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| 1 | Emergency resection surgery for colorectal cancer: Patterns of recurrent disease and survival显示文摘AIM To evaluate prognostic pathological factors associated with early metachronous disease and adverse longterm survival in these patients.METHODS Clinical and histological features were analysed retrospectively over an eight-year period for prognostic impact on recurrent disease and overall survival in patients undergoing curative resection of a primary colorectal cancer. RESULTS A total of 266 patients underwent curative surgery during the study period. The median age of the study cohort was 68 year(range 26 to 91) with a followup of 7.9 years(range 4.6 to 12.6). Resection was undertaken electively in 225(84.6%) patients and emergency resection in 35(13.2%). Data on timing of surgery was missing in 6 patients. Recurrence was noted in 67(25.2%) during the study period and was predominantly early within 3 years(82.1%) and involved hepatic metastasis in 73.1%. Emergency resection(OR = 3.60, P = 0.001), T4 stage(OR = 4.33, P < 0.001) and lymphovascular invasion(LVI) (OR = 2.37, P = 0.032) were associated with higher risk of recurrent disease. Emergency resection, T4 disease and a high lymph node ratio(LNR) were strong independent predictors of adverse long-term survival. CONCLUSION Emergency surgery is associated with adverse disease free and long-term survival. T4 disease, LVI and LNR provide strong independent predictive value of longterm outcome and can inform surveillance strategies to improve outcomes. | Joe Littlechild Muneer Junejo Anne-Marie Simons Finlay Curran Darren Subar | 2018 | World Journal of Gastrointestinal Pathophysiology2018，9，1： | 5 |
| 2 | A history of high-power laser research and development in the United Kingdom显示文摘The first demonstration of laser action in ruby was made in 1960 by T.H.Maiman of Hughes Research Laboratories,USA.Many laboratories worldwide began the search for lasers using different materials,operating at different wavelengths.In the UK,academia,industry and the central laboratories took up the challenge from the earliest days to develop these systems for a broad range of applications.This historical review looks at the contribution the UK has made to the advancement of the technology,the development of systems and components and their exploitation over the last 60 years. | Colin N.Danson Malcolm White John R.M.Barr Thomas Bett Peter Blyth David Bowley Ceri Brenner Robert J.Collins Neal Croxford A.E.Bucker Dangor Laurence Devereux Peter E.Dyer Anthony Dymoke-Bradshaw Christopher B.Edwards Paul Ewart Allister I.Ferguson John M.Girkin Denis R.Hall David C.Hanna Wayne Harris David I.Hillier Christopher J.Hooker Simon M.Hooker Nicholas Hopps Janet Hull David Hunt Dino A.Jaroszynski Mark Kempenaars Helmut Kessler Sir Peter L.Knight Steve Knight Adrian Knowles Ciaran L.S.Lewis Ken S.Lipton Abby Littlechild John Littlechild Peter Maggs Graeme P.A.Malcolm OBE Stuart P.D.Mangles William Martin Paul McKenna Richard O.Moore Clive Morrison Zulfikar Najmudin David Neely Geoff H.C.New Michael J.Norman Ted Paine Anthony W.Parker Rory R.Penman Geoff J.Pert Chris Pietraszewski Andrew Randewich Nadeem H.Rizvi Nigel Seddon MBE Zheng-Ming Sheng David Slater Roland A.Smith Christopher Spindloe Roy Taylor Gary Thomas John W.G.Tisch Justin S.Wark Colin Webb S.Mark Wiggins Dave Willford Trevor Winstone | 2021 | High Power Laser Science and Engineering2021，9，2： | 5 |
| 3 | Stereospecific -/-lac- tamase activity in a Pseudomonas fluorescens species显示文摘 | BRABBAN A D LITTLECHILD J A WISDOM R | 1996 | J ~ Microbiol1996，16，1： | 1 |
| 4 | The regulation of privatised monopolies in the UK显示文摘 | Beesley M Littlechild S | 1989 | Rand Journal of Economics1989，20，3： | 1 |
| 5 | The process of negotiating settlements at FERC显示文摘 | Stephen Littlechild | 2012 | Energy Policy 502012，，： | 1 |
| 6 | The process of negotiating settlements at FERC显示文摘 | Stephen Littlechild | 2012 | Energy Policy 502012，，： | 1 |
| 7 | Crystallization and preliminary X-ray analysis of aγ-lactamase显示文摘 | Gonsalvez I S Isupov M N Littlechild JA | 2001 | Acta Crystallogr D Biol Crystallogr2001，57，2： | 1 |
| 8 | Municipal aggregation and retail competition in the ohio energy sector显示文摘 | Littlechild S | 2008 | Journal of Regulatory Economics2008，34，2： | 1 |
| 9 | The Regulation of Privatized Monopolies in the United Kingdom 显示文摘 | BEESLEY LITTLECHILD | 1989 | RAND Journal of Economics1989，，20： | 1 |
| 10 | Crystal structure of human muscle aldolase complexed with fructose 1, 6-bisphosphate mechanistic implications显示文摘 | Dalby A Dauter Z Littlechild JA | 1999 | Protein Sci1999，8，2： | 1 |
| 11 | Two-part tariffs and consumption externalities 显示文摘 | Littlechild S C | 1975 | Bell Journal of Economics1975，，6： | 1 |
| 12 | A simple expression for the Shapley value in a special case 显示文摘 | Littlechild G Owen | 1973 | Management Science1973，20，4： | 1 |
| 13 | A further note on the nucleoous of the “airport game”显示文摘 | S. C. Littlechild G. Owen | 1976 | International Journal of Game Theory (-)1976，，2： | 1 |
| 14 | A simple expression for the nucleolus in a special case显示文摘 | Prof. S. C. Littlechild | 1974 | International Journal of Game Theory1974，，1： | 1 |
| 15 | Privatisation:Principles,Problems and Prioritives显示文摘 | Beesley M Littlechild S | | 0，，： | 1 |
| 16 | Natural methods of protein stabilization:thermostable biocatalysts显示文摘 | LITTLECHILD J A GUY J CONNELLY S | 2007 | Biochem Soc Trans2007，35，6： | 1 |
| 17 | Reflections on incentive regulation显示文摘 | Littlechild S | 2003 | Review of Network Economivs2003，2，4： | 1 |
| 18 | Stereochemis- try of the decarboxylation of α-acetolactate ( 2-hydroxy-2-meth- yl-3-oxobutanoate) by the acetolactate decarboxylase of Kleb- sieUa aerogenes 显示文摘 | Crout D H G Littlechild J Mitchell M B | 1984 | Journal of the Chemical Society1984，，： | 1 |
| 19 | 显示文摘 | | 1999 | Current Opinion in Chemical Biology1999，3，1： | 1 |
| 20 | Variability in position of the subthalamic nucleus targeted by magnetic resonance imaging and microelectrode recordings as compared to atlas co-ordinates显示文摘 | Littlechild P Varma T Eldridge P | | Stereotact Funct Neurosurg0，80，： | 1 |
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