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| 1 | Evaluating the Phylogenetic Position of Chinese Tree Shrew(Tupaia belangeri chinensis) Based on Complete Mitochondrial Genome:Implication for Using Tree Shrew as an Alternative Experimental Animal to Primates in Biomedical Research显示文摘Tree shrew(Tupaia belangeri) is currently placed in Order Scandentia and has a wide distribution in Southeast Asia and Southwest China.Due to its unique characteristics,such as small body size,high brain-to-body mass ratio,short reproductive cycle and life span,and low-cost of maintenance,tree shrew has been proposed to be an alternative experimental animal to primates in biomedical research.However,there are some debates regarding the exact phylogenetic affinity of tree shrew to primates.In this study,we determined the mtDNA entire genomes of three Chinese tree shrews(T.belangeri chinensis) and one Malayan flying lemur(Galeopterus variegatus).Combined with the published data for species in Euarchonta,we intended to discern the phylogenetic relationship among representative species of Dermoptera,Scandentia and Primates.The mtDNA genomes of Chinese tree shrews and Malayan flying lemur shared similar gene organization and structure with those of other mammals.Phylogenetic analysis based on 12 concatenated mitochondrial proteinencoding genes revealed a closer relationship between species of Scandentia and Glires,whereas species of Dermoptera were clustered with Primates.This pattern was consistent with previously reported phylogeny based on mtDNA data,but differed from the one reconstructed on the basis of nuclear genes.Our result suggested that the matrilineal affinity of tree shrew to primates may not be as close as we had thought.The ongoing project for sequencing the entire genome of Chinese tree shrew will provide more information to clarify this important issue. | Ling Xu Shi-Yi Chen Wen-Hui Nie Xue-Long Jiang Yong-Gang Yao | 2012 | Journal of Genetics and Genomics2012，39，3： | 25 |
| 2 | Involvement of carbon monoxide produced by heme oxygenase in ABA-induced stomatal closure in Vicia faba and its proposed signal transduction pathway显示文摘Carbon monoxide (CO) has recently proven to be an important bioactive or signaling molecule in mammalian cells. Its effects are mainly mediated by nitric oxide (NO) and cyclic GMP (cGMP). In Vicia faba leaves, CO production and heme oxygenase (HO) activity, an important CO synthetic enzyme, are first reported to increase in response to ABA treatment, which could result in stomatal closure. Inter- estingly, ABA-induced stomatal closure in V. faba guard cells is partially blocked when the synthetic CO inhibitor ZnPP, or the CO/NO scavenger Hb is added. Furthermore, we show that, exogenously applied CO donor, hematin, and CO aqueous solution not only result in the enhancement of CO release, but also time-dependently induce stomatal closure, and the latter is mimicked by the application of an NO donor SNP. The above-mentioned stomatal closure effects are differentially reversed by the addition of tungstate, a potent inhibitor of NO synthetic enzyme nitrate reductase (NR), the specific NO scavenger cPTIO, ZnPP, or Hb. During treatment for 4 h, SNP, 0.01% CO aqueous solution or hematin significantly triggers NO synthesis, whereas cPTIO, or tungstate approximately fully inhibits NO fluorescence. Ad- ditionally, application of the GC inhibitor ODQ blocks CO-induced stomatal closure. This inhibition could be reversed when 8-Br-cGMP is added. Thus, the above results suggest that CO produced by HO is involved in ABA-induced stomatal closure, and NO and cGMP may function as downstream interme- diates in the CO signaling responsible for stomatal closure. | CAO ZeYu HUANG BenKai WANG QingYa XUAN Wei LING TengFang ZHANG Bo CHEN Xi NIE Li SHEN WenBiaot | 2007 | Chinese Science Bulletin2007，52，17： | 16 |
| 3 | Microcrack analysis of Sanya grantite fragments from rockburst tests显示文摘Fractures running along a plane reflect the cracking progress.In this paper uniaxial and rockburst tests on a group of granite specimens from Sanya province are described.Scanning electron microscopic imaging was used to characterize the fragments.Fractal fracture mechanics were used to analyze the microcracks in terms of both the crack type and the mineral constituent.A statistical analysis showed that the area of inter-granular cracking exceeds that of intra-granular cracking.Several types of crack were observed in the cracked areas.The percentage of intra-granular cracks in fragments from rockburst tests exceeds that from uniaxial compression tests.The results also showed that feldspar deformation was the main cause of fracture and that the consolidation along quartz grain boundaries was another weak area in the granite.Cracking along quartz grains had enough energy to enter the quartz crystal in the rockburst samples.All these results contribute to further research on rockburst mechanics. | HE, Manchao NIE, Wen HAN, Liqiang LING, Lijing | 2010 | Mining Science and Technology2010，20，2： | 11 |
