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| 1 | Post-marketing safety surveillance and reevaluation of Motherwort injection:A clinical study of 10094 cases显示文摘OBJECTIVE:To investigate the safety profiles of Motherwort injection(MI).METHODS:A multi-center,prospective and drugderived hospital intensive monitoring method was conducted to assess the safety of MI in real world applications.This study was based on a very large population after the injection was approved and marketed in China.All patients using the injection in participating hospitals were monitored to determine the incidence,pattern,severity and outcome of associated adverse events.RESULTS:The post-marketing surveillance was performed in 10 094 female patients from April to December,2015.The incidence of adverse drug reactions(ADRs) was 0.79‰(8/10 094).Among the 8 patients,the reported adverse events mainly included systemic abnormalities,such as fever,chills and eyelid edema;skin and appendages disorders,such as pruritus and rash;gastrointestinal disorders,such as nausea,abdominal distension and pain;heart rate and rhythm disorders,such as palpitation and increased heart rate.All of these ADRs were mild in severity.CONCLUSION:In this study the ADRs incidence rate of MI is very low,which supports that it is generally safe for use in obstetric and gynecological diseases.However,the total number of 8 ADRs recorded over a relatively short time span seems limited,and the low number of reports could not represent an absolute guarantee of safety. | Cao Shan Zhang Wenhao Zhao Ziwei Heng Mingli Bu Huaien Wang Hongwu Liu Xinghui Wang Zhong Cai Yan Ma Yuyan Cui Shihong Deng Jihong Ding Guifeng Ding Yajuan Dong Linhong Duan Zhentao Fan Ling Fan Yang Fu Fen He Jing Ji Shuying Jin Lin Li Hong Li Hongying Liao Tao Lu Wei Luo Xiucui Lü Zhihui Ma Fengchun Ma Dafeng Shi Tianyun Sun Juying Sun Xiaotong Teng Hong Wang Jinhua Wang Ruihua Wang Ying Wang Zhengling Xi Jie Xu Minjuan Xu Zhihong Yan Qian Yang Cuirong Yang Yimei Yin Jie Yu Jinhua Yuan Wenjun Zhang Guanli Zhang Meihua Zhao Renfeng Zhong Yonghong Zhou Jian | 2018 | Journal of Traditional Chinese Medicine2018，38，4： | 4 |
| 2 | Genistein antagonizes inflammatory damage induced by β-amyloid peptide in microglia through TLR4 and NF-κB显示文摘 | Xin Zhou Linhong Yuan Xia Zhao Chengcheng Hou Weiwei Ma Huanling Yu Rong Xiao | 2014 | Nutrition2014，，： | 2 |
| 3 | Long-term effects of high lipid and high energy diet on serum lipid, brain fatty acid composition, and memory and learning ability in mice显示文摘 | Huanling Yu Yanxia Bi Weiwei Ma Lingling He Linhong Yuan Jinfang Feng Rong Xiao | 2009 | International Journal of Developmental Neuroscience2009，，3： | 1 |
| 4 | Expression of hMOF, but not HDAC4, is responsible for the global histoneH4K16 acetylation in gastric carcinoma显示文摘 | Lin Zhu Jiaxing Yang Linhong Zhao Xue Yu Lingyao Wang Fei Wang Yong Cai Jingji Jin | 2015 | International Journal of Oncology2015，，6： | 1 |
| 5 | Experimental research on oxygen-enriched gasification of straw in an entrained-flow gasifier 显示文摘 | Yu Haimiao Li Zeshen Yang Xianyu Jiang Linhong Zhang Ze Chen Dezhen | 2013 | Journal of Renewable and Sustainable Energy2013，5，05： | 1 |
| 6 | Fluid Model of Inductively Cou- pled Plasma Etcher Based on COMSOL显示文摘 | Jia C Linhong J Yu Z | 2010 | Journal of Semi- conductors2010，31，： | 1 |
| 7 | Chemical Composition and Hepatoprotective Effects of Polyphenol-Rich Extract from Houttuynia cordata Tea显示文摘 | Lingmin Tian Xiaolong Shi Linhong Yu | 2012 | J Agric Food Chem2012，60，： | 1 |
| 8 | Genistein Inhibited Amyloid-β-induced Inflammatory Damage in C6 Glial Cells显示文摘 | Xia Zhao Linhong Yuan Huanling Yu Yuandi Xi Weiwei Ma Xin Zhou Juan Ding Rong Xiao | 2013 | Archives of Medical Research2013，，： | 1 |
| 9 | Anti- tumor activities of quercetin and quercetin-5,8-disulfonate in human colon and breast cancer cell lines 显示文摘 | ZHANG Haisheng ZHANG Min YU Linhong | 2012 | Food and Chemical Toxicology2012，50，5： | 1 |
