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| 1 | Effect of Boschniakia rossica on expression of GSTP,p53 and p21^(ras)proteins in early stage of chemical hepatocarcinogenesis and its anti-inflammatory activities in rats显示文摘AIM To investigate the effect of Boschniakiarossica(BR)extract on expression of GST-P,p53 and p21rasproteins in early stage of chemicalhepatocarcinogenesis in rats and its anti-inflammatory activities.METHODS The expression of tumor marker-placental form glutathione S-transferase(GST-P),p53 and p21rasproteins were investigated byimmunohistochemical techniques and ABCmethod.Anti-inflammatory activities of BR werestudied by xylene and croton oil-induced mouseear edema,carrageenin,histamine and hotscald-induced rat pow edema,adjuvant-inducedrat arthritis and cotton pellet-induced mousegranuloma formation methods.RESULTS The 500 mg/kg of BR-H2O extractfractionated from BR-Methanol extract hadinhibitory effect on the formation of DEN-inducedGST-P-positive foci in rat liver(GST-P stainingwas 78% positive in DEN+AAF group vs 20%positive in DEN+AAF+BR group,P<0.05)andthe expression of mutant p53 and p21rasproteinwas lower than that of hepatic preneoplasticlesions(33% and 22% positive respectively inDEN+AAF group vs negative in DEN+AAF+BRgroup).Both CH2Cl2 and H2O extracts from BRhad anti-inflamatory effect in xylene and crotonoil-induced mouse ear edema(inhibitory rateswere 26%-29% and 35%-59%,respectively). BR-H2O extract exhibited inhibitory effect incarrageenin,histamine and hot scald-inducedhind paw edema and adjuvant-induced arthritis inrats and cotton pellet-induced granulomaformation in mice.CONCLUSION BR extract exhibited inhibitory effect on formation of preneoplastic hepatic foci in early stage of rat chemical hepato-carcinogenesis. Both CH2CI2 and H2O extracts from BR exerted anti-inflammatory effect in rats and mice. | Zong Zhu Yin Hai Ling Jin Xue Zhe Yin Tian Zhu Li Ji Shu Quan Zeng Nan Jin Institute for Cancer Research,Yanbian University College of Medicine,Yanji 133000,Jilin Province,China | 2000 | World Journal of Gastroenterology2000，6，6： | 33 |
| 2 | OsCERK1-Mediated Chitin Perception and Immune Signaling Requires Receptor-like Cytoplasmic Kinase 185 to Activate an MAPK Cascade in Rice显示文摘保存联系病原体的分子的模式(PAMP ) 例如几丁质,被在激活 mitogen 的蛋白质 kinase (MAPK ) 的快速的激活串联的宿主细胞表面和扳机定位的模式识别受体(PRR ) 察觉,它为植物抵抗被要求到病原体。然而,到在植物的 MAPK 激活的从 PAMP 感觉的直接连接仍然保持大部分未知。在这研究,我们发现联系 PRR 的像受体的细胞质的 kinase Oryza sativa RLCK185 播送到通过和 MAPK kinase kinase 的相互作用表明串联的 MAPK 的从 PAMP 受体 OsCERK1 的有免疫力的发信号, OsMAPKKK,它是 MAPK 串联的起始的 kinase。OsRLCK185 交往与并且 phosphorylates OsMAPKKK 的 C 终端规章的领域。phosphomimetic OsRLCK185 和 OsMAPKKK 的 Coexpression 在 Nicotiana benthamiana 叶子激活 MAPK3/6 phosphorylation。而且, OsMAPKKK 交往与并且 phosphorylates OsMKK4,关键 MAPK kinase 那 transduces 几丁质信号。OsMAPKKK 的 Overexpression 增加导致几丁质的 MAPK3/6 激活,而 OsMAPKKK 击倒的妥协导致几丁质的 MAPK3/6 激活和抵抗到米饭强风真菌。一起拿,我们的结果在米饭从房间表面几丁质感觉建议一条发信号 phospho 小径的存在到 MAPK 串联的细胞内部的激活。 | Chao Wang Gang Wang Chi Zhang Pinkuan Zhu Huiling Dai Nan Yu Zuhua He Ling Xu Ertao Wang | 2017 | Molecular Plant2017，10，4： | 27 |
| 3 | Parishin C's prevention of Aβ_(1–42)-induced inhibition of long-term potentiation is related to NMDA receptors显示文摘The rhizome of Gastrodia elata(GE), a herb medicine, has been used for treatment of neuronal disorders in Eastern Asia for hundreds of years. Parishin C is a major ingredient of GE. In this study, the i.c.v. injection of soluble Aβ1–42oligomers model of LTP injury was used. We investigated the effects of parishin C on the improvement of LTP in soluble Aβ1–42oligomer–injected rats and the underlying electrophysiological mechanisms. Parishin C(i.p. or i.c.v.) significantly