| 4 | Development of a supercritical and an ultra-supercritical circulating fluidized bed boiler显示文摘The supercritical circulating fluidized bed(CFB)boiler,which combines the advantages of CFB combustion with low cost emission control and supercritical steam cycle with high efficiency of coal energy,is believed to be the future of CFB combustion technology.It is also of greatest importance for low rank coal utilization in China.Different from the supercritical pulverized coal boiler that has been developed more than 50 years,the supercritical CFB boiler is still a new one which requires further investigation.Without any precedentor engineering reference,Chinese researchers have con ducted fundamental research,development,design of the supercritical CFB boilers independently.The design theory and key technology for supercritical CFB boiler were proposed.Key components and novel structures were invented.The first 600 MWe supercritical CFB boiler and its auxiliaries were successfully developed and demonstrated in Baima Power Plant,Shenhua Group as well as the simulator,control technology,installation technology,commissioning technology,system integration and operation technology.Compared with the 460 MWe supercritical CFB in Poland,developed in the same period and the only other supercritical one of commercial running in the word beside Baima,the 600 MWe one in Baima has a better performance.Besides,supercritical CFB boilers of 350 MWe have been developed and widely commercialized in China.In this paper,the updated progress of 660 MWe ultra-supercritical CFB boilers under development is introduced. | Junfu LYU Hairui YANG Wen LING Li NIE Guangxi YUE Ruixin LI Ying CHEN Shilong WANG | 2019 | Frontiers in Energy2019，13，1： | 11 |
| 5 | Stent-grafts for the treatment of TIPS dysfunction:Fluency stent vs Wallgraft stent显示文摘AIM:To evaluate the clinical efficacy of an expanded polytetrafluoro-ethylene-covered Fluency stent compared with that of a polyethylene terephthalate-covered Wallgraft stent for the management of transjugular intrahepatic portosystemic shunt(TIPS)dysfunction.METHODS:A retrospective review of patients who underwent TIPS revision with stent-grafts between May 2007 and June 2011 was conducted.The patients were divided into two groups according to the stentgrafts implanted:the Fluency stent(Bard Incorporated,Karlsruhe,Germany)and the Wallgraft stent(Boston Scientific,Galway,Ireland).The primary patency rates were calculated and compared using the Kaplan-Meier method.RESULTS:A total of 73 patients were evaluated in this study:33 with Fluency stents and 40 with Wallgraft stents.The primary patency rates at 12 and 24 mo were 91% and 85%,respectively,in the Fluency stent group and 78% and 63%,respectively,in the Wallgraft stent group.The primary shunt patency rates after TIPS revision were significantly better with the Fluency stent than with the Wallgraft stent(P = 0.033).CONCLUSION:TIPS revision with the Fluency stent has higher medium-term patency rates than that with the Wallgraft stent. | Xue-Feng Luo Ling Nie Zhu Wang Jiaywei Tsauo Ling-Jun Liu Yang Yu Biao Zhou Cheng-Wei Tang Xiao Li | 2013 | World Journal of Gastroenterology2013，19，30： | 9 |
| 6 | Comparison of basic features and origins of oolitic shoal reservoirs between carbonate platform interior and platform margin locations in the Lower Triassic Feixianguan Formation of the Sichuan Basin,southwest China显示文摘The oolitic shoal reservoirs of the Lower Triassic Feixianguan Formation carbonates in the Sichuan Basin of southwest China are an important target for gas exploration in the basin.Their occurrence,like other cases worldwide,can be divided into two locations in general,i.e.,platform interior and platform margin locations.Their differences of reservoir features and origins,however,have not been investigated comprehensively due to different exploration