|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Tumor cells educate mesenchymal stromal cells to release chemoprotective and immunomodulatory factors显示文摘Factors released by surrounding cells such as cancer-associated mesenchymal stromal cells(CA-MSCs)are involved in tumor progression and chemoresistance.In this study,we characterize the mechanisms by which naYve mesenchymal stromal cells(MSCs)can acquire a CA-MSCs phenotype.Ovarian tumor cells trigger the transformation of MSCs to CA-MSCs by expressing pro-tumoral genes implicated in the chemoresistance of cancer cells,resulting in the secretion of high levels of CXC chemokine receptors 1 and 2(CXCR1/2)ligands such as chemokine(C-X-C motif)ligand 1(CXCL1),CXCL2,and interleukin 8(IL-8).CXCR1/2 ligands can also inhibit the immune response against ovarian tumor cells.Indeed,through their released factors,CA-MSCs promote the differentiation of monocytes towards M2 macrophages,which favors tumor progression.When CXCR1/2 receptors are inhibited,these CA-MSC-activated macrophages lose their M2 properties and acquire an anti-tumoral phenotype.Both ex vivo and in vivo,we used a CXCR1/2 inhibitor to sensitize ovarian tumor cells to carboplatin and circumvent the pro-tumoral effects of CA-MSCs.Since high concentrations of CXCR1/2 ligands in patients*blood are associated with chemoresistance,CXCR1/2 inhibition could be a potential therapeutic strategy to revert carboplatin resistance. | Augustin Le Naour Melissa Prat Benolt Thibault Renaud Mével Léa Lemaitre Helene Leray Marie-Veronique Joubert Kimberley Coulson Muriel Golzio Lise Lefevre Eliane Mery Alejandra Martinez Gwénael Ferron Jean-Pierre Delord Agnès Coste Bettina Couderc | 2020 | Journal of Molecular Cell Biology2020，12，3： | 3 |
| 2 | Immunoadjuvants and analogues of immunomodulatory bacterial structures显示文摘 | Lise L Audibert F | 1989 | Cur Opin in Immunol1989，，2： | 1 |
| 3 | Linking service quality, customer satisfaction, and behavioral intention显示文摘 | ARCH G W LISE L F | 1989 | Journal of Health Care Marketing1989，9，4： | 1 |
| 4 | The Influence of GLP-1 on Glucose-Stimulated Insulin Secretion effects on β-Cell Sensitivity in Type 2 and Nondiabetic Subjects显示文摘 | Lise L Kjems Jens J Holst Aage Vlund | 2003 | Diabetes2003，52，： | 1 |
| 5 | Cellular interactions and signaling in cartilage development显示文摘 | De Lise AM Fischer L Tuan RS | 2000 | J Osteo Cart2000，8，5： | 1 |
| 6 | Soil carbon fractions based on their degree of oxidation, and the development of a carbon management index for agricultural systems显示文摘 | Blair G J Lefroy R D B Lise L | 1995 | Australian Journal of Soil Research1995，46，7： | 1 |
| 7 | Incidence of thyroid cancer in Italy,1991-2005:time trends and age-period-cohort effects显示文摘 | Dal Maso L Lise M Zambon P | 2011 | Ann Oncol2011，22，4： | 1 |
| 8 | Soil carbon fractions based on their degree of oxidation and the development of a carbon management index for agricultural systems显示文摘 | Blair G J Lefroy R D B Lise L | 1995 | Australian Journal of Agricultural Research1995，46，7： | 1 |
| 9 | Soil carbon fractions based on their degree of oxidation,and the development of a carbon management index for agricultural systems显示文摘 | Blair G J Rdb L Lise L | 1995 | Australian Journal of Agricultural Research1995，46，7： | 1 |
| 10 | Distribution of bacterioplankton in meromictic lake saelenvannet,as setermined by denaturing gradient gel electrophoresis of PCR-amplified gene fragments coding for 16S rRNA显示文摘 | Lise V Larry F Frida L D | 1997 | Appl Environ Microbiol1997，63，9： | 1 |
| 11 | Incidence of thyroid cancer in It- aly,1991-2005: time trends and age-period-cohort effects显示文摘 | Maso L Lise M Zambon P | 2011 | Ann Onc2011，22，： | 1 |
| 12 | Stimulation of protein synthesis and expansion of pig blastocysts by insulin in vitro显示文摘 | LEWIS A M KAYE P L LISING R | 1992 | Reprod Fertil Dev1992，4，1： | 1 |
| 13 | Incidence ofthyroid cancer in Italy, 1991-2005: time trends and ageperiod-cohort effects 显示文摘 | DAL MASO L LISE M ZAMBON P | 2011 | Ann Oncol2011，22，4： | 1 |
| 14 | Endogenous neurotrophins and Trk signaling in diffuse large B cell lymphoma cell lines are involved in sensitivity to rituximab-induced apoptosis 显示文摘 | Bellanger C Dubanet L Lise MC | 2011 | PLoS One2011，6，27： | 1 |
| 15 | lncidence of thyroid cancer in Italy, 1991-2005 : time trends and age-period-cohort effects显示文摘 | Maso L Lise M Zambon P | 2011 | Ann Onc2011，22，： | 1 |
| 16 | Clostridium difficile Infection after Allogeneic Hematopoietic Stem Cell Transplantation: Incidence, Risk Factors, and Outcome显示文摘 | Lise Willems Rapha?l Porcher Matthieu Lafaurie Isabelle Casin Marie Robin Aliénor Xhaard Anna Lisa Andreoli Paula Rodriguez-Otero Nathalie Dhedin Gérard Socié Patricia Ribaud Régis Peffault de Latour | 2012 | Biology of Blood and Marrow Transplantation2012，，8： | 1 |
| 17 | Dry deposition of reactive nitrogento marine environments:Recent advances and remaining uncer-tainties显示文摘 | SARA C PRYOR LISE L S | 2002 | Marine Pollution Bulletin2002，44，： | 1 |
| 18 | Soil carbon fractions based on their degree of oxidation, and the development of a carbon management index for agricultural systems 显示文摘 | Blair G J Lefroy R Lise L | 1995 | Australian Journal of Agricultural Research1995，46，7： | 1 |
| 19 | Organizing user search histories显示文摘 | Heasoo H Hady W L Lise G | 2012 | IEEE Transactions on Knowledge and Data Engineering2012，24，5： | 1 |
| 20 | Incidence of thyroid cancer in Italy, 1991-2005: time trends and age-period-cohort effects 显示文摘 | Dal Maso L Lise M Zambon P | 1991 | Ann Oncol1991，22，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员