ameliorated LTP impairment induced by i.c.v. injection of soluble Aβ1–42oligomers. In cultured hippocampal neurons,soluble Aβ1–42oligomers significantly inhibited NMDAR currents while not affecting AMPAR currents and voltage-dependent currents. Pretreatment with parishin C protected NMDA receptor currents from the damage induced by Aβ. In summary, parishin C improved LTP deficits induced by soluble Aβ1–42oligomers. The protection by parishin C against Aβ-induced LTP damage might be related to NMDA receptors. | Zhihui Liu Weiping Wang Nan Feng Ling Wang Jiangong Shi Xiaoliang Wang | 2016 | Acta Pharmaceutica Sinica B2016，6，3： | 25 |
| 4 | The FTO/miR-181b-3p/ARL5B signaling pathway regulates cell migration and invasion in breast cancer显示文摘Background:N6-methyladenosine(m6A)RNA modification has been demonstrated to be a significant regulatory process in the progression of various tumors,including breast cancer.Fat mass and obesity-associated(FTO)enzyme,initially known as the obesity-related protein,is the first identified m6A demethylase.However,the relationship between FTO and breast cancer remains controversial.In this study,we aimed to elucidate the role and clinical significance of FTO in breast cancer and to explore the underlying mechanism.Methods:We first investigated the expression of FTO in breast cancer cell lines and tissues by quantitative reverse transcription-PCR(qRT-PCR),Western blotting,and immunohistochemistry.Wound healing assay and Transwell assay were performed to determine the migration and invasion abilities of SKBR3 and MDAMB453 cells with either knockdown or overexpression of FTO.RNA sequencing(RNA-seq)was conducted to decipher the downstream targets of FTO.qRT-PCR,luciferase reporter assay,and Western blotting were employed to confirm the existence of the FTO/miR-181b-3p/ARL5B axis.The biological function of ADP ribosylation factor like GTPase 5B(ARL5B)in breast cancer cells was evaluated by wound healing assay and Transwell invasion assay.Results:High FTO expression was observed in human epidermal growth factor receptor 2(HER2)-positive breast cancer,predicting advanced progression(tumor size[P<0.001],nuclear grade[P=0.001],peritumoral lymphovascular invasion[P<0.001),lymph node metastasis[P=0.002],and TNM stage[P=0.001])and poor prognosis.Moreover,FTO promoted cell invasion and migration in vitro.Mechanistically,RNA-seq and further confirmation studies suggested that FTO up-regulated ARL5B by inhibiting miR-181b-3p.We further verified that ARL5B also displayed carcinogenic activity in breast cancer cells.Conclusion:Our work demonstrated the carcinogenic activity of FTO in promoting the invasion and migration of breast cancer cells via the FTO/miR-181b-3p/ARL5B signaling pathway. | Yuanyuan Xu Shuang Ye Nan Zhang Shuhui Zheng Huatao Liu Kewen Zhou Ling Wang Yue Cao Peng Sun Tinghuai Wang | 2020 | Cancer Communications2020，40，10： | 24 |
| 5 | Glutamine and recombinant human growth hormone protect intestinal barrier function following portal hypertension surgery显示文摘瞄准:在肠的障碍功能追随者门静脉高血压外科上评估夫酸安(Gln ) 和 recombinant 人生长激素(rhGH ) 的联合治疗的效果。方法:这研究是被设计一未来,使随机化并且控制了临床的试用。在门静脉高血压外科以后的四十二个病人随机被分配进 2 个组:控制组(n = 20 ) 并且补加的组(增加的 Gln 和 rhGH, n = 22 ) 。每耐心的收到的 isocaloric 和 isonitrogenous 标准总计为 7 d 在外科以后开始 3 d 的非肠道的营养(TPN ) 。血样品在外科前并且在第三 and 被获得第 10 白天手术后地。主人免疫被测量 CD4, CD8, CD4/CD8, IgG, IgM 和 IgA 的层次评估,并且煽动性的回答被估计 IL-2, TNF-alpha 和 C 反应的蛋白质(CRP ) 决定层次。肠的渗透和正直被 L/M 测试和组织学的检查分别地评估。结果:在手术后的 d 上 10 ,在补加的组的 CD4 , CD4/CD8 , IgG 和 IL-2 层次比在控制组的那些显著地高( 33.7 +/- 5.5 对 31.0 +/- 5.4 , P <
0.05 ,( 1.17 +/- 0.32 对 1.05 +/- 0.15 , P <
0.05 , 13.94 +/- 1.09 对 12.33 +/- 1.33 , P <
0.05 ,和 368.12 +/- 59.25 对 318.12 +/- 45.65 , P <