degrees.This issue is addressed in this paper,to provide basic data and information for the basin's hydrocarbon exploration and for the study of carbonate platform sedimentology and reservoir geology worldwide.We compared the features of these two types of reservoirs in detail,including the depositional and diagenetic features,pore types and petrophysical features.Based on the comparison,the origin of the reservoirs was further discussed.It is shown that the reservoirs in platform interior and platform margin locations differ significantly.The interior carbonates were deposited in moderate to high energy settings and the dominant lithologic type was limestone,which was weakly compacted and intensely cemented and has undergone meteoric dissolution.Pore types include intragranular dissolution and moldic pores,with low porosities(<6%) and low permeabilities(<0.1 mD).By contrast,the platform margin carbonates were deposited in relatively high energy settings and mainly consisted of dolostones with some limestones.The rocks were strongly compacted but incompletely cemented.As a result,some primary intergranular pores were preserved.Both meteoric solution and burial solution have taken place.There are various types of pore spaces including intergranular and intercrystalline solution pores and residual intergranular pores.This type of reservoir generally has better petrophysical properties(>9% porosity and >0.1 mD permeability) and pore-throat structures than the interior reservoirs.These differences were influenced by both primary depositional features and secondary diagenesis.For the interior carbonate reservoirs,early meteoric dissolution,weak compaction and strong cementation are important controlling factors.By contrast,the factors controlling the formation of the margin carbonate reservoirs mainly include dolomitization,preservation of primary pores and burial dissolution. | Tan Xiucheng Zhao Luzi Luo Bing Jiang Xingfu Cao Jian Liu Hong Li Ling Wu Xingbo Nie Yong | 2012 | Petroleum Science2012，9，4： | 9 |
| 7 | Procalcitonin could be a reliable marker in differential diagnosis of post-implantation syndrome and infection after percutaneous endovascular aortic repair显示文摘 | Xue Ling Luo Songyuan Luo Jianfang Liu Zhen Gu Mengnan Kang Huiyuan Yang Fan Nie Bingrong Liu Yuan Huang Wenhui Xie Nianjin He Pengcheng Dong Haojian Ni Zhonghan Fan Ruixin Chen Jiyan | 2014 | Chinese Medical Journal2014，，14： | 8 |
| 8 | AZD9291-induced Acute Interstitial Lung Disease显示文摘To the Editor:A 32-year-old Chinese male patient with 1 week cough and dyspnea on exertion was presented to hospital.He was a metastatic lung adenocarcinoma patient with 3 years treatment history.In October 2012,the patient complained cough,short of breath,and thoracic computerized axial tomography scan (CAT-scan) revealed left lung hilum mass with the right lung multismall patches or opacities. | Ke-Ke Nie Xiao Zou Chuan-Xin Geng Ling Zhang Shi-Chao Liu Chun-Ling Zhang You-Xin Ji | 2016 | Chinese Medical Journal2016，，12： | 7 |
| 9 | Clinical Analysis on IVF-ET Treatment of 9 Cases of Post-cesarean Section Uterine Diverticulum显示文摘Objective To evaluate the influence of uterine diverticulum patients who have a history of cesarean section on IVF-ET process and pregnancy outcome. Methods Nine patients with uterine diverticulum after cesarean were retrospectively analyzed, who have received IVF-ET treatment. Clinical pregnancy rate and embryo implantation rate were measured. Results There were 9 infertility patients in all, 7 cases with tubal factor, 2 with unexplained factor; 3 cases were associated with prolonged menstruation period, including 1 patient was misdiagnosed as dysfunctioned uterine bleeding. There were a total of 16 transplantation cycles, including14 fresh cycles and 2 thawing cycles. Each cycle had at least one high-quality embryo available for transfer. Five cases were difficult to transfer. Two were clinical pregnancie, the implantation rate was 5.13% (2/39). Conclusion In this study, 14 fresh cycles all had high-quality embryo transfer, uterine diverticulum had no effect on the development of ovums and the formation of high-quality embryos. But forming uterine diverticulum after cesarean section may lead to secondary infertility or patients with prolonged menstruation period, it also may lead it difficult to transfer during the treatment of IVF-ET and affect embryo implantation. So the patients with a history of cesarean section shall receive ultrasonic examination or hysteroscopy routinely before IVF treatment. If necessary surgical treatment is required. | Qiong-fang WU Ling NIE Yin ZHANG | 2011 | Journal of Reproduction and Contraception2011，22，3： | 6 |
