material hardness equals to 50HRC. | Liu Xianli Chen Bo Meng An Chen Liguo Li Zhenjia Dept.of Mechanism Engineering, Harbin University of Science and Technology Yuan Zhejun Harbin Institure of Technology | 1999 | Chinese Journal of Mechanical Engineering1999，12，4： | 2 |
| 7 | Six novel single-nucleotide polymorphisms in SPAG11 gene and their association with sperm quality traits in Chinese Holstein bulls显示文摘 | Xinyan Liu Zhihua Ju Lingling Wang Yan Zhang Jingmin Huang Qiuling Li Jianbin Li Jifeng Zhong Liguo An Changfa Wang | 2011 | Animal Reproduction Science2011，，1： | 1 |
| 8 | Multidose Streptozotocin Induction of Diabetes in BALB/c Mice Induces a Dominant Oxidative Macrophage and a Conversion of T H 1 to T H 2 Phenotypes During Disease Progression显示文摘 | Naxin Sun Guiwen Yang Heng Zhao Huub F. J. Savelkoul Liguo An | 2005 | Mediators of Inflammation2005，，4： | 1 |
| 9 | Ubiquitin ligase Smurf1 targets TRAF family proteins for ubiquitination and degradation显示文摘 | Shan Li Kefeng Lu Jian Wang Liguo An Guiwen Yang Hui Chen Yu Cui Xiushan Yin Ping Xie Guichun Xing Fuchu He Lingqiang Zhang | 2010 | Molecular and Cellular Biochemistry (-)2010，，1： | 1 |
| 10 | Advance in microorganism feed additives 显示文摘 | Miao Yin Guiwen Yang Liguo An | 2001 | Food and Feed Industry2001，4，： | 1 |
| 11 | The production-influencing factors of extracellular polysaccharide(EPS)from a strain of lactic acid bacteria and EPS extraction显示文摘The influencing factors of extracellular polysac-charide(EPS)produced from a strain of lactic acid bacteria(LAB L15)were studied by using the phenol-H2SO4 method.It was demonstrated that the strain produced EPS at the most amount when it was incubated for 40-48 h and when the pH value was 4 under 30℃.Glucose was the most suitable carbon source for LAB-producing EPS.The rough EPS was obtained from L15 culture after centrifugation,dialysis,deprotein,decoloration,and ethanol-precipitation.The sample was at least composed of two polysaccharides that were completely different in molecular weight and the amount.The purified EPS was passed through the SephadexG-200 column and it showed that it was a sample purified by thin layer chromatography. | CHEN Ying SUN Liping ZENG Yong WANG Lei AN Liguo | 2006 | Frontiers in Biology2006，1，3： | 0 |
| 12 | Current Situation and Development Proposals of Agricultural Facilities(Planting)Application in Beijing显示文摘Facility agriculture is an essential carrier for promoting stable production and supply.In2020,the planting area of facility agriculture in Beijing(290098000 m2)accounted for 29.06%of the total planting area of crops(998078000 m2),and the output value accounted for 46.56%.In2022,Beijing Agricultural Technology Extension Station organized relevant departments to summarize and evaluate the agricultural facilities in Beijing through consultation materials,interviews,questionnaires,and field trips,combining survey data and statistical data to draw the following conclusions.Facilities play a major supporting role in stabilizing production and ensuring supply.The number of traditional greenhouses is extensive and covers a large area,so special planning and classification upgrades are urgently needed.Facilities are rich in scientific and technological resources,but the mode of production is out of date.It is of great significance to improve the comprehensive production capacity of facility agriculture and promote the healthy and stable development of facility industry in Beijing to increase the utilization rate of facility agriculture land,strengthen the support of facility science and technology,and cultivate the socialized service organization of facility. | Xihong Lei Wei Li Yanfang Wang Manli Niu Fudong Wang Dong An Liguo Yang | 2023 | Journal of Beijing Institute of Technology2023，32，3： | 0 |
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