0.05 ,分别地)而浆液 TNF-alpha 集中的增加显著地被减少( 41.02 +/- 27.56 对 160.09 +/- 35.17 , P <
0.05 )。L/M 比率的增加比在控制组在补加的组是显著地更低的(0.0166 +/- 0.0017 对 0.0339 +/- 0.0028, P <
0.05 ) 。而且,在补加的组的粘膜完整比在控制组好。结论:在门静脉高血压外科以后在病人与 Gln 和 rhGH 补充的 TPN 的手术后的管理改进有免疫力的功能,调制煽动性的反应,阻止肠的粘膜萎缩并且保存肠的正直。 | Zhao-Feng Tang Yun-Biao Ling Nan Lin Zheng Hao Rui-Yun Xu | 2007 | World Journal of Gastroenterology2007，13，15： | 22 |
| 6 | Aortic Artery and Cardiac Valve Calcification are Associated with Mortality in Chinese Hemodialysis Patients: A 3.5 Years Follow-up显示文摘 | Xiao-Nong Chen Zi-Jin Chen Xiao-Bo Ma Bei Ding Hua-Wei Ling Zhong-Wei Shi Nan Chen | 2015 | Chinese Medical Journal2015，，20： | 20 |
| 7 | Involvement of hepatitis B X-interacting protein (HBXIP) in proliferation regulation of cells显示文摘瞄准:到 investigat 肝炎 B X 交往的效果蛋白质(HBXIP ) oncell proliferation.Methods:对 HBXIP 的兔子抗体是 HBXIP 基因的 generated.The RNA 干扰( RNAi )碎片在编码 HBXIP 基因和 pSilencer-hbxip weretransfected 进人的胸癌 MCF-7 房间, hepatoma H7402 房间,和正常的 pcDNA3-hbxip 的 pSilencer-3.0-H1 向量 termedpSilencer-hbxip.Plasmids 被构造 humanhepatic 房间线 L-O2 ,respectively.3-[ 4,5-dimethylthiazol-2-yl ] -2,5-diphenyltetrazolium 溴化物( MTT )试金和 5-bromo-2-deoxyuridine 加入试金被用于 dete HBXIP 的功能之一是它在房间增长的参与。 | Feng-ze WANG Li SHA Wei-ying ZHANG Lian-ying WU Ling QIAO Nan LI Xiao-dong ZHANG Li-hong YE | 2007 | Acta Pharmacologica Sinica2007，28，3： | 16 |
| 8 | Prevalence, awareness, treatment, and control of hypertension in the non-dialysis chronic kidney disease patients显示文摘 | ZHENG Ying CAI Guang-yan CHEN Xiang-mei FU Ping CHEN Jiang-hua DING Xiao-qiang YU Xue-qing LIN Hong-li LIU Jian XIE Ru-juan WANG Li-ning NI Zhao-hui LIU Fu-you YIN Ai-ping XING Chang-ying WANG Li SHI Wei LIU Jian-she HE Ya-ni DING Guo-hua LI Wen-ge WU Guang-li MIAO Li-ning CHEN Nan SU Zhen MEI Chang-lin ZHAO Jiu-yang GU Yong BAI Yun-kai LUO Hui-min LIN Shan CHEN Meng-hua GONG Li YANG Yi-bin YANG Xiao-ping LI Ying WAN Jian-xin WANG Nian-song LI Hai-ying XI Chun-sheng HAO Li XU Yan FANG Jing-ai LIU Bi-cheng LI Rong-shan WANG Rong ZHANG Jing-hong WANG Jian-qin LOU Tan-qi SHAO Feng-min MEI Feng LIU Zhi-hong YUAN Wei-jie SUN Shi-ren ZHANG Ling ZHOU Chun-hua CHEN Qin-kai JIA Shun-lian GONG Zhi-feng GUAN Guang-ju XIA Tian ZHONG Liang-bao | 2013 | Chinese Medical Journal2013，，12： | 16 |
| 9 | Conversion and pharmacokinetics profiles of a novel pro-drug of 3-n-butylphthalide, potassium 2-(1-hydroxypentyl)-benzoate, in rats and dogs显示文摘钾 2-(1-hydroxypentyl ) 安息香酸盐(dl-PHPB ) 是被用来治疗 ischemic 击的 3-n-butylphthalide (dl-NBP ) 支持药的一篇小说。当前, dl-PHPB 在在中国的阶段 II-III 临床的审判。在这研究,我们在 vitro 并且在 vivo 调查了变换和 dl-PHPB 的 pharmacokinetics 侧面。到 dl-NBP 的 dl-PHPB 的变换是 pH-dependent, 和钙依赖者,并且 paraoxonase 在老鼠血浆为变换作为主要的酶被识别。pharmacokinetics,织物分发和 dl-PHPB 的排泄被学习并且与在老鼠和狗的 dl-NBP 的平等者臼齿的剂量相比。在里面 vivo 研究证明 dl-PHPB 能快速并且完全被变换成 dl-NBP。在静脉内的 dl-PHPB 管理以后的变换 dl-NBP 的血浆集中时间功课是将近与那一样在平等者臼齿的 dl-NBP 以后。C 分别地,在在老鼠和狗的口头的 dl-PHPB 管理以后的 dl-NBP 的最大 和 AUC 比在口头的 dl-NBP 管理以后的那些在 60% 和 170% 是更高的。dl-PHPB 的织物分发的分析表明那变换 dl-NBP 首先在脂肪,大脑和胃被散布。在大脑, dl-NBP 的层次在 dl-PHPB 处理由以后是相对更高的口头上地比在有平等者臼齿的 dl-NBP 的处理以后。近似 dl-NBP 的 3%-4% 与 dl-PHPB 或 dl-NBP 在 dosing 以后在 72 h 以内被排泄,但是没有 dl-PHPB 在尿或排汇物排泄物被检测。我们的结果证明 dl-PHPB 的变换在口头或静脉内的管理以后是快的。而且, dl-PHPB 的 bioavailability 显然比 dl-NBP 的好。 | Jiang LI Shao-feng XU Ying PENG Nan FENG Ling WANG Xiao-liang WANG | 2018 | Acta Pharmacologica Sinica2018，39，2： | 10 |