| 10 | The First Case of Asymptomatic Infection of COVID-19-Kashgar Prefecture, Xinjiang Uygur Autonomous Region, China, October, 2020显示文摘On October 24,2020,a 17-year-old female was detected as having an asymptomatic infection of coronavirus disease 2019(COVID-19)during a regular nucleic acid test in Kashgar Prefecture,Xinjiang Uygur Autonomous Region.She was then transferred to a local designated hospital for medical observation.The patient lived in Shufu County of Kashgar Prefecture and worked in a local garment factory.On the afternoon of October 24 after she was diagnosed as positive,a total of 831 persons in the garment factory were tested and the results were all negative.Afterwards,16 close contacts and 406 of close contacts of close contacts were also tested,and 137 were positive and had asymptomatic infections. | Ji Wang Jun Zhao Xiang Zhao Zhenguo Gao Yang Song Xin Ma Kai Nie Aimin Xu Mahemuti Ling Zhang Wenbo Xu Yan Cui | 2020 | China CDC weekly2020，2，45： | 6 |
| 11 | Effect of long-term weightlessness on retina and optic nerve in tail-suspension rats显示文摘AIM: To evaluate the effect of long-term weightlessness on retina and optic nerve in tail-suspension(TS) rats.METHODS: A stimulated weightlessness model was established by suspending rats' tail. After 12 wk, the ultrastructure and the number of optic nerve axons were observed by transmission electron microscope. The number of survival retinal ganglion cells(RGCs) was calculated by fluorescent gold retrograde labeling. Retina cells apoptosis was detected by TUNEL staining. The function of optic nerve and retina was evaluated by the visual evoked potential(VEP) and oscillatory potentials(Ops).RESULTS: The optic nerve axons were swollen and sparsely aligned, and the lamellar separation and myelin disintegration occurred after 12 wk in TS rats. The density of optic nerve axons was 32.23±3.92(vs 37.43±4.13, P =0.0145), the RGCs density was 1645 ±46 cells/mm2(vs1867±54 cells/mm2P=0.0000), the incidence rate of retinal cells apoptosis was 5.38%±0.53%(vs 4.75%±0.54%, P =0.0238), the amplitude of VEP-P100 was 15.43 ±2.14 μV(vs 17.67 ±2.17 μV, P =0.0424), the latency of VEP-P100 was 69.05±5.34ms(vs 62.43±4.87 ms P =0.0143) and the sum amplitude of Ops was 81.05 ±8.34 μV(vs 91.67 ±10.21 μV, P =0.0280) in TS group and the control group,respectively.CONCLUSION: Long-term weightlessness can induce the ultrastructural changes and functional depress of the optic nerve, as well as retinal cell damages in TS rats. | Hong-Wei Zhao Jun Zhao Lian-Na Hu Jing-Nan Liang Yuan-Yuan Shi Chuang Nie Chang-Yu Qiu Xin-Shuai Nan Yu-Xin Li Fu-Lin Gao Yi Liu Yu Dong Ling Luo | 2016 | International Journal of Ophthalmology(English edition)2016，9，6： | 5 |
| 12 | Effect of electro-scalp acupuncture on acute ischemic stroke: a randomized, single blind, trial显示文摘OBJECTIVE: To determine the clinical efficacy and safety of electro-scalp acupuncture in the treatment of patients with acute ischemic stroke.METHODS: Totally 74 patients with acute ischemic stroke were enrolled and divided into either body acupuncture(Control) or electro-scalp acupuncture(ESA) groups according to randomized controlled principle. The patients in the control group weregiven body acupuncture treatment once daily for28 d, whereas except for the body acupuncture,electro-scalp acupuncture was additional treatment given to the ESA group. Neurological deficits,everyday motor function and muscle strength were evaluated at baseline and the 28 th d by NIH Stroke Scale(NIHSS), Fugl-Meyer Assessment(FMA) and Modified Barthel Index Score(MBI), respectively.RESULTS: There were not obvious between-group differences in the baseline efficacy parameters(NIHSS, FMA and MBI)(all P > 0.05), whereas significant between-group differences were found in post-treatment NIHSS, FMA-UE and MBI scores(all P < 0.05). After acupuncture treatment, systematic within-group improvements were found in the two groups for any of the efficacy parameters assessed(all P < 0.01), and the ESA group showed higher significant improvements in NIHSS, FMA-UE and MBI scores(all P < 0.05).CONCLUSION: Electro-scalp acupuncture was efficacious in the treatment of acute ischemic stroke,which resulted in meaningful improvements in neurologic function, motor function and activities of daily living of patients. | Liu Xiaoxi Zhang Xuezhu Nie Kun Jia Yujie Li Jing Ling Zhenzhen Wang Yao Chang Shichen | 2018 | Journal of Traditional Chinese Medicine2018，38，1： | 5 |
