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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Integration of biocontrol yeast and thiabendazole protects stored apples from fungicide sensitive and resistant isolates of Botrytis cinerea显示文摘 | LIMA G de CURTIS F PIEDIMONTE D | | 0，，03： | 1 |
| 3 | Mood swings in patients with Crohn's disease: incidence and associat ed factors显示文摘 | Lima F D Ribeiro T C Chebli L A | 2012 | Rev Assoc Med Bras2012，58，4： | 1 |
| 4 | Simplified modeling of a DFIG for transient studies in wind power applica- tions显示文摘 | LUNA A LIMA F K RODRIGUEZ D SANTOS P | 2011 | IEEE Transactions on Industrial Electronics2011，58，1： | 1 |
| 5 | Diversity of rotavirus strains circulating in Northern Brazil after introduction of a rotavirus vaccine: High prevalence of G3P[6] genotype显示文摘 | Luana da Silva Soares Sylvia de Fátima dos Santos Guerra Alessilva do Socorro Lima de Oliveira Fabiola da Silva dos Santos Euzeni Maria de Fátima Costa de Menezes Joana d’Arc Pereira Mascarenhas Alexandre C. Linhares | 2014 | Virol2014，，6： | 1 |
| 6 | A prospec- tive, comparative study between endoscopic cyclophotocoagutation and the Ahmed drainage implant in refractory glaucoma显示文摘 | LIMA F E MAGACHO L CARVALHO D M | 2004 | J Glaucoma2004，13，3： | 1 |
| 7 | Microstructural an- alyses and wear behavior of the cemented carbide tools after laser surface treatment and PVD coating 显示文摘 | Neves D Diniz A E Lima M S F | 2013 | Ap- plied Surface Science2013，282，： | 1 |
| 8 | Fumigation of tablegrapes using ethyl formateand carbon dioxide as a quarantine treatment显示文摘 | LIMA F D | 2010 | AustralianViticulture2010，14，3： | 1 |
| 9 | Integrated control of blue mould using new fungicides and biocontrol yeasts lowers levels of fungicides residues and patulin contamination in apples显示文摘 | LIMA G CASTORIA R CURTIS F D | | 0，，02： | 1 |
| 10 | Physical Characterization and Electrochemical Activity of Bimetallic Platinum- Silver Particles for Oxygen Reduction in Alkaline Electrolyte 显示文摘 | Lima F H B Sanches C D Ticianelli E A | 2005 | J Electrochem Soc2005，152，7： | 1 |
| 11 | Impact of genetically modified Enterobacter cloacae on indigenous endophytic community of Citrus sinensis seedlings显示文摘 | Andreote F D Gullo M J M de Souza Lima A O | 2004 | Journal of Microbiology2004，42，3： | 1 |
| 12 | The Wnt signaling pathway and rheumatoid arthritis显示文摘 | Rabelo F D da Mota L M Lima R A | 2010 | Autoimmun Rev2010，9，4： | 1 |
| 13 | 显示文摘 | Abreu F R Lima D G Hamu E H | 2003 | JAOCS2003，80，6： | 1 |
| 14 | Beta-p-I, 3-glu- eanase activity of two saprophytic yeasts and possible mode of action as biocontrol agents against postharvest diseases 显示文摘 | EASTORIA R CURRIS F D LIMA G | 1997 | Posthavest Biology and Technology1997，12，： | 1 |
| 15 | Structural and functional insights to ubiquitin-like protein conjugation显示文摘 | Streich Jr F C Lima C D | 2014 | Annu Rev Biophys2014，43，： | 1 |
| 16 | Population structure and reproductive dynamics of Octopus insularis (Cephalopoda: Octopodidae) in a coastal reef environment along northeastern Brazil 显示文摘 | LIMA F D LEITE T S HAIMOVICI M | 2014 | Fisheries Research2014，，152： | 1 |
| 17 | Serologic marker candidates identified among B-cell linear epi- topes of Nsp2 and structural proteins of a North Ameri- can strain of porcine eproductive and respiratory syn- drome virus显示文摘 | Lima M D Pattnaik A K Flores E F | 2006 | Virology2006，353，： | 1 |
| 18 | Species boundaries inferred from ISSR markers in the Myrcia la- ruotteana complex (Myrtaceae) 显示文摘 | LIMA D F MAUAD A V S SILVA-PEREIRA V D | 2014 | Plant Systematics and Evolu- tion2014，301，1： | 1 |
| 19 | Thermal degradation of biodegradable edible films based on xanthan and starches from different sources显示文摘 | Soares R M D Lima A M F Oliveira R V B | 2005 | Polym Degrad Stab2005，4，7： | 1 |
| 20 | Luminescent properties and lattice defects correlation on zinc oxide显示文摘 | Lima S A M Sigoli F A Jafelicei M et d | 2001 | International Journal of Inorganic Materials2001，3，7： | 1 |
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