| 10 | CD147-spike protein is a novel route for SARS-CoV-2 infection to host cells显示文摘In face of the everlasting battle toward COVID-19 and the rapid evolution of SARS-CoV-2,no specific and effective drugs for treating this disease have been reported until today.Angiotensin-converting enzyme 2(ACE2),a receptor of SARS-CoV-2,mediates the virus infection by binding to spike protein.Although ACE2 is expressed in the lung,kidney,and intestine,its expressing levels are rather low,especially in the lung.Considering the great infectivity of COVID-19,we speculate that SARS-CoV-2 may depend on other routes to facilitate its infection.Here,we first discover an interaction between host cell receptor CD147 and SARS-CoV-2 spike protein.The loss of CD147 or blocking CD147 in Vero E6 and BEAS-2B cell lines by anti-CD147 antibody,Meplazumab,inhibits SARSCoV-2 amplification.Expression of human CD147 allows virus entry into non-susceptible BHK-21 cells,which can be neutralized by CD147 extracellular fragment.Viral loads are detectable in the lungs of human CD147(hCD147)mice infected with SARS-CoV-2,but not in those of virus-infected wild type mice.Interestingly,virions are observed in lymphocytes of lung tissue from a COVID-19 patient.Human T cells with a property of ACE2 natural deficiency can be infected with SARS-CoV-2 pseudovirus in a dosedependent manner,which is specifically inhibited by Meplazumab.Furthermore,CD147 mediates virus entering host cells by endocytosis.Together,our study reveals a novel virus entry route,CD147-spike protein,which provides an important target for developing specific and effective drug against COVID-19. | Ke Wang Wei Chen Zheng Zhang Yongqiang Deng Jian-Qi Lian Peng Du Ding Wei Yang Zhang Xiu-Xuan Sun Li Gong Xu Yang Lei He Lei Zhang Zhiwei Yang Jie-Jie Geng Ruo Chen Hai Zhang Bin Wang Yu-Meng Zhu Gang Nan Jian-Li Jiang Ling Li Jiao Wu Peng Lin Wan Huang Liangzhi Xie Zhao-Hui Zheng Kui Zhang Jin-Lin Miao Hong-Yong Cui Min Huang Jun Zhang Ling Fu Xiang-Min Yang Zhongpeng Zhao Shihui Sun Hongjing Gu Zhe Wang Chun-Fu Wang Yacheng Lu Ying-Ying Liu Qing-Yi Wang Huijie Bian Ping Zhu Zhi-Nan Chen | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 9 |
| 11 | Effects of Heyan Kuntai Capsule(和颜坤泰胶囊)on Follicular Development and Oocyte Cohesin Levels in Aged Mice显示文摘Objective: To evaluate the effect of Heyan Kuntai Capsule(和颜坤泰胶囊, HYKT) on the ovarian function of aged mice and expressions of cohesion complexes in oocytes. Methods: Twenty-five 9-month-old female C57BL/6J mice were randomly divided into 5 groups by block randomization method(n=5 per group), including the control group(saline), 17β-estradiol group [E_2, 100 μg/(kg·d)], and low-, medium-, and highdose of HYKT groups [0.3, 0.9, 2.7 g/(kg·d), respectively]. All mice were treated by intragastric administration for 4 weeks. Hematoxylin and eosin staining and anti-VASA staining were used to detect the amounts of follicles. The apoptosis of follicles was measured by anti-gamma H_2A histone family member X(γH_2AX) staining and Td T-mediated d UTP Nick-End Labeling(TUNEL) assay. The density of cohesin subunits, REC8 meiotic recombination protein(REC8), structural maintenance of chromosome(SMC) 1β and SMC3 in oocytes were evaluated by immunofluorescent staining. Results: After administration of E_2 and high-dose of HYKT, the total number of follicles as well as the number of primordial and primary follicles were significantly increased(P<0.05). Anti-γH_2AX staining and TUNEL assay demonstrated that high-dose of HYKT and E_2 partly suppressed the apoptosis of follicles(P<0.05). Furthermore, it showed an increased trend in the levels of REC8 and SMC1β, after administration with E_2 and HYKT, and no obvious change in the level of SMC3. Conclusion: HYKT could enhance the number of follicles, suppress apoptosis of oocytes and have a trend to elevate the meiotic-specific cohesin subunits(REC8 and SMC1β) in oocytes of aged mice, indicating a beneficial effect on the ovarian function in terms of the quantity and quality of follicles. | ZHANG Bin CHU Nan QIU Xue-min TANG Wei Hans-Jorgen Gober LI Da-jin WANG Ling | 2018 | Chinese Journal of Integrative Medicine2018，24，10： | 7 |