| 13 | Model study of relationship between local temperature and artificial heat release显示文摘In recent decades,it presents a more obvious temperature rise in urban area along with the global warming.City is generally the center of human society,so the study on urban temperature variation will be helpful to our city development planning that is to reduce urban warming.The study is also helpful to a more comprehensive understanding of the causes of climate warming,which could provide a theoretical support to the government to make more reasonable international energy policies.Local temperature rise has different mechanisms with the global warming:large quantities of artificial heat release from the energy consumption will stay in urban areas for a period of time,which will inevitably influence the short-term trend of the local temperature change.Based on that view,a structural thermodynamic model was established in this paper to investigate the effect of the artificial heat release on the urban local temperatures.In the model,the city environment was divided into Human,Local,Outer three blocks,and then the heat and temperatures of the blocks were analyzed based on the laws of thermodynamics.After that,the effect of artificial heat release in Human block on the local temperatures was clarified.The model shows that the artificial heat release has an approximately linearly promoting effect on the local temperature rise,and the more the heat release is,the stronger the effect is.In addition,a validation of that model was carried out based on some national statistical data.The data of temperatures and artificial heat release of some provincial capitals of China were analyzed with linear regression extrapolation method and Pearson correlation statistical method.The results show that in most capital cities,the temperature variations basically depend on the artificial heat release in a linear relationship,which usually becomes more apparent with the increase of the artificial heat release in both spatial and temporal dimensions.The conclusions of the statistics have good conformity with the model and the rationality of the model is verified. | NIU Qiang NIE ChaoQun LIN Feng LI Ling JI LuCheng | 2012 | Science China(Technological Sciences)2012，55，3： | 5 |
| 14 | Reduced function and disassembled microtubules of cultured cardiomyocytes in spaceflight显示文摘Lack of gravity during spaceflight has profound effects on cardiovascular system, but little is known about how the cardiomyocytes respond to microgravity. In the present study, the effects of spaceflight on the structure and function of cultured cardiomyocytes were reported. The primary cultures of neo- natal rat cardiomyocytes were carried on Shenzhou-6 spacecraft and activated at 4 h in orbit. 8 samples were fixed respectively at 4, 48 and 96 h after launching for immunofluorescence of cytoskeleton, and 2 samples remained unfixed to analyze contractile and secretory functions of the cultures. Ground sam- ples were treated in our laboratory in parallel. After 115 h spaceflight, video recordings displayed that the number of spontaneous beating sites in flown samples decreased significantly, and the cells in the beating aggregate contracted in fast frequency without synchrony. Radioimmunoassay of the medium showed that the atrial natriuretic peptide secreted from flown cells reduced by 59.6%. Confocal images demonstrated the time-dependant disassembly of mirotubules versus unchanged distribution and or- ganization of microfilaments. In conclusion, above results indicate reduced function and disorganized cytoskeleton of cardiomyocytes in spaceflight, which might provide some cellular basis for further investigations to probe into the mechanisms underlying space cardiovascular dysfunction. | YANG Fen LI YingHui DING Bai NIE JieLin WANG HongHui ZHANG XiaoYou WANG ChunYan LING ShuKuan NI ChengZhi DAI ZhongQuan TAN YingJun WAN YuMin | 2008 | Chinese Science Bulletin2008，53，8： | 5 |