| 10 | Genistein as a neuroprotective antioxidant attenuates redox imbalance induced by-amyloid peptides 25-35 in PC12 cells 显示文摘 | MA Weiwei YUAN Linhong YU Huanling | 2010 | Devl Neurosci2010，28，4： | 1 |
| 11 | Finding maximal cliques in massive networks显示文摘 | James Cheng Yiping Ke Ada Wai-Chee Fu Jeffrey Xu Yu Linhong Zhu | 2011 | ACM Transactions on Database Systems (TODS)2011，，4： | 1 |
| 12 | Thermally assisted switching in FePt single-domain particles with a Gaussian distribution of temperature显示文摘Magnetic nanoscale systems,including nanodots,nanofibers,nanowires and nanoparticles,are currently attracting great interest due to their interesting physical and promising applications in various fields,such as magnetic recording,sensors,target drugs and catalysts,as well as others.To achieve ultrahigh recording density,the method of heat assisted magnetic recording(HAMR) has been introduced.In this work,with the help of a Monte Carlo method,the mechanisms of thermally assisted magnetization switching in FePt single-domain particles driven by an external magnetic field are investigated,where the temperature in the particles is assumed to follow a Gaussian distribution.Two nucleation modes are observed for different distributions of temperature.One is initiated by many droplets,which join each other at the boundary of the system;the other is ini-tiated by many droplets at the boundary,but in growth tending toward the inner part of the system.An inverse proportional relationship between the metastable lifetime and the distribution is also found. | TANG Ke YANG HongJie CAO LinHong YU HongTao LIU JinSong WANG JunXia | 2011 | Science China(Physics,Mechanics & Astronomy)2011，54，7： | 1 |
| 13 | Genistein as a neuroprotective antioxidant attenuates redox imbalance induced by β-amyloid peptides 25–35 in PC12 cells显示文摘 | Weiwei Ma Linhong Yuan Huanling Yu Bingjie Ding Yuandi Xi Jinfang Feng Rong Xiao | 2010 | International Journal of Developmental Neuroscience2010，，4： | 1 |
| 14 | Genistein as a neuroprotective antioxidant attenuates redox imbalance induced byl3-amyloid peptides 25-35 in PC12 cells显示文摘 | MA Weiwei YUAN Linhong YU Huanling | 2010 | lnt J Develop Neurosci2010，28，： | 1 |
| 15 | Breast Cancer Awareness and Association with Frequency of Screening Among Women—China,2020显示文摘Summary What is already known about this topic?Breast cancer awareness plays a crucial role in promoting screening attendance,enabling early detection,and improving survival rates associated with breast cancer.Nevertheless,a persistent issue is the low public awareness of breast cancer warning signs and risk factors. | Heling Bao Liyuan Liu Shu Cong Fei Wang Lixiang Yu Liwen Fang Xuening Duan Feng Tan Zhigang Yu Linhong Wang | 2023 | China CDC weekly2023，5，15： | 0 |
| 16 | Depressive Symptoms and Sleep Duration as Risk Factors for Breast Cancer—China,2020显示文摘Summary What is already known about this topic?Psychological and lifestyle factors are known to potentially play a significant role in the development of breast cancer.However,current evidence-based studies present controversial findings on the associations between depression,sleep duration,and breast cancer risk. | Liyuan Liu Heling Bao Fei Wang Lixiang Yu Shu Cong Fei Zhou Yujuan Xiang Shuya Huang Chao Zheng Liwen Fang Linhong Wang Zhigang Yu | 2023 | China CDC weekly2023，5，15： | 0 |
| 17 | Variations in the Prevalence of Anemia of Varying Severity Among Urban Non-Pregnant Women—China,2021显示文摘Summary What is already known about this topic?Anemia is a significant public health issue affecting women globally.Prior studies in China predominantly concentrated on anemia in pregnant or reproductiveage women,leaving a gap in available data concerning anemia in non-pregnant women of all age groups in China. | Xiaoxi Liu Bo Wang Sailimai Man Heling Bao Yuanyuan Huang Canqing Yu Jun Lyu Linhong Wang Liming Li Hui Liu | 2024 | China CDC weekly2024，6，10： | 0 |