| 12 | Evaluation of the effects of combined endoscopic variceal ligation and splenectomy with pericardial devascularization on esophageal varices显示文摘AIM: To detect the hemodynamic alterations in collateral circulation before and after combined endoscopic variceal ligation (EVL) and splenectomy with pericardial devascularization by ultrasonography, and to evaluate their effect using hemodynamic parameters. METHODS: Forty-three patients with esophageal varices received combined EVL and splenectomy with pericardial devascularization for variceal eradication. The esophageal vein structures and azygos blood flow (AZBF) were detected by endoscopic ultrasonography and color Doppler ultrasound. The recurrence and rebleeding of esophageal varices were followed up. RESULTS: Patients with moderate or severe varices in the esophageal wall and those with severe peri- esophageal collateral vein varices had improvements after treatment, while the percentage of patients with severe para-esophageal collateral vein varices decreased from 54.49% to 2.33%, and the percentage of patients with detectable perforating veins decreased from 79.07% to 4.65% (P < 0.01). Color Doppler flowmetry showed a significant decrease both in AZBF (43.00%, P < 0.05) and in diameter of the azygos vein (28.85%, P < 0.05), while the blood flow rate was unchanged. The recurrence rate of esophageal varices was 2.5% (1/40, mild), while no re-bleeding cases were recorded. CONCLUSION: EVL in combination with splenectomy with pericardial devascularization can block the collateral veins both inside and outside of the esophageal wall, and is more advantagious over splenectomy in combination with pericardial devascularization or EVL in preventing recurrence and re-bleeding of varices. | Bo Liu Mei-Hai Deng Nan Lin Wei-Dong Pan Yun-Biao Ling Rui-Yun Xu | 2006 | World Journal of Gastroenterology2006，12，42： | 7 |
| 13 | Mobile Web Augmented Reality in 5G and Beyond:Challenges, Opportunities, and Future Directions显示文摘The popularity of wearable devices and smartphones has fueled the development of Mobile Augmented Reality(MAR),which provides immersive experiences over the real world using techniques,such as computer vision and deep learning.However,the hardware-specific MAR is costly and heavy,and the App-based MAR requires an additional download and installation and it also lacks cross-platform ability.These limitations hamper the pervasive promotion of MAR.This paper argues that mobile Web AR(MWAR)holds the potential to become a practical and pervasive solution that can effectively scale to millions of end-users because MWAR can be developed as a lightweight,cross-platform,and low-cost solution for end-to-end delivery of MAR.The main challenges for making MWAR a reality lie in the low efficiency for dense computing in Web browsers,a large delay for real-time interactions over mobile networks,and the lack of standardization.The good news is that the newly emerging 5G and Beyond 5G(B5G)cellular networks can mitigate these issues to some extent via techniques such as network slicing,device-to-device communication,and mobile edge computing.In this paper,we first give an overview of the challenges and opportunities of MWAR in the 5G era.Then we describe our design and development of a generic service-oriented framework(called MWAR5)to provide a scalable,flexible,and easy to deploy MWAR solution.We evaluate the performance of our MWAR5 system in an actually deployed 5G trial network under the collaborative configurations,which shows encouraging results.Moreover,we also share the experiences and insights from our development and deployment,including some exciting future directions of MWAR over 5G and B5G networks. | Xiuquan Qiao Pei Ren Guoshun Nan Ling Liu Schahram Dustdar Junliang Chen | 2019 | China Communications2019，16，9： | 7 |