| 15 | Primary resistance to crizotinib treatment in a non-small cell lung cancer patient with an EML4-ALK rearrangement:a case report显示文摘Crizotinib,a small molecular tyrosine kinase inhibitor,manifests dramatic responses in patients with non-small cell lung cancer with echinoderm microtubule associated protein like 4-anaplastic lymphoma kinase(EML4-ALK)rearrangements.ALK gene point mutation is the primary mechanism of acquired crizotinib resistance;however,the intrinsic mechanism is not fully understood.Here,we report a patient with a low mutant allele fraction(MAF)of EML4-ALK rearrangement,who experienced primary resistance to crizotinib treatment.The patient was a 66-year-old Chinese man,who had a history of metastatic lung cancer and was treated with first-and third-generation epidermal growth factor receptor tyrosine kinase inhibitors(EGFR TKIs).After 14 months of osimertinib treatment,his disease progressed,and next-generation sequencing was performed from a liquid biopsy of the patient’s blood.An EML4-ALK rearrangement was found and crizotinib was administered.The patient’s lung lesions continued to progress after one month of crizotinib treatment,and pemetrexed-bevacizumab was initiated.After two cycles of chemotherapy,the metastatic cancers shrunk,and the patient maintained stable disease at his last follow-up.EML4-ALK rearrangements can happen in patients with EGFR-positive NSCLC,after acquired resistance to EGFR TKI treatment.The EGFR T790M and C797G mutations occur in cis is a critical mechanism of resistance to osimertinib therapy.The MAF of EML4-ALK rearrangements in cancer cells might be a predictive factor for crizotinib treatment. | Ling Zhang Yunxia Li Shaohong Zhang Chen Gao Keke Nie Youxin Ji | 2018 | Cancer Biology & Medicine2018，15，2： | 5 |
| 16 | Fingerprinting 146 Chinese chestnut(Castanea mollissima Blume)accessions and selecting a core collection using SSR markers显示文摘Chinese chestnut is an important nut tree around the world.Although the types of Chinese chestnut resources are abundant,resource utilization and protection of chestnut accessions are still very limited.Here,we fingerprinted and determined the genetic relationships and core collections of Chinese chestnuts using 18 fluorescently labeled SSR markers generated from 146 chestnut accessions.Our analyses showed that these markers from the tested accessions are highly polymorphic,with an average allele number(N_(a))and polymorphic information content(PIC)of 8.100 and 0.622 per locus,respectively.Using these strongly distinguishing markers,we successfully constructed unique fingerprints for 146 chestnut accessions and selected seven of the SSR markers as core markers to rapidly distinguish different accessions.Our exploration of the genetic relationships among the five cultivar groups indicated that Chinese chestnut accessions are divided into three regional type groups:group I(North China(NC)and Northwest China(NWC)cultivar groups),group II(middle and lower reaches of the Yangtze River(MLY)cultivar group)and group III(Southeast China(SEC)and Southwest China(SWC)cultivar groups).Finally,we selected 45 core collection members which represent the most genetic diversity of Chinese chestnut accessions.This study provides valuable information for identifying chestnut accessions and understanding the phylogenetic relationships among cultivar groups,which can serve as the basis for efficient breeding in the future. | NIE Xing-hua WANG Ze-hua LIU Ning-wei SONG Li YAN Bo-qian XING Yu ZHANG Qing FANG Ke-feng ZHAO Yong-lian CHEN Xin WANG Guang-peng QIN Ling CAO Qing-qin | 2021 | Journal of Integrative Agriculture2021，20，5： | 5 |
| 17 | Gastrointestinal bleeding caused by extrahepatic arterioportal fistula associated with portal vein thrombosis显示文摘An extrahepatic arterioportal fistula(APF) involving the gastroduodenal artery and superior mesenteric vein is rare and mostly results from iatrogenic injuries.The clinical symptoms associated with APFs may include abdominal pain,gastrointestinal bleeding,ascites,nausea,vomiting,diarrhea,or even congestive heart failure.We present the case of a 70-year-old man who presented with chronic abdominal pain and gastrointestinal bleeding secondary to APF and portal vein thrombosis.The endovascular embolization of APF was accomplished successfully,and symptoms of portal hypertension resolved immediately after intervention.Unfortunately,the patient did not respond well to anticoagulation therapy with warfarin.Therefore,the patient underwent implantation of a transjugular intrahepatic portosystemic shunt,and the complications of portal hypertension resolved.In conclusion,the embolization of APF is technically feasible and effective and can be considered the first-choice therapy in selected patients. | Ling Nie Xue-Feng Luo Xiao Li | 2012 | World Journal of Gastroenterology2012，18，44： | 4 |
