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| 1 | Therapeutic proteasome inhibition in experimental acute pancreatitis显示文摘AIM: To establish the therapeutic potential of proteasome inhibition, we examined the therapeutic effects of MG132 (Z-Leu-Leu-Leu-aldehyde) in an experimental model of acute pancreatitis.METHODS: Pancreatitis was induced in rats by two hourly intraperitoneal (ip) injections of cholecystokinin octapeptide (CCK; 2 x 100 μg/kg) and the proteasome inhibitor MG132 (10 mg/kg ip) was administered 30 min after the second CCK injection. Animals were sacrificed 4 h after the first injection of CCK.RESULTS: Administering the proteasome inhibitor MG132 (at a dose of 10 mg/kg, ip) 90 min after the onset of pancreatic inflammation induced the expression of cell-protective 72 kDa heat shock protein (HSP72) and decreased DNA-binding of nuclear factor-kB (NF-kB). Furthermore MG132 treatment resulted in milder inflammatory response and cellular damage, as revealed by improved laboratory and histological parameters of pancreatitis and associated oxidative stress.CONCLUSION: Our findings suggest that proteasome inhibition might be beneficial not only for the prevention, but also for the therapy of acute pancreatitis. | Tamás Letoha Liliána Z Fehér László Pecze Csaba Somlai Ilona Varga József Kaszaki Gábor Tóth Csaba Vizler László Tiszlavicz Tamás Takács | 2007 | World Journal of Gastroenterology2007，13，33： | 5 |
| 2 | Interaction of the major inflammatory bowel disease susceptibility alleles in Crohn’s disease patients显示文摘AIM:To investigate the interaction of interleukin-23 receptor(IL23R)(rs1004819 and rs2201841),autophagy-related 16-like 1(ATG16L1)(rs2241880), caspase recruitment domain-containing protein 15 (CARD15)genes,and IBD5 locus in Crohn's disease(CD) patients. METHODS:A total of 315 unrelated subjects with CD and 314 healthy controls were genotyped.Interactions and specific genotype combinations of a total of eight variants were tested.The variants of IBD5locus(IGR2198a_1 rs11739135 and IGR2096a_1 rs12521868),CARD15(R702W rs2066845 and L1007fs rs2066847),ATG16L1(rs2241880)and IL23R (rs1004819,rs2201841)genes were genotyped by PCR-RFLP,the G908R(rs2066844)in CARD15 was determined by direct sequencing. RESULTS:The association of ATG16L1 T300A with CD was confirmed[P=0.004,odds ratio(OR)=1.69, 95%CI:1.19-2.41],and both IL23R variants were found to represent significant risk for the disease(P= 0.008,OR=2.05,95%CI:1.20-3.50 for rs1004819 AA;P<0.001,OR=2.97,95%CI:1.65-5.33 for rs2201841 CC).Logistic regression analysis of pairwise interaction of the inflammatory bowel disease (IBD)loci indicated that IL23R,ATG16L1,CARD15 and IBD5(IGR2198a_1)contribute independently to disease risk.We also analysed the specific combina- tions by pair of individual ATG16L1,IL23R rs1004819, rs2201841,IGR2198a_1,IGR2096a_1 and CARD15 genotypes for disease risk influence.In almost all cases,the combined risk of susceptibility pairs was higher in patients carrying two different risk-associated gene variants together than individuals with just one polymorphism.The highest OR was found for IL23R rs2201841 homozygous genotype with combination of positive CARD15 status(P<0.001,OR=9.15,95% CI:2.05-40.74). CONCLUSION:The present study suggests a cumulative effect of individual IBD susceptibility loci. | Veronika Csngei Luca Járomi EnikSáfrány Csilla Sipeky Lili Magyari Bernadett Faragó Judit Bene Noémi Polgár Lilla Lakner Patrícia Sarlós Márta Varga Béla Melegh | 2010 | World Journal of Gastroenterology2010，16，2： | 2 |
| 3 | The role of colposcopy andtypization of human papillomavirus in further diagnosticproceedings in patients with ASC-US cytological finding of theuterine cervix显示文摘 | Zivadinovi R Lili V Dordevi B | 2009 | Vojnosanit Pregl2009，66，8： | 1 |
| 4 | Multiresidue method for the determination of sulfonamides in pork tissue 显示文摘 | Austin R Long Lily C Hsieh | 1990 | J Agile Food Chem1990，38，： | 1 |
| 5 | Monitoring activities from multiple video streams: establishing a common coordinate frame显示文摘 | LILY L RAQUEL R | 2000 | IEEE Transactions on Pattern Analysis and Machine Intelligence2000，8，： | 1 |
| 6 | L-Arginine hy- drochloride increases the solubility of folded and unfolded re combinant plasminogen activator rPA显示文摘 | TISCHER A LILIE H RUDOLPH R et 01 | 2010 | Protein Science2010，19，： | 1 |
| 7 | Recurrence of cervical intraepithelial neoplasias with negative cone margins: risk faetors显示文摘 | Zivadinovic R Lilic G Lilie V | 2011 | J BUON2011，16，3： | 1 |
| 8 | In vitro folding of inclusion body proteins 显示文摘 | Rudolph R Lili H | 1996 | FASEB J1996，10，1： | 1 |
| 9 | Graphene-based materials as super- capacitor electrodes显示文摘 | Zhang Lili Zhou R Zhao X S | 2010 | J Mater Chem2010，20，29： | 1 |
| 10 | Anticholinergic and antiglutamatergic agents protect against Soman-induced brain damage and cognitive dysfunction显示文摘 | Lily R Ben A W Giora C | 2003 | Toxicol Sci2003，75，： | 1 |
| 11 | In vitro folding of inclusion body proteins 显示文摘 | Rudolph R Lilie H | 1996 | FASEB J1996，10，1： | 1 |
| 12 | In vitro folding of inclusion body proteins显示文摘 | RUDOLPH R Lilie H | 1996 | FasebJ1996，10，： | 1 |
| 13 | Competitive Fuzzy Edge Detection显示文摘 | Lily R L Carl G L | 2003 | Applied Soft Computing2003，3，： | 1 |
| 14 | Cognitive Situation andThreat Assessments of Ground Battlespaces 显示文摘 | Carl G Looney Lily R Liang | 2003 | In-formation Fusion2003，4，2： | 1 |
| 15 | Folding of a synthetic parallel beta-roll protein 显示文摘 | Lilie H Haehnel W Rudolph R | 2000 | FEBS Lett2000，470，2： | 1 |
| 16 | Bicylindrical Coordinate Formulation for the Leakage Flow through the Minimal Clearance in a Rolling piston Compressor显示文摘 | Ferreira R T S Lilie D E B Gasche J L | 1992 | Proceeding of Purdue Compressor Technology Conference1992，，： | 1 |
| 17 | Cognitive Situation and Threat Assessments of Ground Battle Spaces显示文摘 | Carl G L Lily R L | 2003 | Information Fusion2003，4，4： | 1 |
| 18 | Volatiles and Harvest Maturity of Peaches and Nectarines显示文摘 | LILY L I M ROMANI R J | 1963 | J Food Sci1963，29，： | 1 |
| 19 | In vitro folding of inclusion body proteins显示文摘 | Rudolph R Lilie H | 1996 | FASEB1996，10，： | 1 |
| 20 | Human parainfluenza virus type 4 infection in Chinese children with lower respiratory tract infections: A comparison study显示文摘 | Lili R Richard G Zhengde X | 2011 | Journal of Clinical2011，51，3： | 1 |
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