| 14 | Determination of urinary 8-hydroxy-2′-deoxyguanosine by capillary electrophoresis with molecularly imprinted monolith in-tube solid phase microextraction显示文摘Urinary 8-hydroxy-2'-deoxyguanosine(8-OHdG) is an excellent marker of oxidative DNA damage.In this study,employing guanosine as dummy template a novel molecularly imprinted(MIP) monolithic capillary column had been synthesized,and that was used as medium of in-tube solid phase microextraction(SPME).Coupled with capillary electrophoresis-electrochemical detection(CE-ECD),the system of extraction and detection of 8-OHdG in urinary sample had been developed.Because of its greater phase ratio combined with c... | Zhang, Shao Wen Zou, Cun Jie Luo, Nan Weng, Qian Feng Cai, Ling Shuang Wu, Cai Ying Xing, Jun | 2010 | Chinese Chemical Letters2010，21，1： | 6 |
| 15 | Effect of early enteral nutrition on outcomes of trauma patients requiring intensive care显示文摘Purpose: To investigate the effect of early enteral nutrition on outcomes of trauma patients in the intensive care unit (ICU).Methods: Clinical data of trauma patients in the ICU of Daping Hospital, China from January 2012 to December 2017 was retrospectively analyzed, including patient age, gender, injury mechanism, injury severity score (ISS), nutritional treatment, postoperative complications (wound infection, abdominal abscess, anastomotic rupture, pneumonia), mortality, and adverse events (nausea, vomiting, abdominal distention). Only adult trauma patients who developed bloodstream infection after surgery for damage control were included. Patients were divided into early enteral nutrition group (<48 h) and delayed enteral nutrition group (control group, >48 h). Data of all trauma patients were collected by the same investigator. Data were expressed as frequency (percentage), mean ± standard deviation (normal distribution), or median (Q1, Q3) (non-normal distribution) and analyzed by Chi-square test, Student’st-test, or rank-sum test accordingly. Multiple logistic regression analysis was further adopted to investigate the significant variables with enteral nutrition.Results: Altogether 876 patients were assessed and 110 were eligible for this study, including 93 males and 17 females, with the mean age of (50.0 ± 15.4) years. Traffic accidents (46 cases, 41.8%) and fall from height (31 cases, 28.2%) were the dominant injury mechanism. There were 68 cases in the early enteral nutrition group and 42 cases in the control group. Comparison of general variables between early enteral nutrition group and control group revealed significant difference regarding surgeries of enterectomy (1.5% vs. 19.0%,p = 0.01), ileum/transverse colon/sigmoid colostomy (4.4% vs. 16.3%,p = 0.01) and operation time (h) (3.2 (1.9, 6.1) vs. 4.2 (1.8, 8.8),p = 0.02). Other variables like ISS (p = 0.31), acute physiology and chronic health evaluation≥20 (p = 0.79), etc. had no obvious difference. Chi-square test showed a much better result in early enteral nutrition group than in control group regarding morality (0 vs. 11.9%,p = 0.03), length of hospital stay (days) (76.8 ± 41.4vs. 81.4 ± 44.7,p = 0.01) and wound infection (10.3% vs. 26.2%,p = 0.03). Logistic regression analysis showed that the incidence of wound infection was related to the duration required to achieve the enteral nutrition standard (OR = 1.095,p = 0.002). Seventy-six patients (69.1%) achieved the nutritional goal within a week and 105 patients (95.5%) in the end. Trauma patients unable to reach the enteral nutrition target within one week were often combined with abdominal infection, peritonitis, bowel resection, intestinal necrosis, intestinal fistula, or septic shock.Conclusion: Early enteral nutrition for trauma patients in the ICU is correlated with less wound infection, lower mortality, and shorter hospital stay. | Peng-Fei Li Yao-Li Wang Yu-Li Fang Ling Nan Jian Zhou Dan Zhang | 2020 | Chinese Journal of Traumatology2020，23，3： | 6 |
| 16 | Expression of Peroxiredoxins and Pulmonary Surfactant Protein A Induced by Silica in Rat Lung Tissue显示文摘Silicosis is one of the most serious occupational diseases in China and dates back to centuries ago.In this study,we successfully established a rat model of silicosis by intratracheal silica injection for28 days and determined hydroxyproline levels to evaluate collagen metabolism in lung homogenates.Oxidative stress status was evaluated by detecting catalase and glutathione peroxidase activities. | LIU Nan XUE Ling GUAN Yi LI Qing Zhao CAO Fu Yuan PANG Shu Lan GUAN Wei Jun | 2016 | Biomedical and Environmental Sciences2016，29，8： | 6 |
| 17 | Effect of long-term weightlessness on retina and optic nerve in tail-suspension rats显示文摘AIM: To evaluate the effect of long-term weightlessness on retina and optic nerve in tail-suspension(TS) rats.METHODS: A stimulated weightlessness model was established by suspending rats' tail. After 12 wk, the ultrastructure and the number of optic nerve axons were observed by transmission electron microscope. The number of survival retinal ganglion cells(RGCs) was calculated by fluorescent gold retrograde labeling. Retina cells apoptosis was detected by TUNEL staining. The function of optic nerve and retina was evaluated by the visual evoked potential(VEP) and oscillatory potentials(Ops).RESULTS: The optic nerve axons were swollen and sparsely aligned, and the lamellar separation and myelin disintegration occurred after 12 wk in TS rats. The density of optic nerve axons was 32.23±3.92(vs 37.43±4.13, P =0.0145), the RGCs density was 1645 ±46 cells/mm2(vs1867±54 cells/mm2P=0.0000), the incidence rate of retinal cells apoptosis was 5.38%±0.53%(vs 4.75%±0.54%, P =0.0238), the amplitude of VEP-P100 was 15.43 ±2.14 μV(vs 17.67 ±2.17 μV, P =0.0424), the latency of VEP-P100 was 69.05±5.34ms(vs 62.43±4.87 ms P =0.0143) and the sum amplitude of Ops was 81.05 ±8.34 μV(vs 91.67 ±10.21 μV, P =0.0280) in TS group and the control group,respectively.CONCLUSION: Long-term weightlessness can induce the ultrastructural changes and functional depress of the optic nerve, as well as retinal cell damages in TS rats. | Hong-Wei Zhao Jun Zhao Lian-Na Hu Jing-Nan Liang Yuan-Yuan Shi Chuang Nie Chang-Yu Qiu Xin-Shuai Nan Yu-Xin Li Fu-Lin Gao Yi Liu Yu Dong Ling Luo | 2016 | International Journal of Ophthalmology(English edition)2016，9，6： | 5 |
| 18 | The discovery and environmental significance of Chifeng wind route and huge pots of Inner Mongolia and Hebei Province显示文摘The pots discovered in Inner Mongolia and Hebei Province are huge with a maximum diameter of 9 m and a depth of 3.5 m, singular in shape,caused by weathering and wind erosion and have certain direction. They are a kind of typical climatic geomorphology. This | Zhijiu Cui Hongjiang Li Ling Nan Dewen Li | 1999 | Chinese Science Bulletin1999，44，16： | 5 |