| 18 | Sanguinarine Decreases Cell Stiffness and Traction Force and Inhibits the Reactivity of Airway Smooth Muscle Cells in Culture显示文摘Airway hyperresponsiveness(AHR)is the cardinal character of asthma,which involves the biomechanical properties such as cell stiffness and traction force of airway smooth muscle cells(ASMCs).Therefore,these biomechanical properties comprise logical targets of therapy.β2-adrenergic agonist is currently the mainstream drug to target ASMCs in clinical practice for treating asthma.However,this drug is known for side effects such as desensitization and non-responsiveness in some patients.Therefore,it is desirable to search for new drug agents to be alternative ofβ2-adrenergic agonist.In this context,sanguinarine,a natural product derived from plants such as bloodroots,that has been reported to relax gut smooth muscle emerges as a potential candidate.So far,it is unknown whether sanguinarine can regulate the biomechanical properties of ASMCs and reactivity of ASMCs to irritants.Thus,we tested the hypothesis that sanguinarine reduce the contractile potentials of ASMCs in culture.To do so,the primary cultured rat ASMCs were first treated with different concentration of sanguinarine.Then,cell stiffness,traction force,fiber distribution,and calcium signaling of the ASMCs were evaluated by optical magnetic twisting cytometry,Fourier transform traction microscopy,atomic force microscopy,and Fluo-4/AM based fluorescence confocal scanning microscopy,respectively.The results indicated that sanguinarine(0.05 and 0.5μmol/L)significantly decreased cell stiffness and traction force,inhibited reactivity of ASMCs to histamine,and disrupted the fiber structures in ASMCs in dose-dependent manner.These findings establish that sanguinarine can indeed change the biomechanical properties of ASMCs and may be used to treat AHR in asthma. | Mingzhi Luo Kai Ni Peili Yu Yang Jin Lei Liu Jingjing Li Yan Pan Linhong Deng | 2019 | Molecular & Cellular Biomechanics2019，16，2： | 0 |
| 19 | The Utilization of Health Examination by Menopausal and Older Women--6 Provinces,China,2018显示文摘What is already known about this topic?Improving their utilization of health examination is important for improving the health of menopausal and older women.What is added by this report?Only 32.3%and 29.7%of women had been screened for cervical cancer and breast cancer,respectively.The overall utilization rate of health examination for menopausal and older women is low.The health examination services for menopausal and older women were utilized less in the western regions and in rural areas than in the eastern and central regions and in urban areas.What are the implications for public health practice?The imbalance of development is an important factor affecting the utilization of health examination for menopausal and older women.It is necessary to take effective measures to improve the level of service utilization in the western region and rural areas,in order to narrow the gap in health between different regions. | Bo Song Jiangli Di Gengli Zhao Yu Ma Linhong Wang | 2020 | China CDC weekly2020，2，37： | 0 |
| 20 | The Nucleation Process in the Preparation of Graphene Films by Pulsed Laser Deposition显示文摘The nucleation process of graphene films prepared by pulsed laser deposition has been investigated in detail. It is found that graphene nucleates at the steps on the substrate surface firstly, from aggregation of nuclei into particles. High pulsed laser energy offers large incident energy for carbon particles deposited on the surface of the substrate, which is beneficial to the nucleation of graphene. A lot of steps are formed on the copper substrate due to the high temperature, so that the high incident energetic carbon species are able to form a stable nucleus at the steps. As the incident particles increases, the graphene nuclei are combined to grow together. Further, it is found that graphene tends to form few layer graphene particles instead of large graphene sheets. | 王进 WANG Xuemin YU Jian XIAO Tingting PENG Liping XIONG Zhengwei CAO Linhong WANG Chuanbin 沈强 | 2018 | Journal of Wuhan University of Technology(Materials Science)2018，33，2： | 0 |
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