| 18 | Clinical Observation of Bevacizumab Combined with S-1 in the Treatment of Pretreated Advanced Esophageal Carcinoma显示文摘Objective To investigate the clinical effects and safety of bevacizumab combined with S-1 as the second-line treatment of recurrent and/or metastatic esophageal cancer after chemoradiation. Methods Patients with recurrent or metastatic esophageal cancer after chemoradiation were treated with bevacizumab and S-1. Bevacizumab was used by intravenous infusion, 7.5mg/kg body weight on day 1; S-1 was used by oral at 80mg/m^2·d on day 1-14, 21 days as a cycle of treatment and repeated until either progressive disease or intolerable toxicity occurred. Chest CT were performed and RECIST 1.1 was used for response evaluation. Kaplan-Meier method was used for survival analysis. Side effects were recorded and analyzed. Results Totally 78 patients were enrolled in the study, including 67 squamous cell carcinoma and 11 adenocarcinoma histologically. The overall response(CR+PR) rate was 22.4%(17/76) and disease control(CR+PR+SD) rate was 61.8%(47/76) respectively. The median follow-up time was 20 months(range from 9 to 44 months). The median progression-free survival(PFS) was 4.9 months(95% CI 4.4-5.5) and the median overall survival(OS) was 8.1 months(95% CI 7.6-9.2). The median PFS and OS of patients with metastasis diseases were 6.2 months(95% CI 3.3 to 6.3) and 8.5 months(95% CI 5.8 to 11.2), where PFS was longer than that of patients with local regional recurrence(median 5.0 months, 95% CI 3.0 to 5.5, P=0.017) and OS was longer than that of patients with regional disease and metastasis(median 8.0 months, 95% CI 4.6 to 9.5, P=0.010). The common adverse effects were mild to moderate neutropenia(84.2%), grade Ⅰ -Ⅱ hand and foot syndrome(51.3%), grade Ⅰ -Ⅱ nausea(48.7%), mild epistaxis(30.1%) and mild vomiting(14.5%). Esophageal bleeding occurred in 7.9% of patients. One patient(1.3%) died from massive bleeding which was caused by esophageal perforation. Conclusion Bevacizumab combined with S-1 was effective and safe for esophageal cancer patients who had recurrent or metastatic diseases after chemoradiation. | Ke-ke Nie Chuan-xin Geng Ling Zhang Shi-chao Liu Zhong-fa Zhang Rong Wang Xiao Zou You-xin Ji | 2016 | Chinese Medical Sciences Journal2016，31，4： | 4 |
| 19 | Activation of liver X receptors inhibits pancreatic islet beta cell proliferation through cell cycle arrest显示文摘 | Meng, Z. X. Nie, J. Ling, J. J. Sun,J. X. Zhu,Y. X. Gao,L. Lv,J. H. Zhu,D. Y. Sun,Y. J. Han,X. | 2009 | 南京医科大学学报(自然科学版)2009，29，3： | 4 |
| 20 | Sorafenib in Liver Function Impaired Advanced Hepatocellular Carcinoma显示文摘Objective To explore the efficacy and safty of sorafenib in Child-Pugh class B to class C hepatocellular carcinoma(HCC).Methods In this three-center open-label study from November 2011 to May 2013,we randomly assigned 189 patients with advanced Child-Pugh class B or C HCC patients into two groups,one group with 95 patient to receive sorafenib(400 mg a time,twice a day) and the other group with 94 patients to receive best supportive care.The primary end points were progression-free survival and overall survival.Results The median progression-free survival was 2.2 months and 1.9 months in the sorafenib group and best supportive care group respectively(Hazard ratio in the sorafenib group,0.55;95% confidence interval,0.40-0.75;P=0.002).The median overall survival was 4.0 months and 3.5 months in the sorafenib group and best supportive care group respectively(Hazard ratio in the sorafenib group,0.48;95% confidence interval,0.35-0.68;P<0.001).The main adverse effect of sorafenib was rash and acne of the skin(in 51.7% patients).The incidences of severe rash,diarrhea,and dry skin were 5.6%,5.6%,and 2.2% in the sorafenib group.One patient reached partial response in the sorafenib group.Conclusions Sorafenib is safe in patients with liver function impaired advanced HCC.It is effective in terms of progression-free survival and overall survival compared with best supportive care.Liver functions are the important predictive factors. | You-xin Ji Zhong-fa Zhang Ke-tao Lan Ke-ke Nie Chuan-xin Geng Shi-chao Liu Ling Zhang Xing-jun Zhuang Xiao Zou Lei Sun Zong-chun Zhang | 2014 | Chinese Medical Sciences Journal2014，29，1： | 4 |
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