| 19 | Microwave ablation of primary breast cancer inhibits metastatic progression in model mice via activation of natural killer cells显示文摘Surgery is essential for controlling the symptoms and complications of stage IV breast cancer.However,locoregional treatment of primary tumors often results in distant progression,including lung metastasis,the most common type of visceral metastasis.As a minimally invasive thermal therapy,microwave ablation(MWA)has been attempted in the treatment of breast cancer,but the innate immune response after MWA has not yet been reported.Using two murine models of stage IV breast cancer,we found that MWA of primary breast cancer inhibited the progression of lung metastasis and improved survival.NK cells were activated after MWA of the primary tumor and exhibited enhanced cytotoxic functions,and the cytotoxic pathways of NK cells were activated.Depletion experiments showed that NK cells but not CD4+or CD8+T cells played a pivotal role in prolonging survival.Then,we found that compared with surgery or control treatment,MWA of the primary tumor induced completely different NK-cell-related cytokine profiles.Macrophages were activated after MWA of the primary tumor and produced IL-15 that activated NK cells to inhibit the progression of metastasis.In addition,MWA of human breast cancer stimulated an autologous NK-cell response.These results demonstrate that MWA of the primary tumor in metastatic breast cancer inhibits metastatic progression via the macrophage/IL-15/NK-cell axis.MWA of the primary tumor may be a promising treatment strategy for de novo stage IV breast cancer,although further substantiation is essential for clinical testing. | Muxin Yu Hong Pan Nan Che Li Li Cong Wang Yue Wang Ge Ma Mengjia Qian Jiawei Liu Mingjie Zheng Hui Xie Lijun Ling Yi Zhao Xiaoxiang Guan Qiang Ding Wenbin Zhou Shui Wang | 2021 | Cellular & Molecular Immunology2021，18，9： | 5 |
| 20 | Source Contributions to PM2.5 under Unfavorable Weather Conditions in Guangzhou City,China显示文摘Historical haze episodes(2013–16) in Guangzhou were examined and classified according to synoptic weather systems.Four types of weather systems were found to be unfavorable, among which 'foreside of a cold front'(FC) and 'sea high pressure'(SP) were the most frequent(> 75% of the total). Targeted case studies were conducted based on an FC-affected event and an SP-affected event with the aim of understanding the characteristics of the contributions of source regions to fine particulate matter(PM_(2.5)) in Guangzhou. Four kinds of contributions—namely, emissions outside Guangdong Province(super-region), emissions from the Pearl River Delta region(PRD region), emissions from Guangzhou–Foshan–Shenzhen(GFS region), and emissions from Guangzhou(local)—were investigated using the Weather Research and Forecasting–Community Multiscale Air Quality model. The results showed that the source region contribution differed with different weather systems. SP was a stagnant weather condition, and the source region contribution ratio showed that the local region was a major contributor(37%), while the PRD region, GFS region and the super-region only contributed 8%, 2.8% and 7%, respectively, to PM_(2.5) concentrations. By contrast, FC favored regional transport. The super-region became noticeable,contributing 34.8%, while the local region decreased to 12%. A simple method was proposed to quantify the relative impact of meteorology and emissions. Meteorology had a 35% impact, compared with an impact of-18% for emissions, when comparing the FC-affected event with that of the SP. The results from this study can provide guidance to policymakers for the implementation of effective control strategies. | Nan WANG Zhenhao LING Xuejiao DENG Tao DENG Xiaopu LYU Tingyuan LI Xiaorong GAO Xi CHEN | 2018 | Advances in Atmospheric Sciences2018，35，9： | 5 |
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